Role of Viruses in the Pathogenesis of Multiple Sclerosis

Syncytin‐1/HERV‐W envelope is an early activation marker of leukocytes and is upregulated in multiple sclerosis patients

(2020) Marta Garcia‐Montojo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Differential Expression of HERV-W in Peripheral Blood in Multiple Sclerosis and Healthy Patients in Two Different Ethnic Groups

(2020) Rachael Tarlinton et al.   Frontiers in Pharmacology

Activated monocytes and markers of inflammation in newly diagnosed multiple sclerosis

(2020) Mikkel Carstensen et al.   IMMUNOLOGY AND CELL BIOLOGY

The spectrum of progressive multifocal leukoencephalopathy: A practical approach

(2019) Thorsten Bartsch et al.   EUROPEAN JOURNAL OF NEUROLOGY

The Interaction between Viral and Environmental Risk Factors in the Pathogenesis of Multiple Sclerosis

(2019) Rachael Tarlinton et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Do Antiretroviral Drugs Protect From Multiple Sclerosis by Inhibiting Expression of MS-Associated Retrovirus?

(2019) Elena Morandi et al.   Frontiers in Immunology

Anti-HSV-2 antibody in patients with MS and NMO

(2019) Masoud Etemadifar et al.   Multiple Sclerosis and Related Disorders

Prehensile kinematics of the marmoset monkey: Implications for the evolution of visually-guided behaviors

(2019) Dylan M. Fox et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Expression of endogenous retroviruses reflects increased usage of atypical enhancers in T cells

(2019) Saliha Azébi et al.   EMBO JOURNAL

HSV-2-encephalitis in a patient with multiple sclerosis treated with ocrelizumab

(2019) M. I. R. Dudek et al.   JOURNAL OF NEUROLOGY

Cross-reactivity between myelin oligodendrocyte glycoprotein and human endogenous retrovirus W protein: nanotechnological evidence for the potential trigger of multiple sclerosis

(2019) Vanessa de Luca et al.   MICRON

pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis

(2019) David Kremer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the origin of a pathogenic HERV-W envelope protein present in multiple sclerosis lesions

(2019) Klemens Ruprecht et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Herpes Simplex Virus 1 Induces Brain Inflammation and Multifocal Demyelination in the Cotton Rat Sigmodon hispidus

(2019) Marina S. Boukhvalova et al.   JOURNAL OF VIROLOGY

HLA DR2b-binding peptides from human endogenous retrovirus envelope, Epstein-Barr virus and brain proteins in the context of molecular mimicry in multiple sclerosis

(2019) Ranjan Ramasamy et al.   IMMUNOLOGY LETTERS

Low cytomegalovirus seroprevalence in early multiple sclerosis: a case for the ‘hygiene hypothesis’?

(2018) E. Alari-Pahissa et al.   EUROPEAN JOURNAL OF NEUROLOGY

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity

(2018) John B. Harley et al.   NATURE GENETICS

Contributions of neurotropic human herpesviruses herpes simplex virus 1 and human herpesvirus 6 to neurodegenerative disease pathology

(2018) Margot Mayer-Proschel et al.   Neural Regeneration Research

Epstein-Barr virus is present in the brain of most cases of multiple sclerosis and may engage more than just B cells

(2018) Asma Hassani et al.   PLoS One

Herpesviruses: Harmonious Pathogens but Relevant Cofactors in Other Diseases?

(2018) Sharvan Sehrawat et al.   Frontiers in Cellular and Infection Microbiology

Epstein–Barr Virus Epidemiology, Serology, and Genetic Variability of LMP-1 Oncogene Among Healthy Population: An Update

(2018) Maria K. Smatti et al.   Frontiers in Oncology

Herpes simplex virus encephalitis temporally associated with dimethyl fumarate-induced lymphopenia in a multiple sclerosis patient

(2018) Paola Perini et al.   Multiple Sclerosis and Related Disorders

Heterogeneity in association of remote herpesvirus infections and pediatric MS

(2018) Bardia Nourbakhsh et al.   Annals of Clinical and Translational Neurology

Induction of Proinflammatory Multiple Sclerosis-Associated Retrovirus Envelope Protein by Human Herpesvirus-6A and CD46 Receptor Engagement

(2018) Benjamin Charvet et al.   Frontiers in Immunology

Subsets of activated monocytes and markers of inflammation in incipient and progressed multiple sclerosis

(2017) Mikkel Carstensen Gjelstrup et al.   IMMUNOLOGY AND CELL BIOLOGY

Potential molecular mimicry between the human endogenous retrovirus W family envelope proteins and myelin proteins in multiple sclerosis

(2017) Ranjan Ramasamy et al.   IMMUNOLOGY LETTERS

Relationship of human herpes virus 6 and multiple sclerosis: A systematic review and meta-analysis

(2017) Ali Pormohammad et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Antibodies to the Epstein-Barr virus proteins BFRF3 and BRRF2 cross-react with human proteins

(2017) J. William Lindsey   JOURNAL OF NEUROIMMUNOLOGY

Low intrathecal antibody production despite high seroprevalence of Epstein–Barr virus in multiple sclerosis: a review of the literature

(2017) Klemens Ruprecht et al.   JOURNAL OF NEUROLOGY

Prevalence of a history of prior varicella/herpes zoster infection in multiple sclerosis

(2017) Ali Manouchehrinia et al.   JOURNAL OF NEUROVIROLOGY

Active CMV infection in two patients with multiple sclerosis treated with alemtuzumab

(2017) Marinella Clerico et al.   Multiple Sclerosis Journal

Epstein-Barr virus, cytomegalovirus, and multiple sclerosis susceptibility

(2017) Annette Langer-Gould et al.   NEUROLOGY

Type W Human Endogenous Retrovirus (HERV-W) Integrations and Their Mobilization by L1 Machinery: Contribution to the Human Transcriptome and Impact on the Host Physiopathology

(2017) Nicole Grandi et al.   Viruses-Basel

Suppression of IL-12p70 formation by IL-2 or following macrophage depletion causes T-cell autoreactivity leading to CNS demyelination in HSV-1-infected mice

(2017) Dhong Hyun Lee et al.   PLoS Pathogens

Active CMV infection in two patients with multiple sclerosis treated with alemtuzumab

(2017) Marinella Clerico et al.   Multiple Sclerosis Journal

The innovative development in interferon beta treatments of relapsing-remitting multiple sclerosis

(2017) Claus Madsen   Brain and Behavior

Myelin Oligodendrocyte Glycoprotein: Deciphering a Target in Inflammatory Demyelinating Diseases

(2017) Patrick Peschl et al.   Frontiers in Immunology

Human leukemia antigen-A*0201-restricted epitopes of human endogenous retrovirus W family envelope (HERV-W env) induce strong cytotoxic T lymphocyte responses

(2017) Xiaoning Tu et al.   VIROLOGICA SINICA

The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis

(2017) Elena Morandi et al.   PLoS One

Epstein-Barr virus antibodies in serum and DNA load in saliva are not associated with radiological or clinical disease activity in patients with early multiple sclerosis

(2017) René M. Gieß et al.   PLoS One

Cytomegalovirus infection exacerbates autoimmune mediated neuroinflammation

(2017) Marjan Vanheusden et al.   Scientific Reports

Recent Advances in Monoclonal Antibody Therapies for Multiple Sclerosis

(2016) Bharath Wootla et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The MRZ reaction as a highly specific marker of multiple sclerosis: re-evaluation and structured review of the literature

(2016) S. Jarius et al.   JOURNAL OF NEUROLOGY

Classification and characterization of human endogenous retroviruses; mosaic forms are common

(2016) Laura Vargiu et al.   Retrovirology

EBV Infection and Multiple Sclerosis: Lessons from a Marmoset Model

(2016) Bert A. ‘tHart et al.   TRENDS IN MOLECULAR MEDICINE

Prevalence of Cytomegalovirus in Patients With Multiple Sclerosis: A Case-Control Study in Northern Iran

(2016) Saeideh Najafi et al.   Jundishapur Journal of Microbiology

Crystal Structure of Human Herpesvirus 6B Tegument Protein U14

(2016) Bochao Wang et al.   PLoS Pathogens

The life (and death) of CD4+CD28nullT cells in inflammatory diseases

(2015) Ingrid E. Dumitriu   IMMUNOLOGY

Inflammatory response of endothelial cells to a human endogenous retrovirus associated with multiple sclerosis is mediated by TLR4

(2015) Alain Duperray et al.   INTERNATIONAL IMMUNOLOGY

Viral exposures and MS outcome in a prospective cohort of children with acquired demyelination

(2015) Naila Makhani et al.   Multiple Sclerosis Journal

Reactivation of herpesvirus under fingolimod: A case of severe herpes simplex encephalitis

(2015) N. Pfender et al.   NEUROLOGY

Cytomegalovirus: a culprit or protector in multiple sclerosis?

(2015) Marjan Vanheusden et al.   TRENDS IN MOLECULAR MEDICINE

Viral exposures and MS outcome in a prospective cohort of children with acquired demyelination

(2015) Naila Makhani et al.   Multiple Sclerosis Journal

EBNA2 Binds to Genomic Intervals Associated with Multiple Sclerosis and Overlaps with Vitamin D Receptor Occupancy

(2015) Vito A. G. Ricigliano et al.   PLoS One

EBV & HHV6 reactivation is infrequent and not associated with MS clinical course

(2014) S. Simpson et al.   ACTA NEUROLOGICA SCANDINAVICA

The participation of varicella zoster virus in relapses of multiple sclerosis

(2014) Julio Sotelo et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

First reported case of diabetes mellitus type 1 as a possible secondary autoimmune disease following alemtuzumab treatment in MS

(2014) Clas Malmeström et al.   JOURNAL OF NEUROLOGY

The neutralizing antibody GNbAC1 abrogates HERV-W envelope protein-mediated oligodendroglial maturation blockade

(2014) David Kremer et al.   Multiple Sclerosis Journal

Defining the clinical course of multiple sclerosis: The 2013 revisions

(2014) F. D. Lublin et al.   NEUROLOGY

Transcriptomic Profile Reveals Gender-Specific Molecular Mechanisms Driving Multiple Sclerosis Progression

(2014) Haritz Irizar et al.   PLoS One

HERV-W polymorphism in chromosome X is associated with multiple sclerosis risk and with differential expression of MSRV

(2014) Marta García-Montojo et al.   Retrovirology

Evidence linking HHV-6 with multiple sclerosis: an update

(2014) Emily C Leibovitch et al.   Current Opinion in Virology

The Different Clinical Effects of Anti-BLyS, Anti-APRIL and Anti-CD20 Antibodies Point at a Critical Pathogenic Role of γ-Herpesvirus Infected B Cells in the Marmoset EAE Model

(2013) S. Anwar Jagessar et al.   Journal of Neuroimmune Pharmacology

Cytomegalovirus and multiple sclerosis risk

(2013) Julia Pakpoor et al.   JOURNAL OF NEUROLOGY

Immune surveillance and response to JC virus infection and PML

(2013) Sarah Beltrami et al.   JOURNAL OF NEUROVIROLOGY

Cytomegalovirus seropositivity is negatively associated with multiple sclerosis

(2013) E Sundqvist et al.   Multiple Sclerosis Journal

The DNA Copy Number of Human Endogenous Retrovirus-W (MSRV-Type) Is Increased in Multiple Sclerosis Patients and Is Influenced by Gender and Disease Severity

(2013) Marta Garcia-Montojo et al.   PLoS One

Human Endogenous Retrovirus Protein Activates Innate Immunity and Promotes Experimental Allergic Encephalomyelitis in Mice

(2013) Hervé Perron et al.   PLoS One

Activation of MSRV-Type Endogenous Retroviruses during Infectious Mononucleosis and Epstein-Barr Virus Latency: The Missing Link with Multiple Sclerosis?

(2013) Giuseppe Mameli et al.   PLoS One

Varicella Zoster Virus (VZV)-Human Neuron Interaction

(2013) Nicholas Baird et al.   Viruses-Basel

Replication of Epstein-Barr Viral DNA

(2013) W. Hammerschmidt et al.   Cold Spring Harbor Perspectives in Biology

Genomic analysis of ERVWE2 locus in patients with multiple sclerosis: absence of genetic association but potential role of human endogenous retrovirus type W elements in molecular mimicry with myelin antigen

(2013) Guilherme S. do Olival et al.   Frontiers in Microbiology

The risk of developing multiple sclerosis in individuals seronegative for Epstein-Barr virus: a meta-analysis

(2012) J. Pakpoor et al.   Multiple Sclerosis Journal

CMV Infection Attenuates the Disease Course in a Murine Model of Multiple Sclerosis

(2012) Istvan Pirko et al.   PLoS One

Human Peripheral Blood Mononuclear Cells Exhibit Heterogeneous CD52 Expression Levels and Show Differential Sensitivity to Alemtuzumab Mediated Cytolysis

(2012) Sambasiva P. Rao et al.   PLoS One

Herpesvirus infections of the central nervous system in immunocompromised patients

(2012) Uta Meyding-Lamadé et al.   Therapeutic Advances in Neurological Disorders

Progressive Multifocal Leukoencephalopathy (PML) Development Is Associated With Mutations in JC Virus Capsid Protein VP1 That Change Its Receptor Specificity

(2011) Leonid Gorelik et al.   JOURNAL OF INFECTIOUS DISEASES

A Human Endogenous Retrovirus K dUTPase Triggers a TH1, TH17 Cytokine Response: Does It Have a Role in Psoriasis?

(2011) Maria-Eugenia Ariza et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Anti-HHV-6 IgG titer significantly predicts subsequent relapse risk in multiple sclerosis

(2011) Steve Simpson et al.   Multiple Sclerosis Journal

Common viruses associated with lower pediatric multiple sclerosis risk

(2011) E. Waubant et al.   NEUROLOGY

Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth

(2011) B. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natalizumab and Progressive Multifocal Leukoencephalopathy

(2010) Clemens Warnke et al.   ARCHIVES OF NEUROLOGY

An ATM/Chk2-Mediated DNA Damage-Responsive Signaling Pathway Suppresses Epstein-Barr Virus Transformation of Primary Human B Cells

(2010) Pavel A. Nikitin et al.   Cell Host & Microbe

Relation between Epstein-Barr virus and multiple sclerosis: analytic study of scientific production

(2010) O. Santiago et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

JC virus-induced progressive multifocal leukoencephalopathy

(2010) A Sami Saribaş et al.   Future Virology

Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis

(2010) Chen S Tan et al.   LANCET NEUROLOGY

The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro

(2010) J. H. Arbuckle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunobiology of Human Cytomegalovirus: from Bench to Bedside

(2009) T. Crough et al.   CLINICAL MICROBIOLOGY REVIEWS

Investigation of the mechanism of action of alemtuzumab in a human CD52 transgenic mouse model

(2009) Yanping Hu et al.   IMMUNOLOGY

Lymphocryptovirus phylogeny and the origins of Epstein-Barr virus

(2009) B. Ehlers et al.   JOURNAL OF GENERAL VIROLOGY

Potential Mechanisms of the Human Polyomavirus JC in Neural Oncogenesis

(2009) Luis Del Valle et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The natural history of primary progressive multiple sclerosis

(2009) M. Koch et al.   NEUROLOGY

B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity

(2009) Tomasz Brudek et al.   Retrovirology

Review: Natalizumab in the treatment of multiple sclerosis

(2009) Özgür Yaldizli et al.   Therapeutic Advances in Neurological Disorders

Predicting progression in primary progressive multiple sclerosis: A 10-year multicenter study

(2008) Zhaleh Khaleeli et al.   ANNALS OF NEUROLOGY

Effects of Retroviruses on Host Genome Function

(2008) Patric Jern et al.   Annual Review of Genetics

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

(2008) Bruce D. Trapp et al.   Annual Review of Neuroscience

Epstein-Barr virus infection and human malignancies

(2004) Gerald Niedobitek et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY