Innovative HBV Animal Models Based on the Entry Receptor NTCP

Hepatitis B virus entry into HepG2-NTCP cells requires clathrin-mediated endocytosis

(2020) Charline Herrscher et al.   CELLULAR MICROBIOLOGY

N‐terminal PreS1 Sequence Regulates Efficient Infection of Cell Culture‐generated Hepatitis B Virus

(2020) Asako Murayama et al.   HEPATOLOGY

Naturally occurring 5′ preS1 deletions markedly enhance replication and infectivity of HBV genotype B and genotype C

(2020) Jing Li et al.   GUT

Troglitazone Impedes the Oligomerization of Sodium Taurocholate Cotransporting Polypeptide and Entry of Hepatitis B Virus Into Hepatocytes

(2019) Kento Fukano et al.   Frontiers in Microbiology

Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization

(2019) Masashi Iwamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human apolipoprotein E promotes hepatitis B virus infection and production

(2019) Luhua Qiao et al.   PLoS Pathogens

The machinery for endocytosis of epidermal growth factor receptor coordinates the transport of incoming hepatitis B virus to the endosomal network

(2019) Masashi Iwamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipase inhibitor orlistat prevents hepatitis B virus infection by targeting an early step in the virus life cycle

(2018) Knud Esser et al.   ANTIVIRAL RESEARCH

A novel hepatitis B virus species discovered in capuchin monkeys sheds new light on the evolution of primate hepadnaviruses

(2018) Breno Frederico de Carvalho Dominguez Souza et al.   JOURNAL OF HEPATOLOGY

Characterisation of the hepatitis B virus cross-species transmission pattern via Na+/taurocholate co-transporting polypeptides from 11 New World and Old World primate species

(2018) Simon F. Müller et al.   PLoS One

Host functions used by hepatitis B virus to complete its life cycle: Implications for developing host-targeting agents to treat chronic hepatitis B

(2018) Bidisha Mitra et al.   ANTIVIRAL RESEARCH

Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels

(2018) Chunkyu Ko et al.   JOURNAL OF HEPATOLOGY

Evolution of Hepatitis B Virus Receptor NTCP Reveals Differential Pathogenicity and Species-Specificities of Hepadnaviruses in Primates, Rodents and Bats

(2018) Stéphanie Jacquet et al.   JOURNAL OF VIROLOGY

A Single Adaptive Mutation in Sodium Taurocholate Cotransporting Polypeptide Induced by Hepadnaviruses Determines Virus Species Specificity

(2018) Junko S Takeuchi et al.   JOURNAL OF VIROLOGY

Sodium taurocholate cotransporting polypeptide is the limiting host factor of hepatitis B virus infection in macaque and pig hepatocytes

(2017) Florian A. Lempp et al.   HEPATOLOGY

Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity

(2017) Satomi Shimura et al.   JOURNAL OF HEPATOLOGY

HBV DNA Integration: Molecular Mechanisms and Clinical Implications

(2017) Thomas Tu et al.   Viruses-Basel

Nuclear Import of Hepatitis B Virus Capsids and Genome

(2017) Lara Gallucci et al.   Viruses-Basel

Complete and Incomplete Hepatitis B Virus Particles: Formation, Function, and Application

(2017) Jianming Hu et al.   Viruses-Basel

Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques

(2017) Benjamin J. Burwitz et al.   Nature Communications

Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP

(2017) Joanne M. Donkers et al.   Scientific Reports

Short Communication: Comparative Evaluation of Coformulated Injectable Combination Antiretroviral Therapy Regimens in Simian Immunodeficiency Virus-Infected Rhesus Macaques

(2016) Gregory Q. Del Prete et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

The hepatitis delta virus: Replication and pathogenesis

(2016) Camille Sureau et al.   JOURNAL OF HEPATOLOGY

Attacking hepatitis B virus cccDNA – The holy grail to hepatitis B cure

(2016) Julie Lucifora et al.   JOURNAL OF HEPATOLOGY

Modification of Three Amino Acids in Sodium Taurocholate Cotransporting Polypeptide Renders Mice Susceptible to Infection with Hepatitis D VirusIn Vivo

(2016) Wenhui He et al.   JOURNAL OF VIROLOGY

Cell Culture Models for the Investigation of Hepatitis B and D Virus Infection

(2016) Eloi Verrier et al.   Viruses-Basel

The FDA approved drug irbesartan inhibits HBV-infection in HepG2 cells stably expressing sodium taurocholate co-transporting polypeptide

(2015) Chunkyu Ko et al.   ANTIVIRAL THERAPY

A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses

(2015) Eloi R. Verrier et al.   HEPATOLOGY

A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide

(2015) Manabu Kaneko et al.   JOURNAL OF VIROLOGY

Use of FDA approved therapeutics with hNTCP metabolic inhibitory properties to impair the HDV lifecycle

(2014) Matthieu Blanchet et al.   ANTIVIRAL RESEARCH

HBV life cycle is restricted in mouse hepatocytes expressing human NTCP

(2014) Hanjie Li et al.   Cellular & Molecular Immunology

Kinetics of the bile acid transporter and hepatitis B virus receptor Na+/taurocholate cotransporting polypeptide (NTCP) in hepatocytes

(2014) Alexander König et al.   JOURNAL OF HEPATOLOGY

Hepatitis B Virus Infection and Immunopathogenesis in a Humanized Mouse Model: Induction of Human-Specific Liver Fibrosis and M2-Like Macrophages

(2014) Moses T. Bility et al.   PLoS Pathogens

Hepatitis B virus hepatotropism is mediated by specific receptor recognition in the liver and not restricted to susceptible hosts

(2013) Alexa Schieck et al.   HEPATOLOGY

Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP)

(2013) Koichi Watashi et al.   HEPATOLOGY

Cyclosporin A inhibits hepatitis B and hepatitis D virus entry by cyclophilin-independent interference with the NTCP receptor

(2013) Shirin Nkongolo et al.   JOURNAL OF HEPATOLOGY

Molecular Determinants of Hepatitis B and D Virus Entry Restriction in Mouse Sodium Taurocholate Cotransporting Polypeptide

(2013) H. Yan et al.   JOURNAL OF VIROLOGY

Regulation of Hepatitis B Virus Infection by Rab5, Rab7, and the Endolysosomal Compartment

(2013) A. Macovei et al.   JOURNAL OF VIROLOGY

Sodium Taurocholate Cotransporting Polypeptide Mediates Woolly Monkey Hepatitis B Virus Infection of Tupaia Hepatocytes

(2013) G. Zhong et al.   JOURNAL OF VIROLOGY

Ezetimibe blocks hepatitis B virus infection after virus uptake into hepatocytes

(2012) Julie Lucifora et al.   ANTIVIRAL RESEARCH

A conformational heparan sulfate binding site essential to infectivity overlaps with the conserved hepatitis B virus A-determinant

(2012) Camille Sureau et al.   HEPATOLOGY

Myristoylated PreS1-domain of the hepatitis B virus L-protein mediates specific binding to differentiated hepatocytes

(2012) Anja Meier et al.   HEPATOLOGY

IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome

(2012) Laura Belloni et al.   JOURNAL OF CLINICAL INVESTIGATION

A New Class of Synthetic Peptide Inhibitors Blocks Attachment and Entry of Human Pathogenic Viruses

(2012) Marcel Krepstakies et al.   JOURNAL OF INFECTIOUS DISEASES

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

(2012) Huan Yan et al.   eLife

A Humanized Mouse Model to Study Hepatitis C Virus Infection, Immune Response, and Liver Disease

(2011) Michael L. Washburn et al.   GASTROENTEROLOGY

Bile acid transporters

(2009) Paul A. Dawson et al.   JOURNAL OF LIPID RESEARCH

The Size of the Viral Inoculum Contributes to the Outcome of Hepatitis B Virus Infection

(2009) S. Asabe et al.   JOURNAL OF VIROLOGY

Fine Mapping of Pre-S Sequence Requirements for Hepatitis B Virus Large Envelope Protein-Mediated Receptor Interaction

(2009) A. Schulze et al.   JOURNAL OF VIROLOGY