☆ 4.5 Article

Vaccination with dendritic cells pulsed ex vivo with gp100 peptide-decorated liposomes enhances the efficacy of anti PD-1 therapy in a mouse model of melanoma

VACCINE (2020)

Journal

VACCINE

Volume 38, Issue 35, Pages 5665-5677

Publisher

ELSEVIER SCI LTD

DOI: 10.1016/j.vaccine.2020.06.055

Keywords

Melanoma; DC-based vaccine; Liposome; Gp100; PD-1 monoclonal antibody

Categories

Immunology Medicine, Research & Experimental

Funding

Kashan University of Medical Sciences [9523]
Mashhad University of Medical Science [941426]

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Abstract

Background: Targeting antigens to dendritic cells (DCs) via nanoparticles is a powerful strategy which improves the efficacy of ex vivo antigen-pulsed DC vaccines. Methods: In this study, liposomes were first decorated with gp100(25-33) self-antigen and then characterized. Then, DCs were pulsed ex vivo with liposomal gp100 and injected subcutaneously in mice bearing B16F10 established melanoma tumors in combination with anti-PD-1 therapy. Results: Treatment with liposomal pulsed DC vaccine elicited the strongest anticancer immunity and enhanced intratumoral immune responses based on infiltration of gp100-specific CD4+ and CD8+ T cells to the tumor leading to significant tumor growth regression and prolonged survival rate. Treatment with liposomal pulsed DC vaccine also markedly enhanced specific cytotoxic T lymphocytes (CTL) responses with a significant higher titer of IFN-gamma in the spleen. Moreover, a significant increase of PD-1 expressing CD8+ tumor infiltrating lymphocytes (TILs) was detected in tumors. Conclusion: Our results demonstrate an optimum dose of liposomal gp100 significantly increases the efficacy of anti-PD-1 therapy in mice and might be an effective strategy to overcome resistance to anti-PD-1 therapy. (C) 2020 Elsevier Ltd. All rights reserved.

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Prada, Sanjay Prakash, Zahiruddin Quazi Syed, Hedley Quintana, Navid Rabiee, Mohammad Rabiee, Amir Radfar, Alireza Rafiei, Fakher Rahim, Fatemeh Rajati, Muhammed Ahmed Rameto, Kiana Ramezanzadeh, Chhabi Lal Ranabhat, Sowmya J. Rao, Davide Rasella, Prateek Rastogi, Priya Rathi, Salman Rawaf, David Laith Rawaf, Lal Rawal, Reza Rawassizadeh, Ramu Rawat, Vishnu Renjith, Andre M. N. Renzaho, Bhageerathy Reshmi, Melese Abate Reta, Nima Rezaei, Mohammad Sadegh Rezai, Aziz Rezapour, Seyed Mohammad Riahi, Ana Isabel Ribeiro, Jennifer Rickard, Maria Rios-Blancas, Carlos Miguel Rios-Gonzalez, Leonardo Roever, Morteza Rostamian, Salvatore Rubino, Godfrey M. Rwegerera, Anas M. Saad, Seyedmohammad Saadatagah, Siamak Sabour, Ehsan Sadeghi, Sahar Saeedi Moghaddam, Shahram Saeidi, Rajesh Sagar, Amirhossein Sahebkar, Mohammad Ali Sahraian, S. Mohammad Sajadi, Mohammad Reza Salahshoor, Nasir Salam, Hosni Salem, Marwa Rashad Salem, Joshua A. Salomon, Hossein Samadi Kafil, Evanson Zondani Sambala, Abdallah M. Samy, Sivan Yegnanarayana Iyer Saraswathy, Rodrigo Sarmiento-Suarez, Satish Saroshe, Benn Sartorius, Arash Sarveazad, Brijesh Sathian, Thirunavukkarasu Sathish, Lauren E. Schaeffer, David C. Schwebel, Subramanian Senthilkumaran, Hosein Shabaninejad, Saeed Shahabi, Amira A. Shaheen, Masood Ali Shaikh, Ali S. Shalash, Mehran Shams-Beyranvand, MohammadBagher Shamsi, Morteza Shamsizadeh, Kiomars Sharafi, Hamid Sharifi, Aziz Sheikh, Abbas Sheikhtaheri, Ranjitha S. Shetty, Wondimeneh Shibabaw Shiferaw, Mika Shigematsu, Jae Il Shin, Reza Shirkoohi, Soraya Siabani, Tariq Jamal Siddiqi, Jonathan I. S. Silverberg, Biagio Simonetti, Jasvinder A. Singh, Dhirendra Narain Sinha, Abiy H. Sinke, Amin Soheili, Anton Sokhan, Shahin Soltani, Moslem Soofi, Muluken Bekele Sorrie, Ireneous N. Soyiri, Adel Spotin, Emma Elizabeth Spurlock, Chandrashekhar T. Sreeramareddy, Agus Sudaryanto, Mu'awiyyah Babale Sufiyan, Hafiz Ansar Rasul Suleria, Rizwan Suliankatchi Abdulkader, Amir Taherkhani, Leili Tapak, Nuno Taveira, Parvaneh Taymoori, Yonatal Mesfin Tefera, Arash Tehrani-Banih Ashemi, Berhane Fseha Teklehaimanot, Gebretsadkan Hintsa Tekulu, Berhe Etsay Tesfay, Zemenu Tadesse Tessema, Belay Tessema, Kavumpurathu Raman Thankappan, Hamid Reza Tohidinik, Roman Topor-Madry, Marcos Roberto Tova Ni-Palone, Bach Xuan Tran, Riaz Uddin, Irfan Ullah, Chukwuma David Umeokonkwo, Bhaskaran Unnikrishnan, Era Upadhyay, Muhammad Shariq Usman, Maryam Vaezi, Sahel Valadan Tahbaz, Pascual R. Valdez, Yasser Vasseghian, Yousef Veisani, Francesco S. Violante, Sebastian Vollmer, Yasir Waheed, Jon Wakefield, Yafeng Wang, Yuan-Pang Wang, Girmay Teklay Weldesamuel, Andrea Werdecker, Ronny Westerman, Taweewat Wiangkham, Kirsten E. Wiens, Charles Shey Wiysonge, Gebremariam Woldu, Dawit Zewdu Wondafrash, Tewodros Eshete Wonde, Ai-Min Wu, Ali Yadollahpour, Seyed Hossein Yahyazadeh Jabbari, Tomohide Yamada, Sanni Yaya, Vahid Yazdi-Feyzabadi, Tomas Y. Yeheyis, Yigizie Yeshaw, Christopher Sabo Yilgwan, Paul Yip, Naohiro Yonemoto, Mustafa Z. Younis, Zabihollah Yousefi, Mahmoud Yousefifard, Taraneh Yousefinezhadi, Chuanhua Yu, Hasan Yusefzadeh, Siddhesh Zadey, Telma Zahirian Moghadam, Leila Zaki, Sojib Bin Zaman, Mohammad Zamani, Maryam Zamanian, Hamed Zandian, Alireza Zangeneh, Fatemeh Zarei, Taddese Alemu Zerfu, Yunquan Zhang, Zhi-Jiang Zhang, Xiu-Ju George Zhao, Maigeng Zhou, Arash Ziapour, Simon I. Hay, Stephen S. Lim, Jonathan F. Mosser

Summary: Despite the global recommendation of the safe and effective measles vaccine since 1974, there were over 17 million cases of measles in 2017, with the majority occurring in low- and middle-income countries. A study from 2000 to 2019 in 101 LMICs showed that after gains in measles vaccine coverage from 2000 to 2010, there was regression in coverage in over half of the districts from 2010 to 2019, with rural areas having lower coverage than urban areas.

NATURE (2021)

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Review Cardiac & Cardiovascular Systems

Pivotal Role of TGF-β/Smad Signaling in Cardiac Fibrosis: Non-coding RNAs as Effectual Players

Somayeh Saadat, Mahdi Noureddini, Maryam Mahjoubin-Tehran, Sina Nazemi, Layla Shojaie, Michael Aschner, Behnaz Maleki, Mohammad Abbasi-kolli, Hasan Rajabi Moghadam, Behrang Alani, Hamed Mirzaei

Summary: TGF-β induces cardiac fibrosis through activation of cytokines and growth factors, stimulating fibroblast proliferation and ECM protein production via canonical and non-canonical signaling pathways. Non-coding RNAs play crucial roles in regulating these processes, suggesting potential for new diagnostic and therapeutic approaches for cardiac disorders.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Article Allergy

Association of rs3135500 and rs3135499 Polymorphisms in the MicroRNA-binding Site of Nucleotide-binding Oligomerization Domain 2 (NOD2) Gene with Susceptibility to Rheumatoid Arthritis

Naeim Ehtesham, Behrang Alani, Deniz Mortazavi, Sara Azhdari, Taiebe Kenarangi, Emran Esmaeilzadeh, Bahram Pakzad

Summary: The study found a significant association between NOD2 gene SNPs rs3135500 and the risk of rheumatoid arthritis, as well as a relationship with disease activity in patients.

IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY (2021)

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Article Microbiology

The combined effect of stressful factors (temperature and pH) on the expression of biofilm, stress, and virulence genes in Salmonella enterica ser. Enteritidis and Typhimurium

Fereshteh Badie, Mahmood Saffari, Rezvan Moniri, Behrang Alani, Fatemeh Atoof, Ahmad Khorshidi, Mohammad Shayestehpour

Summary: The study evaluated the combined effects of temperature and pH on the expression of biofilm, stress, and virulence genes in Salmonella Enteritidis and Salmonella Typhimurium. The findings indicated that temperature and pH did not have a significant effect on the gene expression levels in these Salmonella strains.

ARCHIVES OF MICROBIOLOGY (2021)

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Article Rheumatology

Strong association of common variants in the miRNA-binding site of NOD2 gene with clinicopathological characteristics and disease activity of systemic lupus erythematosus

Emran Esmaeilzadeh, Mostafa Saghi, Mehdi Hassani, Saeideh Davar, Behrang Alani, Bahram Pakzad, Sepideh Ghobakhloo, Sharifeh Khosravi, Mehrdad Nasrollahzadeh Sabet

Summary: The study found no significant association between NOD2 gene polymorphisms rs3135500 and rs3135499 with SLE risk in the Iranian population. However, these polymorphisms were associated with laboratory factors related to disease activity and some clinical manifestations associated with disease severity.

CLINICAL RHEUMATOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Mesenchymal stem cell (MSC)-derived exosomes as novel vehicles for delivery of miRNAs in cancer therapy

Behnoush Sohrabi, Behnaz Dayeri, Elahe Zahedi, Shahrouz Khoshbakht, Najme Nezamabadi Pour, Hamta Ranjbar, Abolfazl Davari Nejad, Mahdi Noureddini, Behrang Alani

Summary: Mesenchymal stem cells (MSCs) have potential in cancer therapy and can be used as vehicles in cancer gene therapy. MSC-derived exosomes, as novel cell-free alternatives to MSC-based cell therapy, have advantages in safety, stability, and convenience. Unmodified MSC-derived exosomes can promote or inhibit tumors, while modified exosomes can suppress cancer development by delivering therapeutic molecules.

CANCER GENE THERAPY (2022)

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Article Pathology

MicroRNAs and exosomes: Cardiac stem cells in heart diseases

Behnaz Maleki, Behrang Alani, Seyed Saeed Tamehri Zadeh, Somayeh Saadat, Ali Rajabi, Seyed Mohammad Jalal Ayoubzadeh, Javad Verdi, Alireza Farrokhian, Hossein Ghanbarian, Mahdi Noureddini, Majid Nejati

Summary: Treating cardiovascular diseases with CSCs is effective, but the molecular pathways that regulate their functions are not fully understood. miRNAs may play a crucial role in regulating CSC behavior, and studying the secretome of these cells can provide valuable insights into their functions.

PATHOLOGY RESEARCH AND PRACTICE (2022)

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Article Cell Biology

LncRNA-miRNA network analysis across the Th17 cell line reveals biomarker potency of lncRNA NEAT1 and KCNQ1OT1 in multiple sclerosis

Elham Karimi, Hanieh Azari, Ahmad Tahmasebi, Amin Reza Nikpoor, Ahmad Agha Negahi, Nima Sanadgol, Mohammad Shekari, Pegah Mousavi

Summary: This study analyzed the lncRNA-miRNA network involved in multiple sclerosis (MS) and its role in the differentiation of Th17 cells. The results showed dysregulated expression of key genes related to the pathogenesis of MS.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

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Article Rheumatology

Assessment of the association between TNIP1 polymorphism with clinical features and risk of systemic lupus erythematosus

Sara Azhdari, Mostafa Saghi, Behrang Alani, Maryam Zare Rafie, Taiebe Kenarangi, Mehrdad Nasrollahzadeh Sabet, Bahram Pakzad, Tahereh Ghorashi, Milad Gholami, Mohsen Soosanabadi

Summary: This study evaluated the association between TNIP1 gene rs6889239 polymorphism and the risk and clinical characteristics of RA and SLE in the Iranian population. The results showed a significant association between the CC genotype and C allele of rs6889239 with an increased risk of SLE. However, there was no significant association between genotypes and allele frequencies of rs6889239 with the occurrence risk of RA. Stratification analysis also revealed a link between the C allele in rs6889239 and renal involvement in SLE patients and lower age of onset in the RA group.

LUPUS (2022)

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Article Biochemistry & Molecular Biology

Cinnamaldehyde Regulates Insulin and Caspase-3 Signaling Pathways in the Sporadic Alzheimer's Disease Model: Involvement of Hippocampal Function via IRS-1, Akt, and GSK-3β Phosphorylation

Saeid Bagheri-Mohammadi, Sahar Askari, Behrang Alani, Maryam Moosavi, Rasoul Ghasemi

Summary: This study investigated the regulatory effects of cinnamaldehyde on insulin and caspase-3 signaling pathways in an Alzheimer's disease (AD) rat model. The results demonstrated that cinnamaldehyde could improve memory deficits and anxiety-like behavior, and modulate the IRS-1/AKT/GSK-3β signaling pathway and inhibit Aβ aggregation and caspase-3 cleavage in the hippocampus. These findings suggest that cinnamaldehyde may have therapeutic potential for AD treatment.

JOURNAL OF MOLECULAR NEUROSCIENCE (2022)

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Article Cell Biology

Study of frequency and inheritance model of ACE1 I/D and ACE2 rs2285666 polymorphisms in COVID-19 patients with varying severity of lung involvement and its effect on serum cytokines levels

Shirin Beyranvand, Parivash Davoodian, Hesam Alizade, Hamed Gouklani, Azim Nejatizadeh, Ebrahim Eftekhar, Amin Reza Nikpoor

Summary: This study aimed to evaluate the frequency and inheritance of ACE1 I/D and ACE2 rs2285666 polymorphisms in COVID-19 patients and their impact on disease severity and cytokine levels. The results showed no significant association between ACE2 rs2285666 polymorphism genotypes and ACE1 I/D with the severity of lung involvement. However, there was a significant association between ACE1 I/D polymorphism genotypes and IL-6, WBC, and NLR levels.

CELL BIOLOGY INTERNATIONAL (2023)

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Article Behavioral Sciences

The effect of vitamin D on morphine preference in rats: Possible biochemical and DRD2-GDNF signaling

Mahbubeh Saeedfar, Abolfazl Ardjmand, Behrang Alani, Amir Ghaderi, Hamid Reza Banafshe, Mohammad Esmaeil Shahaboddin, Gholamreza Ghavipanjeh

Summary: Vitamin D has been found to be associated with substance abuse and dependence, potentially through its effect on dopamine signaling pathway. The study suggests that vitamin D can be considered as an effective therapeutic approach for narcotic addiction and substance abuse. These findings have important implications for the treatment of drug addiction.

BRAIN AND BEHAVIOR (2023)

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Article Biochemistry & Molecular Biology

Silymarin pretreatment protects against ethanol-induced memory impairment: Biochemical and histopathological evidence

A. Jabbari, B. Alani, A. Arjmand, T. Mazoochi, N. Kheiripour, A. Ardjmand

Summary: This study investigated the effects of ethanol on memory impairment and the neuroprotective role of silymarin. The results showed that ethanol caused memory deficits and increased oxidative stress and hippocampal apoptosis. However, administration of silymarin alleviated these adverse effects induced by ethanol.

JOURNAL OF CHEMICAL NEUROANATOMY (2023)

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Article Medicine, Research & Experimental

Molecular typing of clinical and environmental isolates of Klebsiella pneumoniae producing ESBLs by PFGE

Mohammad Esmaeilnia, Mahmood Saffari, Somaye Rashki, Zeynab Marzhoseyni, Azad Khaledi, Gholam Abbas Moosavi, Fatemeh Atoof, Behrang Alani

Summary: This study investigated the molecular typing of extended-spectrum beta-lactamase (ESBL) producing Klebsiella pneumoniae isolates from Beheshti Hospital in Iran. The results showed that there was a common molecular signature among both clinical and environmental K. pneumoniae isolates, indicating a similar genotype and likely a common origin. Therefore, it is important for hospitals to implement effective infection control systems to reduce the spread of ESBL strains.

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES (2022)

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