Article
Genetics & Heredity
Shuo Huang, Fengyuan Tian, Xiaoxuan Yang, Sijia Fang, Yongsheng Fan, Jie Bao
Summary: This study found no causal relationship between physical activity and systemic lupus erythematosus among European populations, according to a two-sample Mendelian randomization analysis.
FRONTIERS IN GENETICS
(2022)
Article
Rheumatology
Jianzhao Zhai, Ping Zhang, Naidan Zhang, Yubin Luo, Yongkang Wu
Summary: The study revealed that the PHLDB1 rs7389T/G and WDFY4 rs7097397G/A polymorphisms were associated with SLE susceptibility in western China. The rs7389T/G variant was linked to increased TNF-alpha levels, while the rs7097397G/A variant was correlated with decreased IL-1 beta and IL-6 levels as well as an elevated positive rate of antinuclear antibodies.
CLINICAL RHEUMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Yuan-yuan Qi, Yan Cui, Hui Lang, Ya-ling Zhai, Xiao-xue Zhang, Xiao-yang Wang, Xin-ran Liu, Ya-fei Zhao, Xiang-hui Ning, Zhan-zheng Zhao
Summary: Genetic studies have linked the rs10947540 single-nucleotide polymorphism (SNP) in the ZNF76 gene with susceptibility to systemic lupus erythematosus (SLE) in Chinese populations. Carrier individuals of the C allele of rs10947540 were found to have a higher risk of developing SLE with elevated levels of serum creatinine. Bioinformatic analysis revealed a correlation between this SNP and decreased expression of ZNF76, suggesting a potential role in the pathogenesis of SLE.
SCIENTIFIC REPORTS
(2021)
Review
Rheumatology
Mary K. Crow
Summary: Research has identified type I interferon (IFN-I) and autoantibodies targeting nucleic acids and nucleic acid-binding proteins as fundamental contributors to the pathogenesis of systemic lupus erythematosus (SLE). This review summarizes recent genetic analyses of SLE patients and current studies on innate and adaptive immune function, which contribute to sustained IFN-I pathway activation, immune activation, autoantibody production, inflammatory mediator generation, and tissue damage. The goal of these studies is to understand disease mechanisms, identify therapeutic targets, and develop better treatments for patients.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Qing Zhang, Ruifang Wu, Yixin Tan, Junke Huang, Shuaihantian Luo
Summary: This study aimed to evaluate the association between IFI44L rs273259 polymorphism and the susceptibility and clinical characteristics of Systemic lupus erythematosus (SLE) in a Chinese population. The results showed significant differences in the genotype and allele frequencies of IFI44L rs273259 between SLE patients and healthy controls. IFI44L rs273259 polymorphism was associated with clinical characteristics of SLE including malar rash, discoid rash, lupus nephritis, and anti-Smith antibodies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria Radanova, Mariya Levkova, Galya Mihaylova, Rostislav Manev, Margarita Maneva, Rossen Hadgiev, Nikolay Conev, Ivan Donev
Summary: There is a growing interest in studying single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, as they may be associated with susceptibility, prognosis, and treatment response in colorectal cancer (CRC). These miRNA-SNPs could serve as non-invasive biomarkers for early detection of CRC. However, contradictory findings have been reported when different research groups investigated the same SNP in a gene for a specific miRNA, highlighting the need for more case-control studies involving participants from different ethnic backgrounds. According to our review, three miRNA-SNPs - miR-146a rs2910164, miR-27a rs895819, and miR-608 rs4919510 - appear to be promising prognostic, diagnostic, and predictive biomarkers for CRC.
Article
Public, Environmental & Occupational Health
Mansour Karimifar, Nafiseh Sereshti, Rasoul Salehi, Maryam Mousavi, Hadi Karimzadeh, Amirhossein Salehi, Bahram Pakzad
Summary: This study demonstrated a significant association between the rs6445975 polymorphism in the PXK gene and susceptibility to SLE as well as clinical characteristics in the Iranian population. The GG and TG genotypes were associated with an increased risk of SLE, and individuals carrying the G allele were more susceptible to SLE. Furthermore, the G allele was correlated with serum markers and clinical manifestations.
IRANIAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Rheumatology
Xianyong Yin, Kwangwoo Kim, Hiroyuki Suetsugu, So-Young Bang, Leilei Wen, Masaru Koido, Eunji Ha, Lu Liu, Yuma Sakamoto, Sungsin Jo, Rui-Xue Leng, Nao Otomo, Viktoryia Laurynenka, Young-Chang Kwon, Yujun Sheng, Nobuhiko Sugano, Mi Yeong Hwang, Weiran Li, Masaya Mukai, Kyungheon Yoon, Minglong Cai, Kazuyoshi Ishigaki, Won Tae Chung, He Huang, Daisuke Takahashi, Shin-Seok Lee, Mengwei Wang, Kohei Karino, Seung-Cheol Shim, Xiaodong Zheng, Tomoya Miyamura, Young Mo Kang, Dongqing Ye, Junichi Nakamura, Chang-Hee Suh, Yuanjia Tang, Goro Motomura, Yong-Beom Park, Huihua Ding, Takeshi Kuroda, Jung-Yoon Choe, Chengxu Li, Hiroaki Niiro, Youngho Park, Changbing Shen, Takeshi Miyamoto, Ga-Young Ahn, Wenmin Fei, Tsutomu Takeuchi, Jung-Min Shin, Keke Li, Yasushi Kawaguchi, Yeon-Kyung Lee, Yongfei Wang, Koichi Amano, Dae Jin Park, Wanling Yang, Yoshifumi Tada, Ken Yamaji, Masato Shimizu, Takashi Atsumi, Akari Suzuki, Takayuki Sumida, Yukinori Okada, Koichi Matsuda, Keitaro Matsuo, Yuta Kochi, Leah C. Kottyan, Matthew T. Weirauch, Sreeja Parameswaran, Shruti Eswar, Hanan Salim, Xiaoting Chen, Kazuhiko Yamamoto, John B. Harley, Koichiro Ohmura, Tae-Hwan Kim, Sen Yang, Takuaki Yamamoto, Bong-Jo Kim, Nan Shen, Shiro Ikegawa, Hye-Soon Lee, Xuejun Zhang, Chikashi Terao, Yong Cui, Sang-Cheol Bae
Summary: This study conducted the largest genome-wide meta-analysis for SLE in East Asian populations, identifying 46 novel loci and prioritizing putative causal variants using Bayesian statistical approach. The findings highlight the power of large-scale genetic discovery in shedding light on the genetic and biological understandings of SLE.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Immunology
Ding-Ping Chen, Wei-Tzu Lin, Kuang-Hui Yu
Summary: This study investigated the correlation between SLE and the genetic polymorphisms of co-stimulatory/co-inhibitory molecules, and found nine SNPs associated with SLE. These SNPs play an important role in immune regulation and pathogenic mechanisms.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Wenyu Xu, Yueyue Zhang, Xiaoqin Wang, Peiyu Liu, Dayu Gao, Bingjie Gu, Junyu Zhang, Chunmei Li, Qijie Ren, Leilei Yang, Hai Yuan, Minning Shen, Xingguo Chen
Summary: The study found that SLE patients harboring the CD11b rs1143679 polymorphism exhibited significant differences in 24-hour urinary protein levels and serum C3 levels, along with higher expression levels of type I interferon-inducible genes. These findings suggest that the rs1143679 SNP may precipitate relapses in inactive SLE patients.
CLINICAL RHEUMATOLOGY
(2021)
Article
Rheumatology
Xianyong Yin, Kwangwoo Kim, Hiroyuki Suetsugu, So-Young Bang, Leilei Wen, Masaru Koido, Eunji Ha, Lu Liu, Yuma Sakamoto, Sungsin Jo, Rui-Xue Leng, Nao Otomo, Young-Chang Kwon, Yujun Sheng, Nobuhiko Sugano, Mi Yeong Hwang, Weiran Li, Masaya Mukai, Kyungheon Yoon, Minglong Cai, Kazuyoshi Ishigaki, Won Tae Chung, He Huang, Daisuke Takahashi, Shin-Seok Lee, Mengwei Wang, Kohei Karino, Seung-Cheol Shim, Xiaodong Zheng, Tomoya Miyamura, Young Mo Kang, Dongqing Ye, Junichi Nakamura, Chang-Hee Suh, Yuanjia Tang, Goro Motomura, Yong-Beom Park, Huihua Ding, Takeshi Kuroda, Jung-Yoon Choe, Chengxu Li, Hiroaki Niiro, Youngho Park, Changbing Shen, Takeshi Miyamoto, Ga-Young Ahn, Wenmin Fei, Tsutomu Takeuchi, Jung-Min Shin, Keke Li, Yasushi Kawaguchi, Yeon-Kyung Lee, Yong-Fei Wang, Koichi Amano, Dae Jin Park, Wanling Yang, Yoshifumi Tada, Yu Lung Lau, Ken Yamaji, Zhengwei Zhu, Masato Shimizu, Takashi Atsumi, Akari Suzuki, Takayuki Sumida, Yukinori Okada, Koichi Matsuda, Keitaro Matsuo, Yuta Kochi, Kazuhiko Yamamoto, Koichiro Ohmura, Tae-Hwan Kim, Sen Yang, Takuaki Yamamoto, Bong-Jo Kim, Nan Shen, Shiro Ikegawa, Hye-Soon Lee, Xuejun Zhang, Chikashi Terao, Yong Cui, Sang-Cheol Bae
Summary: By combining genome-wide association studies and transcriptome-wide association studies, we identified candidate genes associated with systemic lupus erythematosus and discovered a strong association between the CD83 gene and SLE. We also identified 276 gene candidates at the 110 SLE loci and demonstrated a regulatory effect of a putative causal variant on the ACAP1 gene.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Medicine, Research & Experimental
Weijie Wang, Xinchang Wang, Kepeng Yang, Yongsheng Fan
Summary: This study showed that the polymorphisms of BCL2 and the IL19 SNP rs2243188 are closely related to the pathogenesis of SLE. Carrying specific genotypes of these genes may increase the risk of developing SLE.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Rheumatology
Yasser B. M. Ali, Basima A. El-Akhras, R. El-Shazly, Iman H. Bassyouni
Summary: Cytokine polymorphisms are associated with SLE pathogenicity, including the important cytokine IL-27. A study on Egyptian population showed that the TG genotype and G allele of the IL-27p28 gene may be risk factors for SLE susceptibility.
CLINICAL RHEUMATOLOGY
(2021)
Article
Rheumatology
G. Olivieri, F. Ceccarelli, C. Perricone, C. Ciccacci, C. Pirone, F. Natalucci, F. R. Spinelli, C. Alessandri, P. Borgiani, F. Conti
Summary: Fever has been included as a new classification criterion for systemic lupus erythematosus (SLE). This study explored the association of fever with other clinical manifestations and found significant correlations with serositis and hematological manifestations. A specific SNP (rs13361189) in the IRGM gene was also found to be associated with fever.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Immunology
Melissa Northcott, Linden J. Gearing, Julie Bonin, Rachel Koelmeyer, Alberta Hoi, Paul J. Hertzog, Eric F. Morand
Summary: The effects of medication on gene module expression in SLE patients are significant, emphasizing the need to control for medication exposure in studies of gene expression in SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Mona Yazdani, Mahmoud Reza Jaafari, Javad Verdi, Behrang Alani, Mahdi Noureddini, Ali Badiee
Review
Biotechnology & Applied Microbiology
Mohammad Reza Karimzadeh, Peyman Pourdavoud, Naeim Ehtesham, Mohaddese Qadbeigi, Masood Movahedi Asl, Behrang Alani, Meysam Mosallaei, Bahram Pakzad
Summary: Disruption in DNA methylation processes can lead to gene expression alterations and malignancy. Regulating DNA methylation machinery through epi-miRNAs may be a promising approach for cancer therapy.
CANCER GENE THERAPY
(2021)
Review
Cardiac & Cardiovascular Systems
Somayeh Saadat, Mahdi Noureddini, Maryam Mahjoubin-Tehran, Sina Nazemi, Layla Shojaie, Michael Aschner, Behnaz Maleki, Mohammad Abbasi-kolli, Hasan Rajabi Moghadam, Behrang Alani, Hamed Mirzaei
Summary: TGF-β induces cardiac fibrosis through activation of cytokines and growth factors, stimulating fibroblast proliferation and ECM protein production via canonical and non-canonical signaling pathways. Non-coding RNAs play crucial roles in regulating these processes, suggesting potential for new diagnostic and therapeutic approaches for cardiac disorders.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Allergy
Naeim Ehtesham, Behrang Alani, Deniz Mortazavi, Sara Azhdari, Taiebe Kenarangi, Emran Esmaeilzadeh, Bahram Pakzad
Summary: The study found a significant association between NOD2 gene SNPs rs3135500 and the risk of rheumatoid arthritis, as well as a relationship with disease activity in patients.
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2021)
Article
Microbiology
Fereshteh Badie, Mahmood Saffari, Rezvan Moniri, Behrang Alani, Fatemeh Atoof, Ahmad Khorshidi, Mohammad Shayestehpour
Summary: The study evaluated the combined effects of temperature and pH on the expression of biofilm, stress, and virulence genes in Salmonella Enteritidis and Salmonella Typhimurium. The findings indicated that temperature and pH did not have a significant effect on the gene expression levels in these Salmonella strains.
ARCHIVES OF MICROBIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Behnoush Sohrabi, Behnaz Dayeri, Elahe Zahedi, Shahrouz Khoshbakht, Najme Nezamabadi Pour, Hamta Ranjbar, Abolfazl Davari Nejad, Mahdi Noureddini, Behrang Alani
Summary: Mesenchymal stem cells (MSCs) have potential in cancer therapy and can be used as vehicles in cancer gene therapy. MSC-derived exosomes, as novel cell-free alternatives to MSC-based cell therapy, have advantages in safety, stability, and convenience. Unmodified MSC-derived exosomes can promote or inhibit tumors, while modified exosomes can suppress cancer development by delivering therapeutic molecules.
CANCER GENE THERAPY
(2022)
Article
Pathology
Behnaz Maleki, Behrang Alani, Seyed Saeed Tamehri Zadeh, Somayeh Saadat, Ali Rajabi, Seyed Mohammad Jalal Ayoubzadeh, Javad Verdi, Alireza Farrokhian, Hossein Ghanbarian, Mahdi Noureddini, Majid Nejati
Summary: Treating cardiovascular diseases with CSCs is effective, but the molecular pathways that regulate their functions are not fully understood. miRNAs may play a crucial role in regulating CSC behavior, and studying the secretome of these cells can provide valuable insights into their functions.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Rheumatology
Sara Azhdari, Mostafa Saghi, Behrang Alani, Maryam Zare Rafie, Taiebe Kenarangi, Mehrdad Nasrollahzadeh Sabet, Bahram Pakzad, Tahereh Ghorashi, Milad Gholami, Mohsen Soosanabadi
Summary: This study evaluated the association between TNIP1 gene rs6889239 polymorphism and the risk and clinical characteristics of RA and SLE in the Iranian population. The results showed a significant association between the CC genotype and C allele of rs6889239 with an increased risk of SLE. However, there was no significant association between genotypes and allele frequencies of rs6889239 with the occurrence risk of RA. Stratification analysis also revealed a link between the C allele in rs6889239 and renal involvement in SLE patients and lower age of onset in the RA group.
Article
Biochemistry & Molecular Biology
Saeid Bagheri-Mohammadi, Sahar Askari, Behrang Alani, Maryam Moosavi, Rasoul Ghasemi
Summary: This study investigated the regulatory effects of cinnamaldehyde on insulin and caspase-3 signaling pathways in an Alzheimer's disease (AD) rat model. The results demonstrated that cinnamaldehyde could improve memory deficits and anxiety-like behavior, and modulate the IRS-1/AKT/GSK-3β signaling pathway and inhibit Aβ aggregation and caspase-3 cleavage in the hippocampus. These findings suggest that cinnamaldehyde may have therapeutic potential for AD treatment.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Mahbubeh Saeedfar, Abolfazl Ardjmand, Behrang Alani, Amir Ghaderi, Hamid Reza Banafshe, Mohammad Esmaeil Shahaboddin, Gholamreza Ghavipanjeh
Summary: Vitamin D has been found to be associated with substance abuse and dependence, potentially through its effect on dopamine signaling pathway. The study suggests that vitamin D can be considered as an effective therapeutic approach for narcotic addiction and substance abuse. These findings have important implications for the treatment of drug addiction.
BRAIN AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
A. Jabbari, B. Alani, A. Arjmand, T. Mazoochi, N. Kheiripour, A. Ardjmand
Summary: This study investigated the effects of ethanol on memory impairment and the neuroprotective role of silymarin. The results showed that ethanol caused memory deficits and increased oxidative stress and hippocampal apoptosis. However, administration of silymarin alleviated these adverse effects induced by ethanol.
JOURNAL OF CHEMICAL NEUROANATOMY
(2023)
Article
Medicine, Research & Experimental
Mohammad Esmaeilnia, Mahmood Saffari, Somaye Rashki, Zeynab Marzhoseyni, Azad Khaledi, Gholam Abbas Moosavi, Fatemeh Atoof, Behrang Alani
Summary: This study investigated the molecular typing of extended-spectrum beta-lactamase (ESBL) producing Klebsiella pneumoniae isolates from Beheshti Hospital in Iran. The results showed that there was a common molecular signature among both clinical and environmental K. pneumoniae isolates, indicating a similar genotype and likely a common origin. Therefore, it is important for hospitals to implement effective infection control systems to reduce the spread of ESBL strains.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Mehrdad Nasrollahzadeh Sabet, Masood Movahedi Asl, Mahtab Kazemi Esfeh, Navid Nasrabadi, Maryam Shakarami, Behrang Alani, Asma Alimolaie, Sara Azhdari, Ebrahim Cheraghi
Summary: Given the challenges in gastrointestinal cancer treatment, there is a need to find more effective approaches. Mesenchymal stem cells serve as potential carriers to overcome treatment limitations and deliver anticancer agents, while secreted molecules from unmodified MSCs can also eradicate cancer cells.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Mona Yazdani, Mahdi Hatamipour, Behrang Alani, Hossein Nikzad, Nema Mohamadian Roshan, Javad Verdi, Mahmoud Reza Jaafari, Mahdi Noureddini, Ali Badiee
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2020)