Review
Immunology
Kazuko Tajiri, Saori Yonebayashi, Siqi Li, Masaki Ieda
Summary: Accumulating evidence indicates that the breakdown of immune tolerance may lead to the development of myocarditis, with TN-C playing a crucial role as a local regulator of inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ismail Hendaoui, Ahlem Lahmar, Luca Campo, Sihem Mebarki, Sandrine Bichet, Daniel Hess, Martin Degen, Nidhameddine Kchir, Leila Charrada-Ben Farhat, Rania Hefaiedh, Christian Ruiz, Luigi M. Terracciano, Richard P. Tucker, Lotfi Hendaoui, Ruth Chiquet-Ehrismann
Summary: The study found that tenascin-C and tenascin-W were expressed in all biliary tract tumors, with tenascin-W not detected in normal hepatobiliary tissue. Additionally, the formation and organization of tenascin-W required co-culture of Huh-28 cells with bone marrow-derived stromal cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yucai Wang, Guangfu Wang, Hao Liu
Summary: This study provides a comprehensive review of the dynamic changes and functions of Tenascin-C (TNC) during tissue regeneration. The review highlights the multiple mechanisms of TNC at different stages of restoration, with a specific emphasis on its role in angiogenesis and wound healing.
Article
Medicine, General & Internal
Paolo Formenti, Silvia Coppola, Laura Massironi, Giacomo Annibali, Francesco Mazza, Lisa Gilardi, Tommaso Pozzi, Davide Chiumello
Summary: This study aimed to evaluate the presence of diastolic dysfunction in mechanically ventilated ARDS patients and found those with diastolic dysfunction had higher lung edema and worse outcomes, but the impact on oxygenation and respiratory mechanics was not significant.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Nicoline W. E. van den Berg, Jolien Neefs, Makiri Kawasaki, Fransisca A. Nariswari, Robin Wesselink, Benedetta Fabrizi, Aldo Jongejan, Martijn N. Klaver, Hanna Havenaar, Elise L. Hulsman, Lisette I. S. Wintgens, Sarah W. E. Baalman, Eva R. Meulendijks, Wim Jan van Boven, Jonas S. S. G. de Jong, Bart P. van Putte, Antoine H. G. Driessen, Lucas V. A. Boersma, Joris R. de Groot
Summary: The PREDICT-AF study indicates that atrial remodeling occurs before incident AF, suggesting potential for early identification of patients at risk for AF and preventive therapies.
Article
Cell Biology
Juliane Bauch, Sina Vom Ort, Annika Ulc, Andreas Faissner
Summary: Recent research has demonstrated the inhibitory effects of tenascin-C (Tnc) and tenascin-R (Tnr) on the formation of myelin membranes through an ex vivo approach. In addition, the cuprizone-based acute demyelination model was successfully used to analyze the remyelination behavior in Tnc(-/-) and Tnr(-/-) mice, revealing inhibitory properties of Tnc and Tnr in myelin membrane formation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ljuba Bacharova, Marta Kollarova, Branislav Bezak, Allan Bohm
Summary: Left ventricular hypertrophy (LVH) refers to the complex rebuilding of the left ventricle, which can lead to heart failure and life-threatening ventricular arrhythmias. Imaging methods such as echocardiography and cardiac magnetic resonance can diagnose the increase in left ventricle size, while other methods can evaluate the functional status and underlying processes of LVH. Molecular and genetic biomarkers offer insights and potential for targeted therapy. This review summarizes the main biomarkers used in LVH evaluation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bing-Hua Chen, Chong-Wen Wu, Dong-Aolei An, Ting Yue, Yin-Su Zhu, Lang-Lang Tang, Takahiro Ouchi, Erika Ouchi, Jiani Hu, Jian-Rong Xu, Jun Pu, Lian-Ming Wu
Summary: This study aimed to investigate the correlation between increased extracellular matrix estimated by cardiac magnetic resonance (CMR) and left ventricular aneurysm after acute myocardial infarction. The results showed that acute LGE and ECV of the myocardium provided predictive significance for LVA, and the discriminative significance of ECV for functional versus anatomical LVA was better than the discriminative significance of LGE.
EUROPEAN RADIOLOGY
(2023)
Review
Immunology
Sophie Liot, Jonathan Balas, Alexandre Aubert, Laura Prigent, Perrine Mercier-Gouy, Bernard Verrier, Philippe Bertolino, Ana Hennino, Ulrich Valcourt, Elise Lambert
Summary: Pancreatic cancer, especially PDAC, has a poor prognosis with low survival rates, mainly due to its dense stroma deposition and immune suppression in the TME. Research on TME composition may lead to new therapeutic targets for better treatment outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Physiology
Sandrine Gremlich, Tiziana P. Cremona, Eveline Yao, Farah Chabenet, Kleanthis Fytianos, Matthias Roth-Kleiner, Johannes C. Schittny
Summary: In 18-month-old TNC-deficient mice, exaggerated features of normal structural lung aging were observed, including increased lung volume, proliferation, and collagen content, while respiratory physiological parameters were similar to wild-type. TNC may play a significant role in lung aging processes.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alissa Domaingo, Philipp Jokesch, Alexandra Schweiger, Martha Gschwandtner, Tanja Gerlza, Manuel Koch, Kim S. Midwood, Andreas J. Kungl
Summary: Tenascin-C (TNC) is a complex glycoprotein involved in various physiological processes such as oncogenesis and inflammation. This study investigated the binding of TNC to key chemokines and found a differential chemokine-TNC binding pattern. It was observed that TNC acts as an attenuator in monocyte mobilization and an amplifier in eosinophil mobilization. These effects may be due to TNC impeding the binding of CCL2 to heparan sulfate while reinforcing the binding of CCL26.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Olivier Huttin, Masatake Kobayashi, Joao Pedro Ferreira, Stefano Coiro, Erwan Bozec, Christine Selton-Suty, Laura Filipetti, Zohra Lamiral, Patrick Rossignol, Faiez Zannad, Nicolas Girerd
Summary: The combination of multiple biomarkers with clinical variables can effectively predict LVH and DD, with Gal3, P3NP, and ST2 significantly improving the predictive value for DD.
Review
Biotechnology & Applied Microbiology
Victor Alfonso Solarte David, Viviana Raquel Guiza-Argueello, Martha L. Arango-Rodriguez, Claudia L. Sossa, Silvia M. Becerra-Bayona
Summary: The absence or damage of tissue is a major cause of diseases, and novel therapeutic alternatives aim to recover lost functions through tissue regeneration. Chronic cutaneous lesions are common wounds that require regenerative medicine and tissue engineering interventions to develop bioactive medical products for proper healing and prevention of complications. The coordination of cells, extracellular matrix (ECM), and biomolecules is crucial in tissue repair and regeneration, with ECM acting as a biological platform for their interactions. Tissue engineering utilizes synthetic polymers and decellularized tissues to mimic native ECM and provide necessary functionalities for cell differentiation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alexander L. Reese-Petersen, Federica Genovese, Lei Zhao, Glen Banks, David A. Gordon, Morten A. Karsdal
Summary: Extracellular matrix proteins contain signaling domains that can activate cellular responses when released. Endotrophin, a fragment of type VI collagen, has been linked to increased risk of adverse outcome in heart failure with preserved ejection fraction (HFpEF). This study demonstrates that endotrophin stimulation of human cardiac fibroblasts leads to increased synthesis of type I collagen, which accumulates in the myocardium during fibrogenesis. These findings provide a possible mechanistic explanation for the association between circulating endotrophin levels and HFpEF outcomes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Respiratory System
Paul Leong, Christian R. Osadnik, Paul T. King, Martin MacDonald, Brian S. Ko, Kenneth K. Lau, Simon A. Joosten, Gayan Kathriachchige, Alexander Chua, Kais Hamza, Ahilan Kuganesan, John M. Troupis, Philip G. Bardin
Summary: This study revealed that higher right ventricular end-diastolic volume during hospitalized acute exacerbations of COPD is associated with worse acute clinical parameters and greater mortality in long-term follow-up.
Article
Cardiac & Cardiovascular Systems
Rosa Maria Ortiz-Comino, Arturo Morales, Rosa Lopez-Lisbona, Noelia Cubero, Marta Diez-Ferrer, Cristian Tebe, Antoni Rosell
Summary: The study compared the efficacy and complications of a fully covered self-expandable metal stent (SEMS) and a silicone stent in treating malignant central airway obstruction. Both stents were found to be equally successful and safe, with complications such as mucus retention, granulation tissue, and migration. The incidence of complications increased over time to over 90% at 6 months for both types of stents.
ANNALS OF THORACIC SURGERY
(2021)
Article
Medicine, General & Internal
Jesus Ribas, Esther Alba, Yuliana Pascual-Gonzalez, Yolanda Ruiz, Adriana Iriarte, Jose Maria Mora-Lujan, Joana Valcarcel, Xavier Corbella, Salud Santos, Elena Escalante, Antoni Riera-Mestre
Summary: The main preventable cause of non-retrieval of temporary IVC filters was lack of planning / follow-up. In patients with indwelling filters, the main cause of death was cancer and extended anticoagulation was not associated with survival.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Letter
Medicine, General & Internal
M. Diez-Ferrer, C. Martin-Cabeza, N. Cubero, J. Sabater-Riera, S. Santos, R. M. Lopez-Lisbona
REVISTA CLINICA ESPANOLA
(2021)
Letter
Respiratory System
Marta Diez-Ferrer, Benjamin Torrejon-Escribano, Nuria Baixeras, Cristian Tebe, Noelia Cubero, Rosa Lopez-Lisbona, Jordi Dorca, Antoni Rosell
ARCHIVOS DE BRONCONEUMOLOGIA
(2021)
Article
Multidisciplinary Sciences
Ana Merino, Martin J. Hoogduijn, Maria Molina-Molina, Elena G. Arias-Salgado, Sander S. Korevaar, Carla C. Baan, Ana Montes-Worboys
Summary: The study shows that Membrane Particles (MP) derived from mesenchymal stromal cells (MSC) have anti-fibrotic effects by targeting lung cells and reducing the expression of fibrotic proteins without cytotoxic effects. These findings suggest that MP may serve as an alternative therapeutic approach to traditional MSC administration in treating idiopathic pulmonary fibrosis.
Article
Critical Care Medicine
Pere Trias-Sabria, Maria Molina-Molina, Samantha Aso, Marta Hernandez Argudo, Marta Diez-Ferrer, Joan Sabater, Jordi Dorca, Salud Santos, Guillermo Suarez-Cuartin
Summary: This study investigated the potential role of lung ultrasound score (LUS) in patients with COVID-19 and found that LUS >= 24 points could help identify patients at higher risk of ICU admission or death. LUS also showed significant correlations with clinical and laboratory markers of COVID-19 severity.
Letter
Respiratory System
Jose Luis Lopez-Campos, Myriam Calle Rubio, Jose Luis Izquierdo Alonso, Alberto Fernandez-Villar, Beatriz Abascal-Bolado, Bernardino Alcazar, Francisco Garcia-Rio, German Peces-Barba, Joan Serra Batlles, Jose Javier Martinez Garceran, Juan Antonio Riesco Miranda, Juan Marco Figueira-Goncalves, Juan Jose Soler-Cataluna, Mikel Temprano, Francisco Ortega Ruiz, Salud Santos Perez, Carlos Jose alvarez Martinez
ARCHIVOS DE BRONCONEUMOLOGIA
(2021)
Article
Medicine, General & Internal
Lurdes Planas-Cerezales, Elena G. Arias-Salgado, Cristina Berastegui, Ana Montes-Worboys, Rafaela Gonzalez-Montelongo, Jose M. Lorenzo-Salazar, Vanesa Vicens-Zygmunt, Marta Garcia-Moyano, Jordi Dorca, Carlos Flores, Rosario Perona, Antonio Roman, Maria Molina-Molina
Summary: The study showed that fibrotic ILD patients with telomere dysfunction after lung transplantation have higher morbidity, require more medical interventions, but still have a high 1-year survival rate, leading to improved quality of life and withdrawal of oxygen therapy.
FRONTIERS IN MEDICINE
(2021)
Article
Respiratory System
Theodoros Karampitsakos, Paolo Spagnolo, Nesrin Mogulkoc, Wim A. Wuyts, Sara Tomassetti, Elisabeth Bendstrup, Maria Molina-Molina, Effrosyni D. Manali, Omer Selim Unat, Francesco Bonella, Nicolas Kahn, Lykourgos Kolilekas, Elisabetta Rosi, Leonardo Gori, Claudia Ravaglia, Venerino Poletti, Zoe Daniil, Thomas Skovhus Prior, Ilias C. Papanikolaou, Samantha Aso, Stavros Tryfon, Despoina Papakosta, Vasillios Tzilas, Elisabetta Balestro, Spyridon Papiris, Katerina Antoniou, Demosthenes Bouros, Athol Wells, Michael Kreuter, Argyris Tzouvelekis
Summary: This study aimed to create a large database for patients with idiopathic pulmonary fibrosis (IPF) and lung cancer in Europe. The results showed that 10.2% of IPF patients also had lung cancer, and IPF patients with lung cancer had a higher risk of all-cause mortality. Lung cancer patients who received antifibrotic treatment had lower all-cause mortality, and surgically treated IPF patients with operable lung cancer had lower all-cause mortality.
Article
Environmental Sciences
Merce Gasa, Yolanda Ruiz-Albert, Ana Cordoba-Izquierdo, Mikel Sarasate, Ester Cuevas, Guillermo Suarez-Cuartin, Lidia Mendez, Julio-Cesar Alfaro-Alvarez, Joan Sabater-Riera, Xose L. Perez-Fernandez, Maria Molina-Molina, Salud Santos
Summary: The aim of this study was to assess factors associated with survival, ICU admission, and intubation likelihood in COVID-19 patients admitted to IRCUs. Older age and lack of corticosteroid treatment were associated with higher mortality and intubation risk.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Letter
Respiratory System
E. M. Tinoco, G. Bermudo, V. Vicens-Zygmunt, P. Luburich, R. Llatjos, M. Molina-Molina
Article
Medicine, General & Internal
Jaume Bordas-Martinez, Lluis Mateu Gomez, David Camara Menoyo, Marta Lopez-Sanchez, Salud Santos, Maria Molina-Molina, Rosa Planas
Summary: Telemedicine has proven to be a useful tool in telemonitoring and telerehabilitation programs for respiratory patients. This pilot program aims to evaluate the feasibility of a telerehabilitation program for COVID-19 patients from hospital to home. Initial results show that telerehabilitation encourages and empowers patients, with high levels of patient satisfaction.
Article
Respiratory System
Kevin L. Winthrop, Patrick A. Flume, Rachel Thomson, Kevin C. Mange, Dayton W. Yuen, Monika Ciesielska, Kozo Morimoto, Stephen J. Ruoss, Luigi R. Codecasa, Jae-Joon Yim, Theodore K. Marras, Jakko van Ingen, Richard J. Wallace, Barbara A. Brown-Elliott, Chris Coulter, David E. Griffith
Summary: This study evaluated the safety, tolerability, and efficacy of ALIS combined with GBT in patients with refractory MAC lung disease for 12 months. The results showed that respiratory treatment-emergent adverse events were common, nephrotoxicity and hearing decline were infrequent, and culture conversion continued beyond 6 months of therapy.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Respiratory System
Carlos Machahua, Sabina A. Guler, Michael P. Horn, Lurdes Planas-Cerezales, Ana Montes-Worboys, Thomas K. Geiser, Maria Molina-Molina, Manuela Funke-Chambour
Summary: In this study, it was found that serum calprotectin levels are significantly increased in patients with IPF compared to healthy controls, and are correlated with DLCO and CPI. This suggests that calprotectin may be a potential new biomarker for disease severity in IPF.
BMJ OPEN RESPIRATORY RESEARCH
(2021)
Article
Respiratory System
Jessica Germaine Shull, Maria Teresa Pay, Carla Lara Compte, Miriam Olid, Guadalupe Bermudo, Karina Portillo, Jacobo Sellares, Eva Balcells, Vanesa Vicens-Zygmunt, Lurdes Planas-Cerezales, Diana Badenes-Bonet, Rosana Blavia, Pilar Rivera-Ortega, Amalia Moreno, Jordi Sans, Damia Perich, Silvia Barril, Leonardo Esteban, Laia Garcia-Bellmunt, Jordi Esplugas, Guillermo Suarez-Cuartin, Jaume Bordas-Martinez, Diego Castillo, Rosa Jolis, Inma Salvador, Saioa Eizaguirre Anton, Ana Villar, Alejandro Robles-Perez, M. Josefa Cardona, Enric Barbeta, Maria Guadalupe Silveira, Claudia Guevara, Jordi Dorca, Antoni Rosell, Patricio Luburich, Roger Llatjos, Oriol Jorba, Maria Molina-Molina
Summary: This study analyzed the relationship between IPF cases and air pollution concentration in the region of Catalonia, Spain, finding that areas with higher PM2.5 concentrations had a higher prevalence of IPF. Prospect studies with targeted pollution mapping are needed to compile a broader profile of environmental factors involved in the development of pulmonary fibrosis.