Challenges and Hurdles to Business as Usual in Drug Development for Treatment of Rare Diseases

A New Initiative on Precision Medicine

(2015) Francis S. Collins et al.   NEW ENGLAND JOURNAL OF MEDICINE

The discovery of medicines for rare diseases

(2014) David C Swinney et al.   Future Medicinal Chemistry

Important Role of Translational Science in Rare Disease Innovation, Discovery, and Drug Development

(2014) Anne R. Pariser et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

An Improved Approach To Measuring Drug Innovation Finds Steady Rates Of First-In-Class Pharmaceuticals, 1987–2011

(2013) Michael Lanthier et al.   HEALTH AFFAIRS

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Lessons from 60 years of pharmaceutical innovation

(2009) Bernard Munos   NATURE REVIEWS DRUG DISCOVERY