BMP-1 disrupts cell adhesion and enhances TGF-β activation through cleavage of the matricellular protein thrombospondin-1

Integration of two in-depth quantitative proteomics approaches determines the kallikrein-related peptidase 7 (KLK7) degradome in ovarian cancer cell secretome.

(2019) Lakmali Munasinghage Silva et al.   MOLECULAR & CELLULAR PROTEOMICS

Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction

(2019) Julian Friebel et al.   EUROPEAN HEART JOURNAL

LncRNA HOXA-AS3 Sponges miR-29c to Facilitate Cell Proliferation, Metastasis, and EMT Process and Activate the MEK/ERK Signaling Pathway in Hepatocellular Carcinoma

(2019) Yongxi Tong et al.   Human Gene Therapy Clinical Development

Overexpression of BMP1 reflects poor prognosis in clear cell renal cell carcinoma

(2019) Wen Xiao et al.   CANCER GENE THERAPY

C-terminal proteolysis of the collagen VI α3 chain by BMP-1 and proprotein convertase(s) releases endotrophin in fragments of different sizes

(2019) Stefanie Elisabeth Heumüller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Corneal injury: Clinical and molecular aspects

(2019) Brayden Barrientez et al.   EXPERIMENTAL EYE RESEARCH

Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake

(2019) Sreemoti Banerjee et al.   Scientific Reports

Upregulation of bone morphogenetic protein 1 is associated with poor prognosis of late-stage gastric Cancer patients

(2018) Yung-Yu Hsieh et al.   BMC CANCER

N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration

(2018) Chia-yi Chen et al.   MATRIX BIOLOGY

Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease

(2018) Joanne E. Murphy-Ullrich et al.   MATRIX BIOLOGY

Thrombospondin-1 promotes matrix homeostasis by interacting with collagen and lysyl oxidase precursors and collagen cross-linking sites

(2018) Silvia Rosini et al.   Science Signaling

Thrombospondin-1 promotes matrix homeostasis by interacting with collagen and lysyl oxidase precursors and collagen cross-linking sites

(2018) Silvia Rosini et al.   Science Signaling

Neutrophil-Mediated Proteolysis of Thrombospondin-1 Promotes Platelet Adhesion and String Formation

(2018) Katharina Seif et al.   THROMBOSIS AND HAEMOSTASIS

Inhibitors of BMP-1/tolloid-like proteinases: efficacy, selectivity and cellular toxicity

(2018) Maya Talantikite et al.   FEBS Open Bio

Aberrant connective tissue differentiation towards cartilage and bone underlies human keloids in African Americans

(2017) Judilyn Fuentes-Duculan et al.   EXPERIMENTAL DERMATOLOGY

BMP1 and TLL1 Are Required for Maintaining Periodontal Homeostasis

(2017) J. Wang et al.   JOURNAL OF DENTAL RESEARCH

Transcriptional Regulation of Connective Tissue Metabolism Genes in Women With Pelvic Organ Prolapse

(2017) Ali Borazjani et al.   Female Pelvic Medicine and Reconstructive Surgery

Influence of WFIKKN1 on BMP1-mediated activation of latent myostatin

(2016) György Szláma et al.   FEBS Journal

Characterization of post-translational modifications in full-length human BMP-1 confirms the presence of a rare vicinal disulfide linkage in the catalytic domain and highlights novel features of the EGF domain

(2016) Chien-Wen Hung et al.   Journal of Proteomics

BMP1-like proteinases are essential to the structure and wound healing of skin

(2016) Alison M. Muir et al.   MATRIX BIOLOGY

RNA-binding proteins are a major target of silica nanoparticles in cell extracts

(2016) Géraldine Klein et al.   Nanotoxicology

Defective Proteolytic Processing of Fibrillar Procollagens and Prodecorin Due to BiallelicBMP1Mutations Results in a Severe, Progressive Form of Osteogenesis Imperfecta

(2015) Delfien Syx et al.   JOURNAL OF BONE AND MINERAL RESEARCH

BMP-1/tolloid-like proteinases synchronize matrix assembly with growth factor activation to promote morphogenesis and tissue remodeling

(2015) Sandrine Vadon-Le Goff et al.   MATRIX BIOLOGY

Intermolecular interactions of thrombospondins drive their accumulation in extracellular matrix

(2015) Dae Joong Kim et al.   MOLECULAR BIOLOGY OF THE CELL

LOX Expression and Functional Analysis in Astrocytomas and Impact of IDH1 Mutation

(2015) Roseli da Silva et al.   PLoS One

Placental antiangiogenic prolactin fragments are increased in human and rat maternal diabetes

(2014) P. Perimenis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Proteolytic control of TGF-β co-receptor activity by BMP-1/tolloid-like proteases revealed by quantitative iTRAQ proteomics

(2014) Frédéric Delolme et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Induced ablation of Bmp1 and Tll1 produces osteogenesis imperfecta in mice

(2014) A. M. Muir et al.   HUMAN MOLECULAR GENETICS

Upregulation of Bone Morphogenetic Protein-1/Mammalian Tolloid and Procollagen C-Proteinase Enhancer-1 in Corneal Scarring

(2014) F. Malecaze et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters

(2014) Alexandra Naba et al.   eLife

microRNA-122down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-β1up-regulation

(2013) Javier Beaumont et al.   CLINICAL SCIENCE

miR-194 suppresses metastasis of non-small cell lung cancer through regulating expression of BMP1 and p27kip1

(2013) X Wu et al.   ONCOGENE

Molecular Basis for the Regulation of Angiogenesis by Thrombospondin-1 and -2

(2013) P. R. Lawler et al.   Cold Spring Harbor Perspectives in Medicine

Design and synthesis of procollagen C-proteinase inhibitors

(2012) Eric Turtle et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sizzled Is Unique among Secreted Frizzled-related Proteins for Its Ability to Specifically Inhibit Bone Morphogenetic Protein-1 (BMP-1)/Tolloid-like Proteinases

(2012) Cécile Bijakowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Localization of thrombospondin-1 and myofibroblasts during corneal wound repair

(2011) Mariko Matsuba et al.   EXPERIMENTAL EYE RESEARCH

Bone Morphogenetic Protein-1 Processes Insulin-like Growth Factor-binding Protein 3

(2011) Byoungjae Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

The Thrombospondins

(2011) J. C. Adams et al.   Cold Spring Harbor Perspectives in Biology

ADAMTS-2 functions as anti-angiogenic and anti-tumoral molecule independently of its catalytic activity

(2010) J. Dubail et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Broad Coverage Identification of Multiple Proteolytic Cleavage Site Sequences in Complex High Molecular Weight Proteins Using Quantitative Proteomics as a Complement to Edman Sequencing

(2010) Alain Doucet et al.   MOLECULAR & CELLULAR PROTEOMICS

Ovarian Cancer Cell Detachment and Multicellular Aggregate Formation Are Regulated by Membrane Type 1 Matrix Metalloproteinase: A Potential Role in I.p. Metastatic Dissemination

(2009) N. M. Moss et al.   CANCER RESEARCH

Identification of differentially expressed genes in trabecular bone from the iliac crest of osteoarthritic patients

(2009) E. Sánchez-Sabaté et al.   OSTEOARTHRITIS AND CARTILAGE

Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid

(2009) R. Berry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular matrix retention of thrombospondin 1 is controlled by its conserved C-terminal region

(2008) J. C. Adams et al.   JOURNAL OF CELL SCIENCE