Nanoparticles presenting clusters of CD4 expose a universal vulnerability of HIV-1 by mimicking target cells

eCD4-Ig limits HIV-1 escape more effectively than CD4-Ig or a broadly neutralizing antibody

(2019) Christoph H. Fellinger et al.   JOURNAL OF VIROLOGY

Markers of the HIV-1 reservoir

(2018) Timothée Bruel et al.   Current Opinion in HIV and AIDS

Relationship between latent and rebound viruses in a clinical trial of anti–HIV-1 antibody 3BNC117

(2018) Yehuda Z. Cohen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

(2018) Pilar Mendoza et al.   NATURE

The low spike density of HIV may have evolved because of the effects of T helper cell depletion on affinity maturation

(2018) Assaf Amitai et al.   PLoS Computational Biology

Eliminating HIV-1 Packaging Sequences from Lentiviral Vector Proviruses Enhances Safety and Expedites Gene Transfer for Gene Therapy

(2017) Conrad A. Vink et al.   MOLECULAR THERAPY

Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

(2017) Marina Caskey et al.   NATURE MEDICINE

Engineering antibody-like inhibitors to prevent and treat HIV-1 infection

(2017) Matthew R. Gardner et al.   Current Opinion in HIV and AIDS

Human immunodeficiency virus type-1 (HIV-1) evades antibody-dependent phagocytosis

(2017) Johannes S. Gach et al.   PLoS Pathogens

Further Characterization of the Bifunctional HIV Entry Inhibitor sCD4-FI T45

(2017) Alexander Falkenhagen et al.   Molecular Therapy-Nucleic Acids

Mouse Liver Sinusoidal Endothelium Eliminates HIV-Like Particles from Blood at a Rate of 100 Million per Minute by a Second-Order Kinetic Process

(2017) Jessica M. Mates et al.   Frontiers in Immunology

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA

(2016) Julio C. C. Lorenzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Envelope residue 375 substitutions in simian–human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques

(2016) Hui Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intra-Spike Crosslinking Overcomes Antibody Evasion by HIV-1

(2015) Rachel P. Galimidi et al.   CELL

CD4 binding site broadly neutralizing antibody selection of HIV-1 escape mutants

(2015) Hanna Dreja et al.   JOURNAL OF GENERAL VIROLOGY

HIV-1 Fitness Cost Associated with Escape from the VRC01 Class of CD4 Binding Site Neutralizing Antibodies

(2015) Rebecca M. Lynch et al.   JOURNAL OF VIROLOGY

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

(2015) Marina Caskey et al.   NATURE

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

(2015) Matthew R. Gardner et al.   NATURE

The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck

(2015) Kyung-Ho Roh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral membrane fusion

(2015) Stephen C. Harrison   VIROLOGY

Partial rescue of V1V2 mutant infectivity by HIV-1 cell-cell transmission supports the domain’s exceptional capacity for sequence variation

(2014) Oliver F Brandenberg et al.   Retrovirology

Global Panel of HIV-1 Env Reference Strains for Standardized Assessments of Vaccine-Elicited Neutralizing Antibodies

(2013) A. deCamp et al.   JOURNAL OF VIROLOGY

Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs

(2013) Christine Katlama et al.   LANCET

Detection of HIV-1 Neutralizing Antibodies in a Human CD4+/CXCR4+/CCR5+ T-Lymphoblastoid Cell Assay System

(2013) Robert J. McLinden et al.   PLoS One

Computational analysis of anti-HIV-1 antibody neutralization panel data to identify potential functional epitope residues

(2013) A. P. West et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV Latency

(2013) R. F. Siliciano et al.   Cold Spring Harbor Perspectives in Medicine

HIV therapy by a combination of broadly neutralizing antibodies in humanized mice

(2012) Florian Klein et al.   NATURE

MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency

(2012) Katrijn Grupping et al.   Retrovirology

Maturation-Dependent HIV-1 Surface Protein Redistribution Revealed by Fluorescence Nanoscopy

(2012) J. Chojnacki et al.   SCIENCE

Curing HIV: Pharmacologic Approaches to Target HIV-1 Latency

(2011) Shailesh K. Choudhary et al.   Annual Review of Pharmacology and Toxicology

Structure and Stoichiometry of Template-Directed Recombinant HIV-1 Gag Particles

(2011) Nancy L. Goicochea et al.   JOURNAL OF MOLECULAR BIOLOGY

Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design

(2011) R. Diskin et al.   SCIENCE

Few and Far Between: How HIV May Be Evading Antibody Avidity

(2010) Joshua S. Klein et al.   PLoS Pathogens

Three-Dimensional Analysis of Budding Sites and Released Virus Suggests a Revised Model for HIV-1 Morphogenesis

(2008) Lars-Anders Carlson et al.   Cell Host & Microbe