Structure-guided engineering of the affinity and specificity of CARs against Tn-glycopeptides
Published 2020 View Full Article
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Title
Structure-guided engineering of the affinity and specificity of CARs against Tn-glycopeptides
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 117, Issue 26, Pages 15148-15159
Publisher
Proceedings of the National Academy of Sciences
Online
2020-06-16
DOI
10.1073/pnas.1920662117
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- (2017) Preeti Sharma et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2017) Daniel T. Harris et al. JOURNAL OF IMMUNOLOGY
- Fully human CD19-specific chimeric antigen receptors for T-cell therapy
- (2017) D Sommermeyer et al. LEUKEMIA
- The Cosmc connection to the Tn antigen in cancer
- (2017) Tongzhong Ju et al. Cancer Biomarkers
- Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma
- (2016) Avery D. Posey et al. IMMUNITY
- Deep Mutational Scans as a Guide to Engineering High Affinity T Cell Receptor Interactions with Peptide-bound Major Histocompatibility Complex
- (2016) Daniel T. Harris et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2016) R C Lynn et al. LEUKEMIA
- Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
- (2016) John G Doench et al. NATURE BIOTECHNOLOGY
- An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry
- (2016) Daniel T. Harris et al. STRUCTURE
- Tales of Antigen Evasion from CAR Therapy
- (2016) M. Sadelain Cancer Immunology Research
- Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice
- (2015) X. Liu et al. CANCER RESEARCH
- Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity
- (2015) H. G. Caruso et al. CANCER RESEARCH
- Adoptive cellular therapy: A race to the finish line
- (2015) Carl H. June et al. Science Translational Medicine
- Overcoming Antigen Escape with CAR T-cell Therapy
- (2015) H. J. Jackson et al. Cancer Discovery
- A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor control
- (2014) Jennifer D. Stone et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
- (2014) Erik Procko et al. CELL
- Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
- (2014) Shannon L. Maude et al. NEW ENGLAND JOURNAL OF MEDICINE
- Immature truncated O-glycophenotype of cancer directly induces oncogenic features
- (2014) Prakash Radhakrishnan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Receptor Affinity and Extracellular Domain Modifications Affect Tumor Recognition by ROR1-Specific Chimeric Antigen Receptor T Cells
- (2013) M. Hudecek et al. CLINICAL CANCER RESEARCH
- Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology
- (2013) Catharina Steentoft et al. EMBO JOURNAL
- Computational Design of a Protein-Based Enzyme Inhibitor
- (2013) Erik Procko et al. JOURNAL OF MOLECULAR BIOLOGY
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- Aberrantly glycosylated MUC1 is expressed on the surface of breast cancer cells and a target for antibody-dependent cell-mediated cytotoxicity
- (2012) Kirstine Lavrsen et al. GLYCOCONJUGATE JOURNAL
- Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing
- (2012) Timothy A Whitehead et al. NATURE BIOTECHNOLOGY
- MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches
- (2012) D W Kufe ONCOGENE
- A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs)
- (2012) Jennifer D. Stone et al. OncoImmunology
- Mining the O-glycoproteome using zinc-finger nuclease–glycoengineered SimpleCell lines
- (2011) Catharina Steentoft et al. NATURE METHODS
- Cancer Biomarkers Defined by Autoantibody Signatures to Aberrant O-Glycopeptide Epitopes
- (2010) H. H. Wandall et al. CANCER RESEARCH
- Characterization of an immunodominant cancer-specific O-glycopeptide epitope in murine podoplanin (OTS8)
- (2010) Catharina Steentoft et al. GLYCOCONJUGATE JOURNAL
- High-resolution mapping of protein sequence-function relationships
- (2010) Douglas M Fowler et al. NATURE METHODS
- Antibody recognition of a unique tumor-specific glycopeptide antigen
- (2010) C. L. Brooks et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Impact of TCR-Binding Properties and Antigen Presentation Format on T Cell Responsiveness
- (2009) A. S. Chervin et al. JOURNAL OF IMMUNOLOGY
- Specificity in cancer immunotherapy
- (2008) Andrea Schietinger et al. SEMINARS IN IMMUNOLOGY
- Mucin-type O-glycosylation and its potential use in drug and vaccine development
- (2007) Mads Agervig Tarp et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
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