Mechanistic dissection of the PD-L1:B7-1 co-inhibitory immune complex

Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses

(2019) Daisuke Sugiura et al.   SCIENCE

PD-L1 binds to B7-1 only in cis on the same cell surface

(2018) Apoorvi Chaudhri et al.   Cancer Immunology Research

Revealing the atomistic details behind the binding of B7–1 to CD28 and CTLA-4: A comprehensive protein-protein modelling study

(2018) Aravindhan Ganesan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Inhibitory Receptors and Pathways of Lymphocytes: The Role of PD-1 in Treg Development and Their Involvement in Autoimmunity Onset and Cancer Progression

(2018) Elena Gianchecchi et al.   Frontiers in Immunology

PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells

(2017) Xiong Ni et al.   JOURNAL OF CLINICAL INVESTIGATION

Highlights on immune checkpoint inhibitors in non–small cell lung cancer

(2017) Meng Shen et al.   TUMOR BIOLOGY

CD80 Expressed by CD8+ T Cells Contributes to PD-L1-Induced Apoptosis of Activated CD8+ T Cells

(2017) Meagan R. Rollins et al.   Journal of Immunology Research

Pembrolizumab versus Ipilimumab in Advanced Melanoma

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1

(2015) Krzysztof M. Zak et al.   STRUCTURE

RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance

(2014) Yanping Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial

(2014) Caroline Robert et al.   LANCET

Pembrolizumab for treatment of refractory melanoma

(2014) Sanjeet Bagcchi   LANCET ONCOLOGY

T Cell Receptor Signaling Can Directly Enhance the Avidity of CD28 Ligand Binding

(2014) Mariano Sanchez-Lockhart et al.   PLoS One

A Soluble Form of CD80 Enhances Antitumor Immunity by Neutralizing Programmed Death Ligand-1 and Simultaneously Providing Costimulation

(2014) S. T. Haile et al.   Cancer Immunology Research

Soluble CD80 Restores T Cell Activation and Overcomes Tumor Cell Programmed Death Ligand 1-Mediated Immune Suppression

(2013) S. T. Haile et al.   JOURNAL OF IMMUNOLOGY

A secreted protein microarray platform for extracellular protein interaction discovery

(2011) Sree R. Ramani et al.   ANALYTICAL BIOCHEMISTRY

B7-H2 Is a Costimulatory Ligand for CD28 in Human

(2011) Sheng Yao et al.   IMMUNITY

Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family

(2011) Hélène Bour-Jordan et al.   IMMUNOLOGICAL REVIEWS

Tumor Cell Programmed Death Ligand 1-Mediated T Cell Suppression Is Overcome by Coexpression of CD80

(2011) S. T. Haile et al.   JOURNAL OF IMMUNOLOGY

The Programmed Death-1 Ligand 1:B7-1 Pathway Restrains Diabetogenic Effector T Cells In Vivo

(2011) A. M. Paterson et al.   JOURNAL OF IMMUNOLOGY

The Novel Costimulatory Programmed Death Ligand 1/B7.1 Pathway Is Functional in Inhibiting Alloimmune Responses In Vivo

(2011) J. Yang et al.   JOURNAL OF IMMUNOLOGY

Belatacept

(2011) Flavio Vincenti et al.   NATURE REVIEWS DRUG DISCOVERY

The PD-1 pathway in tolerance and autoimmunity

(2010) Loise M. Francisco et al.   IMMUNOLOGICAL REVIEWS

PD-L1 and PD-L2 differ in their molecular mechanisms of interaction with PD-1

(2010) M. Ghiotto et al.   INTERNATIONAL IMMUNOLOGY

Dynamic Equilibrium of B7-1 Dimers and Monomers Differentially Affects Immunological Synapse Formation and T Cell Activation in Response to TCR/CD28 Stimulation

(2010) Sumeena Bhatia et al.   JOURNAL OF IMMUNOLOGY

Therapeutic efficacy of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with metastatic melanoma unresponsive to prior systemic treatments: clinical and immunological evidence from three patient cases

(2009) Anna Maria Di Giacomo et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Sequence, structure, function, immunity: structural genomics of costimulation

(2009) Kausik Chattopadhyay et al.   IMMUNOLOGICAL REVIEWS

Yin-Yang of costimulation: crucial controls of immune tolerance and function

(2009) Roza I. Nurieva et al.   IMMUNOLOGICAL REVIEWS

Interaction of human PD-L1 and B7-1

(2008) Manish J. Butte et al.   MOLECULAR IMMUNOLOGY

The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors

(2008) D. Y.-w. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA