Physiologically-Based Pharmacokinetic Predictions of the Effect of Curcumin on Metabolism of Imatinib and Bosutinib: In Vitro and In Vivo Disconnect

Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Inter-correlations in the Human Small Intestine

(2020) Narciso Couto et al.   DRUG METABOLISM AND DISPOSITION

Pharmacokinetics, Pharmacodynamics, and PKPD Modeling of Curcumin in Regulating Antioxidant and Epigenetic Gene Expression in Healthy Human Volunteers

(2019) David Cheng et al.   MOLECULAR PHARMACEUTICS

Physiologically Based Pharmacokinetic Modelling of Hyperforin to Predict Drug Interactions with St John’s Wort

(2019) Jeffry Adiwidjaja et al.   CLINICAL PHARMACOKINETICS

Improved Oral Absorption of Poorly Soluble Curcumin via the Concomitant Use of Borneol

(2019) Ying Gao et al.   AAPS PHARMSCITECH

Predictive Performance of Physiologically-Based Pharmacokinetic Models in Predicting Drug–Drug Interactions Involving Enzyme Modulation

(2018) Chia-Hsiang Hsueh et al.   CLINICAL PHARMACOKINETICS

The Ontogeny of UDP-glucuronosyltransferase Enzymes, Recommendations for Future Profiling Studies and Application Through Physiologically Based Pharmacokinetic Modelling

(2018) Justine Badée et al.   CLINICAL PHARMACOKINETICS

Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product–Drug Interactions: A NaPDI Center Recommended Approach

(2018) Emily J. Johnson et al.   DRUG METABOLISM AND DISPOSITION

Bosutinib Versus Imatinib for Newly Diagnosed Chronic Myeloid Leukemia: Results From the Randomized BFORE Trial

(2018) Jorge E. Cortes et al.   JOURNAL OF CLINICAL ONCOLOGY

A phase 1 dose-escalation study on the safety, tolerability and activity of liposomal curcumin (Lipocurc™) in patients with locally advanced or metastatic cancer

(2018) Richard Greil et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Pharmacokinetics of liposomal curcumin (Lipocurc™) infusion: effect of co-medication in cancer patients and comparison with healthy individuals

(2018) Gordon T. Bolger et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Physiologically Based Pharmacokinetic Modeling in Regulatory Science: An Update From the U.S. Food and Drug Administration’s Office of Clinical Pharmacology

(2018) Manuela Grimstein et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The therapeutic potential of curcumin: A review of clinical trials

(2018) Bahare Salehi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Curcumin as a clinically-promising anti-cancer agent: pharmacokinetics and drug interactions

(2017) Jeffry Adiwidjaja et al.   Expert Opinion on Drug Metabolism & Toxicology

Liposomal curcumin and its application in cancer

(2017) Ting Feng et al.   International Journal of Nanomedicine

The Essential Medicinal Chemistry of Curcumin

(2017) Kathryn M. Nelson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of human cytochromes P450 in vitro by ritonavir and cobicistat

(2017) Md Amin Hossain et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia

(2017) Andreas Hochhaus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Assessing Natural Product–Drug Interactions: An End-to-End Safety Framework

(2016) Amy L. Roe et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Direct and quantitative evaluation of the human CYP3A4 contribution (fm) to drug clearance using the in vitro SILENSOMES model

(2016) Yannick Parmentier et al.   XENOBIOTICA

Adjunctive Chinese Herbal Medicine therapy improves survival of patients with chronic myeloid leukemia: a nationwide population-based cohort study

(2016) Tom Fleischer et al.   Cancer Medicine

Clinical development of curcumin in neurodegenerative disease

(2015) Shuxin Hu et al.   Expert Review of Neurotherapeutics

Safety, tolerability and pharmacokinetics of liposomal curcumin in healthy humans

(2015) Angela Storka et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity

(2015) Natalie L. Trevaskis et al.   NATURE REVIEWS DRUG DISCOVERY

Clinical development of curcumin in neurodegenerative disease

(2015) Shuxin Hu et al.   Expert Review of Neurotherapeutics

Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population

(2014) Katherine HM Cox et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Protein Abundance of Clinically Relevant Multidrug Transporters along the Entire Length of the Human Intestine

(2014) Marek Drozdzik et al.   MOLECULAR PHARMACEUTICS

Application of Pharmacokinetic and Pharmacodynamic Analysis to the Development of Liposomal Formulations for Oncology

(2014) Sihem Ait-Oudhia et al.   Pharmaceutics

Evaluation of Various Static In Vitro–In Vivo Extrapolation Models for Risk Assessment of the CYP3A Inhibition Potential of an Investigational Drug

(2013) Md L T Vieira et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Evaluation of Various Static and Dynamic Modeling Methods to Predict Clinical CYP3A Induction Using In Vitro CYP3A4 mRNA Induction Data

(2013) H J Einolf et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Utilization of solid lipid nanoparticles for enhanced delivery of curcumin in cocultures of HT29-MTX and Caco-2 cells

(2013) Anilda Guri et al.   Food & Function

Predicting drug–drug interactions: application of physiologically based pharmacokinetic models under a systems biology approach

(2013) Karen Rowland Yeo et al.   Expert Review of Clinical Pharmacology

Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers

(2012) Laurie P. Volak et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP

(2012) Hiroyuki Kusuhara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Determination of unbound fraction of imatinib and N-desmethyl imatinib, validation of an UPLC–MS/MS assay and ultrafiltration method

(2012) Cécile Arellano et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Effects of curcumin on the pharmacokinetics of talinolol in human withABCB1polymorphism

(2012) X. He et al.   XENOBIOTICA

Inhibition of paracetamol glucuronidation by tyrosine kinase inhibitors

(2011) Yong Liu et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model

(2011) A. S. Darwich et al.   CURRENT DRUG METABOLISM

Characterization of Niflumic Acid as a Selective Inhibitor of Human Liver Microsomal UDP-Glucuronosyltransferase 1A9: Application to the Reaction Phenotyping of Acetaminophen Glucuronidation

(2011) J. O. Miners et al.   DRUG METABOLISM AND DISPOSITION

In vitro–in vivo extrapolation of CYP2C8-catalyzed paclitaxel 6α-hydroxylation: effects of albumin on in vitro kinetic parameters and assessment of interindividual variability in predicted clearance

(2011) Nitsupa Wattanachai et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Safety assessment of a solid lipid curcumin particle preparation: Acute and subchronic toxicity studies

(2011) Paresh Dadhaniya et al.   FOOD AND CHEMICAL TOXICOLOGY

Assessment of algorithms for predicting drug-drug interactions via inhibition mechanisms: comparison of dynamic and static models

(2010) Eleanor J. Guest et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Effects of imatinib mesylate on the pharmacokinetics of paracetamol (acetaminophen) in Korean patients with chronic myelogenous leukaemia

(2010) Dong-Wook Kim et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Safety and Pharmacokinetics of a Solid Lipid Curcumin Particle Formulation in Osteosarcoma Patients and Healthy Volunteers

(2010) Vikram S. Gota et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Population-Based Mechanistic Prediction of Oral Drug Absorption

(2009) Masoud Jamei et al.   AAPS Journal

Comparison of Different Algorithms for Predicting Clinical Drug-Drug Interactions, Based on the Use of CYP3A4 in Vitro Data: Predictions of Compounds as Precipitants of Interaction

(2009) O. A. Fahmi et al.   DRUG METABOLISM AND DISPOSITION

Pharmacokinetics of Curcumin Conjugate Metabolites in Healthy Human Subjects

(2008) S. K. Vareed et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Covariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling

(2008) Z. E. Barter et al.   DRUG METABOLISM AND DISPOSITION

Patient Disclosure about Herb and Supplement Use among Adults in the US

(2007) Jae Kennedy et al.   Evidence-based Complementary and Alternative Medicine