Article
Cardiac & Cardiovascular Systems
Caitlin C. Fermoyle, Glenn M. Stewart, Barry A. Borlaug, Bruce D. Johnson
Summary: Patients with heart failure with preserved ejection fraction (HFpEF) exhibit lower lung diffusing capacity at rest and during exercise due to impaired gas conductance across the alveolar-capillary membrane. DLCO is impaired for a given pulmonary capillary wedge pressure and pulmonary arterial compliance. These findings provide new insights into the complex relationships between hemodynamic perturbations and gas exchange abnormalities in HFpEF.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Physiology
Alessandra Magini, Gerald S. Zavorsky, Anna Apostolo, Mauro Contini, Simone Barbieri, Piergiuseppe Agostoni
Summary: In heart failure patients, the week-to-week variability in DMCO was lowest when using the single-step NO-CO technique, while Vcap estimation was unreliable. The DMCO derived from double diffusion most closely matched that from the RF method.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Article
Sport Sciences
Iker Garcia, Franchek Drobnic, Victoria Pons, Gines Viscor
Summary: This study evaluated changes in lung diffusing capacity in artistic swimmers during training, finding a significant increase after apnoeic swimming and a decrease after figures and choreography. Despite large inter-individual variability, there were no significant differences in lung diffusing capacity from pre- to post-training.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2021)
Article
Respiratory System
Natalie Terzikhan, Hanfei Xu, Ahmed Edris, Ken R. Bracke, Fien M. Verhamme, Bruno H. C. Stricker, Josee Dupuis, Lies Lahousse, George T. O'Connor, Guy G. Brusselle
Summary: This study identified epigenetic markers associated with pulmonary gas exchange capacity, revealing the mechanistic impact of smoking-induced gene demethylation on lung health. The findings emphasize the significant role of the EXOC3 gene in this process.
Article
Biochemical Research Methods
Barbora Spackova, Henrik Klein Moberg, Joachim Fritzsche, Johan Tenghamn, Gustaf Sjosten, Hana Sipova-Jungova, David Albinsson, Quentin Lubart, Daniel van Leeuwen, Fredrik Westerlund, Daniel Midtvedt, Elin K. Esbjorner, Mikael Kall, Giovanni Volpe, Christoph Langhammer
Summary: Nanofluidic scattering microscopy (NSM) is a label-free, real-time imaging technique that enables measurement of the molecular weight and hydrodynamic radius of biological molecules and nanoparticles inside a nanofluidic channel. It provides a method for characterizing single biomolecules without the need for labeling, which can compromise data interpretation.
Article
Respiratory System
Sherri L. Katz, Jean K. Mah, Hugh J. McMillan, Craig Campbell, Vid Bijelic, Nick Barrowman, Franco Momoli, Henrietta Blinder, Shawn D. Aaron, Laura C. McAdam, The Thanh Diem Nguyen, Mark Tarnopolsky, David F. Wensley, David Zielinski, Louise Rose, Nicole Sheers, David J. Berlowitz, Lisa Wolfe, Doug McKim
Summary: This randomized controlled trial aimed to determine whether twice-daily lung volume recruitment (LVR) therapy attenuates the decline in forced vital capacity (FVC) at 2 years in boys with Duchenne muscular dystrophy (DMD). The results showed that there was no difference in decline in FVC with the use of twice-daily LVR for boys with relatively normal lung function.
Article
Environmental Sciences
Ruijun Jiang, Tonglu Li, Zhijie Jia, Yonglu Dong
Summary: This study investigated the soil properties and groundwater resources of Hailiutu pasture in Inner Mongolia, China, and measured the soil water characteristics. The results showed that the pasture had an available water capacity of 218.0 mm and acted as a natural capillary barrier optimizing irrigation. Therefore, a drip irrigation method was designed for irrigation in dryland pastures.
Article
Medicine, General & Internal
Kyuho Lee, Young Jun Oh, Mina Kim, Sei Han Song, Namo Kim
Summary: The protective mechanism of hypoxic pulmonary vasoconstriction is impaired in patients with low DLCO during one-lung ventilation. Inhalation of iloprost can improve oxygenation and lung mechanics in these patients, reducing alveolar dead space.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Environmental Sciences
Rim Dridi, Nadia Dridi, Karuppasamy Govindasamy, Nabil Gmada, Ridha Aouadi, Herve Guenard, Ismail Laher, Ayoub Saeidi, Katsuhiko Suzuki, Anthony C. Hackney, Hassane Zouhal
Summary: This study found that varying aerobic training intensities have significant effects on pulmonary function in young athletes, with higher intensity training leading to greater improvements in pulmonary vascular function.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Cardiac & Cardiovascular Systems
John K. Peel, Duane J. Funk, Peter Slinger, Sadeesh Srinathan, Biniam Kidane
Summary: Low tidal volumes during 1-lung ventilation do not worsen oxygenation or compliance. A low tidal volume ventilation strategy during 1-lung ventilation was associated with a significant reduction in postoperative pulmonary complications.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Multidisciplinary Sciences
Timothy Howarth, Helmi Ben Saad, Ara J. Perez, Charmain B. Atos, Elisha White, Subash S. Heraganahally
Summary: This study identified significant differences in DLCO and TLC parameters between Indigenous Australians compared to Australian Caucasians, highlighting the need for establishing appropriate norms for Indigenous Australians.
Article
Respiratory System
Aaron B. Holley, Thomas Carbone, Arthur W. Holtzclaw, Nikhil A. Huprikar, Rory Wagner, Michael J. Morris
Summary: This study aimed to investigate the effects of body mass index (BMI) on measures of lung function. The results showed that BMI was significantly associated with KCO and VA, but not with DLCO. These findings have implications for the sensitivity in detecting gas-exchange abnormalities.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Respiratory System
Kathrin Kahnert, Lilli Maria Lempert, Juergen Behr, Laura Elsner, Toki Bolt, Amanda Tufman, Diego Kauffmann-Guerrero
Summary: This study found that lung function testing results are associated with prognosis in SCLC patients. Hyperinflation and reduced diffusing capacity were correlated with poorer outcomes. Therefore, body plethysmography and measurement of diffusing capacity should be included in the pre-therapeutic assessment of SCLC patients.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2023)
Article
Respiratory System
Apama Balasubramanian, Nirupama Putcha, Neil R. MacIntyre, Robert L. Jensen, Gregory Kinney, William W. Stlinger, Craig P. Hersh, Russell P. Bowler, Richard Casaburi, MeiLan K. Han, Janos Porszasz, R. Graham Barr, Elizabeth Regan, Barry J. Make, Nadia N. Hansel, Robert A. Wise, Meredith C. McCormack
Summary: DLCO is a potential predictor of mortality in COPD patients, independent of BODE index and CT evidence. For every 10% decrease in DLCO percent predicted, mortality increases by 28%. Adding DLCO to BODE improves the predictive accuracy of the model for COPD.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Multidisciplinary Sciences
Hendrik Wisselink, Danielle J. D. A. Steerenberg, Mieneke Rook, Gert-Jan H. Pelgrim, Marjolein Heuvelmans, Maarten van den Berge, Geertruida de Bock, Rozemarijn Vliegenthart
Summary: Predicted lung volumes based on the GLI model are used in pulmonary disease detection and monitoring. This study aimed to compare the GLI-2021 model predictions of TLC with CT-derived TLV.
Article
Biochemistry & Molecular Biology
Ayoub Saeidi, Farnaz Seifi-Ski-Shahr, Mohammad Soltani, Ali Daraei, Hossein Shirvani, Ismail Laher, Anthony C. Hackney, Kelly E. Johnson, Gholam Basati, Hassane Zouhal
Summary: This study aimed to determine the effects of different resistance training protocols on gremlin 1, macrophage migration inhibitory factor (MIF), cardiometabolic, and anthropometric measures in obese men. The results showed that circuit resistance training (CRT) and interval resistance training (IRT) had greater beneficial effects on gremlin 1, MIF, body composition, and cardiometabolic risk factors compared to traditional resistance training (TRT) protocol.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Immunology
Golnaz Vaseghi, Ahmad Ghasemi, Ismail Laher, HojjatAllah Alaei, Nasim Dana, Hajar Naji Esfahani, Shaghayegh Haghjooy Javanmard
Summary: Morphine can increase the progression of melanoma and may be related to the increased expression of TLR4. Our results suggest caution should be exercised when using morphine in patients with melanoma.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2023)
Article
Geriatrics & Gerontology
Ebrahim Banitalebi, Elahe Banitalebi, Majid Mardaniyan Ghahfarokhi, Mostafa Rahimi, Ismail Laher, Kade Davison
Summary: This study aimed to evaluate the effects of resistance elastic band exercises (REBEs) on cardiometabolic/obesity-related biomarkers in older females with osteosarcopenic obesity. A total of 63 patients aged 65-80 years with osteosarcopenic obesity and a body mass index exceeding 30 kg/m2 were randomly assigned to either an experimental group (REBE, n = 32) or a usual care group (n = 31). The experimental group completed a 12-week REBE program, three times a week and 60 min per session. Compared with the usual care group, the experimental group showed decreases in lipid accumulation product (p = .033), visceral adipose index (p = .001), triglyceride-glucose-body mass index (p = .034), and atherogenic index of plasma (p = .028). The findings highlight the importance of an REBE program in improving combined cardiometabolic/obesity-related indices in older women with osteosarcopenic obesity, especially for those who cannot tolerate or participate in more strenuous exercise programs.
JOURNAL OF AGING AND PHYSICAL ACTIVITY
(2023)
Correction
Sport Sciences
Jed M. Tijani, Fatma Rhibi, Hassane Zouhal, Athanasios A. Dalamitros, Abderraouf Ben Abderrahman
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2023)
Article
Medicine, Research & Experimental
Saeed Daneshyar, Gholamreza Tavoosidana, Mahdi Bahmani, Saeed Shokati Basir, Maryam Delfan, Ismail Laher, Ayoub Saeidi, Urs Granacher, Hassane Zouhal
Summary: This study aims to investigate the combined effects of high-fat diets and exercise training on autophagy in mouse white adipose tissue. The results show that both the high-fat diet and exercise training groups had increased levels of autophagy-related genes and proteins. The combination of high-fat diet and exercise enhances autophagosome formation and modulates lysosomal degradation in white adipose tissue.
Article
Nutrition & Dietetics
Hossein Shirvani, Behzad Bazgir, Alireza Shamsoddini, Ayoub Saeidi, Seyed Morteza Tayebi, Kurt A. A. Escobar, Ismail Laher, Trisha A. A. VanDusseldorp, Katja Weiss, Beat Knechtle, Hassane Zouhal
Summary: This study investigated the effects of oregano supplementation on muscle damage, oxidative stress, and plasma antioxidant markers of soldiers performing military training. The results showed that oregano supplementation can reduce muscle damage and increase oxidative capacity. Therefore, supplementation with oregano may serve as a dietary strategy to increase preparedness and promote recovery in military recruits.
Article
Nutrition & Dietetics
Manda Wang, Gangqiang Wang, Xiaoli Pang, Jiacheng Ma, Jinghan Yuan, Yanrong Pan, Yu Fu, Ismail Laher, Shunchang Li
Summary: Cardiac structure remodeling and dysfunction are common complications of diabetes, often leading to serious cardiovascular events. MOTS-c, a mitochondria-derived peptide, regulates metabolic homeostasis and improves vascular endothelial function, making it a novel therapeutic target for the cardiovascular complications of diabetes.
FRONTIERS IN NUTRITION
(2023)
Review
Obstetrics & Gynecology
Claire Tourny, Amira Zouita, Samira El Kababi, Lea Feuillet, Ayoub Saeidi, Ismail Laher, Katja Weiss, Beat Knechtle, Hassane Zouhal
Summary: This article reviews the effects of physical activity on the management and quality of life in patients with endometriosis. The findings suggest that body awareness practices such as Hatha yoga and progressive muscle relaxation can reduce pain and stress and improve the quality of life associated with endometriosis. However, caution should be taken in considering patients' physical abilities and avoiding intense physical activities. More research is needed to explore nonmedicinal or surgical techniques for different forms of endometriosis and its symptoms.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Sport Sciences
Bahram Sheikhi, Amir Letafatkar, Paulo Henrique Marchetti, Fereshteh Eftekhari, Brian J. Wallace, Filippo Maselli, Giacomo Rossettini, Urs Granacher, Hassane Zouhal
Summary: This study aimed to examine the immediate and delayed effects of kinesio taping at different stretches on tuck jump performance in active individuals. However, the results showed no improvement in tuck jump performance after the application of kinesio taping, regardless of the stretch level. There were no significant differences in tuck jump performance between the different kinesio taping groups at any time point.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2023)
Article
Sport Sciences
Ammar Nebigh, Imed Touhami, Mokhtar Chtara, Karuppasamy Govindasamy, Chandrababu Surech, Rawad El Hage, Ayoub Saeidi, Daniel Boullosa, Cain C. T. Clark, Urs Granacher, Hassane Zouhal
Summary: This study aimed to investigate the impact of sex and sport-discipline on physical fitness and bone markers in young sub-elite track and field athletes. The results showed significant differences in bone markers between males and females, with higher levels observed in males. Additionally, there was a significant difference in bone marker levels between athletes in endurance and power sports, with endurance athletes having higher levels.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2023)
Article
Physiology
Raoua Triki, Hassane Zouhal, Hamdi Chtourou, Iyed Salhi, Nidhal Jebabli, Ayoub Saeidi, Ismail Laher, Anthony C. Hackney, Urs Granacher, Abderraouf Ben Abderrahman
Summary: This study investigated the effects of timing of resistance training (RT) during Ramadan intermittent fasting (RIF) on muscle strength and hypertrophy in healthy male adults. The results suggest that practicing RT during RIF does not have adverse effects on muscle hypertrophy and strength, regardless of whether it is done in a fed or fasted state. However, RT has greater effects on muscle strength when done in a fed state. Therefore, training sessions during Ramadan should be scheduled after breaking the fast.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
Review
Physiology
Taylor A. Ricci, Nicha Boonpattrawong, Ismail Laher, Angela M. Devlin
Summary: Maternal nutrition during pregnancy can have long-lasting effects on fetal development and increase the risk of cardiovascular disease in later life. This review examines the impact of maternal diet on offspring vascular function, including the effects of maternal micronutrient intake, high-fat diets, caloric restriction, and low protein intake on endothelial function. The review also discusses study design differences, potential underlying mechanisms, and identifies areas for future research.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Review
Sport Sciences
Amira Zouita, Manel Darragi, Mariem Bousselmi, Zouita Sghaeir, Cain C. T. Clark, Anthony C. Hackney, Urs Granacher, Hassane Zouhal
Summary: This systematic review summarizes the recent evidence on the long-term effects of resistance training on muscular fitness, muscle morphology, and body composition in female elite athletes. The findings suggest that resistance training leads to significant improvements in muscle power, strength, speed, and jump performance in this population. However, further research is needed to determine the optimal training parameters for maximizing these outcomes in female elite athletes.
Article
Sport Sciences
El Mokhtar El Ouali, Hassane Zouhal, Loubna Bahije, Azeddine Ibrahimi, Bahae Benamar, Jihan Kartibou, Ayoub Saeidi, Ismail Laher, Sanae El Harane, Urs Granacher, Abdelhalem Mesfioui
Summary: The aim of this study was to determine the effect of malocclusion on maximal aerobic capacity in young athletes, and the study found that malocclusion does not affect the maximal aerobic capacity and athletic performance of track and field athletes.
