Impact of kinesin Eg5 inhibition by 3,4-dihydropyrimidin-2(1H)-one derivatives on various breast cancer cell features

Structural Basis of New Allosteric Inhibition in Kinesin Spindle Protein Eg5

(2015) Hideshi Yokoyama et al.   ACS Chemical Biology

Cancer Stem Cells in Solid and Liquid Tissues of Breast Cancer Patients: Characterization and Therapeutic Perspectives

(2015) Rena Chiotaki et al.   CURRENT CANCER DRUG TARGETS

Association of microRNA 17–92 cluster host gene (MIR17HG) polymorphisms with breast cancer

(2015) Diego Chacon-Cortes et al.   TUMOR BIOLOGY

Synthetic studies on mitotic kinesin Eg5 inhibitors: Synthesis and structure–activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives

(2014) Junichiro Yamamoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

From nature to bedside: Pro-survival and cell death mechanisms as therapeutic targets in cancer treatment

(2014) Claudia Cerella et al.   BIOTECHNOLOGY ADVANCES

Regioselective synthesis of novel 4,5-diaryl functionalized 3,4-dihydropyrimidine-2(1H)-thiones via a non-Biginelli-type approach and evaluation of their in vitro anticancer activity

(2014) Jacek G. Sośnicki et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Protein Kinase C α Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells

(2013) Wai Leong Tam et al.   CANCER CELL

The Biginelli Reaction with an Imidazolium-Tagged Recyclable Iron Catalyst: Kinetics, Mechanism, and Antitumoral Activity

(2013) Luciana M. Ramos et al.   CHEMISTRY-A EUROPEAN JOURNAL

Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents

(2013) Hala Bakr El-Nassan   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Molecular Interactions in the Development of Brain Metastases

(2013) Nina Martinez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Photocontrol of mitotic kinesin Eg5 facilitated by thiol-reactive photochromic molecules incorporated into the loop L5 functional loop

(2013) K. Ishikawa et al.   JOURNAL OF BIOCHEMISTRY

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity

(2012) Appalaraju Jaggupilli et al.   Clinical & Developmental Immunology

CD44+/CD24− breast cancer cells isolated from MCF-7 cultures exhibit enhanced angiogenic properties

(2012) Hongmei Sun et al.   Clinical & Translational Oncology

Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5

(2011) Xiao-dong Sun et al.   ACTA PHARMACOLOGICA SINICA

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Preferential killing of tetraploid tumor cells by targeting the mitotic kinesin Eg5

(2011) Santiago Rello-Varona et al.   CELL CYCLE

Synthesis and biological evaluation of conformationally flexible as well as restricted dimers of monastrol and related dihydropyrimidones

(2011) Ahmed Kamal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype

(2011) S. Ricardo et al.   JOURNAL OF CLINICAL PATHOLOGY

Synthesis of dihydropyrimidin-2-one/thione library and cytotoxic activity against the human U138-MG and Rat C6 glioma cell lines

(2011) Rômulo F. S Canto et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

Mitotic catastrophe: a mechanism for avoiding genomic instability

(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content

(2010) Salvatore Pece et al.   CELL

Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl- l -cysteine in tumor derived cell lines

(2009) Sergey Tcherniuk et al.   BIOCHEMICAL PHARMACOLOGY

Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

(2009) Emmanuelle Charafe-Jauffret et al.   CANCER RESEARCH

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells

(2009) B Z Carter et al.   LEUKEMIA

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

(2009) Bin-Bing S. Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

(2009) C. J. Creighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-Specific Promoters Active in CD44+CD24-/low Breast Cancer Cells

(2008) G. J. Bauerschmitz et al.   CANCER RESEARCH

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Chemotherapy-induced peripheral neuropathy

(2008) Bushra Malik et al.   Current Pain and Headache Reports

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation