Andrographolide Exerts Antihyperglycemic Effect through Strengthening Intestinal Barrier Function and Increasing Microbial Composition of Akkermansia muciniphila

Andrographolide derivative ameliorates dextran sulfate sodium-induced experimental colitis in mice

(2019) Bao-Jian Guo et al.   BIOCHEMICAL PHARMACOLOGY

Pelargonidin-3-O-glucoside Derived from Wild Raspberry Exerts Antihyperglycemic Effect by Inducing Autophagy and Modulating Gut Microbiota

(2019) Hongming Su et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer

(2018) Muhammad Torequl Islam et al.   CANCER LETTERS

Hold the Door: Role of the Gut Barrier in Diabetes

(2018) Anthony Martin et al.   Cell Metabolism

Gut commensalParabacteroides goldsteiniiplays a predominant role in the anti-obesity effects of polysaccharides isolated fromHirsutella sinensis

(2018) Tsung-Ru Wu et al.   GUT

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

(2018) Liping Zhao et al.   SCIENCE

Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

(2018) Christoph A. Thaiss et al.   SCIENCE

Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model

(2018) Guangxin Chen et al.   EBioMedicine

Procyanidin B2 ameliorates free fatty acids-induced hepatic steatosis through regulating TFEB-mediated lysosomal pathway and redox state

(2018) Hongming Su et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cathelicidin-WA attenuates LPS-induced inflammation and redox imbalance through activation of AMPK signaling

(2018) Weiche Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

The gut microbiota at the intersection of diet and human health

(2018) Christopher L. Gentile et al.   SCIENCE

Akkermansia muciniphilainduces gut microbiota remodelling and controls islet autoimmunity in NOD mice

(2017) Arno Hänninen et al.   GUT

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

(2017) Hao Wu et al.   NATURE MEDICINE

Andrographolide suppresses preadipocytes proliferation through glutathione antioxidant systems abrogation

(2016) Wei Chen et al.   LIFE SCIENCES

Andrographolide ameliorates diabetic nephropathy by attenuating hyperglycemia-mediated renal oxidative stress and inflammation via Akt/NF-κB pathway

(2016) Xiaoqian Ji et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Kuwanon G Preserves LPS-Induced Disruption of Gut Epithelial Barrier In Vitro

(2016) Hengli Guo et al.   MOLECULES

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

The intestinal epithelial barrier: a therapeutic target?

(2016) Matthew A. Odenwald et al.   Nature Reviews Gastroenterology & Hepatology

Beneficial effects of anAndrographis paniculataextract and andrographolide on cognitive functions in streptozotocin-induced diabetic rats

(2016) Ajit Kumar Thakur et al.   PHARMACEUTICAL BIOLOGY

Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism

(2016) Renee L. Greer et al.   Nature Communications

Andrographolide ameliorates diabetic retinopathy by inhibiting retinal angiogenesis and inflammation

(2015) Zengyang Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Dietary Polyphenols Promote Growth of the Gut BacteriumAkkermansia muciniphilaand Attenuate High-Fat Diet–Induced Metabolic Syndrome

(2015) Diana E. Roopchand et al.   DIABETES

Biomarkers of oxidative stress study VI. Endogenous plasma antioxidants fail as useful biomarkers of endotoxin-induced oxidative stress

(2015) Maria B. Kadiiska et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatic and Fecal Metabolomic Analysis of the Effects of Lactobacillus rhamnosus GG on Alcoholic Fatty Liver Disease in Mice

(2015) Xue Shi et al.   JOURNAL OF PROTEOME RESEARCH

Type 2 diabetes mellitus

(2015) Ralph A. DeFronzo et al.   Nature Reviews Disease Primers

Andrographolide inhibits TNFα-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP-1 pathways in human endothelial cells

(2014) Chia-Yang Lu et al.   BIOCHEMICAL PHARMACOLOGY

A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increasedAkkermansiaspp. population in the gut microbiota of mice

(2014) Fernando F Anhê et al.   GUT

Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity

(2014) Amandine Everard et al.   ISME Journal

Preventive effects of andrographolide on the development of diabetes in autoimmune diabetic NOD mice by inducing immune tolerance

(2013) Chengliang Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Andrographolide induces autophagic cell death in human liver cancer cells through cyclophilin D-mediated mitochondrial permeability transition pore

(2012) Wei Chen et al.   CARCINOGENESIS

The Impact of the Gut Microbiota on Human Health: An Integrative View

(2012) Jose C. Clemente et al.   CELL

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

Overlapping elution–extrusion counter-current chromatography: A novel method for efficient purification of natural cytotoxic andrographolides from Andrographis paniculata

(2011) Dingfang Wu et al.   JOURNAL OF CHROMATOGRAPHY A

The endocannabinoid system links gut microbiota to adipogenesis

(2010) Giulio G Muccioli et al.   Molecular Systems Biology

Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment

(2009) Zaijun Zhang et al.   Journal of Translational Medicine

Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials

(2009) Nigel A. Calcutt et al.   NATURE REVIEWS DRUG DISCOVERY

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES