Article
Neurosciences
Keyvan Mehri, Zohreh Zavvari Oskuye, Ehsan Nassireslami, Esmail Karami, Mohammad Reza Parvizi
Summary: This study investigated the effects of Botulinum toxin on spatial memory and biochemical and histological parameters in the hippocampus of male rats. Results showed that Botox significantly impaired memory performance and led to a decrease in acetylcholine levels, increase in acetylcholinesterase activity, and morphological damage in the hippocampus. Administration of Rivastigmine partially alleviated these effects and could serve as a protective approach.
Article
Biochemistry & Molecular Biology
Jagadeesh Dhamodharan, Ganthimathy Sekhar, Arunachalam Muthuraman
Summary: This study aimed to explore the ameliorative potential of gefitinib (GE) in Alzheimer's disease (AD) mice. The results showed that GE significantly improved AD-associated behavioral, biochemical, and histopathological changes by inhibiting EGFR kinase activation and having antioxidant and antilipid peroxidative effects against A beta(1-42) oligomer-induced neurotoxicity.
Article
Multidisciplinary Sciences
Chao Chen, Xiaoxin Zhang, Hao Huang, Hongyi Bao, Xiaodong Li, Ye Cheng, Jing Zhang, Yin Ding, Yanguang Yang, Haiying Gu, Donglin Xia
Summary: The study showed that poly(lactic-co-glycolic acid) meso-particles containing superoxide dismutase and catalase were effective in attenuating lead-induced cognitive impairment by inhibiting oxidative stress. The bi-enzymes platform displayed a remarkable protective mechanism in preventing memory impairment and reversing lead-induced cognitive impairments.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Khian Giap Lim, Rajavel Varatharajan, Arunachalam Muthuraman
Summary: This study investigated the beneficial effects of beta-carotene on diabetes-associated vascular dementia and its antioxidative actions. Beta-carotene treatment improved cognitive function and reduced oxidative stress markers in rats with diabetic vascular dementia.
Article
Plant Sciences
Razvan Stefan Boiangiu, Eyup Bagci, Gabriela Dumitru, Lucian Hritcu, Elena Todirascu-Ciornea
Summary: This study investigates the protective effect of Angelica purpurascens essential oil (APO) on memory impairments induced by scopolamine in zebrafish. The results show that APO can restore cholinergic system function and improve brain antioxidant state, thereby alleviating the memory deficits.
Article
Neurosciences
Lisa Wintzell, Samuel Klemetz, Stefan Lange, Eric Hanse, Caroline Wass, Joakim Strandberg
Summary: The endogenous peptide antisecretory factor (AF) enhances long-term potentiation (LTP) and spatial learning and memory by disinhibiting GABAergic transmission in the rat hippocampus.
Article
Behavioral Sciences
Amanda Dyer, Maxine De Butte
Summary: This study aimed to examine the effects of chronic low-dose vanadium administration on the behavior of young male rats. The findings suggest that vanadium does not significantly affect exploration, locomotion, or anxiety-like behavior in rats, but does affect novel object recognition performance. Additionally, vanadium administration led to lower latency times in the Morris Water maze task.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Endocrinology & Metabolism
Maryam Sajjadi, Ehsan Oskoueian, Ehsan Karimi, Mahdi Ebrahimi
Summary: The root extract of Amygdalus spinosissima plant contains bioactive phenolic and flavonoid compounds with antioxidant and anti-inflammatory properties, improving learning and memory function in mice. This extract shows promising potential in retarding the development of neurodegenerative diseases such as Alzheimer's disease.
METABOLIC BRAIN DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Fernanda Cardoso Teixeira, Bruna da Silveira de Mattos, Julia Eisenhardt de Mello, Juliane Cardoso, Luiza Spohr, Karina Pereira Luduvico, Mayara Sandrielly Pereira Soares, Fabiano Barbosa Carvalho, Jessie Martins Gutierres, Anelize de Oliveira Campello Felix, Francieli Moro Stefanello, Roselia Maria Spanevello
Summary: This study found that inosine could protect against scopolamine-induced memory consolidation impairment, improve redox status, and modulate neurotransmitter signaling and ion pump activity in rats. This compound may have potential therapeutic and preventive effects against neurodegenerative mechanisms involved in Alzheimer's disease.
NEUROCHEMICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Takujiro Homma, Hiroki Fujiwara, Tsukasa Osaki, Satoshi Fujii, Junichi Fujii
Summary: This study investigated the learning and memory abilities of Prdx4 knockout mice and found that Prdx4-KO mice performed poorly in spatial memory tasks. In contrast, their locomotor activity was significantly increased. Molecular analysis revealed increased expression of genes related to ER-associated degradation mechanisms and aberrant expression of proteins associated with calcium homeostasis and synaptogenesis in the brains of Prdx4-KO mice.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Vicko Suswidiantoro, Nuriza Ulul Azmi, Donny Lukmanto, Fadlina Chany Saputri, Abdul Mun'im, Ahmad Aulia Jusuf
Summary: Extracts of turmeric rhizome and bitter melon fruit exhibit antioxidant activity and can provide neuroprotective effects against aspartame-induced memory impairment.
Article
Biochemistry & Molecular Biology
Baban S. S. Thawkar, Ginpreet Kaur
Summary: This study evaluated the neuroprotective properties of betanin obtained from Beta vulgaris in a scopolamine-induced zebrafish paradigm. The results showed that betanin could reduce memory impairment, anxiety, and brain oxidative stress caused by scopolamine, suggesting its therapeutic potential for cognitive deficits.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Food Science & Technology
Chi Heung Cho, Young Sung Jung, Jong Min Kim, Tae Gyu Nam, Sang-Hoon Lee, Hye Sung Cho, Myoung Chong Song, Ho Jin Heo, Dae-Ok Kim
Summary: The Actinidia eriantha cv. Bidan extract (AEE) showed neuroprotective effects by reducing reactive oxygen species levels and suppressing apoptotic cell death, resulting in improvements in learning and spatial memory in Aβ1-42-treated mice. AEE also increased endogenous antioxidant systems in mouse brain tissue and contained caffeic acid derivatives, suggesting its potential to improve cognitive function as a source of antioxidant phenolics.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Agriculture, Multidisciplinary
Nan Zhang, Pu Jing
Summary: Research suggests that red cabbage anthocyanins may have health benefits associated with antiaging. In a study on aging mice, it was found that extracts rich in red cabbage anthocyanins and cyanidin-3-diglucoside-5-glucoside significantly reduced cognitive impairment and had no effect on motor disorder. These extracts also increased antioxidant activity and reduced neuronal damage and neuroinflammation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Behavioral Sciences
Ewa Zwierzynska, Boguslawa Pietrzak
Summary: Lacosamide does not impair memory and learning processes, with temporary disruption of emotional memory observed only after a single high dose administration.
EPILEPSY & BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Richa Rai, Sudhir Kumar Chauhan, Vikas Vikram Singh, Madhukar Rai, Geeta Rai
Article
Education, Scientific Disciplines
Yogesh Kumar, Ajit Kumar Thakur, Ramesh Kishorilal Goyal
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Sakshi Singh, Vinay K. Singh, Geeta Rai
Article
Chemistry, Medicinal
Yash Pal Singh, Gullanki Naga Venkata Charan Tej, Amruta Pandey, Khushbu Priya, Pankaj Pandey, Gauri Shankar, Prasanta Kumar Nayak, Geeta Rai, Amar G. Chittiboyina, Robert J. Doerksen, Swati Vishwakarma, Gyan Modi
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Clinical Neurology
Mukesh Kumar, Ajit Kumar Thakur
NEUROLOGICAL SCIENCES
(2020)
Article
Biochemical Research Methods
Sakshi Singh, Geeta Rai
Summary: This study presents a computational method that successfully designs the structure of IL12R and reveals its tight binding with IL12 ligand. The simulated molecular structure of IL12:IL12R complex provides a promising target complex for future IL12-based drug design.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2022)
Article
Biochemistry & Molecular Biology
Sakshi Tyagi, Nikhila Shekhar, Ajit Kumar Thakur
Summary: Various pathological conditions lead to protein misfolding, causing loss of neurons and synapses. Capsaicin has been shown to have neuroprotective effects and may be a potential constituent for neuro-pharmacotherapeutics.
NEUROCHEMICAL RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Parul Kamboj, Ajit Kumar Thakur
Summary: Extracts of Glycyrrhiza glabra showed significant improvement in stress-induced learning and memory deficiency in rats, possibly through modulation of acetylcholinesterase and antioxidant enzyme activity. GGGE has a higher potential compared to GGFE, likely due to the presence of glycyrrhizin responsible for the observed effects.
CURRENT TRADITIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Nikhila Shekhar, Sakshi Tyagi, Sweta Rani, Ajit Kumar Thakur
Summary: The modified medium-chain triglyceride diet, supplemented with capric acid, offers an alternative source of energy to the brain, leading to potential improvement in neurological diseases. Further research is needed to confirm its efficacy.
NEUROCHEMICAL RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Ruchika Sharma, Anoop Kumar, Jaseela Majeed, Ajit K. Thakur, Geeta Aggarwal
Summary: Based on available evidence, there is no significant association between ACEi/ARBs and mortality of COVID-19 patients.
EGYPTIAN HEART JOURNAL
(2022)
Review
Psychiatry
Sakshi Tyagi, Nikhila Shekhar, Ajit Kumar Thakur
Summary: Fatigue is a normal response to physical exertion or stressful situations, but its treatment options remain ambiguous, leading patients to seek complementary and alternative medicines. Medicinal herbs, especially from traditional systems like Ayurveda and Chinese Traditional Medicines, show promise in managing fatigue and improving symptoms. Further research is needed to validate the potential role of herbal medicines in targeted therapy for fatigue.
CURRENT PSYCHIATRY RESEARCH AND REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Geeta Rai, Doli Das, Khushbu Priya
FRONTIERS IN BIOSCIENCE-LANDMARK
(2020)
Article
Mathematical & Computational Biology
Sakshi Singh, Navaneet Chaturvedi, Geeta Rai
NETWORK MODELING AND ANALYSIS IN HEALTH INFORMATICS AND BIOINFORMATICS
(2020)
Review
Multidisciplinary Sciences
Ramesh K. Goyal, Ajit K. Thakur
PROCEEDINGS OF THE INDIAN NATIONAL SCIENCE ACADEMY
(2018)