Article
Obstetrics & Gynecology
Ayman Al-Hendy, Linda Bradley, Charlotte D. Owens, Hui Wang, Kurt T. Barnhart, Eve Feinberg, William D. Schlaff, Elizabeth E. Puscheck, Alice Wang, Veronica Gillispie, Sandra Hurtado, Ozgul Muneyyirci-Delale, David F. Archer, Bruce R. Carr, James A. Simon, Elizabeth A. Stewart
Summary: The study evaluated the safety and efficacy of elagolix with add-back therapy in reducing heavy menstrual bleeding associated with uterine fibroids in different subgroups of women. Results showed that elagolix was significantly more effective than placebo in all subgroups.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Elizabeth A. Stewart, David F. Archer, Charlotte D. Owens, Kurt T. Barnhart, Linda D. Bradley, Eve C. Feinberg, Veronica Gillispie-Bell, Anthony N. Imudia, Ran Liu, Jin Hee Kim, Ayman Al-Hendy
Summary: In women with uterine fibroids and heavy menstrual bleeding who were not responders in previous clinical trials, treatment with elagolix plus add-back therapy showed a trend towards greater reduction in menstrual blood loss compared to placebo. Adverse events did not differ significantly between responders and nonresponders.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Pharmacology & Pharmacy
Mohamed Ali, A. R. Sara, Ayman Al Hendy
Summary: Uterine fibroids (UFs) are common benign tumors in women of reproductive age, with limitations in current treatment options, creating a need for noninvasive therapeutics. Elagolix, a new-generation oral GnRH antagonist, shows potential for future UF therapy, having been FDA-approved for treating benign gynecological diseases.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2021)
Review
Public, Environmental & Occupational Health
Juliawati Muhammad, Yusnita Yusof, Imran Ahmad, Mohd Noor Norhayati
Summary: This systematic review and meta-analysis found that elagolix is effective in reducing heavy menstrual bleeding caused by uterine fibroid. Combination with estradiol/norethindrone acetate can alleviate the side effects of hypoestrogenism. However, elagolix treatment may lead to hot flush and bone mineral density loss.
Article
Hematology
Bethany T. Samuelson Bannow, Vivia Chi, Paul Sochacki, Owen J. T. McCarty, Maureen K. Baldwin, Alison B. Edelman
Summary: The study investigated rates of heavy menstrual bleeding (HMB) in users of rivaroxaban and apixaban, finding an association between rivaroxaban use and the need for medical or surgical intervention for HMB. Most women did not have a documented menstrual history, indicating that many providers do not inquire about menstrual bleeding when initiating anticoagulant therapy. Menstruating women, especially those with a history of HMB, may be at increased risk for HMB requiring medical treatment depending on the type of OAC used.
THROMBOSIS RESEARCH
(2021)
Article
Obstetrics & Gynecology
Varsha Jain, Malcolm G. Munro, Hilary O. D. Critchley
Summary: Abnormal uterine bleeding (AUB) is a common and debilitating condition that affects more than 50% of reproductive-aged women and girls. It includes symptoms such as intermenstrual bleeding and abnormalities in period duration, cycle length, and regularity. Heavy menstrual bleeding (HMB) is the most significant contributor to iron deficiency and anemia. The FIGO Systems 1 and 2 provide a comprehensive approach to assess and classify AUB, improving diagnosis and management outcomes globally.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Silvia Vannuccini, Sara Clemenza, Emanuele Cassioli, Eleonora Rossi, Giovanni Castellini, Valdo Ricca, Felice Petraglia
Summary: Uterine fibroids (UFs) are associated with pain symptoms and heavy menstrual bleeding (HMB), leading to impaired quality of life. This study evaluated the global perception of stress and menstrual distress in patients with UFs. Patients with UFs had higher levels of perceived stress and menstrual distress compared to controls, with HMB playing a major role in determining these conditions.
REPRODUCTIVE SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Alice Wang, Siting Wang, Charlotte D. Owens, Jamie B. Vora, Michael P. Diamond
Summary: This study compared the direct costs and treatment patterns for women diagnosed with UF+HMB, UF only, and HMB only in the United States. The results showed that UF+HMB treatment costs were significantly higher than UF only and HMB only, primarily driven by surgical/procedural costs and treatment patterns.
JOURNAL OF WOMENS HEALTH
(2022)
Review
Biology
Maria Effrosyni Livanou, Alkis Matsas, Serena Valsami, Dimitrios T. Papadimitriou, Athanasios Kontogiannis, Panagiotis Christopoulos
Summary: Clotting Factor deficiencies present a diagnostic and therapeutic challenge, particularly for primary health care providers who are most likely to encounter these patients. Abnormal Uterine Bleeding, specifically Heavy Menstrual Bleeding, is a common manifestation and can lead to life-threatening bleeding in severe cases. Awareness and knowledge among physicians is crucial for proper management and prophylactic treatment options should be considered in some cases.
Article
Obstetrics & Gynecology
Sanjay K. Agarwal, Michael Stokes, Tiffany Kung, Rong Tilney, Cassandra Lickert
Summary: This retrospective database analysis examined the clinical characteristics and treatment patterns of commercially insured American women with uterine fibroids and heavy menstrual bleeding. The results showed that fewer than half of the patients received hormonal therapy within 6 months of diagnosis, while one quarter received no treatment and one quarter underwent a hysterectomy or other gynecologic procedures.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2023)
Article
Obstetrics & Gynecology
Gabriela P. Mena, Gregore Mielke, Wendy J. Brown
Summary: The study found that overweight and obese women are more likely to have irregular periods and heavy menstrual bleeding, but high levels of physical activity can reduce the odds of heavy menstrual bleeding.
HUMAN REPRODUCTION
(2021)
Article
Public, Environmental & Occupational Health
Laura McKain, Kaitlyn Edsall, Robert Dufour, Cassandra Lickert
Summary: This study analyzed the clinical characteristics and treatment patterns of women with uterine fibroids in the United States, finding that patients with heavy menstrual bleeding were more likely to receive treatment and pain was a common symptom.
JOURNAL OF WOMENS HEALTH
(2023)
Article
Obstetrics & Gynecology
Hae Nam Lee, Hui Ryeon Ju, Ji Min Seo, Gi Soo Um, Min Jeong Kim
Summary: The study investigated the prevalence of anxiety and depression in Korean women with abnormal uterine bleeding (AUB) and found a higher proportion of anxiety and depression symptoms in AUB patients. Common menstrual associated symptoms included heavy menstrual bleeding, dysmenorrhea, and irregular menstrual cycles. Anxiety was related to a history of abortion and cesarean section, while depression was related to a history of minor surgery.
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Carey Y. Zhang, Huichu Li, Shunan Zhang, Sanaa Suharwardy, Uvika Chaturvedi, Tyler Fischer-Colbrie, Lindsey A. Maratta, Jukka-Pekka Onnela, Brent A. Coull, Russ Hauser, Michelle A. Williams, Donna D. Baird, Anne Marie Z. Jukic, Shruthi Mahalingaiah, Christine L. Curry
Summary: This study aimed to identify abnormal uterine bleeding patterns and their prevalence and confirm existing and expected associations between abnormal uterine bleeding patterns, demographics, and medical conditions. The results showed that 16.4% of the 18,875 participants had abnormal uterine bleeding after accurate tracking was confirmed. Black or obese participants had increased prevalence of abnormal uterine bleeding, and participants with conditions such as polycystic ovary syndrome, thyroid disease, endometriosis, and cervical dysplasia had a higher prevalence of abnormal uterine bleeding.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Gal Issakov, Yossi Tzur, Talia Friedman, Tamar Tzur
Summary: The objective of this research was to investigate the menstrual changes in COVID-19 vaccinated and infected women. The study found that nearly half of the women experienced changes in their menstrual patterns after vaccination or infection, with excessive bleeding being the most common disturbance. The type of menstrual disturbances was similar between the vaccinated and infected women, but further investigation is needed to determine the precise incidence and long-term consequences.
REPRODUCTIVE SCIENCES
(2023)