Journal
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
Volume 14, Issue 4, Pages 427-437Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17512433.2021.1900726
Keywords
Add-back Therapy; elagolix; GnRH Antagonists; heavy Menstrual Bleeding; leiomyoma; uterine Fibroids
Categories
Funding
- National Institutes of Health [R01 HD094378-04, R01 ES 028615-02, R01 HD100367-01, U54 MD007602, R01 HD094380-02]
Ask authors/readers for more resources
Uterine fibroids (UFs) are common benign tumors in women of reproductive age, with limitations in current treatment options, creating a need for noninvasive therapeutics. Elagolix, a new-generation oral GnRH antagonist, shows potential for future UF therapy, having been FDA-approved for treating benign gynecological diseases.
Introduction Uterine fibroids (UFs) are the most common benign tumor arising from myometrium of reproductive age women, with significant financial burden estimated in hundreds of billions of dollars. Unfortunately, there are limitations in available long-term treatment options. Thus, there is a large unmet need in the UF space for noninvasive therapeutics. Areas covered Authors reviewed the literature available for elagolix; an orally bioavailable, second-generation, non-peptide gonadotropin-releasing hormone (GnRH) antagonist recently approved by the US Food and Drug Administration (FDA) in combination with estradiol/norethindrone acetate for the management of heavy menstrual bleeding associated with UFs in premenopausal women. Expert opinion The utility of new-generation oral GnRH-antagonists, such as elagolix, relugolix and linzagolix, is offering a new potential opportunity for the future therapy of UFs: elagolix has been the most studied drug of this class for treating benign gynecological diseases, including endometriosis and UFs, for which it has been US FDA-approved in 2018 and 2020, respectively.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available