Article
Medicine, General & Internal
Yu-Mi Seo, Seok Hwang-Bo, Soo-Ah Im, Myungshin Kim, Young-Ah Youn
Summary: This study aims to evaluate the significant gene expression in severe hypoxic ischemic encephalopathy (HIE) in newborns. The study found that the levels of heat-shock protein 70 and 47 were significantly elevated in the severe-HIE group, possibly playing a protective role in inhibiting exacerbated neuroinflammation and maintaining cellular homeostasis. Additionally, the >= moderate-HIE group showed significant language delay at 18-24 months.
Review
Biochemistry & Molecular Biology
Gian Pietro Sechi, Flaminia Bardanzellu, Maria Cristina Pintus, Maria Margherita Sechi, Maria Antonietta Marcialis, Vassilios Fanos
Summary: This review discusses the potential therapeutic role of thiamine and its derivatives in the management of neonatal hypoxic-ischemic encephalopathy (HIE), highlighting its antioxidant properties and ability to rescue mitochondrial function. It suggests a synergistic effect between thiamine treatment and therapeutic hypothermia.
Review
Biochemistry & Molecular Biology
Yue Zhou, Luqiang Sun, Haichuan Wang
Summary: The prevalence of neonatal hypoxic-ischemic encephalopathy (HIE) is increasing, leading to the need for effective treatments and preventions. Research has focused on understanding the underlying pathology and the potential of dietary interventions, such as a ketogenic diet (KD). The KD has shown promising effects in animal models and brain injury patients, including potential neuroprotection and improvement of mitochondrial function.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Pediatrics
Suresh Victor, Eridan Rocha-Ferreira, Ahad Rahim, Henrik Hagberg, David Edwards
Summary: Around 0.75 million babies suffer from HIE each year, leading to neurodevelopmental impairment. Therapeutic hypothermia is effective but improvements are needed. Challenges for the next decade include better animal models, industry support, and well-designed clinical trials to enhance treatment outcomes.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Computer Science, Artificial Intelligence
Mark E. O'Sullivan, Gordon Lightbody, Sean R. Mathieson, William P. Marnane, Geraldine B. Boylan, John M. O'Toole
Summary: The study aims to develop and evaluate algorithms for detecting neonatal EEG artefacts and assessing their application in automated EEG grading of neonatal hypoxic-ischemic encephalopathy (HIE). The study used machine learning and deep learning methods, with a deep learning convolutional neural network achieving the best performance for artefact detection. The inclusion of artefact detection in the grading algorithm slightly improved its accuracy.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Pediatrics
Eric S. Peeples, Rakesh Rao, Maria L. Dizon, Yvette R. Johnson, Priscilla Joe, John Flibotte, Tanzeema Hossain, Danielle Smith, Shannon Hamrick, Robert DiGeronimo, Girija Natarajan, Kyong-Soon Lee, Toby D. Yanowitz, Ulrike Mietzsch, Tai-Wei Wu, Nathalie L. Maitre, Eugenia K. Pallotto, Mark Speziale, Amit M. Mathur, Isabella Zaniletti, An Massaro
Summary: This study used data from the CHND to develop predictive models for death or neurodevelopmental impairment after neonatal hypoxic-ischemic encephalopathy. Results showed that the early and cumulative models had good performance in both discovery and validation cohorts.
Article
Pediatrics
Meredith Monaco-Brown, Upender Munshi, Michael Joseph Horgan, Jamie L. Gifford, Rubia Khalak
Summary: This study aimed to investigate whether maternal obesity increases the risk of neonatal hypoxic ischemic encephalopathy (HIE). Retrospectively reviewing data from the New York State Perinatal Data System, it was found that infants of obese mothers were more frequently diagnosed with HIE, showing a significant increase in risk.
FRONTIERS IN PEDIATRICS
(2022)
Editorial Material
Biochemistry & Molecular Biology
GianPietro Sechi, M. Margherita Sechi
Summary: In neonatal hypoxic-ischemic encephalopathy (HIE), therapeutic hypothermia (TH) is the standard care in developed countries, but it may not be beneficial or suitable in developing nations. Moreover, hypothermic neuroprotection is often incomplete, with infants still experiencing death or significant neurological issues. Therefore, there is a need to find innovative neuroprotective compounds for HIE, such as ketone bodies and thiamine, which may provide additional neuroprotection in conjunction with TH and improve treatment strategies in low-middle-income countries.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Integrative & Complementary Medicine
Rui-Ze Niu, Liu-Lin Xiong, Hao-Li Zhou, Lu-Lu Xue, Qing-Jie Xia, Zheng Ma, Yuan Jin, Li Chen, Ya Jiang, Ting-Hua Wang, Jia Liu
Summary: The study showed that Scutellarin treatment attenuates long-term neurological impairments after hypoxic-ischemic injury by suppressing neuronal death and enhancing neurite elongation through a GAP43-dependent pathway, providing a potential therapeutic agent for neonatal HIE.
Article
Clinical Neurology
Julien Gotchac, Laura Cardoit, Muriel Thoby-Brisson, Olivier Brissaud
Summary: A new and more accurate Hypoxic Ischemic Encephalopathy (HIE) model was developed in juvenile rats, inducing a 9-minute hypoxic cardiac arrest followed by cardiopulmonary resuscitation. The rats in the study showed an anxiolytic-like behavioral profile in adulthood after the cardiac arrest, with signs of neurodegeneration in the hippocampus observed post-arrest.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Andreea M. Pavel, John M. O'Toole, Jacopo Proietti, Vicki Livingstone, Subhabrata Mitra, William P. Marnane, Mikael Finder, Eugene M. Dempsey, Deirdre M. Murray, Geraldine B. Boylan, ANSeR Consortium
Summary: The study aimed to assess whether early clinical and electroencephalography (EEG) features can predict seizures in infants with hypoxic-ischemic encephalopathy (HIE). Machine learning models were developed using clinical and EEG parameters to predict infants at high risk of seizures. The results showed that the combination of clinical and EEG analysis can accurately predict seizure development in HIE infants.
Article
Medicine, General & Internal
Inn-Chi Lee, Swee-Hee Wong, Xing-An Wang, Chin-Sheng Yu
Summary: The study found that the combination of lactate and LDH within 6 hours of birth can effectively diagnose HIE in neonates. Using combined biomarkers can improve the accuracy of predicting moderate or severe HIE, making it a feasible approach for early treatment.
Review
Biochemistry & Molecular Biology
Eric S. Peeples, Thiago C. Genaro-Mattos
Summary: This review summarizes the current understanding of ferroptosis in neonatal hypoxic-ischemic brain injury, including its pathways and potential interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Andrea Pozo-Rodrigalvarez, YiXian Li, Anna Stokowska, Jingyun Wu, Verena Dehm, Hana Sourkova, Harry Steinbusch, Carina Mallard, Henrik Hagberg, Milos Pekny, Marcela Pekna
Summary: Perinatal asphyxia leading to hypoxic-ischemic neonatal encephalopathy is a major cause of brain injury in newborns, potentially resulting in long-lasting neurodegeneration. Activation of C3aR signaling may reduce neurodegeneration and modulate reactive gliosis in the brain, providing a potential therapeutic target for treating neonatal brain injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Hao Lyu, Dong Ming Sun, Chi Ping Ng, Jun Fan Chen, Yu Zhong He, Sin Yu Lam, Zhi Yuan Zheng, Hadi Askarifirouzjaei, Chi Chiu Wang, Wise Young, Wai Sang Poon
Summary: HIE is a condition where a baby's brain is damaged due to lack of blood and oxygen supply, with current treatment involving supportive care and hypothermia. Researchers have modified the Vannucci model to establish an experimental model closer to human neonatal HIE, which shows mild brain damage and a surgical mortality rate of 30%.
Article
Medicine, General & Internal
Isabelle Dehaene, Caroline Van Holsbeke, Kristien Roelens, Noortje Nvh van Oostrum, Katrien Nulens, Koenraad Smets, Marie-Rose Van Hoestenberghe, Gunnar Naulaers, Roland Devlieger
Summary: The impact of COVID-19 and its mitigation measures on preterm birth incidence is still unclear and varies across countries. In three Belgian tertiary care hospitals, there were no differences in preterm birth rates between 2019 and 2020.
ACTA CLINICA BELGICA
(2023)
Review
Pediatrics
Eva Maes, Filip Cools, Anneleen Dereymaeker, Katrien Jansen, Gunnar Naulaers, Liesbeth Thewissen
Summary: This systematic review and meta-analysis investigated the effect of body position on rScO2 in preterm infants during the first 2 weeks after birth. The results showed that the prone position led to significantly higher rScO2 in the second week after birth compared to the supine position, but no difference was observed in extremely preterm and preterm infants.
Letter
Respiratory System
Paul Desbordes, Maarten De Vos, Julie Maes, Frans de Jongh, Karl Sylvester, Claus Franz Vogelmeier, Anh Tuan Dinh-Xuan, Jann Mortensen, Wim Janssens, Marko Topalovic
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Engineering, Biomedical
Tim Hermans, Laura Smets, Katrien Lemmens, Anneleen Dereymaeker, Katrien Jansen, Gunnar Naulaers, Filippo Zappasodi, Sabine Van Huffel, Silvia Comani, Maarten De Vos
Summary: This paper proposes a semi-supervised deep learning approach for artefact detection in neonatal EEG. The proposed method outperforms existing state-of-the-art models and achieves good performance on two separate datasets. The results demonstrate the effectiveness of the semi-supervised multi-task training strategy and the relevance of artefact detection for automated EEG analysis.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Clinical Neurology
Lyssa de Vries, Steffie Amelynck, Paer Nystroem, Lotte van Esch, Thijs Van Lierde, Petra Warreyn, Herbert Roeyers, Ilse Noens, Gunnar Naulaers, Bart Boets, Jean Steyaert, TIARA Team
Summary: This study aimed to investigate the developmental trajectories of the autonomic nervous system (ANS) in infants, with or without increased likelihood for atypical ANS development. The pupillary light reflex (PLR) was used as an index and eye-tracking was employed to capture the PLR in 216 infants. The results revealed an increase in PLR parameters with age, as well as group differences in baseline pupil diameter and latency to constriction.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Biotechnology & Applied Microbiology
Miguel Bhagubai, Kaat Vandecasteele, Lauren Swinnen, Jaiver Macea, Christos Chatzichristos, Maarten De Vos, Wim Van Paesschen
Summary: This study evaluated a semi-automated multimodal wearable seizure detection framework using bte-EEG and ECG data. The results showed that combining ECG with bte-EEG can improve the accuracy of seizure detection and reduce false alarm rates, while also saving time for both clinicians and patients.
BIOENGINEERING-BASEL
(2023)
Article
Clinical Neurology
Tim Hermans, Mohammad Khazaei, Khadijeh Raeisi, Pierpaolo Croce, Gabriella Tamburro, Anneleen Dereymaeker, Maarten De Vos, Filippo Zappasodi, Silvia Comani
Summary: This study aims to explore the use of microstate (MS) analysis to evaluate global brain dynamics changes during maturation in preterm neonates with normal neurodevelopmental outcome. The study found that MS duration decreased and occurrence increased with age in preterm neonates, and significant changes in MS topographies and transitions occurred when neonates reached 37 weeks. Additionally, the Hurst exponent of the individual MS sequence decreased with age.
Article
Clinical Neurology
Nathalie De Beukelaer, Ines Vandekerckhove, Geert Molenberghs, Gunnar Naulaers, Liesbeth Thewissen, Domiziana Costamagna, Anja Van Campenhout, Kaat Desloovere, Els Ortibus
Summary: This study found that muscle growth is already affected in infants with spastic cerebral palsy. Muscle size growth further reduces with decreasing functional levels, regardless of the brain lesion. Early monitoring and intervention for muscle growth is necessary.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Pediatrics
Aurelie Pascal, Nele de Bruyn, Gunnar Naulaers, Els Ortibus, Britta Hanssen, Ann Oostra, Kris de Coen, Michel Sonnaert, Eva Cloet, Alexandra Casaer, James D'Haese, Sabine Laroche, An Jonckheere, Katleen Plaskie, Christine van Mol, Els Bruneel, Marie-Rose van Hoestenberghe, Bieke Samijn, Paul Govaert, Christine Van den Broeck
Summary: This study investigated the incidence of intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL) in relation to gestational age, as well as the impact on mortality and neurodevelopmental outcomes in very preterm/very low birthweight infants. The results showed that both the prevalence and severity of IVH/PVL decreased significantly as gestational age advanced. More than 75% of infants with low grades of IVH/PVL had normal motor and cognitive outcomes at 2 years of age. High-grade PVL/IVH has become less common and is associated with adverse outcomes.
JOURNAL OF PEDIATRICS
(2023)
Meeting Abstract
Neurosciences
Laure Sillisa, Cleo Vandegoor, Cato Vercaeren, Karel Allegaert, Annick Bogaerts, Maarten De Vos, Titia Hompes, Anne Smits, Kristel Van Calsteren, Jan Y. Verbakel, Veerle Foulon, Michael Ceulemans
NEUROTOXICOLOGY AND TERATOLOGY
(2023)
Meeting Abstract
Critical Care Medicine
M. Topalovic, M. De Vos, J. Maes, J. Kaspers, N. Stachowicz, P. Desbordes
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Transplantation
Amelie Dendooven, Aristotelis Styanidis, Louis Raes, Amaryllis Van Craenenbroeck, Matthias Maeyens, Konstantinos Kotras, Maarten De Vos
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Respiratory System
Kenneth Verstraete, Nilakash Das, Iwein Gyselinck, Marko Topalovic, Thierry Troosters, James D. Crapo, Edwin K. Silverman, Barry J. Make, Elizabeth A. Regan, Robert Jensen, Maarten De Vos, Wim Janssens
Summary: The shape of MEFVC is associated with CT parameters of emphysema, small airways disease (SAD), and bronchial wall thickening (BWT) in COPD. It is a valuable predictor for emphysema and SAD in moderate-severe COPD, but not a suitable screening tool for early disease phenotypes identified by CT scan.
RESPIRATORY RESEARCH
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Oliver Y. Chen, Vu Duy Thanh, Gilbert Greub, Hengyi Cao, Xingru He, Yannick Muller, Constantinos Petrovas, Haochang Shou, Viet-Dung Nguyen, Bangdong Zhi, Laurent Perez, Jean-Louis Raisaro, Guy Nagels, Maarten de Vos, Wei He, Gottardo Palie Smart, Marcus Munafo, Giuseppe Pantaleo
Summary: This article presents a systematic approach to studying varying brain. It discusses different types of brain variability and provides examples for each. It explores classical analysis of covariance as well as advanced residual analysis methods that aim to decompose the total variance of brain or behavior data. The article also considers innate and acquired brain variability, the neural law of large numbers for big brain data, and the gut-brain axis as an important source of brain variability.
2023 IEEE STATISTICAL SIGNAL PROCESSING WORKSHOP, SSP
(2023)
Article
Clinical Neurology
Jaakko Vallinoja, Timo Nurmi, Julia Jaatela, Vincent Wens, Mathieu Bourguignon, Helena Maenpaa, Harri Piitulainen
Summary: The study aimed to assess the effects of lesions related to spastic diplegic cerebral palsy on functional connectivity. Using multiple imaging modalities, the researchers found enhanced functional connectivity in the sensorimotor network of individuals with spastic diplegic cerebral palsy, which was not correlated with hand coordination performance.
CLINICAL NEUROPHYSIOLOGY
(2024)
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)
