Phosphorylation of 5-LOX: The Potential Set-point of Inflammation

Nitrosative Stress and Lipid Homeostasis as a Mechanism for Zileuton Hepatotoxicity and Resistance in Genetically Sensitive Mice

(2020) Dahea You et al.   TOXICOLOGICAL SCIENCES

Beyond leukotriene formation – the noncanonical functions of 5-lipoxygenase

(2019) Ann-Kathrin Häfner et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Tau Oligomers and Fibrils Induce Activation of Microglial Cells

(2018) Inelia Morales et al.   JOURNAL OF ALZHEIMERS DISEASE

Involvement of 5-Lipoxygenase in Alzheimer's Disease: A Role for DNA Methylation

(2018) Andrea Di Francesco et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of COX1-2/5-LOX blockade in Alzheimer transgenic 3xTg-AD mice

(2017) Alessandra Bitto et al.   INFLAMMATION RESEARCH

Glutamate Neurotransmission in Rodent Models of Traumatic Brain Injury

(2017) Christopher R. Dorsett et al.   JOURNAL OF NEUROTRAUMA

Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift

(2017) Yasir N. Jassam et al.   NEURON

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

The 5-Lipoxygenase as modulator of Alzheimer’s γ-secretase and therapeutic target

(2016) Jin Chu et al.   BRAIN RESEARCH BULLETIN

Tau and tauopathies

(2016) Thomas Arendt et al.   BRAIN RESEARCH BULLETIN

Chronic adventitial inflammation, vasa vasorum expansion, and 5-lipoxygenase up-regulation in irradiated arteries from cancer survivors

(2016) Martin Halle et al.   FASEB JOURNAL

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease

(2015) Olof Rådmark et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Pharmacologic Inhibition of 5-Lipoxygenase Improves Memory, Rescues Synaptic Dysfunction, and Ameliorates Tau Pathology in a Transgenic Model of Tauopathy

(2015) Phillip F. Giannopoulos et al.   BIOLOGICAL PSYCHIATRY

The role of the nitric oxide pathway in brain injury and its treatment — From bench to bedside

(2015) P.S. Garry et al.   EXPERIMENTAL NEUROLOGY

The Lipoxygenases: Their Regulation and Implication in Alzheimer’s Disease

(2015) Grzegorz A. Czapski et al.   NEUROCHEMICAL RESEARCH

Phosphorylation of serine 523 on 5-lipoxygenase in human B lymphocytes

(2015) Yilmaz Mahshid et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation

(2015) Sean J. Humphrey et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Intracellular Localisation and Phosphorylation Profile of the Human 5-Lipoxygenase Δ13 Isoform Differs from That of Its Full Length Counterpart

(2015) Eric P. Allain et al.   PLoS One

Phosphorylation of 5-Lipoxygenase at Ser523 by Protein Kinase A Determines Whether Pioglitazone and Atorvastatin Induce Proinflammatory Leukotriene B4 or Anti-Inflammatory 15-Epi-Lipoxin A4 Production

(2014) Y. Ye et al.   JOURNAL OF IMMUNOLOGY

The neglected co-star in the dementia drama: the putative roles of astrocytes in the pathogeneses of major neurocognitive disorders

(2014) W K Jo et al.   MOLECULAR PSYCHIATRY

Montelukast targeting the cysteinyl leukotriene receptor 1 ameliorates Aβ1-42-induced memory impairment and neuroinflammatory and apoptotic responses in mice

(2014) Jin'e Lai et al.   NEUROPHARMACOLOGY

Neuroprotective Effects of Lipoxin A4 in Central Nervous System Pathologies

(2014) Alessandra Cadete Martini et al.   Biomed Research International

5-Lipoxygenase mRNA and Protein Isoforms

(2013) Meike J. Ochs et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease

(2013) P F Giannopoulos et al.   MOLECULAR PSYCHIATRY

Animal models of traumatic brain injury

(2013) Ye Xiong et al.   NATURE REVIEWS NEUROSCIENCE

Modulation of lipopolysaccharide-induced memory insult, γ-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase

(2013) Yash B. Joshi et al.   NEUROBIOLOGY OF AGING

Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease

(2013) Amanda L. Wright et al.   PLoS One

5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of alzheimer disease

(2012) Jin Chu et al.   ANNALS OF NEUROLOGY

Profiles of Smokers and Non-Smokers with Diabetes Attending Diabetes Education Centres.

(2012) Rebecca Mlathew et al.   Canadian Journal of Diabetes

The nuclear membrane leukotriene synthetic complex is a signal integrator and transducer

(2012) Angela M. Bair et al.   MOLECULAR BIOLOGY OF THE CELL

Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice

(2012) Jin Chu et al.   Molecular Neurodegeneration

Pharmacologic Blockade of 5-Lipoxygenase Improves the Amyloidotic Phenotype of an Alzheimer's Disease Transgenic Mouse Model

(2011) Jin Chu et al.   AMERICAN JOURNAL OF PATHOLOGY

The Structure of Human 5-Lipoxygenase

(2011) N. C. Gilbert et al.   SCIENCE

5-lipoxygenase as an endogenous modulator of amyloid beta formation in vivo

(2010) Jin Chu et al.   ANNALS OF NEUROLOGY

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

Novel 5-lipoxygenase isoforms affect the biosynthesis of 5-lipoxygenase products

(2010) Luc H. Boudreau et al.   FASEB JOURNAL

Zileuton Reduces Inflammatory Reaction and Brain Damage Following Permanent Cerebral Ischemia in Rats

(2010) Xian-kun Tu et al.   INFLAMMATION

Location, Location, Location: Compartmentalization of Early Events in Leukotriene Biosynthesis

(2010) Marcia E. Newcomer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclooxygenases and 5-lipoxygenase in Alzheimer's disease

(2010) Hari Manev et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Synthesis of Lipoxin A4 by 5-Lipoxygenase Mediates PPAR -Dependent, Neuroprotective Effects of Rosiglitazone in Experimental Stroke

(2009) M. Sobrado et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of Serine 271 on 5-Lipoxygenase and Its Role in Nuclear Export

(2008) Nicolas Flamand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased 5-Lipoxygenase Immunoreactivity in the Hippocampus of Patients With Alzheimer's Disease

(2008) Milos D. Ikonomovic et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Moderate and severe traumatic brain injury in adults

(2008) Andrew IR Maas et al.   LANCET NEUROLOGY

The nuclear membrane organization of leukotriene synthesis

(2008) A. K. Mandal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

5-Lipoxygenase gene disruption reduces amyloid-β pathology in a mouse model of Alzheimer’s disease

(2007) Omidreza Firuzi et al.   FASEB JOURNAL