IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy

Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells

(2019) Sema Kurtulus et al.   IMMUNITY

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

(2019) Brian C. Miller et al.   NATURE IMMUNOLOGY

Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity

(2019) Alberto Mantovani et al.   IMMUNITY

Inherited IL-18BP deficiency in human fulminant viral hepatitis

(2019) Serkan Belkaya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TOX is a critical regulator of tumour-specific T cell differentiation

(2019) Andrew C. Scott et al.   NATURE

TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion

(2019) Hyungseok Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection

(2019) William H. Hudson et al.   IMMUNITY

Dysregulated IL-18 Is a Key Driver of Immunosuppression and a Possible Therapeutic Target in the Multiple Myeloma Microenvironment

(2018) Kyohei Nakamura et al.   CANCER CELL

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

(2018) Yannick Simoni et al.   NATURE

High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy

(2018) Matthew M. Gubin et al.   CELL

UV-induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model

(2017) Jake Wang et al.   Pigment Cell & Melanoma Research

Cytokines in Cancer Immunotherapy

(2017) Thomas A. Waldmann   Cold Spring Harbor Perspectives in Biology

Resistance to checkpoint blockade therapy through inactivation of antigen presentation

(2017) Moshe Sade-Feldman et al.   Nature Communications

Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18

(2017) Biliang Hu et al.   Cell Reports

A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells

(2016) Meromit Singer et al.   CELL

Augmentation of Immune Checkpoint Cancer Immunotherapy with IL18

(2016) Z. Ma et al.   CLINICAL CANCER RESEARCH

Expansion and Activation of CD103 + Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

(2016) Hélène Salmon et al.   IMMUNITY

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

Insights into Cytokine–Receptor Interactions from Cytokine Engineering

(2015) Jamie B. Spangler et al.   Annual Review of Immunology

Consensus nomenclature for CD8+T cell phenotypes in cancer

(2015) Lionel Apetoh et al.   OncoImmunology

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Cytokine therapy reverses NK cell anergy in MHC-deficient tumors

(2014) Michele Ardolino et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-2: The First Effective Immunotherapy for Human Cancer

(2014) S. A. Rosenberg   JOURNAL OF IMMUNOLOGY

The IL-18 Antagonist IL-18-Binding Protein Is Produced in the Human Ovarian Cancer Microenvironment

(2013) G. Carbotti et al.   CLINICAL CANCER RESEARCH

Transcriptional insights into the CD8+ T cell response to infection and memory T cell formation

(2013) J Adam Best et al.   NATURE IMMUNOLOGY

Cytokine-induced cytokine production by conventional and innate lymphoid cells

(2012) Liying Guo et al.   TRENDS IN IMMUNOLOGY

IL-18 Induces PD-1-Dependent Immunosuppression in Cancer

(2011) M. Terme et al.   CANCER RESEARCH

Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory

(2010) G. Jeannet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A phase 2, randomized study of SB-485232, rhIL-18, in patients with previously untreated metastatic melanoma

(2009) Ahmad A. Tarhini et al.   CANCER

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

(2009) Luca Gattinoni et al.   NATURE MEDICINE

A Dose-Escalation Study of Recombinant Human Interleukin-18 Using Two Different Schedules of Administration in Patients with Cancer

(2008) M. J. Robertson et al.   CLINICAL CANCER RESEARCH

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY