RNA Granules: A View from the RNA Perspective

RNA Droplets

(2020) Kevin Rhine et al.   Annual Review of Biophysics

Modulation of RNA Condensation by the DEAD-Box Protein eIF4A

(2020) Devin Tauber et al.   CELL

Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins

(2020) Chih-Yung S Lee et al.   eLife

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

(2020) Peiguo Yang et al.   CELL

Sequence-Independent Self-Assembly of Germ Granule mRNAs into Homotypic Clusters

(2020) Tatjana Trcek et al.   MOLECULAR CELL

BR-Bodies Provide Selectively Permeable Condensates that Stimulate mRNA Decay and Prevent Release of Decay Intermediates

(2020) Nadra Al-Husini et al.   MOLECULAR CELL

The regulation and functions of DNA and RNA G-quadruplexes

(2020) Dhaval Varshney et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia

(2020) Gregory G Fuller et al.   eLife

Structural Insights into RNA Dimerization: Motifs, Interfaces and Functions

(2020) Charles Bou-Nader et al.   MOLECULES

RPS28B mRNA acts as a scaffold promoting cis-translational interaction of proteins driving P-body assembly

(2020) Nikita Fernandes et al.   NUCLEIC ACIDS RESEARCH

Single-Molecule Imaging of mRNA Localization and Regulation during the Integrated Stress Response

(2019) Johannes H. Wilbertz et al.   MOLECULAR CELL

Multicolour single-molecule tracking of mRNA interactions with RNP granules

(2019) Stephanie L. Moon et al.   NATURE CELL BIOLOGY

A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos

(2019) Andrea Putnam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Aggregation, segregation, and dispersal of homotypic germ plasm RNPs in the early zebrafish embryo

(2019) Celeste Eno et al.   DEVELOPMENTAL DYNAMICS

Dynamic Recruitment of Single RNAs to Processing Bodies Depends on RNA Functionality

(2019) Sethuramasundaram Pitchiaya et al.   MOLECULAR CELL

ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97

(2019) Bo Wang et al.   MOLECULAR CELL

m6A enhances the phase separation potential of mRNA

(2019) Ryan J. Ries et al.   NATURE

Germ granules in Drosophila

(2019) Tatjana Trcek et al.   TRAFFIC

Disordered RNA chaperones can enhance nucleic acid folding via local charge screening

(2019) Erik D. Holmstrom et al.   Nature Communications

RNA structure drives interaction with proteins

(2019) Natalia Sanchez de Groot et al.   Nature Communications

P Granules Protect RNA Interference Genes from Silencing by piRNAs

(2019) John Paul T. Ouyang et al.   DEVELOPMENTAL CELL

Proximity RNA Labeling by APEX-Seq Reveals the Organization of Translation Initiation Complexes and Repressive RNA Granules

(2019) Alejandro Padrón et al.   MOLECULAR CELL

The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis

(2019) Bruno Di Stefano et al.   Cell Stem Cell

Transcriptome-Wide Comparison of Stress Granules and P-Bodies Reveals that Translation Plays a Major Role in RNA Partitioning

(2019) Tyler Matheny et al.   MOLECULAR AND CELLULAR BIOLOGY

G-quadruplex structures trigger RNA phase separation

(2019) Yueying Zhang et al.   NUCLEIC ACIDS RESEARCH

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

(2018) Jie Wang et al.   CELL

Stochastic Seeding Coupled with mRNA Self-Recruitment Generates Heterogeneous Drosophila Germ Granules

(2018) Matthew G. Niepielko et al.   CURRENT BIOLOGY

Systematic Characterization of Stress-Induced RNA Granulation

(2018) Sim Namkoong et al.   MOLECULAR CELL

RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome

(2018) Briana Van Treeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA buffers the phase separation behavior of prion-like RNA binding proteins

(2018) Shovamayee Maharana et al.   SCIENCE

mRNA structure determines specificity of a polyQ-driven phase separation

(2018) Erin M. Langdon et al.   SCIENCE

P-Bodies: Cytosolic Droplets for Coordinated mRNA Storage

(2018) Nancy Standart et al.   TRENDS IN GENETICS

Context-dependent deposition and regulation of mRNAs in P-bodies

(2018) Congwei Wang et al.   eLife

Emerging Roles for Intermolecular RNA-RNA Interactions in RNP Assemblies

(2018) Briana Van Treeck et al.   CELL

Tdrd6a Regulates the Aggregation of Buc into Functional Subcellular Compartments that Drive Germ Cell Specification

(2018) Elke F. Roovers et al.   DEVELOPMENTAL CELL

Spatiotemporal regulation of liquid-like condensates in epigenetic inheritance

(2018) Gang Wan et al.   NATURE

Fragile X mental retardation 1 gene enhances the translation of large autism-related proteins

(2018) Ethan J. Greenblatt et al.   SCIENCE

Phase transitioned nuclear Oskar promotes cell division of Drosophila primordial germ cells

(2018) Kathryn E Kistler et al.   eLife

A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3′UTR-Mediated Protein-Protein Interactions

(2018) Weirui Ma et al.   CELL

mRNP architecture in translating and stress conditions reveals an ordered pathway of mRNP compaction

(2018) Anthony Khong et al.   JOURNAL OF CELL BIOLOGY

Spatial Organization of Single mRNPs at Different Stages of the Gene Expression Pathway

(2018) Srivathsan Adivarahan et al.   MOLECULAR CELL

P-Body Purification Reveals the Condensation of Repressed mRNA Regulons

(2017) Arnaud Hubstenberger et al.   MOLECULAR CELL

The Dynamics of mRNA Turnover Revealed by Single-Molecule Imaging in Single Cells

(2017) Ivana Horvathova et al.   MOLECULAR CELL

The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules

(2017) Anthony Khong et al.   MOLECULAR CELL

RNA phase transitions in repeat expansion disorders

(2017) Ankur Jain et al.   NATURE

N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein

(2017) Nian Liu et al.   NUCLEIC ACIDS RESEARCH

piRNA Biogenesis in Drosophila melanogaster

(2017) Xiawei Huang et al.   TRENDS IN GENETICS

The m6A pathway facilitates sex determination in Drosophila

(2017) Lijuan Kan et al.   Nature Communications

ALS/FTD-Associated C9ORF72 Repeat RNA Promotes Phase Transitions In Vitro and in Cells

(2017) Marta M. Fay et al.   Cell Reports

Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B

(2017) Chih-Yung Sean Lee et al.   eLife

Intermolecular base stacking mediates RNA-RNA interaction in a crystal structure of the RNA chaperone Hfq

(2017) Eike C. Schulz et al.   Scientific Reports

Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism

(2016) Shambaditya Saha et al.   CELL

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure

(2016) Saumya Jain et al.   CELL

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

(2016) Marina Feric et al.   CELL

Long Oskar Controls Mitochondrial Inheritance in Drosophila melanogaster

(2016) Thomas Ryan Hurd et al.   DEVELOPMENTAL CELL

G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits

(2016) Nancy Kedersha et al.   JOURNAL OF CELL BIOLOGY

Membraneless organelles can melt nucleic acid duplexes and act as biomolecular filters

(2016) Timothy J. Nott et al.   Nature Chemistry

GW-Bodies and P-Bodies Constitute Two Separate Pools of Sequestered Non-Translating RNAs

(2016) Prajal H. Patel et al.   PLoS One

Hypo- and Hyper-Assembly Diseases of RNA–Protein Complexes

(2016) Siddharth Shukla et al.   TRENDS IN MOLECULAR MEDICINE

Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3

(2016) Jarrett Smith et al.   eLife

Distinct stages in stress granule assembly and disassembly

(2016) Joshua R Wheeler et al.   eLife

In vivo mapping of a dynamic ribonucleoprotein granule interactome in early Drosophila embryos

(2016) Jimiao Zheng et al.   FEBS Open Bio

Stress granules, P-bodies and cancer

(2015) Paul Anderson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

RNA Controls PolyQ Protein Phase Transitions

(2015) Huaiying Zhang et al.   MOLECULAR CELL

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

(2015) Yuan Lin et al.   MOLECULAR CELL

Structural imprints in vivo decode RNA regulatory mechanisms

(2015) Robert C. Spitale et al.   NATURE

Independent and coordinate trafficking of single Drosophila germ plasm mRNAs

(2015) Shawn C. Little et al.   NATURE CELL BIOLOGY

Structure ofDrosophilaOskar reveals a novel RNA binding protein

(2015) Na Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila germ granules are structured and contain homotypic mRNA clusters

(2015) Tatjana Trcek et al.   Nature Communications

The Crystal Structure of the Drosophila Germline Inducer Oskar Identifies Two Domains with Distinct Vasa Helicase- and RNA-Binding Activities

(2015) Mandy Jeske et al.   Cell Reports

Muscle wasting in myotonic dystrophies: a model of premature aging

(2015) Alba Judith Mateos-Aierdi et al.   Frontiers in Aging Neuroscience

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Quantifying mRNA targeting to P-bodies in living human cells reveals their dual role in mRNA decay and storage

(2014) Adva Aizer et al.   JOURNAL OF CELL SCIENCE

Granules Harboring Translationally Active mRNAs Provide a Platform for P-Body Formation following Stress

(2014) Jennifer Lui et al.   Cell Reports

XRN 5′→3′ exoribonucleases: Structure, mechanisms and functions

(2013) Vinay K. Nagarajan et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Homeland security in theC. elegansgerm line

(2013) Dionna M Kasper et al.   Epigenetics

Myotonic dystrophy type 1 (DM1): A triplet repeat expansion disorder

(2013) Ashok Kumar et al.   GENE

Phase transitions and size scaling of membrane-less organelles

(2013) Clifford P. Brangwynne   JOURNAL OF CELL BIOLOGY

RNA Seeds Higher-Order Assembly of FUS Protein

(2013) Jacob C. Schwartz et al.   Cell Reports

Drosophila patterning is established by differential association of mRNAs with P bodies

(2012) Timothy T. Weil et al.   NATURE CELL BIOLOGY

Guanine base stacking in G-quadruplex nucleic acids

(2012) Christopher Jacques Lech et al.   NUCLEIC ACIDS RESEARCH

Reversible RNA adenosine methylation in biological regulation

(2012) Guifang Jia et al.   TRENDS IN GENETICS

Regulation of stress granules in virus systems

(2012) James P. White et al.   TRENDS IN MICROBIOLOGY

Viral modulation of stress granules

(2012) Fernando Valiente-Echeverría et al.   VIRUS RESEARCH

P granules extend the nuclear pore complex environment in theC. elegansgerm line

(2011) Dustin L. Updike et al.   JOURNAL OF CELL BIOLOGY

PGL proteins self associate and bind RNPs to mediate germ granule assembly inC. elegans

(2011) Momoyo Hanazawa et al.   JOURNAL OF CELL BIOLOGY

Dimerization of oskar 3' UTRs promotes hitchhiking for RNA localization in the Drosophila oocyte

(2011) H. Jambor et al.   RNA

RNA Granules in Germ Cells

(2011) E. Voronina et al.   Cold Spring Harbor Perspectives in Biology

The C. elegans homolog of nucleoporin Nup98 is required for the integrity and function of germline P granules

(2010) E. Voronina et al.   DEVELOPMENT

Perinuclear P granules are the principal sites of mRNA export in adult C. elegans germ cells

(2010) U. Sheth et al.   DEVELOPMENT

Systematic image-driven analysis of the spatial Drosophila embryonic expression landscape

(2010) Erwin Frise et al.   Molecular Systems Biology

Cytoplasmic Partitioning of P Granule Components Is Not Required to Specify the Germline in C. elegans

(2010) C. M. Gallo et al.   SCIENCE

Genome-wide analysis of mRNA decay patterns during early Drosophila development

(2010) Stefan Thomsen et al.   GENOME BIOLOGY

Bucky Ball Organizes Germ Plasm Assembly in Zebrafish

(2009) Franck Bontems et al.   CURRENT BIOLOGY

Unravelling the ultrastructure of stress granules and associated P-bodies in human cells

(2009) S. Souquere et al.   JOURNAL OF CELL SCIENCE

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

Temporal and Spatial Control of Germ-Plasm RNAs

(2008) Prashanth Rangan et al.   CURRENT BIOLOGY

Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells

(2008) Dinghai Zheng et al.   JOURNAL OF CELL BIOLOGY

Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies

(2008) J. N. Savas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA