Herbal Remedies as Potential in Cartilage Tissue Engineering: An Overview of New Therapeutic Approaches and Strategies

Dual Role of Chondrocytes in Rheumatoid Arthritis: The Chicken and the Egg

(2020) Chia-Chun Tseng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Avocado–Soybean Unsaponifiables: A Panoply of Potentialities to Be Exploited

(2020) Bahare Salehi et al.   Biomolecules

Excellent histological results in terms of articular cartilage regeneration after spheroid-based autologous chondrocyte implantation (ACI)

(2020) David Grevenstein et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review

(2020) Xiao Meng et al.   Foods

Icariin-conditioned serum engineered with hyaluronic acid promote repair of articular cartilage defects in rabbit knees

(2019) Juntao Zhang et al.   BMC Complementary and Alternative Medicine

Biological behavior of the curcumin incorporated chitosan/poly(vinyl alcohol) nanofibers for biomedical applications

(2019) Ali Golchin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Salidroside enhances proliferation and maintains phenotype of articular chondrocytes for autologous chondrocyte implantation (ACI) via TGF-β/Smad3 Signal

(2019) Miao Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

Icariin conjugated hyaluronic acid/collagen hydrogel for osteochondral interface restoration

(2018) Jirong Yang et al.   Acta Biomaterialia

Biomaterials for articular cartilage tissue engineering: Learning from biology

(2018) A.R. Armiento et al.   Acta Biomaterialia

Cartilage regeneration and ageing: Targeting cellular plasticity in osteoarthritis

(2018) Marta Varela-Eirin et al.   AGEING RESEARCH REVIEWS

Resveratrol Protects Murine Chondrogenic ATDC5 Cells Against LPS-Induced Inflammatory Injury Through Up-Regulating MiR-146b

(2018) Hui Jin et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Icariin Activates Autophagy via Down-Regulation of the NF-κB Signaling-Mediated Apoptosis in Chondrocytes

(2018) Bobin Mi et al.   Frontiers in Pharmacology

Effect of Icariin on Engineered 3D-Printed Porous Scaffolds for Cartilage Repair

(2018) Ranjith Kankala et al.   Materials

Icariin Reduces Cartilage Degeneration in a Mouse Model of Osteoarthritis and is Associated with the Changes in Expression of Indian Hedgehog and Parathyroid Hormone-Related Protein

(2018) Yuan Luo et al.   MEDICAL SCIENCE MONITOR

Resveratrol: Twenty Years of Growth, Development and Controversy

(2018) John M. Pezzuto   Biomolecules & Therapeutics

Icariin possesses chondroprotective efficacy in a rat model of dexamethasone-induced cartilage injury through the activation of miR-206 targeting of cathepsin K

(2017) Ning Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Local intra-articular injection of resveratrol delays cartilage degeneration in C57BL/6 mice by inducing autophagy via AMPK/mTOR pathway

(2017) Na Qin et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Synthesis and characterization of curcumin loaded PLA—Hyperbranched polyglycerol electrospun blend for wound dressing applications

(2017) Govindaraj Perumal et al.   Materials Science & Engineering C-Materials for Biological Applications

Bioengineered porous composite curcumin/silk scaffolds for cartilage regeneration

(2017) Do Kyung Kim et al.   Materials Science & Engineering C-Materials for Biological Applications

Regulation of type II collagen, matrix metalloproteinase-13 and cell proliferation by interleukin-1β is mediated by curcumin via inhibition of NF-κB signaling in rat chondrocytes

(2017) Jian Wang et al.   Molecular Medicine Reports

Pomegranate for Prevention and Treatment of Cancer: An Update

(2017) Pooja Sharma et al.   MOLECULES

Inhibition of cartilage degradation and suppression of PGE2 and MMPs expression by pomegranate fruit extract in a model of posttraumatic osteoarthritis

(2017) Nahid Akhtar et al.   NUTRITION

A Polyphenol-rich Pomegranate Fruit Extract Suppresses NF-κB and IL-6 Expression by Blocking the Activation of IKKβ and NIK in Primary Human Chondrocytes

(2017) Abdul Haseeb et al.   PHYTOTHERAPY RESEARCH

α-Lipoic Acid Potentiates the Anti-Inflammatory Activity of Avocado/Soybean Unsaponifiables in Chondrocyte Cultures

(2017) Carmelita G. Frondoza et al.   Cartilage

Resveratrol downregulates inflammatory pathway activated by lymphotoxin α (TNF-β) in articular chondrocytes: Comparison with TNF-α

(2017) Constanze Buhrmann et al.   PLoS One

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

(2016) Ajaikumar B Kunnumakkara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of resveratrol on collagen type II protein in the superficial and middle zone chondrocytes of porcine articular cartilage

(2016) Makwese Maepa et al.   JOURNAL OF ETHNOPHARMACOLOGY

The effect of pomegranate juice on clinical signs, matrix metalloproteinases and antioxidant status in patients with knee osteoarthritis

(2016) Nasrin Ghoochani et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Suppression of Cartilage Degradation by Zingerone Involving the p38 and JNK MAPK Signaling Pathway

(2016) Jetsada Ruangsuriya et al.   PLANTA MEDICA

Flavonoid Compound Icariin Activates Hypoxia Inducible Factor-1α in Chondrocytes and Promotes Articular Cartilage Repair

(2016) Pengzhen Wang et al.   PLoS One

Function of sustained released resveratrol on IL-1β-induced hBMSC MMP13 secretion inhibition and chondrogenic differentiation promotion

(2015) Gang Wu et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Intra-articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF-2α

(2015) Wuyin Li et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials

(2015) E.M. Bartels et al.   OSTEOARTHRITIS AND CARTILAGE

An anti-inflammatory cell-free collagen/resveratrol scaffold for repairing osteochondral defects in rabbits

(2014) Wei Wang et al.   Acta Biomaterialia

Sirtuin-1 (SIRT1) Is Required for Promoting Chondrogenic Differentiation of Mesenchymal Stem Cells

(2014) Constanze Buhrmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Icariin promotes directed chondrogenic differentiation of bone marrow mesenchymal stem cells but not hypertrophy in vitro

(2014) ZHI CONG WANG et al.   Experimental and Therapeutic Medicine

Pomegranate Fruit as a Rich Source of Biologically Active Compounds

(2014) Sreeja Sreekumar et al.   Biomed Research International

The effect of resveratrol on normal and osteoarthritic chondrocyte metabolism

(2014) H. J. Kim et al.   Bone & Joint Research

Osteogenic effects of resveratrolin vitro: potential for the prevention and treatment of osteoporosis

(2013) Ali Mobasheri et al.   Annals of the New York Academy of Sciences

Resveratrol Inhibits Nitric Oxide-Induced Apoptosis via the NF-Kappa B Pathway in Rabbit Articular Chondrocytes

(2013) Seong-Hui Eo et al.   Biomolecules & Therapeutics

Biological characterization of oxidized hyaluronic acid/resveratrol hydrogel for cartilage tissue engineering

(2013) Shiow-Yunn Sheu et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Icariin: Does It Have An Osteoinductive Potential for Bone Tissue Engineering?

(2013) Xin Zhang et al.   PHYTOTHERAPY RESEARCH

Evidence that TNF-β (lymphotoxin α) can activate the inflammatory environment in human chondrocytes

(2013) Constanze Buhrmann et al.   ARTHRITIS RESEARCH & THERAPY

Effects of FGF-2 on human adipose tissue derived adult stem cells morphology and chondrogenesis enhancement in Transwell culture

(2012) Azadeh Kabiri et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1β-Induced NF-κB Activation in Canine Articular Chondrocytes

(2012) Mehdi Shakibaei et al.   Evidence-based Complementary and Alternative Medicine

Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health

(2012) Ali Mobasheri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biological effects of the plant-derived polyphenol resveratrol in human articular cartilage and chondrosarcoma cells

(2012) Hee-Jeong Im et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling

(2012) Lei-Guo Ming et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dietary polyphenols and mechanisms of osteoarthritis

(2012) Chwan-Li Shen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Icariin: a potential promoting compound for cartilage tissue engineering

(2012) D. Li et al.   OSTEOARTHRITIS AND CARTILAGE

Icariin Promotes Extracellular Matrix Synthesis and Gene Expression of Chondrocytes In Vitro

(2012) Lei Zhang et al.   PHYTOTHERAPY RESEARCH

Intersection of Inflammation and Herbal Medicine in the Treatment of Osteoarthritis

(2012) Ali Mobasheri   Current Rheumatology Reports

Current nutraceuticals in the management of osteoarthritis: a review

(2012) Nahid Akhtar et al.   Therapeutic Advances in Musculoskeletal Disease

Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease

(2011) Anna Csiszar   Annals of the New York Academy of Sciences

Effects of pomegranate extracts on cartilage, bone and mesenchymal cells of mouse fetuses

(2011) Malihezaman Monsefi et al.   BRITISH JOURNAL OF NUTRITION

Effect of resveratrol on cartilage protection and apoptosis inhibition in experimental osteoarthritis of rabbit

(2011) Jing Wang et al.   RHEUMATOLOGY INTERNATIONAL

Icariin attenuates LPS-induced acute inflammatory responses: Involvement of PI3K/Akt and NF-κB signaling pathway

(2010) Chang-Qing Xu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Preparation and characterization of electrospinning PLA/curcumin composite membranes

(2010) Yan Chen et al.   FIBERS AND POLYMERS

Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale)

(2010) Richard B. van Breemen et al.   FITOTERAPIA

Curcumin synergizes with resveratrol to stimulate the MAPK signaling pathway in human articular chondrocytes in vitro

(2010) Mehdi Shakibaei et al.   Genes and Nutrition

Icariin protects murine chondrocytes from lipopolysaccharide-induced inflammatory responses and extracellular matrix degradation

(2010) Man-Hai Liu et al.   NUTRITION RESEARCH

Nutraceuticals: do they represent a new era in the management of osteoarthritis? – a narrative review from the lessons taken with five products

(2010) Y. Henrotin et al.   OSTEOARTHRITIS AND CARTILAGE

Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment

(2010) Constanze Buhrmann et al.   ARTHRITIS RESEARCH & THERAPY

Pomegranate extract inhibits the interleukin-1β-induced activation of MKK-3, p38α-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes

(2010) Zafar Rasheed et al.   ARTHRITIS RESEARCH & THERAPY

Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes

(2010) Feng-Cheng Liu et al.   ARTHRITIS RESEARCH & THERAPY

Resveratrol protects bone marrow mesenchymal stem cell derived chondrocytes cultured on chitosan-gelatin scaffolds from the inhibitory effect of interleukin-1β

(2009) Ming Lei et al.   ACTA PHARMACOLOGICA SINICA

Interleukin-1β-Induced Extracellular Matrix Degradation and Glycosaminoglycan Release Is Inhibited by Curcumin in an Explant Model of Cartilage Inflammation

(2009) Abigail L. Clutterbuck et al.   Annals of the New York Academy of Sciences

Lifestyle and gout

(2009) A Elisabeth Hak et al.   CURRENT OPINION IN RHEUMATOLOGY

Biological actions of curcumin on articular chondrocytes

(2009) Y. Henrotin et al.   OSTEOARTHRITIS AND CARTILAGE

Chondroprotective effects of pomegranate juice on monoiodoacetate-induced osteoarthritis of the knee joint of mice

(2009) Mahsa Hadipour-Jahromy et al.   PHYTOTHERAPY RESEARCH

Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13

(2009) Christelle Boileau et al.   ARTHRITIS RESEARCH & THERAPY

Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis

(2009) Constanze Csaki et al.   ARTHRITIS RESEARCH & THERAPY

Mesenchymal stem cells as a potential pool for cartilage tissue engineering

(2008) C. Csaki et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP production

(2008) Mandar Dave et al.   ARTHRITIS AND RHEUMATISM

Resveratrol suppresses interleukin-1β-induced inflammatory signaling and apoptosis in human articular chondrocytes: Potential for use as a novel nutraceutical for the treatment of osteoarthritis

(2008) Mehdi Shakibaei et al.   BIOCHEMICAL PHARMACOLOGY

Bioavailable constituents/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE2 production in human chondrocytes in vitro

(2008) Meenakshi Shukla et al.   Journal of Inflammation-London

Resveratrol addiction: To die or not to die

(2008) Mehdi Shakibaei et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Comparison between chondroprotective effects of glucosamine, curcumin, and diacerein in IL-1β-stimulated C-28/I2 chondrocytes

(2008) S. Toegel et al.   OSTEOARTHRITIS AND CARTILAGE

Regulation of inflammation signalling by resveratrol in human chondrocytes in vitro

(2007) Constanze Csaki et al.   BIOCHEMICAL PHARMACOLOGY

Metabolic Effects of Avocado/Soy Unsaponifiables on Articular Chondrocytes

(2007) Louis Lippiello et al.   Evidence-based Complementary and Alternative Medicine

Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research

(2007) Badreldin H. Ali et al.   FOOD AND CHEMICAL TOXICOLOGY

The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis

(2007) Saski Sutton et al.   VETERINARY JOURNAL