Chemistry and Biological Activities of 1,2,4-Triazolethiones—Antiviral and Anti-Infective Drugs

Eschenmoser-Coupling Reaction Furnishes Diazenyl-1,2,4-triazole-5(4H )-thione Derivatives

(2019) Alaa A. Hassan et al.   ChemistrySelect

1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships

(2019) Zhi Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vitro antimicrobial activity screening of new pipemidic acid derivatives

(2018) Łukasz Popiołek et al.   ARCHIVES OF PHARMACAL RESEARCH

Design, Synthesis and Antibacterial Evaluation of 1-[(1R, 2S)-2-Fluorocyclopropyl]ciprofloxacin-1,2,4-triazole-5(4H )-thione Hybrids

(2018) Yang Gao et al.   CHEMISTRY & BIODIVERSITY

Synthesis, Molecular Docking and Anticancer Activity of Diflunisal Derivatives as Cyclooxygenase Enzyme Inhibitors

(2018) Göknil Coşkun et al.   MOLECULES

Microwave-Assisted Synthesis, In Vivo Anti-Inflammatory and In Vitro Anti-Oxidant Activities, and Molecular Docking Study of New Substituted Schiff Base Derivatives

(2018) Muhammad Hanif et al.   PHARMACEUTICAL CHEMISTRY JOURNAL

In vitro cytotoxic and in vivo antitumoral activities of some aminomethyl derivatives of 2,4-dihydro-3H-1,2,4-triazole-3-thiones-Evaluation of their acetylcholinesterase and carbonic anhydrase enzymes inhibition profiles

(2018) İrfan Timur et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Design, Synthesis and Anticancer Screening of Novel Benzothiazole-Piperazine-1,2,3-Triazole Hybrids

(2018) Mohamed Aouad et al.   MOLECULES

Reactive intermediates in the reaction of hydrazinecarbothioamides with 2-(bis(methylthio)methylene)malononitrile and ethyl 2-cyano-3,3-bis(methylthio)acrylate

(2018) Ashraf A. Aly et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Synthesis of New Phosphorylated 1,2,4-Triazole-3-thiones. N,S-Functionalization Methods

(2018) E. L. Gavrilova et al.   RUSSIAN JOURNAL OF GENERAL CHEMISTRY

Synthesis, experimental and theoretical characterizations of a 1,2,4-triazole Schiff base and its nickel(II) complex

(2018) Hamide Raouf et al.   JOURNAL OF MOLECULAR STRUCTURE

Development of the 1,2,4-triazole-based anticonvulsant drug candidates acting on the voltage-gated sodium channels. Insights from in-vivo, in-vitro, and in-silico studies

(2018) Barbara Kaproń et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Design, selective alkylation and X-ray crystal structure determination of dihydro-indolyl-1,2,4-triazole-3-thione and its 3-benzylsulfanyl analogue as potent anticancer agents

(2017) Ahmed T.A. Boraei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of some novel pyridine compounds containing bis-1,2,4-triazole/thiosemicarbazide moiety and investigation of their antioxidant properties, carbonic anhydrase, and acetylcholinesterase enzymes inhibition profiles

(2017) Nilufer Bulut et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

1,2,4-triazole derivative with Schiff base; thiol-thione tautomerism, DFT study and antileishmanial activity

(2017) Nevin Süleymanoğlu et al.   JOURNAL OF MOLECULAR STRUCTURE

Catalyst-free glycerol-mediated green synthesis of 5′-thioxospiro[indoline-3,3′-[1,2,4]triazolidin]-2-ones/spiro[indoline-3,3′-[1,2,4]triazolidine]-2,5′-diones

(2017) Jyoti Tiwari et al.   SYNTHETIC COMMUNICATIONS

Synthesis and anticancer activity of long chain substituted 1,3,4-oxadiazol-2-thione, 1,2,4-triazol-3-thione and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine derivatives

(2017) Aiman Ahmad et al.   Arabian Journal of Chemistry

Synthesis and biological activities of novel 1,2,4-triazole thiones and bis(1,2,4-triazole thiones) containing phenylpyrazole and piperazine moieties

(2016) Bao-Lei Wang et al.   JOURNAL OF FLUORINE CHEMISTRY

Utilization of Cyanoacetohydrazide and Oxadiazolyl Acetonitrile in the Synthesis of Some New Cytotoxic Heterocyclic Compounds

(2016) Soheir Shaker et al.   MOLECULES

Regioselective synthesis, antitumor and antioxidant activities of some 1,2,4-triazole derivatives based on 4-phenyl-5-(quinolin-8-yloxy)methyl-4H-1,2,4-triazole-3-thiol

(2016) M. S. Behalo et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Synthesis of 3-Pyrazolyl-1,2,4-Triazoles via One-Pot Multicomponent Reaction in Phosphoric Acid

(2016) Amer Amer et al.   SYNLETT

Synthesis, antimicrobial and antioxidant activities of 2-oxo-6-phenyl-2-yl-4-(2′-phenyl-5′-substituted 1H-indol-3′-yl)-1,2-dihydro pyridin-3-carbonitriles and their derivatives

(2016) Anand Raghunath Saundane et al.   Arabian Journal of Chemistry

Facile and Green Chemistry Access to 5-aryl-1,2,4-Triazolidine-3-thiones in Aqueous Medium

(2016) Rathinam Ramesh et al.   ChemistrySelect

Recent advances bioactive 1,2,4-triazole-3-thiones

(2015) Ş.Güniz Küçükgüzel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Green synthesis and evaluation of the antitumor activity of a novel series of 3-[4-bi-(4-fluorophenyl)methylpiperazinyl]-4-amino-5-thione-1,2,4-triazole Schiff bases

(2015) Yong Ding et al.   RESEARCH ON CHEMICAL INTERMEDIATES

An efficient synthesis of anti-microbial 1,2,4-triazole-3-thiones promoted by acidic ionic liquid

(2015) Pradeep B. Patil et al.   RESEARCH ON CHEMICAL INTERMEDIATES

First regioselective iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles

(2015) Navnath D. Rode et al.   TETRAHEDRON LETTERS

Synthesis of novel 1,2,4-triazoles and triazolo-thiadiazines as anticancer agents

(2015) Thoraya Abd El-Reheem FARGHALY et al.   TURKISH JOURNAL OF CHEMISTRY

One step synthesis of highly functionalized thiazolo[3,2-b][1,2,4]triazole, triazolo[1,5-a]pyrimidine and triazolo[3,4-b][1,3,4]thiadiazine

(2015) Tariq A. Shah et al.   RSC Advances

Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines

(2014) Imtiaz Khan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Studies on the anticonvulsant activity of 4-alkyl-1,2,4-triazole-3-thiones and their effect on GABAergic system

(2014) Tomasz Plech et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and 3D-QSAR studies of new diphenylamine containing 1,2,4-triazoles as potential antitubercular agents

(2014) K. Mohan Krishna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Antioxidant Activity Evaluation of New Compounds from Hydrazinecarbothioamide and 1,2,4-Triazole Class Containing Diarylsulfone and 2,4-Difluorophenyl Moieties

(2014) Stefania-Felicia Barbuceanu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel one pot multi-component strategy for facile synthesis of 5-aryl-[1,2,4]triazolidine-3-thiones

(2014) M.M. Mane et al.   TETRAHEDRON LETTERS

Efficient synthesis and antimicrobial activity of some novel S-β-d-glucosides of 5-aryl-1,2,4-triazole-3-thiones derivatives

(2013) Dan Ji et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Nonclassical antifolates, part 4. 5-(2-Aminothiazol-4-yl)-4-phenyl-4H-1,2,4-triazole-3-thiols as a new class of DHFR inhibitors: Synthesis, biological evaluation and molecular modeling study

(2013) Ghada S. Hassan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New pyrazole derivatives containing 1,2,4-triazoles and benzoxazoles as potent antimicrobial and analgesic agents

(2013) A.M. Vijesh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

1,2,4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities

(2013) Gamal El-Din A.A. Abuo-Rahma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis and Trypanocidal Evaluation of Novel 1,2,4-Triazoles-3-thiones Derived from Natural Piperine

(2013) Tatiany Franklim et al.   MOLECULES

The unprecedented synthesis of novel spiro-1,2,4-triazolidinones

(2013) Dattaprasad M. Pore et al.   RSC Advances

Synthesis, Characterization, and Biological Activity of Novel Schiff and Mannich Bases of 4-Amino-3-(N-phthalimidomethyl)-1,2,4-triazole-5-thione

(2013) Uzma Yunus et al.   Journal of Chemistry

Synthesis and characterization of transition metal complexes of 4-Amino-5-pyridyl-4H-1,2,4-triazole-3-thiol

(2013) Raghad Haddad et al.   SpringerPlus

Synthesis and Evaluation of Analgesic/ Anti-inflammatory and Antimicrobial Activities of 3-Substituted-1,2,4-triazole-5-thiones

(2012) Birsen Tozkoparan et al.   ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH

Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents

(2012) Keriman Özadalı et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Antimicrobial Activity of 2-[4-(Substituted Benzylidenamino)-5-(Substituted Phenoxymethyl)-4H-1,2,4-Triazol-3-yl thio] Acetic Acid Derivatives

(2012) R. D. Hunashal et al.   E-Journal of Chemistry

Facile synthesis, cytotoxic and antimicrobial activity studies of a new group of 6-aryl-3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines

(2012) V. Sumangala et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Effect of 4-(4-bromophenyl)-5-(3-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione on the anticonvulsant action of different classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model

(2012) Jarogniew J. Luszczki et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Synthesis of Bis-Heterocyclic 1H-Imidazole 3-Oxides from 3-Oxido-1H-imidazole-4-carbohydrazides

(2012) Adam Marek Pieczonka et al.   HELVETICA CHIMICA ACTA

Synthesis, urease inhibition, antioxidant and antibacterial studies of some 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones and their 3,6-disubstituted 1,2,4-triazolo[3,4-b]1,3,4-thiadiazole derivatives

(2012) Muhammad Hanif et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

Synthesis and biological evaluation of some Schiff bases of 4-amino-5-(4-methylsulfonyl)benzyl-2,4-dihydro-3H-[1,2,4]-triazole-3-thione

(2012) V. Sumangala et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and Antimicrobial Properties of New Thiosemicarbazide, 1,2,4-Triazole, and 1,3,4-Thiadiazole Derivatives of Sulfanylacetic Acid

(2012) Łukasz Popiołek et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Synthesis and biological activities of thio-triazole derivatives as novel potential antibacterial and antifungal agents

(2012) QingPeng Wang et al.   Science China-Chemistry

Studies on the synthesis and some reactions of (S)-proline hydrazides

(2012) Grzegorz Mlostoń et al.   TETRAHEDRON-ASYMMETRY

Synthesis, Structure and Biological Activity of Novel 1,2,4-Triazole Mannich Bases Containing a Substituted Benzylpiperazine Moiety

(2011) Bao-Lei Wang et al.   Chemical Biology & Drug Design

Fluorescent gallium and indium bis(thiosemicarbazonates) and their radiolabelled analogues: Synthesis, structures and cellular confocal fluorescence imaging investigations

(2011) Rory L. Arrowsmith et al.   DALTON TRANSACTIONS

Synthesis and in vitro microbiological evaluation of novel 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9,5′-spiro-1′,2′,4′-triazolidine-3′-thiones

(2011) V. Kanagarajan et al.   MEDICINAL CHEMISTRY RESEARCH

Triazole incorporated thiazoles as a new class of anticonvulsants: Design, synthesis and in vivo screening

(2010) Nadeem Siddiqui et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterisation and antimicrobial activities of novel 7,9-diphenyl-1,2,4-triaza-8-oxa-spiro[4.5]-decan-3-thiones

(2010) Senthamaraikannan Kabilan et al.   MEDICINAL CHEMISTRY RESEARCH

Manganese Dioxide Mediated Stereoselective, One-step Synthesis of Novel Steroidal (6R)-Spiro-1',2′,4′-triazoline-3′-thiones

(2009) SHAMSUZZAMAN et al.   CHINESE JOURNAL OF CHEMISTRY

Synthesis of substituted-phenyl-1,2,4-triazol-3-thione analogues with modified d-glucopyranosyl residues and their antiproliferative activities

(2009) Zhizhang Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of 3,6-disubstituted 7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines as novel analgesic/anti-inflammatory compounds

(2009) S. Peri Aytaç et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Regioselective reaction: Synthesis and pharmacological study of Mannich bases containing ibuprofen moiety

(2009) K.V. Sujith et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel one-pot synthesis of 1,2,4-triazolidin-3-thiones comprising piperidine moiety

(2009) M. Gopalakrishnan et al.   Green Chemistry Letters and Reviews

Synthesis and antioxidant properties of novel N-methyl-1,3,4-thiadiazol-2-amine and 4-methyl-2H-1,2,4-triazole-3(4H)-thione derivatives of benzimidazole class

(2008) Canan Kuş et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Biological Activities of Alkyl Substituted Triazolethione Schiff Base

(2008) Xiao-Hong SUN et al.   CHINESE JOURNAL OF CHEMISTRY

Letrozole is Superior to Anastrozole in Suppressing Breast Cancer Tissue and Plasma Estrogen Levels

(2008) J. Geisler et al.   CLINICAL CANCER RESEARCH

Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1,3-thiazol-2-yl]-1H-pyrazoles

(2008) Bakr F. Abdel-Wahab et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis andin vitromicrobiological evaluation of 6,6-dimethyl-7,9-diaryl-1,2,4,8-tetraazaspiro[4.5]decan-3-thiones - A new series of ‘tailor-made’ compounds

(2008) M. Gopalakrishnan et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition

(2008) Stefan G. Sarafianos et al.   JOURNAL OF MOLECULAR BIOLOGY

Sulfonamide-1,2,4-triazole derivatives as antifungal and antibacterial agents: Synthesis, biological evaluation, lipophilicity, and conformational studies

(2007) Iraj Rahavi Ezabadi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, antimicrobial and anti-inflammatory activities of some 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines bearing trichlorophenyl moiety

(2007) Prakash Karegoudar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Condensed bridgehead nitrogen heterocyclic system: Synthesis and pharmacological activities of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives of ibuprofen and biphenyl-4-yloxy acetic acid

(2007) Mohd. Amir et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents

(2007) İlkay Küçükgüzel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY