Article
Multidisciplinary Sciences
Alejandro Serna Gonzalez, Victor H. Soto Tellini, Dora Maria Benjumea Gutierrez
Summary: Pinostrobin, a flavanone with various biological activities such as antioxidant, analgesic, and dermal anti-inflammatory effects, can be improved by inclusion in cyclodextrins. Both beta cyclodextrin and hydroxypropyl beta cyclodextrin enhance the effects of pinostrobin, indicating greater bioavailability.
Article
Plant Sciences
Layza Fernanda Gomes Bezerra, Ana Paula Sant Anna da Silva, Rebeca Xavier da Cunha, Joao Ricardhis Saturnino de Oliveira, Mateus Domingues de Barros, Vycttor Mateus de Melo Alves da Silva, Vera Lucia de Menezes Lima
Summary: This study investigated the antioxidant, anti-inflammatory, analgesic, and antipyretic activity of Mimosa acutistipula leaves. The results showed that the leaves contain phenolic compounds and exhibit antioxidant and anti-inflammatory effects. It can be used for the treatment of alopecia and pharyngitis.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Plant Sciences
Marcello Nicoletti
Summary: The therapeutic story of European mistletoe has had ups and downs. In ancient times, it was considered a panacea, but recent concerns about its toxicity led to doubts about its medicinal value. However, its selective action on tumor cells has brought back medical interest in mistletoe.
Article
Pharmacology & Pharmacy
Saraswati Patel, Jyoti Shukla, Smita Jain, Vartika Paliwal, Neetika Tripathi, Sarvesh Paliwal, Swapnil Sharma
Summary: This study evaluates the analgesic and anti-inflammatory activity of Tubocurarine (d-TC) and suggests its repositioning in the treatment of pain and inflammation-related issues. The results showed significant inhibitory effects of d-TC on pain and inflammation in both in vitro and in vivo models, as well as good oral absorption capability.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mohammad Ashiqur Rahman Bhuiyan Shovo, Marzia Rahman Tona, Jannatul Mouah, Fayza Islam, Md. Helal Uddin Chowdhury, Tuhin Das, Arkajyoti Paul, Duygu Agagunduz, Md. Masudur Rahman, Bin Emran, Raffaele Capasso, Jesus Simal-Gandara
Summary: Molineria capitulata is an ornamental plant traditionally used to treat chronic diseases; a study found that its leaf extract has antioxidant, anti-inflammatory, thrombolytic, and analgesic activities, with computational analysis showing strong binding affinity of its components to receptors.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Samar Rezq, Mona F. Mahmoud, Assem M. El-Shazly, Mohamed A. El Raey, Mansour Sobeh
Summary: The study found that Potamogeton perfoliatus extract exhibited anti-inflammatory, antioxidant, analgesic, and antipyretic effects, supporting its traditional use and potential as a candidate for treating diseases associated with oxidative stress. It identified 15 secondary metabolites that likely contributed to these biological activities. The extract showed potent inhibition of enzymes and significant effects in in vivo models, indicating its promising medicinal properties.
Review
Biochemistry & Molecular Biology
Agnieszka Gegotek, Elzbieta Skrzydlewska
Summary: This review highlights the importance of ascorbate as a strong antioxidant and its various mechanisms of action. It also emphasizes the interaction of ascorbate with other antioxidants and its role in promoting antioxidant proteins and transcription factors.
Article
Pharmacology & Pharmacy
Yan-Qing Xie, Jing-Yao Huang, Yun-Xiu Chen, Qian Zhou, Qi-Xiu Zhou, Zhu-Ya Yang, Shi-Kui Xu, Wen-Hong Tan, Lu Liu
Summary: This study investigates the metabolites in the bark and leaves of Streblus indicus for their anti-inflammatory and analgesic effects. The results provide scientific evidence for the traditional use of S. indicus and offer a theoretical foundation for the development of new anti-inflammatory and analgesic drugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Narisara Paradee, Pimpisid Koonyosying, Winthana Kusirisin, Rattanaporn Janthip, Duangta Kanjanapothi, Kovit Pattanapanyasat, Somdet Srichairatanakool
Summary: Perilla frutescens fruit oil (PFO) possesses analgesic, anti-inflammatory and anti-ulcer properties in animal models, offering potential benefits in treatment of inflammatory diseases and gastric ulcer.
BIOSCIENCE REPORTS
(2021)
Article
Immunology
Minda Asefa, Nathnael Teshome, Abel Degu
Summary: The 80% methanol root extract of Verbasicum sinaiticum was found to possess peripheral and central analgesic as well as anti-inflammatory activity, possibly due to the presence of phytochemicals.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Plant Sciences
Nadjat Righi, Sabah Boumerfeg, Amirouche Deghima, Pedro A. R. Fernandes, Elisabete Coelho, Faiza Baali, Susana M. Cardoso, Manuel A. Coimbra, Abderrahmane Baghiani
Summary: The hydromethanolic extract of Salvia verbenaca showed strong antioxidant and anti-inflammatory activities both in vitro and in vivo, with no acute/subacute toxicity effects on mice. This indicates its potential as a safe and effective option for wound healing and anti-ulcer treatments.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Abid Ali Ahmad, Kashif Hussain, Muhammad Raza Shah, Syed Muhammad Ashhad Halimi, Fazle Rabbi, Zahoor Ahmad, Inamullah Khan, Abdur Rauf, Abdulrahman Alshammari, Metab Alharbi, Hafiz Ansar Rasul Suleria
Summary: The aim of this study was to discover and explore highly potent and efficacious cyclooxygenase inhibitors using indole acetic acid drugs as a starting point. Derivatives of indomethacin, the selected lead compound, were synthesized and their structure and analogues were determined through spectroscopic procedures. The synthesized analogues were then screened for acute toxicity, anti-nociceptive and anti-inflammatory activity, and protein-ligand interaction. The results showed that the derivatives exhibited significant analgesic and anti-inflammatory activities, suggesting their potential as new drug candidates for pain and inflammation.
Article
Chemistry, Medicinal
Maria J. Ortega, Belen Parra-Torrejon, Fatima Cano-Cano, Laura Gomez-Jaramillo, M. Carmen Gonzalez-Montelongo, Eva Zubia
Summary: This study designed and synthesized a series of 3-arylphthalide derivatives to evaluate their antioxidant and anti-inflammatory activities. Compound 3-(2,4-dihydroxyphenyl)phthalide (5a) showed excellent antioxidant activity and strong inhibition of NO production in LPS-stimulated cells. These findings suggest that compound 5a could be a promising candidate for further anti-inflammatory studies.
Article
Biochemistry & Molecular Biology
Gisele Atsang A. Kiki, Raluca Maria Pop, Octavia Sabin, Ioana Corina Bocsan, Veronica Sanda Chedea, Sonia Ancuta Socaci, Alina Elena Parvu, Egre Finsia, Takvou Francis, Zramah Mathieu, Anca Dana Buzoianu
Summary: The fruit extracts of DC have potential anti-inflammatory, analgesic, and antioxidative properties, making them a potential treatment option for inflammatory diseases such as rheumatoid arthritis in traditional medicine. The extracts are rich in polyphenolic compounds and have antioxidant capacity. The effects of the extracts after administration depend on the dosage and type of extract.
Article
Plant Sciences
Rubaet Sharmin Ema, S. M. Neamul Kabir Zihad, Md Naharul Islam, Nazifa Sifat, Razina Rouf, Jamil A. Shilpi, Shaikh Jamal Uddin
Summary: This study investigated the traditional use of Callicarpa arborea Roxb. in the treatment of various painful and inflammatory conditions in Bangladesh and Indian subcontinent. The methanolic extract of C. arborea Roxb. leaves showed significant analgesic and anti-inflammatory activities in different animal models. The study also identified twenty one compounds in the extract.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Songul Unuvar, Hamza Aslanhan, Zubeyde Tanriverdi, Fuat Karakus
Article
Medicine, General & Internal
Fuat Karakus, Ergul Eyol, Kadir Yilmaz, Songul Unuvar
AFRICAN HEALTH SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Goeknur Aktay, Sule Oner Gursoy, Umut Uyumlu, Songuel Unuvar, Nevin Ilhan
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2019)
Article
Chemistry, Medicinal
Fuat Karakus, Kadir Yilmaz, Ergul Eyol, Songul Unuvar
NATURAL PRODUCT COMMUNICATIONS
(2019)
Article
Toxicology
Zubeyde Tanriverdi, Fatih Meteroglu, Hande Yuce, Abdurrahman Senyigit, Mumtaz Iscan, Songul Unuvar
Summary: The study showed that neopterin, periostin, YKL-40, TNC, and IDO were significantly elevated in patients with malignant pleural mesothelioma (MPM) and were positively correlated with each other. These non-invasive biomarkers can contribute to the early diagnosis of MPM.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nese B. Turkmen, Hande Yuce, Yasemin Sahin, Asli C. Taslidere, Dilan A. Ozek, Songul Unuvar, Osman Ciftci
Summary: The present study investigates the protective effects of resveratrol on brain and liver tissues in rats with pembrolizumab-induced toxicity. Resveratrol treatment reduced the levels of thiobarbituric acid reactive substance and increased the activities of glutathione peroxidase, catalase, and superoxide dismutase, as well as the levels of glutathione. It also decreased the expression of caspase-3 protein and histopathological changes in the liver and brain tissues.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Yasemin Sahin, Hande Yuce, Songul Unuvar, Osman Ciftci
Summary: Monkeypox is a zoonotic viral infection first identified in humans in 1970 in the Democratic Republic of Congo, with the current cases reaching 78,000 as of May 2022. The World Health Organization declared the monkeypox outbreak a public health emergency on July 23, 2022. Understanding the transmission sources, symptoms, protective measures, mutation status, and treatment approaches for monkeypox is crucial for early diagnosis and effective management.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2023)
Article
Obstetrics & Gynecology
Rauf Melekoglu, Songul Unuvar, Nese Basak Turkmen, Asli Cetin, Nesibe Zeyveli Celik, Hande Yuce, Seyma Yasar
Summary: This study aimed to investigate the role of extracellular matrix proteins in the molecular mechanism of inflammatory response in obese pregnant women. The study found that class II-III obese pregnant women had significantly higher serum levels of neopterin, periostin, Tenascin-C, and tissue inhibitor of metalloproteinase-1. These higher serum levels may be associated with the adverse perinatal effects of obesity during pregnancy.
TURKISH JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gozde Girgin, Saziye Sezin Palabiyik-Yucelik, Hande Sipahi, Bilge Kilicarslan, Songul Unuvar, Engin Tutkun, Omer Hinc Yilmaz, Terken Baydar
Summary: Amalgam, a dental restorative material, has been widely used for over 150 years. It has been found that dental amalgam releases mercury, posing a risk of occupational mercury exposure for dental workers. A study evaluated the changes in neopterin levels and tryptophan degradation in dental technicians and found that low levels of mercury exposure resulted in decreased neopterin and kynurenine levels. This suggests a possible immune suppression with low level of occupational mercury exposure.
Article
Endocrinology & Metabolism
Songul Unuvar, Rauf Melekoglu, Emine Salva, Ceren Acar, Seyma Yasar
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2020)
Article
Medical Laboratory Technology
Songul Unuvar, Duygu Erge, Bilge Kilicarslan, Harika Gozde Gozukara Bag, Ferhat Catal, Gozde Girgin, Terken Baydar
ANNALS OF LABORATORY MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Songul Unuvar, Hamza Aslanhan
JOURNAL OF MEDICAL BIOCHEMISTRY
(2019)
Article
Chemistry, Medicinal
Kadir Yilmaz, Fuat Karakus, Ergul Eyol, Emir Tosun, Ismet Yilmaz, Songul Unuvar
NATURAL PRODUCT COMMUNICATIONS
(2018)
Article
Medicine, General & Internal
Songul Unuvar, Gozde Girgin, Tevfik Tolga Sahin, Bilge Kilicarslan, Ferit Taneri, Osman Yuksel, Terken Baydar
ARCHIVES OF IRANIAN MEDICINE
(2018)
Article
Biochemistry & Molecular Biology
Songul Unuvar, Zubeyde Tanriverdi, Hamza Aslanhan
JOURNAL OF MEDICAL BIOCHEMISTRY
(2018)
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)