Article
Oncology
Javier Ramirez-Ricardo, Elizabeth Leal-Orta, Alejandra Garcia-Hernandez, Ricardo Diaz-Aragon, Pedro Cortes-Reynosa, Rocio Thompson-Bonilla, Eduardo Perez Salazar
Summary: The study shows that LA EVs promote migration and invasion of breast cancer cells by triggering the Src/FAK signaling pathway.
Article
Multidisciplinary Sciences
Xingjian Zhang, Trevor Chan, Michael Mak
Summary: This study investigated the phenotypes of highly aggressive cancer cells in confined microenvironments, revealing two distinct migratory phenotypes in fast migrating single cells and an increase in protrusions at the leading edge of cells under geometric confinement. The findings elucidate the impact of geometric constraints on cell behavior and morphodynamics associated with different cell phenotypes.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Carolinne Amorim, Clara Luisa Docasar, Daniel Guimaraes-Bastos, Ana Clara Frony, Christina Barja-Fidalgo, Mariana Renovato-Martins, Joao Alfredo Moraes
Summary: Tumor-associated neutrophils (TAN) in the tumor microenvironment play a crucial role in tumor growth, and extracellular vesicles (Evs) released by tumor cells can modulate the phenotype of immune system cells, contributing to tumor development. In this study, we investigated the effects of MDA-MB-231-derived Evs on neutrophil polarization and found that MDA-Evs induce an N2-like phenotype, leading to increased tumor cell viability.
Article
Biochemistry & Molecular Biology
Rafaela de Assiz Louback, Karina Martins-Cardoso, Luzineide W. W. Tinoco, Federica Collino, Ana Paula D. N. de Barros, Anneliese Fortuna-Costa, Robson Q. Q. Monteiro, Maria Isabel Doria Rossi, Rafael Soares Lindoso
Summary: Long-term administration of aspirin reduces cancer risk incidence, potentially by interfering with tumor communication. In this study, ASA was found to decrease the amount and alter the size distribution of EVs secreted by breast tumor cells. These EVs stimulated fibroblasts to become cancer-associated fibroblasts, but ASA treatment led to reduced expression of specific proteins and decreased invasiveness of breast cancer cells. This suggests that ASA can inhibit the ability of tumor EVs to stimulate CAFs and promote cancer invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Florian Keller, Roman Bruch, Franziska Clauder, Mathias Hafner, Ruediger Rudolf
Summary: The study found that extracellular matrix components play a significant role in regulating BSP expression, suggesting mechanisms for the formation of bone-associated metastasis in breast cancer that may involve local control of BSP levels through extracellular matrix degradation and release of growth factors.
Article
Biochemistry & Molecular Biology
Bashir Mosayyebi, Leila Mohammadi, Ashkan Kalantary-Charvadeh, Mohammad Rahmati
Summary: The study demonstrated that amygdalin has cytotoxic effects on breast cancer cell lines, while being non-toxic to human skin fibroblast cell line. Amygdalin treatment resulted in decreased adhesion of cancer cells to fibronectin and collagen I, as well as reduced cell migration, particularly in MDA-MB-231 cells. Integrin alpha and beta levels were differentially regulated by amygdalin in both cancer cell lines, suggesting a role in cancer cell adhesion and migration.
CURRENT MOLECULAR PHARMACOLOGY
(2021)
Article
Food Science & Technology
Ling Xie, Jun Yi, Yongjia Song, Mengyao Zhao, Liqiang Fan, Liming Zhao
Summary: GOLM1 has been identified as a prime target for cancer therapy, and EGCG is the first natural product found to downregulate GOLM1 expression, inhibiting MDA-MB-231 cell migration through the HGF/HGFR/AKT/GSK-3/ beta-catenin/c-Myc signaling pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Oncology
Yong-Jin Kwon, Eun-Bi Seo, Ae Jin Jeong, Song-Hee Lee, Kum Hee Noh, Sangsik Lee, Chung-Hyun Cho, Chang-Han Lee, Hyun Mu Shin, Hang-Rae Kim, Hyeong-Gon Moon, Sang-Kyu Ye
Summary: Under conditions of tumor acidosis, the expression of PD-L1 significantly increases and it is likely mediated by activation of the STAT3 signaling pathway. This finding provides new insights into the study of tumor immune evasion mechanisms.
Article
Biochemistry & Molecular Biology
Ninive Rodriguez-Ochoa, Pedro Cortes-Reynosa, Karem Rodriguez-Rojas, Mireya de la Garza, Eduardo Perez Salazar
Summary: Holo-lactoferrin inhibits migration and invasion processes in breast cancer cells.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Cell Biology
Mauro Vismara, Sharon Negri, Francesca Scolari, Valentina Brunetti, Silvia Maria Grazia Trivigno, Pawan Faris, Luca Galgano, Teresa Soda, Roberto Berra-Romani, Ilaria Canobbio, Mauro Torti, Gianni Francesco Guidetti, Francesco Moccia
Summary: PEVs stimulate migration and invasiveness in the highly metastatic MDA-MB-231 breast cancer cell line by inducing a partial remodelling of the Ca2+ handling machinery.
Article
Cell Biology
Elizabeth Leal-Orta, Javier Ramirez-Ricardo, Alejandra Garcia-Hernandez, Pedro Cortes-Reynosa, Eduardo Perez Salazar
Summary: IGF-1 EVs induce EMT process in mammary non-tumorigenic epithelial cells MCF10A by decreasing E-cadherin levels, increasing the expression of vimentin and N-cadherin, and stimulating the secretion of metalloproteinase-9.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Sebastian Simu, Iasmina Marcovici, Amadeus Dobrescu, Daniel Malita, Cristina Adriana Dehelean, Dorina Coricovac, Flavius Olaru, George Andrei Draghici, Dan Navolan
Summary: Translate: Oral contraceptives (OCs) are widely used for preventing unplanned pregnancies and treating human diseases. Despite their medical benefits, concerns about their toxicity, particularly their potential link to hormone-dependent malignancies such as breast cancer, have been raised. This study found that the active ingredients in modern OCs, 17 beta-Ethinylestradiol and Levonorgestrel, have differential effects on TNBC cells, with 17 beta-Ethinylestradiol showing potential anticancer effects and Levonorgestrel having proliferative effects. Further research is needed to understand the mechanisms of action of these hormones on TNBC cells.
Article
Chemistry, Medicinal
Huankai Yao, Xiuli Zhang, Nan Zhang, Jindong Li, Yan Li, Qunli Wei
Summary: In the study, it was found that wikstromol inhibited cell growth and induced apoptosis in TNBC cells, suppressed cell migration, and the inhibitory effects were involved in the inactivation of the PI3K/Akt pathway.
JOURNAL OF NATURAL MEDICINES
(2021)
Article
Oncology
Kamolporn Amornsupak, Suyanee Thongchot, Chanida Thinyakul, Carol Box, Somaieh Hedayat, Peti Thuwajit, Suzanne A. Eccles, Chanitra Thuwajit
Summary: This study revealed that HMGB1 promotes breast cancer cell invasion through the RAGE-PI3K/AKT pathway and also upregulates PD-L1 expression, leading to destruction of effector T cells.
Article
Biotechnology & Applied Microbiology
Neelam Mishra, Kavita Rana, Siva Deepthi Seelam, Rakesh Kumar, Vijyendra Pandey, Bharathi P. Salimath, Dayanand Agsar
Summary: Pseudomonas aeruginosa DNM50 was identified as a biosurfactant-producing bacterium with 12 different congeners of rhamnolipid identified through structural characterization. The rhamnolipid showed radical scavenging activity with an IC50 value of 101.8 μg/ml and exhibited cytotoxic activity against MDA-MB-231 breast cancer cell line with a low IC50 of 0.05 μg/ml at 72 h of treatment. This suggests that DNM50RL may have potential in breast cancer treatment by targeting inhibition of p38MAPK.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Medicine, General & Internal
Christian O. Ramirez-Serrano Torres, Edgardo Roman-Guzman, Carlos-Manuel Ortiz-Mendoza
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2017)
Letter
Obstetrics & Gynecology
Carlos Manuel Ortiz-Mendoza
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2018)
Article
Oncology
Pedro Cruz-Nova, Michael Schnoor, Jose Correa-Basurto, Martiniano Bello, Paola Briseno-Diaz, Arturo Rojo-Dominguez, Carlos M. Ortiz-Mendoza, Jorge Guerrero-Aguirre, Francisco J. Garcia-Vazquez, Rosaura Hernandez-Rivas, Maria del Rocio Thompson-Bonilla, Miguel Vargas
Article
Surgery
Sheyla P. Serrano-Gonzalez, Jerath A. Najera-Reyes, Carlos M. Ortiz-Mendoza
Summary: The characteristics of Mexican Government's workers undergoing emergency surgery underwent significant changes during the COVID-19 pandemic. There was an increase in the number of days between the onset of symptoms and surgery, a decrease in acute appendicitis cases, and an increase in acute calculous cholecystitis cases.
CIRUGIA Y CIRUJANOS
(2022)
Article
Anatomy & Morphology
Victor Hugo Arzate-Ramirez, Carlos Manuel Ortiz-Mendoza
Summary: The study aimed to assess the frequency of Langer's arch in patients undergoing axillary dissection for breast cancer. The results showed that Langer's arch finding occurred in 33 out of 123 axillary dissections (26.8%). The conclusion of the study is that Langer's arch is frequent in patients undergoing axillary dissection for breast cancer.
SURGICAL AND RADIOLOGIC ANATOMY
(2023)
Article
Medicine, General & Internal
Carlos Manuel Ortiz-Mendoza
Summary: This study aimed to investigate the rate of Pap smears performed on women with total hysterectomy at ISSSTE hospital in Mexico City. The results showed that the proportion of Pap smear tests was significantly higher in patients with ISSSTE insurance compared to those without insurance.
INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
(2022)
Letter
Public, Environmental & Occupational Health
Carlos Manuel Ortiz-Mendoza
INDIAN JOURNAL OF COMMUNITY MEDICINE
(2021)
Letter
Cardiac & Cardiovascular Systems
Carlos Manuel Ortiz-Mendoza
ANNALS OF THORACIC MEDICINE
(2020)
Article
Medicine, General & Internal
Carlos M. Ortiz-Mendoza, Amira G. Sanchez-Hernandez
INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
(2019)
Article
Oncology
Amira G. Sanchez-Hernandez, Carlos M. Ortiz-Mendoza
GACETA MEXICANA DE ONCOLOGIA
(2019)
Article
Medicine, General & Internal
Carlos Manuel Ortiz-Mendoza
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2019)
Article
Obstetrics & Gynecology
Carlos Manuel Ortiz-Mendoza, Sandra Adriana Vera-Vazquez, Manuel Gomez-Rodriguez, Jose Luis Lopez-Gomez, Leticia Bornstein-Quevedo
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2017)
Article
Oncology
Carlos-Manuel Ortiz-Mendoza, Ernesto Perez-Chavez, Tania-Angelica De-la Fuente-Vera
SOUTH ASIAN JOURNAL OF CANCER
(2016)
Article
Obstetrics & Gynecology
Carlos Manuel Ortiz-Mendoza, Norma Alicia Acosta Sanchez, Arturo Catarino Dircio
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2018)