Journal
MEDICAL ONCOLOGY
Volume 38, Issue 4, Pages -Publisher
HUMANA PRESS INC
DOI: 10.1007/s12032-021-01485-y
Keywords
Extracellular vesicles; Linoleic acid; Src; FAK; Akt2; Invasion; MDA-MB-231; Breast cancer
Categories
Funding
- CONACYT
- CONACYT-FOSISS, Mexico [Salud 2015-1-261637]
- CONACYT [255429]
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The study shows that LA EVs promote migration and invasion of breast cancer cells by triggering the Src/FAK signaling pathway.
Linoleic acid (LA) is the most abundant polyunsaturated fatty acid in occidental diets, which mediate a variety of processes in human breast cancer cells, including migration and invasion. Extracellular vesicles (EVs) are vesicles released from endosomes and plasma membrane that are composed of a variety of molecules, including proteins, nucleic acids and lipids. EVs from cancer cells promote processes related with cancer progression. In the present study, we demonstrate that treatment of MDA-MB-231 cells with EVs from MDA-MB-231 cells stimulated with LA (LA EVs) promote migration and invasion via Src activity. LA EVs induce activation of FAK via Src activity and of Src and Akt2. LA EVs also induce the assembly of focal adhesions and MMP-9 secretion. These findings demonstrate that LA EVs mediate an autocrine and/or paracrine Src/FAK signaling pathway to promote migration and invasion.
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