Article
Chemistry, Medicinal
Izabela Dziedzic, Alona Voronkina, Martyna Pajewska-Szmyt, Martyna Kotula, Anita Kubiak, Heike Meissner, Tomas Duminis, Hermann Ehrlich
Summary: Chitin, a polysaccharide found in sponges, plays a crucial role in providing mechanical stability to their unique 3D-structured skeletons. By using a 1% LiOH solution and sonication, researchers were able to extract multilayered, tube-like chitin from cultivated Aplysina aerophoba sponge skeletons. Surprisingly, this extraction method not only isolated chitinous scaffolds but also resulted in their dissolution and the formation of amorphous-like matter. Evaluation of the chitin revealed no differences between the sponge-derived chitin and chitin derived from arthropods, suggesting that lithium ions are responsible for the formation of LiBr and the dissolution of chitin in the sponge.
Article
Chemistry, Medicinal
Tomas Duminis, Marcin Heljak, Wojciech Swieszkowski, Alexander Ereskovsky, Izabela Dziedzic, Marek Nowicki, Martyna Pajewska-Szmyt, Alona Voronkina, Stefan R. Bornstein, Hermann Ehrlich
Summary: Skeletal constructs of marine sponges, especially those isolated from cultivated demosponges, have the potential to be sustainable sources of biocompatible porous biopolymer-based 3D scaffolds for tissue engineering. These chitinous scaffolds have shown promising results in biomimetics and tissue engineering due to their renewability and broad diversity of cells. However, the mechanical features of these constructs have been poorly studied before.
Article
Biotechnology & Applied Microbiology
Anna Zawadzka-Knefel, Agnieszka Rusak, Monika Mrozowska, Tomasz Machalowski, Andrzej Zak, Katarzyna Haczkiewicz-Lesniak, Michal Kulus, Piotr Kuropka, Marzenna Podhorska-Okolow, Katarzyna Skoskiewicz-Malinowska
Summary: The use of stem cells for tissue regeneration is a prominent trend in regenerative medicine and tissue engineering. Dental pulp stem cells (DPSCs) have attracted attention due to their ability to differentiate into osteoblasts and odontoblasts. This study explored the biological responses of human DPSCs to a purified 3D chitin scaffold derived from the marine demosponge Aplysina fistularis. Results showed that the chitin scaffold, especially with hydroxyapatite (HAp) modification, supported cell adhesion, proliferation, and differentiation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Fajun Chen, Jian Han, Zeyong Guo, Chongjing Mu, Chuandi Yu, Zhibo Ji, Lei Sun, Yujuan Wang, Junfeng Wang
Summary: To address the challenge of infectious bone defects in the clinical setting, antibacterial scaffolds were fabricated using a silver nanoparticle/poly lactic-co-glycolic acid (AgNP/PLGA) material via direct ink writing (DIW) 3D printing technique. The scaffolds exhibited uniform surface pores, enhanced mechanical strength, and continuous release of silver ions, promoting hydroxyapatite growth. The scaffolds showed excellent antibacterial properties against Staphylococcus aureus and Escherichia coli, and demonstrated excellent biocompatibility with osteoblast precursor cells. These findings highlight the potential application of 3D-printed AgNPs/PLGA scaffolds in bone tissue engineering.
Article
Biochemistry & Molecular Biology
Maria Orfanoudaki, Anja Hartmann, Mostafa Alilou, Naida Mehic, Marcel Kwiatkowski, Karin Joehrer, Hieu Nguyen Ngoc, Andreas Hensel, Richard Greil, Markus Ganzera
Summary: The study focused on investigating the chemical compositions of two Mediterranean demosponges, isolating 20 pure secondary metabolites with interesting biological activities, including 5 new natural products. These compounds were found to have diverse chemical scaffolds and exhibited cytotoxic properties in multiple cell lines, with one compound showing particularly promising activities.
Article
Chemistry, Physical
Tomasz Machalowski, Agnieszka Rusak, Benita Wiatrak, Katarzyna Haczkiewicz-Lesniak, Aneta Popiel, Jakub Jaroszewicz, Andrzej Zak, Marzenna Podhorska-Okolow, Teofil Jesionowski
Summary: TE is a rapidly growing field in regenerative medicine, with naturally formed chitinous materials showing promise as support for cell cultivation. The study successfully isolated chitinous skeleton from a marine sponge, demonstrating a thermostable pure alpha-chitin scaffold with high biocompatibility through cell attachment and proliferation tests. The results suggest that the chitinous scaffold from this marine sponge could be a promising biomaterial for future tissue regeneration research.
Article
Materials Science, Biomaterials
Zhengyun Ling, Jian Zhao, Shiyu Song, Shuwei Xiao, Pengchao Wang, Ziyan An, Zhouyang Fu, Jinpeng Shao, Zhuang Zhang, Weijun Fu, Shenghan Song
Summary: In recent years, hydrogels have gained increasing attention in tissue engineering, and the integration of 3D bioprinting has expanded the range of applications. Gelatin methacrylate (GelMA) is commonly used in 3D bioprinting due to its good biocompatibility, but its low mechanical properties limit its use. In this study, the researchers developed a biomaterial ink composed of GelMA and chitin nanocrystal (ChiNC) to enhance the mechanical properties and printability of GelMA hydrogels, promote cell adhesion and proliferation, enable vascularization, and print complex 3D scaffolds.
REGENERATIVE BIOMATERIALS
(2023)
Article
Multidisciplinary Sciences
Barbara Gonzalez-Acosta, Aaron Barraza, Cesar Guadarrama-Analco, Claudia J. Hernandez-Guerrero, Sergio Francisco Martinez-Diaz, Cesar Salvador Cardona-Felix, Ruth Noemi Aguila-Ramirez
Summary: This study investigated the microbial communities associated with two marine sponges and found that depth was a stronger factor than host in structuring the microbiome.
Article
Engineering, Biomedical
Shanshan Li, Bin Gu, Xiaoyun Li, Shuwei Tang, Lu Zheng, Eduardo Ruiz-Hitzky, Zeyu Sun, Changliang Xu, Xiaoying Wang
Summary: This study demonstrates the effective use of MXene-based nanomaterials in improving the performance of biocomposite sponges for wound healing. By incorporating MXene nanomaterials with different morphologies into the network of chitin sponge, the hemostatic efficacy of the sponge is enhanced, and the composite sponges exhibit excellent antibacterial activity. The addition of gold nanoparticles further improves the hemostatic performance and wound closure rates.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Inorganic & Nuclear
Muntadher I. Rahmah
Summary: In this study, the author suggests doping commercial titanium oxide nanoparticles with graphene and silver nanoparticles to enhance their properties. Structural results show that the diffraction angles change as the crystal size increases after doping. Morphological results demonstrate the presence of nanostructures like clusters of spherical nanoparticles. Incorporation of graphene and silver nanoparticles into the matrix leads to increased absorption and decreased energy gap. The inhibitory action results indicate significant inhibition of Staphylococcus aureus growth and slight inhibition of Escherichia coli growth, attributed to the sample's charge and its effect on attractive and repulsive forces. This work represents a promising advancement in improving metal oxide properties.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Applied
Andreii S. Kritchenkov, Alexey V. Kletskov, Anton R. Egorov, Alexander G. Tskhovrebov, Aleh V. Kurliuk, Natallia V. Zhaliazniak, Tatsiana V. Shakola, Victor N. Khrustalev
Summary: This study presents the synthesis of new chitin derivatives under Green Chemistry conditions using ultrasound-assisted treatment, resulting in water-soluble azido chitin derivatives with high antibacterial activity. These derivatives showed comparable antibacterial properties to commercial antibiotics, and were used for film coating of Ricotta cheese samples to effectively prolong their shelf life.
Article
Materials Science, Coatings & Films
Alejandra Rodriguez-Contreras, Diego Torres, Belal Rafik, Monica Ortiz-Hernandez, Maria Pau Ginebra, Jose A. Calero, Jose Maria Manero, Elisa Ruperez
Summary: In this study, a thermochemical treatment was used to produce silver-doped calcium titanate coatings on titanium surfaces, enhancing bioactivity and providing antibacterial properties. The release of Ag ions from the coatings showed strong antibacterial effects, preventing bacterial adhesion and proliferation. Additionally, nanostructured topography of the coating reduced bacterial adhesion and proliferation even without Ag, maintaining bioactivity of the implants.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yalei Liu, Jie Mao, Zhiyong Guo, Yufang Hu, Sui Wang
Summary: The authors prepared a bifunctional hydrogel with antibacterial and self-healing properties by cross-linking polyvinyl alcohol and carboxymethyl chitosan through hydrogen bonds and borate ester bonds. The hydrogel showed improved mechanical properties and the addition of silver nanoparticles effectively inhibited bacterial growth, providing potential applications in biological wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Teresa Carranza, Jone Uranga, Ainhoa Irastorza, Ander Izeta, Pedro Guerrero, Koro de la Caba
Summary: Novel scaffolds based on natural polymers were developed by combining 3D printing and electrospinning techniques. The 3DP ink was prepared with gelatin and chitin, while the ES ink was prepared with gelatin and poly(vinyl alcohol) (PVA). The combination of these biopolymers resulted in a multilayered scaffold with unique properties suitable for tissue regeneration.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Materials Science, Coatings & Films
Hao Wang, Langping Wang, Xiaofeng Wang
Summary: Silver doped diamond-like carbon (DLC) films were prepared using dual-targets high power impulse magnetron sputtering, and the size of Ag nanoparticles (AgNPs) affected the antibacterial properties, with smaller AgNPs showing better antibacterial efficiency.
SURFACE & COATINGS TECHNOLOGY
(2021)
Review
Food Science & Technology
Esmaeil Sheibani, Asieh Hosseini, Ali Sobhani Nasab, Kourosh Adib, Mohammad Reza Ganjali, Seied Mahdi Pourmortazavi, Farhad Ahmadi, Elnaz Marzi Khosrowshahi, Somayeh Mirsadeghi, Mehdi Rahimi-Nasrabadi, Hermann Ehrlich
Summary: This paper reviews the reports on the extraction and determination of organic and inorganic analytes using polysaccharide-based biopolymers as solid phase sorbents for sample preparation. It explores the suitability of biopolymers as a choice for sample preparation methods.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biotechnology & Applied Microbiology
Arjumand Riaz, Umme Kalsoom, Haq Nawaz Bhatti, Teofil Jesionowski, Muhammad Bilal
Summary: Dye-contaminated toxic waste is a significant environmental problem, but peroxidase from lemon peels has been found to efficiently degrade dyes. In this study, the enzyme successfully degraded two dyes with environmental and cost advantages.
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2023)
Article
Chemistry, Applied
Ahmet Kertmen, Izabela Dziedzic, Hermann Ehrlich
Summary: Cationic chitosan, as a derivative of chitin, has specific physicochemical properties, biodegradability, and biocompatibility, and is widely used in patents related to biomedical, material science, biotechnology, and chemical fields.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Inorganic & Nuclear
Junaid Munawar, Muhammad Shahzeb Khan, Shan E. Zehra Syeda, Shahid Nawaz, Farooque Ahmed Janjhi, Hameed Ul Haq, Ehsan Ullah Rashid, Teofil Jesionowski, Muhammad Bilal
Summary: Metal-organic frameworks (MOFs) have excellent intrinsic characteristics that make them suitable for various applications such as energy storage, catalysis, optics, sensory responses, and biomedical sciences. Current research is focused on designing novel MOF composites with multifunctional attributes and physicochemical structures, as well as exploiting their morphological and size properties for new applications. MOFs have been shown to be effective nanoplatforms for cancer diagnosis, drug delivery, and bioimaging, thanks to their unique features including low cytotoxicity, high porosity, biodegradability, and tunable framework. This review not only explores the potential of MOFs in cancer therapy and imaging, but also highlights their future prospects and challenges in this field.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Stefan Neumann, Azita Rezvani, Matthaeus Barasinski, Georg Garnweitner, Doris Segets, David Rafaja
Summary: This paper presents a multiscale approach using transmission electron microscopy (TEM) to study the characteristics of gold nanocrystals (NCs). The approach combines high-resolution TEM to observe the atomic-scale features of NCs with a semi-automatic analysis of low-magnification high-angle annular dark-field scanning TEM images to provide statistical information about the morphological attributes of NCs. The results of these complementary techniques are combined and correlated to quantify and understand the crystallographic orientations, configurations, and defects of different types of gold nanocrystals.
MICROSCOPY AND MICROANALYSIS
(2023)
Article
Endocrinology & Metabolism
Alessa Fischer, Simon Kloos, Umberto Maccio, Juliane Friemel, Hanna Remde, Martin Fassnacht, Christina Pamporaki, Graeme Eisenhofer, Henri J. L. M. Timmers, Mercedes Robledo, Stephanie M. J. Fliedner, Katharina Wang, Julian Maurer, Astrid Reul, Kathrin Zitzmann, Nicole Bechmann, Gintare Zygiene, Susan Richter, Constanze Hantel, Diana Vetter, Kuno Lehmann, Hermine Mohr, Natalia S. Pellegata, Martin Ullrich, Jens Pietzsch, Christian G. Ziegler, Stefan R. Bornstein, Matthias Kroiss, Martin Reincke, Karel Pacak, Ashley B. Grossman, Felix Beuschlein, Svenja Noelting
Summary: This study investigated the relationship between SSTR2 immunoreactivity and SDHB immunoreactivity, mutational status, and clinical behavior of PPGLs. It also evaluated SSTR-based therapies in metastatic PPGLs. The results showed that SSTR2 expression was associated with SDHB/SDHx mutations and metastatic disease. Somatostatin receptor-based therapies had a high disease control rate in metastatic PPGLs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Materials Science, Multidisciplinary
Patryk J. Jedrzejczak, Anna Parus, Sebastian Balicki, Kamil Kornaus, Marcin Janczarek, Kazimiera A. Wilk, Teofil Jesionowski, Agnieszka Slosarczyk, Ukasz Klapiszewski
Summary: An experimental and statistical analysis was conducted to investigate the effects of six different types of titanium dioxide on various properties of cement composites. The study found that the size and surface area of the titanium dioxide particles significantly influenced the mechanical and rheological properties of the composites. The choice of polymorph also played a role in determining the photocatalytic and antibacterial properties. The results obtained from the experimental design model were highly correlated with the experimental data, confirming that the anatase form of titanium dioxide was the most effective additive for inducing antibacterial and photocatalytic properties.
MATERIALS RESEARCH BULLETIN
(2023)
Article
Chemistry, Physical
Hafiz Adnan Akram, Muhammad Imran, Ayesha Javaid, Shoomaila Latif, Nayab Batool Rizvi, Teofil Jesionowski, Muhammad Bilal
Summary: Developing countries face the challenges of energy crisis and increasing pollution. Hydrogen is considered a promising next-generation energy resource due to its sustainability and carbon-free nature. Various methods have been explored to extract hydrogen from algal and lignocellulosic biomass. This review analyzes pretreatment methods and biohydrogen yields from these biomass sources, and also discusses the catalytic conversion of pretreated biomass using metal organic frameworks for biofuel production.
MOLECULAR CATALYSIS
(2023)
Article
Environmental Sciences
Ahmad Farhan, Misbah Zulfiqar, Samiah, Ehsan Ullah Rashid, Shahid Nawaz, Hafiz M. N. Iqbal, Teofil Jesionowski, Muhammad Bilal, Jakub Zdarta
Summary: The presence of heavy and toxic metals in water sources has negative implications for human health and ecosystems. Recent research has focused on the use of nanomaterials for the removal of these metals, leading to the development of advanced techniques.
CURRENT POLLUTION REPORTS
(2023)
Article
Engineering, Multidisciplinary
Alona Voronkina, Eliza Romanczuk-Ruszuk, Robert E. Przekop, Pawel Lipowicz, Ewa Gabriel, Korbinian Heimler, Anika Rogoll, Carla Vogt, Milosz Frydrych, Pawel Wienclaw, Allison L. Stelling, Konstantin Tabachnick, Dmitry Tsurkan, Hermann Ehrlich
Summary: Structural bioinspiration is a current trend in modern material science and biomimetics, which is based on the diversity of invertebrate skeletons, particularly the honeycomb structures. In this study, we investigated the unique bioarchitecture principles of the biosilica-based honeycomb-like skeleton of the deep-sea glass sponge Aphrocallistes beatrix. Experimental data provided convincing evidence of the location of actin filaments within the hierarchical siliceous walls of the honeycomb structure. Inspired by the poriferan honeycomb biosilica, we designed various models using 3D printing and microtomography-based 3D reconstruction with PLA, resin, and synthetic glass materials.
Article
Agricultural Engineering
Agnieszka Rybarczyk, Wojciech Smu, Adam Grzywaczyk, Ewa Kaczorek, Teofil Jesionowski, Long D. Nghiem, Jakub Zdarta
Summary: This study presents a biocatalytic system using immobilized laccase and 3D printed biopolymer scaffoldings. The scaffoldings were computer-designed and 3D printed using PLA filament. The immobilization of laccase onto the PLA scaffolds was optimized, resulting in improved stability and reusability. The immobilized laccase showed higher enzymatic activity and removal efficiency of estrogens from wastewater compared to free laccase.
BIORESOURCE TECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Nicole Bechmann, Mats Leif Moskopp, Georgiana Constantinescu, Anthony Stell, Angela Ernst, Frank Berthold, Frank Westermann, Jingjing Jiang, Longfei Lui, Elisabeth Nowak, Stephanie Zopp, Karel Pacak, Mirko Peitzsch, Andreas Schedl, Martin Reincke, Felix Beuschlein, Stefan R. Bornstein, Martin Fassnacht, Graeme Eisenhofer, Int Network Adrenal Tumours
Summary: This study investigated the occurrence of adrenal tumors in relation to sex and adrenal asymmetry. It was found that females were more prone to adrenal cortical carcinoma, aldosterone-producing adenoma, and cortisol-secreting adrenocortical adenomas, while males were more prone to pheochromocytoma. Adrenal tumors were more commonly located on the left side, except for pheochromocytoma which was more commonly on the right. Additionally, females had smaller adrenals compared to males.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Chemistry, Medicinal
Anita Kubiak, Martyna Pajewska-Szmyt, Martyna Kotula, Bartosz Lesniewski, Alona Voronkina, Parvaneh Rahimi, Sedigheh Falahi, Korbinian Heimler, Anika Rogoll, Carla Vogt, Alexander Ereskovsky, Paul Simon, Enrico Langer, Armin Springer, Maik Foerste, Alexandros Charitos, Yvonne Joseph, Teofil Jesionowski, Hermann Ehrlich
Summary: This study presents a new biomimetic approach for the development of a lepidocrocite-containing 3D spongin scaffold using artificial seawater and iron. The research proposes a mechanism of lepidocrocite formation and suggests the potential application of the biocomposite as an electrochemical dopamine sensor.
Article
Chemistry, Physical
Matthias Krause, Mareen Hoppe, Carlos Romero-Muniz, Alvaro Mendez, Frans Munnik, Aurelio Garcia-Valenzuela, Christian Schimpf, David Rafaja, Ramon Escobar-Galindo
Summary: The stability of transparent conductive oxide SnO2:Ta (1.25 at% Ta) thin films was studied under isothermal conditions at 650°C and 800°C in air. The elemental composition and optical spectra remained unchanged after high-temperature treatment. X-ray diffraction confirmed the preservation of a single rutile-type phase. The presence of point defects, identified as Sn vacancies and O interstitials, was observed but did not affect the material's transmittance and reflectance.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Multidisciplinary
Faezeh Gandomi, Mohammad Javad Taghizadeh, Elnaz Marzi Khosrowshahi, Maryam Saleh Mohammadnia, Neda Irannejad, Esmail Sohouli, Hermann Ehrlich, Yvonne Joseph, Mehdi Rahimi-Nasrabadi
Summary: Azaperone is a phenylbutanone-based neurotransmitter used in veterinary clinics. In this study, a Fe3O4@SiO2-NH2/CS2 nanocomposite was synthesized and used to modify a glassy carbon electrode, creating a sensor for the analysis of Azaperone in ostrich meat and rat plasma. The electrochemical behavior of Azaperone was tested, and the optimal experimental variables, including pH and accumulation time, were determined. The sensor showed a linear response to Azaperone concentration in the range of 0.01-100.0 mu M.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2023)
