Article
Food Science & Technology
Mohammed Abdo Yahya, Ghedeir M. Alshammari, Magdi A. Osman, Laila Naif Al-Harbi, Abu El Gasim A. Yagoub, Sahar Abdulaziz Al Sedairy
Summary: Isoliquiritigenin (ISL) can attenuate high-fat diet-induced intestinal damage and inflammation by modulating Nrf2. It improves the structure of the duodenum, reduces oxidative stress and inflammation, and enhances antioxidant enzyme activity to strengthen the intestinal barrier.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Huijie Fan, Yanrong Li, Mengying Sun, Wushuai Xiao, Lijuan Song, Qing Wang, Bo Zhang, Jiezhong Yu, Xiaoming Jin, Cungen Ma, Zhi Chai
Summary: Hyperoside has shown neuroprotective effects in rotenone-induced PD rat model and SH-SY5Y cell model by affecting autophagy pathways, providing potential therapeutic benefits for Parkinson's disease treatment.
NEUROCHEMICAL RESEARCH
(2021)
Article
Immunology
Bing Sun, Ranteng Zhang, Zicong Liang, Aoqiang Fan, Dongmei Kang
Summary: The study demonstrates that hyperoside has a protective effect against high-fat diet-induced NAFLD and regulates macrophage polarization, alleviating hepatic steatosis, insulin resistance, and inflammatory responses. It shows that hyperoside may have therapeutic potential in preventing the pathological progression of NAFLD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Fangfang Zhu, Jie Gao, Fuling Zeng, Yuling Lai, Xiaofeng Ruan, Gaopi Deng
Summary: This study investigated the protective effects and mechanisms of hyperoside against cyclophosphamide-induced ovarian damage and reduced fertility. The results showed that hyperoside can diminish follicular depletion, prevent excessive hypoxia and autophagy activation, and increase follicular reserve, thereby improving fertility in mice.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
Xiao Chen, Ademola C. Famurewa, Jian Tang, Oladipupo Odunayo Olatunde, Opeyemi Joshua Olatunji
Summary: The study found that hyperoside can prevent diabetes-induced cognitive dysfunction, neuroinflammation, and oxidative stress through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms in rats.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Immunology
Weifeng Zhu, Ming Ge, Xiuyu Li, Jiangfeng Wang, PanPan Wang, Tiange Tai, Yuxi Wang, Jianxu Sun, Guangliang Shi
Summary: The study found that hyperoside inhibited spleen injury caused by zearalenone through its antioxidant and anti-apoptotic effects. This provides a new treatment option for immune system diseases caused by zearalenone.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Lingli Zhou, Huasong Zeng, Jun Cui, Shouheng Jin
Summary: Dysregulation of NOD2 signaling is associated with susceptibility to immunological and inflammatory diseases. Palmitoylation of NOD2 can modulate its stability and influence inflammation. A recently discovered variant enhances inflammation through increased palmitoylation and decreased autophagic degradation.
Article
Food Science & Technology
Yang Yang, Jia-Jie Huang, Gao-Sheng Zhu, Wei Hu
Summary: This study investigated the protective role of hyperoside in the development of osteoarthritis (OA) and its potential molecular mechanism. In vitro experiments demonstrated that hyperoside reversed IL-1 beta-induced secretion of proinflammatory mediators and extracellular matrix damage, possibly through inhibiting the PI3K/Akt and NF kappa B pathways. In a mouse model, hyperoside showed therapeutic effects in cartilage degeneration and pain symptoms. These findings suggest that hyperoside may be a promising treatment strategy for suppressing OA progression.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Gastroenterology & Hepatology
Tianci Zhang, Ruofei Zhang, Guangfu Zhao, Wei Liu, Liwei Pan, Ying Tong, Mingshan Jiang, Hu Zhang, Zhixiong Xiao, Stephen J. Pandol, Xiansheng Fu, Yuan-Ping Han, Xiaofeng Zheng
Summary: Inflammatory bowel disease (IBD) is a chronic and recurrent gastrointestinal disease, and its etiology is still poorly understood. This study found that autophagy in the intestinal tissue of IBD mice was persistently activated. Chlorophyllin (CHL), a water-soluble derivative of chlorophyll, can attenuate colitis by regulating autophagy and inflammation. Therefore, consumption of green vegetables and chlorophyllin may be beneficial for IBD recovery.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Wenyu Dai, Manyi Wang, Peiqi Wang, Ji Wen, Jiangyue Wang, Sa Cha, Xueling Xiao, Yiruo He, Rui Shu, Ding Bai
Summary: The study found that stimulation of MG63 cells with LPS led to downregulation of NEAT1, increase in expression of inflammatory cytokines, inhibition of autophagy and osteogenesis-related proteins, promotion of apoptosis, and alteration of the cell cycle.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Wanqiu Zhang, Jinghua Lu, Yangyang Wang, Pengbo Sun, Tong Gao, Naihan Xu, Yaou Zhang, Weidong Xie
Summary: Diabetic cardiomyopathy (DCM) is a myocardial disease independent of other cardiovascular diseases, and lipotoxicity is closely related to DCM. This study investigated the mechanism of lipid metabolism disturbance in DCM using HL-1 cells. Canagliflozin (CAN) was found to inhibit the expression of inflammatory factors and regulate ferroptosis through the AMPK pathway. The study provides new insights into myocardial lipotoxicity and potential treatment of DCM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Peng Wang, Shuo Zhang, Weijian Liu, Songfeng Chen, Xiao Lv, Binwu Hu, Zengwu Shao
Summary: This study found that selenium can protect against oxidative stress induced by peroxides, promote mitochondrial function, and inhibit cell apoptosis by activating the Nrf2 pathway, thereby improving intervertebral disc degeneration.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Plant Sciences
Yongkang Yang, Jing Li, Tingcai Rao, Zhirui Fang, Junyan Zhang
Summary: Hyperoside extracted from Hypericum perforatum and Crataegus pinnatifida has a protective effect on heart injury, improving cardiac function, reducing myocardial hypertrophy, and suppressing inflammation through regulating the autophagy pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Meng Zhang, Wenhai Sui, Yanqiu Xing, Jing Cheng, Cheng Cheng, Fei Xue, Jie Zhang, Xiaohong Wang, Cheng Zhang, Panpan Hao, Yun Zhang
Summary: The study demonstrated that Ang IV dose-dependently attenuated left ventricular dysfunction and remodeling in diabetic mice by activating AT4R and suppressing FoxO1-mediated fibrosis, apoptosis, and overactive autophagy.
Article
Multidisciplinary Sciences
Sung Il Cho, Eu-Ri Jo, Hansoo Song
Summary: This study found that Urolithin A (UA) induces mitophagy in premature senescent auditory cells, preventing premature aging. This suggests that UA administration may be a promising strategy for preventing mitochondrial dysfunction in patients with age-related hearing loss.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.