Computational and structural studies of MeCP2 and associated mutants

Novel Directions in Free Energy Methods and Applications

(2020) Kira A. Armacost et al.   Journal of Chemical Information and Modeling

First report of an unusual novel double mutation affecting the transcription repression domain of MeCP2 and causing a severe phenotype of Rett syndrome: Molecular analyses and computational investigation

(2018) Rania Ghorbel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tyr120Asp mutation alters domain flexibility and dynamics of MeCP2 DNA binding domain leading to impaired DNA interaction: Atomistic characterization of a Rett syndrome causing mutation

(2018) Ilda D'Annessa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA

(2018) Ke Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Mecp2Y120D Knock-in Model Displays Similar Behavioral Traits But Distinct Molecular Features Compared to the Mecp2-Null Mouse Implying Precision Medicine for the Treatment of Rett Syndrome

(2018) Anna Gandaglia et al.   MOLECULAR NEUROBIOLOGY

RettBASE: Rett syndrome database update

(2017) Rahul Krishnaraj et al.   HUMAN MUTATION

Clinical, Molecular, and Computational Analysis in Patients With a Novel Double Mutation and a New Synonymous Variant in MeCP2: Report of the First Missense Mutation Within the AT-hook1 Cluster in Rett Syndrome

(2017) Marwa Kharrat et al.   JOURNAL OF CHILD NEUROLOGY

Predicting the Effect of Amino Acid Single-Point Mutations on Protein Stability—Large-Scale Validation of MD-Based Relative Free Energy Calculations

(2017) Thomas Steinbrecher et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the MeCP2–TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders

(2017) Valdeko Kruusvee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binding Analysis of Methyl-CpG Binding Domain of MeCP2 and Rett Syndrome Mutations

(2016) Ye Yang et al.   ACS Chemical Biology

From Function to Phenotype: Impaired DNA Binding and Clustering Correlates with Clinical Severity in Males with Missense Mutations in MECP2

(2016) Taimoor I. Sheikh et al.   Scientific Reports

Impact of Rett Syndrome Mutations on MeCP2 MBD Stability

(2015) Tugba G. Kucukkal et al.   BIOCHEMISTRY

Structural, Dynamical, and Energetical Consequences of Rett Syndrome Mutation R133C in MeCP2

(2015) Tugba G. Kucukkal et al.   Computational and Mathematical Methods in Medicine

The molecular basis of variable phenotypic severity among common missense mutations causing Rett syndrome

(2015) Kyla Brown et al.   HUMAN MOLECULAR GENETICS

Methyl-CpG-binding protein 2(MECP2) mutation type is associated with disease severity in Rett syndrome

(2014) Vishnu Anand Cuddapah et al.   JOURNAL OF MEDICAL GENETICS

MeCP2: the long trip from a chromatin protein to neurological disorders

(2014) Juan Ausió et al.   TRENDS IN MOLECULAR MEDICINE

By Hook or by Crook: Multifaceted DNA-Binding Properties of MeCP2

(2013) Jaehoon Shin et al.   CELL

The American History of Rett Syndrome

(2013) Alan Percy   PEDIATRIC NEUROLOGY

A case of a Tunisian Rett patient with a novel double-mutation of the MECP2 gene

(2011) Nourhene Fendri-Kriaa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DNA Binding Restricts the Intrinsic Conformational Flexibility of Methyl CpG Binding Protein 2 (MeCP2)

(2011) Jeffrey C. Hansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent advances in MeCP2 structure and functionThis paper is one of a selection of papers published in this Special Issue, entitled 29th Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal’s usual peer review process.

(2009) Kristopher C. Hite et al.   Biochemistry and Cell Biology

Non–cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology

(2009) Nurit Ballas et al.   NATURE NEUROSCIENCE

Rett Syndrome-causing Mutations in Human MeCP2 Result in Diverse Structural Changes That Impact Folding and DNA Interactions

(2008) Rajarshi P. Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MeCP2 Binding to DNA Depends upon Hydration at Methyl-CpG

(2008) Kok Lian Ho et al.   MOLECULAR CELL

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

(2008) M. Chahrour et al.   SCIENCE