Article
Multidisciplinary Sciences
Aziza Kantri, Jihane Ziati, Mohamed Khalis, Amal Haoudar, Karim El Aidaoui, Youssef Daoudi, Inas Chikhaoui, Khalid El Yamani, Mohammed Mouhaoui, Jalila El Bakkouri, Nezha Dini, Mohammed Mahi, Abdelhamid Naitlho, Abdelkrim Bahlaoui, Ahmed Bennana, Mustapha Noussair, Lahcen Belyamani, Chafik El Kettani
Summary: This study critically analyzed the clinical and biological characteristics of 134 patients from the North African Mediterranean region with COVID-19, finding that factors such as age, comorbidities, gender, and infection type were associated with disease progression to a severe state. Abnormalities in certain parameters were closely linked to disease deterioration.
Article
Cardiac & Cardiovascular Systems
Thomas S. Metkus, Lori J. Sokoll, Andreas S. Barth, Matthew J. Czarny, Allison G. Hays, Charles J. Lowenstein, Erin D. Michos, Eric P. Nolley, Wendy S. Post, Jon R. Resar, David R. Thiemann, Jeffrey C. Trost, Rani K. Hasan
Summary: The study found that over 50% of intubated patients with severe COVID-19 had myocardial injury, which was associated with a higher mortality rate. Myocardial injury in COVID-19 was closely related to baseline comorbidities, age, and multisystem organ dysfunction. Compared with ARDS patients without COVID-19, COVID-19 patients were older and had poorer cardiac function, but had a lower incidence of myocardial injury.
Article
Multidisciplinary Sciences
Jun Wu, Boyun Liang, Cunrong Chen, Hua Wang, Yaohui Fang, Shu Shen, Xiaoli Yang, Baoju Wang, Liangkai Chen, Qi Chen, Yang Wu, Jia Liu, Xuecheng Yang, Wei Li, Bin Zhu, Wenqing Zhou, Huan Wang, Sumeng Li, Sihong Lu, Di Liu, Huadong Li, Adalbert Krawczyk, Mengji Lu, Dongliang Yang, Fei Deng, Ulf Dittmer, Mirko Trilling, Xin Zheng
Summary: The study quantified IgM and IgG antibodies recognizing SARS-CoV-2 in 349 symptomatic COVID-19 patients over 6 months, showing that IgM levels dropped after 3 months while IgG responses contracted but remained high at 6 months.
NATURE COMMUNICATIONS
(2021)
Article
Virology
Enric Monreal, Sainz S. de la Maza, Pedro Gullon, Elena Natera-Villalba, Juan Luis Chico-Garcia, Alvaro Beltran-Corbellini, Javier Martinez-Sanz, Nuria Garcia-Barragan, Javier Buisan, Rafael Toledano, Araceli Alonso-Canovas, Paula Perez-Torre, Maria C. Matute-Lozano, Jose Luis Lopez-Sendon, Guillermo Garcia-Ribas, Inigo Corral, Jesus Fortun, Beatriz Montero-Errasquin, Luis Manzano, Luis Maiz-Carro, Lucienne Costa-Frossard, Jaime Masjuan
Summary: This study found that immunosuppression may reduce the risk of moderate to severe ARDS in COVID-19 patients, especially among those with autoimmune diseases.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Critical Care Medicine
George L. Anesi, Adair Andrews, He Julia Bai, Pavan K. M. Bhatraju, David M. Brett-Major, M. Jana Broadhurst, Elizabeth Salvagio Campbell, J. Perren Cobb, Martin Gonzalez, Sonya D. Homami, Cameron D. Hypes, Amy J. Irwin, Christopher J. Kratochvil, Kelsey K. Krolikowski, Vishakha K. P. Kumar, Douglas P. A. Landsittel, Richard A. M. Lee, Janice M. Liebler, Karen T. Lutrick, Lucian T. M. Marts, Jarrod M. Mosier, Vikramjit Mukherjee, Radu Postelnicu, Valentina N. Rodina, Leopoldo N. E. Segal, Jonathan E. Sevransky, Christine Spainhour, Avantika M. Srivastava, Timothy M. Uyeki, Mark M. Wurfel, David Wyles, Laura Evans
Summary: This study aimed to understand the impact of the COVID-19 pandemic on hospital operations and its relationship with local viral activity. The results showed that hospitals experienced high stress in dealing with severe acute respiratory infection patients during the pandemic, and there were also some instances of care deviations. This stress was closely related to the stress in the wards and emergency departments, and it was influenced by the increase in local cases. After the peak of the Delta variant surge, the overall hospital stress persisted for a certain period of time, while the stress in the ICU and emergency departments resolved relatively earlier. Similar patterns were observed during the Omicron BA.1 subvariant surge.
CRITICAL CARE MEDICINE
(2023)
Article
Chemistry, Medicinal
Zhengnan Shen, Kiira Ratia, Laura Cooper, Deyu Kong, Hyun Lee, Youngjin Kwon, Yangfeng Li, Saad Alqarni, Fei Huang, Oleksii Dubrovskyi, Lijun Rong, Gregory R. J. Thatcher, Rui Xiong
Summary: Researchers have discovered a new antiviral drug that targets the SARS-CoV-2 papain-like protease (PLpro) to inhibit viral replication and improve antiviral potency in human cells.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Harpal Singh Sandhu, Joshua Lambert, Zach Steckler, Lee Park, Arnold Stromberg, Julio Ramirez, Chi-fu Jeffrey Yang
Summary: This study aimed to evaluate whether outpatient medications approved by the FDA reduce the risk of COVID-19 hospitalization. A retrospective cohort study of COVID-19 patients in the US in 2020 found that rosuvastatin, empagliflozin-metformin, metformin, and enoxaparin showed protective effects against COVID-19 hospitalization. Well-designed clinical trials are needed to assess the efficacy of these agents in therapeutic or prophylactic settings.
Article
Multidisciplinary Sciences
Julia Diaz-Escobar, Nelson E. Ordonez-Guillen, Salvador Villarreal-Reyes, Alejandro Galaviz-Mosqueda, Vitaly Kober, Raul Rivera-Rodriguez, Jose E. Lozano Rizk
Summary: The study evaluates and compares deep-learning techniques for detecting COVID-19 infections from lung ultrasound imagery. The findings suggest that the InceptionV3 network provides the most promising predictive results, which can be used to further develop a viable computer-assisted screening tool for COVID-19 based on ultrasound imagery.
Review
Microbiology
Jessica A. Plante, Brooke M. Mitchell, Kenneth S. Plante, Kari Debbink, Scott C. Weaver, Vineet D. Menachery
Summary: Despite the development of vaccines, COVID-19 caused by SARS-CoV-2 continues to be a global concern due to the emergence of new variants, raising worries about increased spread and potential impacts on immunity.
CELL HOST & MICROBE
(2021)
Article
Biochemistry & Molecular Biology
Atsuko Deguchi, Tomoko Yamamoto, Noriyuki Shibata, Yoshiro Maru
Summary: This study investigates the potential role of S100A8 in COVID-19-associated ARDS and proposes a treatment method. Pathological similarities, clinical information, and experimental results collectively support the importance of S100A8 in COVID-19.
Article
Oncology
Dax Kurbegov, Suanna S. Bruinooge, Xiudong Jennifer Lei, M. Kelsey Kirkwood, Natalie Dickson, Trupti Hattiangadi, Kathryn F. Mileham, Alicia Patrick, Jen Hanley Williams, Melinda Kaltenbaugh, Julie R. Gralow, Elizabeth Garrett-Mayer
Summary: The study found that age, cancer type, comorbidity, area-level education attainment, and unemployment rates were associated with differential COVID-19 vaccine uptake rates. These findings should be applied to strategies to communicate about vaccine safety and efficacy to patients with cancer.
Letter
Immunology
Nadine Muller, Mareike Kunze, Fabienne Steitz, Neil J. Saad, Barbara Muehlemann, Joern I. Beheim-Schwarzbach, Julia Schneider, Christian Drosten, Lukas Murajda, Sandra Kochs, Claudia Ruscher, Jan Walter, Nadine Zeitlmann, Victor M. Corman
Summary: An outbreak of coronavirus disease with 74 cases related to a nightclub in Germany in March 2020 highlighted the potential for superspreader events, with staff members being particularly affected (56% attack rate) and likely causing sustained viral transmission after an event at the club. This event supports the current club closures as a precautionary measure to prevent further spread of the virus.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Adam K. Wheatley, Jennifer A. Juno, Jing J. Wang, Kevin J. Selva, Arnold Reynaldi, Hyon-Xhi Tan, Wen Shi Lee, Kathleen M. Wragg, Hannah G. Kelly, Robyn Esterbauer, Samantha K. Davis, Helen E. Kent, Francesca L. Mordant, Timothy E. Schlub, David L. Gordon, David S. Khoury, Kanta Subbarao, Deborah Cromer, Tom P. Gordon, Amy W. Chung, Miles P. Davenport, Stephen J. Kent
Summary: The durability of infection-induced SARS-CoV-2 immunity has major implications for reinfection and vaccine development. Antibody, B cell, and T cell responses decline over the first 4 months post-infection, while S-specific IgG(+) memory B cells consistently accumulate. The study suggests that natural infection may only provide transient protection at a population level, highlighting the need for more immunogenic and durable vaccines.
NATURE COMMUNICATIONS
(2021)
Article
Pediatrics
Tina Hsu, Jacquelyn R. Sink, Veronica Alaniz, Lida Zheng, Anthony J. Mancini
Summary: The study described three cases of acute genital ulceration in female patients after receiving COVID-19 vaccination or natural infection, confirming the possible association between ulceration and viral infection.
JOURNAL OF PEDIATRICS
(2022)
Review
Pediatrics
Reza Sinaei, Sara Pezeshki, Saeedeh Parvaresh, Roya Sinaei
Summary: Research suggests that children are less frequently and severely affected by SARS-CoV-2 infection compared to adults, potentially due to factors such as a healthier respiratory system, less vigorous immune response, and other immune characteristics.
WORLD JOURNAL OF PEDIATRICS
(2021)
Article
Immunology
Cedric Annweiler, Guillaume Sacco, Nathalie Salles, Jean-Pierre Aquino, Jennifer Gautier, Gilles Berrut, Olivier Guerin, Gaetan Gavazzi
Summary: This national French survey aimed to determine the clinical features of COVID-19 in seniors, reporting that most patients exhibited few symptoms, such as thermal dysregulation and cough. Older patients aged 80 years and above were more likely to experience falls and weakness, while those with neurocognitive disorders may present with delirium and altered consciousness.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Nutrition & Dietetics
Pierre Menager, Olivier Briere, Jennifer Gautier, Jeremie Riou, Guillaume Sacco, Antoine Brangier, Cedric Annweiler
Summary: Regular use of VKA was associated with increased mortality at day 7 in hospitalized frail elderly patients with COVID-19.
Article
Nutrition & Dietetics
Spyridon N. Karras, Erdinc Dursun, Merve Alaylioglu, Duygu Gezen-Ak, Cedric Annweiler, Dimitrios Skoutas, Dimosthenis Evangelidis, Dimitrios Kiortsis
Summary: This study evaluated the impact of VDR gene polymorphisms and 25(OH)D levels on neonatal birth anthropometry, finding that maternal TAQI VDR gene polymorphism significantly affected birth outcomes when maternal 25(OH) concentrations were <50 nmol/L. Additionally, the study revealed that neonatal TAQI polymorphism had an effect when neonatal 25(OH)D levels were <25 nmol/L.
Letter
Geriatrics & Gerontology
Nathalie Barth, Pauline Gouttefarde, Ludovic Lafaie, Salome Vignon, Luc Goethals, Bienvenu Bongue, Thomas Celarier
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Geriatrics & Gerontology
Dolores Sanchez-Rodriguez, Guillaume Sacco, Jennifer Gautier, Olivier Briere, Cedric Annweiler
Summary: The study found no association between malnutrition assessed by GNRI and mortality in the first 3 months after COVID-19 diagnosis among oldest-old inpatients aged 80 years and older.
Article
Pharmacology & Pharmacy
M. Chappe, M. Corvaisier, A. Brangier, C. Annweiler, L. Spiesser-Robelet
Summary: During the COVID-19 pandemic, there was an increase in drug related problems and therapeutic advice in a geriatric acute care unit, particularly focused on medications for the management of COVID-19.
ANNALES PHARMACEUTIQUES FRANCAISES
(2022)
Review
Biochemistry & Molecular Biology
George El-Arif, Shaymaa Khazaal, Antonella Farhat, Julien Harb, Cedric Annweiler, Yingliang Wu, Zhijian Cao, Herve Kovacic, Ziad Abi Khattar, Ziad Fajloun, Jean-Marc Sabatier
Summary: The binding of SARS-CoV-2 to ACE2 causes dysregulation of the renin-angiotensin system, leading to various complications. Activation of the Ang II-AT1R axis causes inflammation and lung injury, while RAS blockers may be potential drugs for COVID-19 treatment.
Review
Rehabilitation
Etienne Ojardias, Edouard Ollier, Ludovic Lafaie, Thomas Celarier, Pascal Giraux, Laurent Bertoletti
Summary: A pharmacodynamic model-based meta-analysis revealed that injections of BoNT-A for post-stroke spasticity have maximal effect at 5 weeks for all BoNT-A preparations. The half-life of abobotulinumtoxinA is longer compared to other preparations.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Environmental Sciences
Romain David, Maxime Billot, Etienne Ojardias, Bernard Parratte, Manuel Roulaud, Amine Ounajim, Frederic Louis, Hachemi Meklat, Philippe Foucault, Christophe Lombard, Anne Jossart, Laura Mainini, Martin Lavalliere, Lisa Goudman, Maarten Moens, Davy Laroche, Marjorie Salga, Francois Genet, Jean-Christophe Daviet, Anaick Perrochon, Maxence Compagnat, Philippe Rigoard
Summary: Foot drop is a common disability in post-stroke patients. Ankle foot orthosis (AFO) combined with conventional rehabilitation is the gold standard of rehabilitation management. Functional electrical stimulation (FES) can be an alternative approach to improve walking capacity by stimulating the peroneal nerve pathway.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Cedric Annweiler, Melinda Beaudenon, Jennifer Gautier, Justine Gonsard, Sophie Boucher, Guillaume Chapelet, Astrid Darsonval, Bertrand Fougere, Olivier Guerin, Marjorie Houvet, Pierre Menager, Claire Roubaud-Baudron, Achille Tchalla, Jean-Claude Souberbielle, Jeremie Riou, Elsa Parot-Schinkel, Thomas Celarier
Summary: This study suggests that early administration of high-dose vitamin D3 via oral route can improve 14-day overall mortality in older patients at risk of COVID-19, but the effect is not sustained after 28 days.
Article
Health Care Sciences & Services
Frederic Noublanche, Romain Simon, Gregory Ben-Sadoun, Cedric Annweiler
Summary: This study aims to assess the feasibility of implementing a physical activity intervention, consisting of three types of exercises, in elderly patients hospitalized in a geriatric acute care unit. The study also aims to determine the difficulty of the exercises for patients with different fall risk levels, evaluate the healthcare team's perception of the intervention's feasibility, and examine the benefits for patients.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Environmental Sciences
Maxime Le Floch, Jennifer Gautier, Cedric Annweiler
Summary: This study found that hypovitaminosis D was commonly associated with individuals in the MCR stage who were without dementia. In addition to hypovitaminosis D, other factors such as body mass index, cognitive assessment scores, number of chronic diseases, and use of psychoactive drugs were also associated with MCR.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Guillaume T. Duval, Anne-Marie Schott, Dolores Sanchez-Rodriguez, Francois R. Herrmann, Cedric Annweiler
Summary: The study suggests that older women born in the summer to early fall months have higher muscle mass and strength.
Article
Multidisciplinary Sciences
Guillaume Duval, Anne-Marie Schott, Yves Rolland, Jennifer Gautier, Hubert Blain, Gustavo Duque, Cedric Annweiler
Summary: This study found that a decrease in systolic blood pressure while standing was associated with baseline cognitive impairment in older women, but orthostatic hypotension itself and a decrease in diastolic blood pressure while standing were not. Furthermore, none of these factors could predict incident cognitive decline after 7 years. This suggests that the relationship between orthostatic hypotension and cognitive impairment is more complex than previously thought.
Article
Nutrition & Dietetics
Dorien De Meester, Mathijs Goossens, Ester Marco, Marie Claessens, Jennifer Gautier, Cedric Annweiler, Siddhartha Lieten, Florence Benoit, Murielle Surquin, Dolores Sanchez-Rodriguez
Summary: The Geriatric Nutritional Risk Index (GNRI) on hospital admission was found to be associated with increased 14-day mortality risk in older inpatients with COVID-19. A GNRI score of <= 98 indicated a risk of malnutrition. However, no association was found between GNRI and 12-month mortality risk. Further studies are needed to validate the short-term predictive value of GNRI in this population.
CLINICAL NUTRITION ESPEN
(2023)
