Article
Multidisciplinary Sciences
Yang You, Meixiang Yin, Xiao Zheng, Qiuying Liang, Hui Zhang, Bu-Ling Wu, Wenan Xu
Summary: By analyzing samples from different ages and sexes of children, we found that Acinetobacter and Clostridiales were associated with caries in plaque and saliva, respectively. We also found the presence of Firmicutes and Clostridia in plaque from children of different ages. However, these bacterial markers varied greatly between different populations, with only Saccharibacteria being a consistent signal for childhood caries.
Article
Medicine, General & Internal
Padraig Dixon, William Hollingworth, Katie Pike, Rosy Reynolds, Margaret Stoddart, Alasdair MacGowan
Summary: This study assessed the cost-effectiveness of rapid microbial identification by MALDI-TOF mass spectrometry for bloodstream infections. The results indicate that adjunctive MALDI-TOF diagnosis may not be cost-effective when measured as cost per death avoided at 28 days.
Article
Immunology
Giulia Melo Lettieri, Luander Medrado Santiago, Giancarlo Crosara Lettieri, Luiz Gustavo dos Anjos Borges, Leticia Marconatto, Laudimar Alves de Oliveira, Naile Dame-Teixeira, Loise Pedrosa Salles
Summary: This study characterized the oral phenotype and salivary microbiome of three sisters with Papillon-Lefevre syndrome (PLS). The main phenotypic characteristics of PLS were bone loss and premature tooth loss. They all presented hyposalivation, but the salivary microbiota differed among the sisters.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Crystallography
Silvia Balhuc, Radu Campian, Anca Labunet, Marius Negucioiu, Smaranda Buduru, Andreea Kui
Summary: Hydroxyapatite nanoparticles have significant benefits in dentistry, including remineralizing effects on initial enamel lesions and improving existing dental materials. Further research is needed to confirm the advantages of using them in various dental interventions.
Article
Biochemical Research Methods
Luis Fernando B. Miranda, Carolina V. Lima, Rafaela Pagin, Raphael C. Costa, Marta Maria A. Pereira, Erica D. de Avila, Martinna Bertolini, Belen Retamal-Valdes, Jamil A. Shibli, Magda Feres, Valentim A. R. Barao, Joao Gabriel S. Souza
Summary: This study investigated the effect of different processing methods on the proteomic profile of saliva. The results showed that the processing methods had an impact on the protein composition of saliva, with differences in the types and quantities of proteins in the processed saliva. However, the different processing methods had minimal effect on microbial adhesion and cell viability.
JOURNAL OF PROTEOME RESEARCH
(2023)
Review
Dentistry, Oral Surgery & Medicine
Nagihan Bostanci, Georgios N. N. Belibasakis
Summary: The interface of molecular science and technology is guiding the transformation of personalized to precision healthcare. The application of proteomics, genomics, transcriptomics, and metabolomics is shaping the suitability of biomarkers for disease. Incorporation of molecular discoveries into routine clinical practice relies on the development of customized assays and devices that enable the rapid delivery of analytical data to the clinician, while the patient is still in session.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Purnima S. Kumar, Maria L. Geisinger, Gustavo Avila-Ortiz
Summary: Infection control measures are crucial in preventing disease spread in dental settings, especially in procedures involving aerosol generation. Various infection control methods can be implemented to reduce the risk of infection transmission in dental environments.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Medicine, General & Internal
Madline P. Gund, Jusef Naim, Matthias Hannig, Alexander Halfmann, Barbara Gaertner, Gabor Boros, Stefan Rupf
Summary: This study found that pre-procedural mouth rinsing with chlorhexidine during dental treatments can significantly reduce bacterial contamination on surgical masks. Rinsing with water also helps reduce bacteria. The use of a face shield as additional personal protective equipment can contribute to minimizing bacterial transmission.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Tsz Yuen Au, Chanika Assavarittirong
Summary: Antimicrobial resistance (AMR) poses a significant challenge in various fields. Bacteriophage therapy, which involves infecting bacteria with a virus, has shown promise in treating AMR. However, limited clinical trials have been conducted, and further research is needed to determine the efficacy and dosage of specific bacteriophage strains.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Review
Dentistry, Oral Surgery & Medicine
Sanket Nagarkar, Alessandro D. Loguercio, Jorge Perdigao
Summary: This paper aims to reduce uncertainty about the effectiveness of selective procedures in restorative dentistry by critically examining their necessity based on the best available evidence. The review of literature indicates that some common restorative procedures lack adequate support from high-quality research evidence.
CLINICAL ORAL INVESTIGATIONS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Catherine M. C. Volgenant, Ilona F. Persoon, Rolf A. G. de Ruijter, J. J. (Hans) de Soet
Summary: COVID-19 is an emerging infectious disease caused by the widespread transmission of the coronavirus SARS-CoV-2. The virus can be spread via aerosols in the oral cavity, posing risks in dental health care where additional infection control measures are strongly recommended. Care providers should carefully consider necessary infection control measures when attending to patients in both current and future situations.
Article
Dentistry, Oral Surgery & Medicine
A. Rafiee, R. Carvalho, D. Lunardon, C. Flores-Mir, P. Major, B. Quemerais, K. Altabtbaei
Summary: Many dental procedures generate aerosols that can put dental operators and patients at risk of infection. This study aims to characterize the particles emitted from different dental procedures and estimate the contribution of nasal and salivary fluids to the bioaerosol. The findings suggest that nasal and salivary fluids have a minor impact on the operator's bioaerosol exposure, which is important for controlling the spread of aerosols.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Microbiology
Marcia Dinis, Melissa Agnello, Lujia Cen, Bhumika Shokeen, Xuesong He, Wenyuan Shi, David T. W. Wong, Renate Lux, Nini Chaichanasakul Tran
Summary: Dental caries is the most common chronic disease in children, and the role of Streptococcus mutans in its development is still not fully understood. This study explored the correlation between S. mutans levels and other microorganisms in the saliva of caries-concordant and discordant populations. The results showed that the salivary microbial communities clustered based on S. mutans levels and were independent of caries experience. Disease-associated species were increased in populations with high S. mutans levels, while health-associated species were more abundant in populations with low S. mutans levels. The study highlights the importance of considering additional microbial markers in conjunction with S. mutans for the diagnosis and management of dental caries in the discordant population.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hsin-Chung Cheng, Yan-Ju Chang, Shin-Ru Liao, Pallop Siewchaisakul, Sam Li-Sheng Chen
Summary: This study found a significant impact of COVID-19 on the knowledge, attitude, and infection control behaviors among dentists, particularly in the use of hair caps, protective eye masks/face shields, and environmental disinfection protocols.
Review
Dentistry, Oral Surgery & Medicine
Antonio Silva, Maria Azevedo, Benedita Sampaio-Maia, Bernardo Sousa-Pinto
Summary: This systematic review assessed the efficacy of mouthrinses on reducing SARS-CoV-2 viral load, with povidone-iodine being identified as the best option in dental settings. Conflicting results were found for chlorhexidine gluconate and hydrogen peroxide in both in vitro and in vivo studies.
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2022)
Editorial Material
Dentistry, Oral Surgery & Medicine
Purnima Kumar, Maria Geisinger, Hillary R. DeLong, Ruth D. Lipman, Marcelo W. B. Araujo
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2020)
Article
Dentistry, Oral Surgery & Medicine
P. S. Kumar, M. F. Monteiro, S. M. Dabdoub, G. L. Miranda, M. Z. Casati, F. V. Ribeiro, F. R. Cirano, S. P. Pimentel, R. C. V. Casarin
JOURNAL OF DENTAL RESEARCH
(2020)
Article
Multidisciplinary Sciences
Sukirth M. Ganesan, Shareef M. Dabdoub, Haikady N. Nagaraja, Michelle L. Scott, Surya Pamulapati, Micah L. Berman, Peter G. Shields, Mary Ellen Wewers, Purnima S. Kumar
Article
Dentistry, Oral Surgery & Medicine
Purnima S. Kumar, Maria L. Geisinger, Gustavo Avila-Ortiz
Summary: Infection control measures are crucial in preventing disease spread in dental settings, especially in procedures involving aerosol generation. Various infection control methods can be implemented to reduce the risk of infection transmission in dental environments.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
A. P. Meethil, S. Saraswat, P. P. Chaudhary, S. M. Dabdoub, P. S. Kumar
Summary: The study tracked the origins of microbiota in aerosols generated during dental procedures and found that most of the microbiota came from the dental irrigant, while saliva contributed minimally. The results indicate that dental treatment does not increase the risk of SARS-CoV-2 transmission in asymptomatic patients when infection control measures are used.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Microbiology
Khaled Altabtbaei, Pooja Maney, Sukirth M. Ganesan, Shareef M. Dabdoub, Haikady N. Nagaraja, Purnima S. Kumar
Summary: The study identified dysbiotic signatures in aggressive periodontitis, with LAP showing more phenotype-specific indicators. Genetic capabilities and metabolic pathways play important roles in all three forms of periodontitis.
Article
Dentistry, Oral Surgery & Medicine
Purnima S. Kumar
JOURNAL OF PERIODONTOLOGY
(2021)
Letter
Dentistry, Oral Surgery & Medicine
A. Meethil, S. Saraswat, P. P. Chaudhary, S. Dabdoub, P. Kumar
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Helvis E. S. Paz, Mabelle F. Monteiro, Camila S. Stolf, Khaled Altabtbaei, Marcio Z. Casati, Renato C. Casarin, Purnima S. Kumar
Summary: This study evaluated the taxonomic and predicted functional content of the subgingival microbiome of young patients with Grade C periodontitis under supportive periodontal therapy. The results showed that despite clinical improvements, the microbiome of these patients remained different from individuals without a history of disease.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sukirth M. Ganesan, Shareef M. Dabdoub, Haikady N. Nagaraja, Angelo J. Mariotti, Christopher W. Ludden, Purnima S. Kumar
Summary: This study revealed that there is an active transcriptional activity of the peri-implant microbiome surrounding healthy implants. In disease conditions, an upregulation of microbial genes correlated with human genes, suggesting a potential role of commensals in maintaining epithelial integrity.
JOURNAL OF PERIODONTOLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Purnima S. Kumar
Article
Dentistry, Oral Surgery & Medicine
Aurelio Amorim Reis, Mabelle Freitas Monteiro, Gabriela Martin Bonilha, Luciana Saraiva, Cassia Araujo, Mauro Pedrine Santamaria, Marcio Zaffalon Casati, Purnima Kumar, Renato Correa Viana Casarin
Summary: The aim of this study was to evaluate microbial colonization in different dentition phases among individuals from 0 to 18 years old with a family history of periodontitis compared to descendants of periodontally healthy parents. The results showed that the parents' periodontal status significantly affected the microbiome composition of their offspring, and descendants with a family history of periodontitis exhibited different microbial diversity and a higher prevalence of periodontitis-associated species in the mixed and permanent dentition phases.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Khaled Sinjab, Shriya Sawant, Alice Ou, J. Christopher Fenno, Hom-Lay Wang, Purnima Kumar
Summary: This study aimed to investigate the impact of implant surface modifications on the peri-implant microbiome. The results showed that surface modifications did not significantly affect the microbiome of healthy implants, but had a significant impact on peri-implantitis (PI) implants. Furthermore, different surface modifications led to changes in the composition of bacterial species in healthy and PI implants.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Tamires Pereira Dutra, Mabelle Freitas Monteiro, Isabela Lima Franca-Grohmann, Renato Correa Viana Casarin, Marcio Zaffalon Casati, Karina Gonzalez Silverio Ruiz, Purnima S. Kumar, Enilson Antonio Sallum
Summary: This study compared individuals with a history of periodontitis to periodontally healthy subjects in terms of immunological and microbiological changes during experimental peri-implant mucositis and gingivitis. The results showed that different microbial shifts contribute to the onset and progression of inflammatory responses around teeth and implants, while the history of periodontal disease plays a role in modulating the immune response.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)