Review
Cell Biology
Mohamed Ali, Michal Ciebiera, Somayeh Vafaei, Samar Alkhrait, Hsin-Yuan Chen, Yi-Fen Chiang, Ko-Chieh Huang, Stepan Feduniw, Shih-Min Hsia, Ayman Al-Hendy
Summary: Uterine fibroids are a significant benign neoplastic threat to women's health globally, affecting up to 80% of premenopausal women and causing symptoms such as heavy menstrual bleeding, pain, and infertility. Progesterone signaling is crucial for the development and growth of uterine fibroids, promoting cell proliferation through genetic and epigenetic pathways. This review discusses the role of progesterone signaling in uterine fibroid pathogenesis and explores the therapeutic potential of compounds that modulate progesterone signaling, including selective progesterone receptor modulator drugs and natural compounds. Further research is needed to ensure safety and understand the exact molecular mechanisms of selective progesterone receptor modulator drugs, while clinical trials are necessary to confirm the effectiveness of natural compounds as a potential long-term treatment option, particularly for women planning pregnancy.
Review
Medicine, General & Internal
Aleksandra O. Tsolova, Rocio Martinez Aguilar, Jacqueline A. Maybin, Hilary O. D. Critchley
Summary: Abnormal uterine bleeding (AUB) is a common and debilitating condition that significantly impacts the quality of life for women of reproductive age. The lack of reliable pre-clinical models hinders progress in understanding the pathophysiology of AUB and discovering effective therapies.
Article
Obstetrics & Gynecology
Ayman Al-Hendy, Linda Bradley, Charlotte D. Owens, Hui Wang, Kurt T. Barnhart, Eve Feinberg, William D. Schlaff, Elizabeth E. Puscheck, Alice Wang, Veronica Gillispie, Sandra Hurtado, Ozgul Muneyyirci-Delale, David F. Archer, Bruce R. Carr, James A. Simon, Elizabeth A. Stewart
Summary: The study evaluated the safety and efficacy of elagolix with add-back therapy in reducing heavy menstrual bleeding associated with uterine fibroids in different subgroups of women. Results showed that elagolix was significantly more effective than placebo in all subgroups.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Nutrition & Dietetics
Andrea C. Salcedo, Jane Yun, Cody Carter, Elaine Hart
Summary: Therapeutic carbohydrate restriction diets can lead to weight loss and improve metabolic disorders, potentially preventing and treating gynecologic disorders.
Article
Medicine, General & Internal
Pamela Warner, Lucy Harriet Ravenscroft Whitaker, Richard Anthony Parker, Christopher John Weir, Anne Douglas, Christian Holm Hansen, Mayank Madhra, Stephen Gilbert Hillier, Philippa Tansy Kemp Saunders, John Peter Iredale, Scott Semple, Ov Daniel Slayden, Brian Robert Walker, Hilary Octavia Dawn Critchley
Summary: This adaptive trial on HMB showed that daily dexamethasone 1.8 mg reduced menstrual blood loss, indicating that the role of dexamethasone in HMB management warrants further investigation.
Article
Biochemistry & Molecular Biology
F. Saritha, N. Aiswarya, R. Aswath Kumar, K. V. Dileep
Summary: Uterine fibroids are benign smooth muscle tumors that significantly impact women's quality of life. Traditional treatments have high recurrence rates and selective progesterone receptor modulators have been withdrawn due to side effects. Therefore, there is a need for novel, highly efficient, and low side effect therapeutics for the treatment of uterine fibroids.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Medicine, General & Internal
Tanvi T. Bhardwaj, K. M. Hiwale, Sunita Vagha
Summary: Abnormal uterine bleeding (AUB) is a common menstrual condition that negatively affects a female's well-being. It is caused by factors such as chronic endometritis, endometrial erosions, and hormonal imbalance.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Obstetrics & Gynecology
Kapil Wattamwar, Moona Arabkhazaeli, JaHyun Shin, Ricki Korff, Jacob Cynamon, Yosef Golowa
Summary: This study demonstrates the effectiveness of uterine artery embolization (UAE) in treating anticoagulant-associated abnormal uterine bleeding (AUB-I). UAE can reduce bleeding while allowing for the continuation of anticoagulation therapy, with high rates of uterine preservation and preserved menses.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2022)
Article
Chemistry, Medicinal
Antonia Navarro, Maria Victoria Bariani, Hang-Soo Park, Ami R. Zota, Ayman Al-Hendy
Summary: Uterine leiomyomas are common pelvic tumors in women of reproductive age and their pathophysiology is not well understood. This study found that exosomes derived from uterine leiomyoma tumor cells can promote proliferation and angiogenesis of endometrial microvascular endothelial cells. These findings may contribute to the identification of novel biomarkers for the treatment of uterine leiomyomas.
Article
Obstetrics & Gynecology
Christina N. Cordeiro Mitchell, Soriful Islam, Sadia Afrin, Joshua Brennan, Kevin J. Psoter, James H. Segars
Summary: The study found that fibroid cells cultured on mechanically stiff substrates had enhanced progesterone receptor B activation compared to cells cultured on soft plates, and the activation was regulated through various signaling pathways. Overexpression of Rho-guanine nucleotide exchange factor AKAP13 significantly increased PRB-dependent reporter activity. These findings provide insights into the mechanisms by which mechanical substrate stiffness influences progesterone receptor activation.
FERTILITY AND STERILITY
(2021)
Review
Public, Environmental & Occupational Health
Juliawati Muhammad, Yusnita Yusof, Imran Ahmad, Mohd Noor Norhayati
Summary: This systematic review and meta-analysis found that elagolix is effective in reducing heavy menstrual bleeding caused by uterine fibroid. Combination with estradiol/norethindrone acetate can alleviate the side effects of hypoestrogenism. However, elagolix treatment may lead to hot flush and bone mineral density loss.
Review
Public, Environmental & Occupational Health
Outi Uimari, Kavita S. Subramaniam, Beverley Vollenhoven, Thomas T. Tapmeier
Summary: Uterine fibroids, a common condition in women, can cause heavy menstrual bleeding and other discomfort symptoms. The current treatment options are limited, often involving hysterectomy. Research has found that genetic mutations and abnormal expression of angiogenic factors are related to the growth of fibroids.
FRONTIERS IN REPRODUCTIVE HEALTH
(2022)
Article
Obstetrics & Gynecology
Ally Murji, Ari P. Sanders, Ilza Monteiro, Shabbir Haiderbhai, John Matelski, Chris Walsh, Jason A. Abbott, Malcolm G. Munro, Sarah Maheux-Lacroix
Summary: The study found a strong association between cesarean scar defects (CSDs) and abnormal uterine bleeding (AUB). Patients with CSD were more likely to experience AUB and presented a unique bleeding pattern, including prolonged menstruation and early-cycle intermenstrual bleeding.
FERTILITY AND STERILITY
(2022)
Review
Obstetrics & Gynecology
Janique R. J. Dreessen, Julia F. F. van Der Meulen, Marlies Y. Y. Bongers, Ben W. J. Mol, Josje Langenveld
Summary: This study reviewed the research trends on hysteroscopic myomectomy from 2002 to 2019 and assessed the usefulness of these studies. Despite the amount of research, questions about the optimal treatment of heavy menstrual bleeding remain.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Public, Environmental & Occupational Health
Laura McKain, Kaitlyn Edsall, Robert Dufour, Cassandra Lickert
Summary: This study analyzed the clinical characteristics and treatment patterns of women with uterine fibroids in the United States, finding that patients with heavy menstrual bleeding were more likely to receive treatment and pain was a common symptom.
JOURNAL OF WOMENS HEALTH
(2023)
