Article
Multidisciplinary Sciences
Manfred Nairz, Sabina Sahanic, Alex Pizzini, Anna Boehm, Piotr Tymoszuk, Anna-Maria Mitterstiller, Laura von Raffay, Philipp Grubwieser, Rosa Bellmann-Weiler, Sabine Koppelstatter, Andrea Schroll, David Haschka, Martina Zimmermann, Silvia Blunder, Kristina Trattnig, Helene Naschberger, Werner Klotz, Igor Theurl, Verena Petzer, Clemens Gehrer, John E. Mindur, Anna Luger, Christoph Schwabl, Gerlig Widmann, Guenter Weiss, Judith Loeffler-Ragg, Ivan Tancevski, Thomas Sonnweber
Summary: The CovILD study systematically followed up COVID-19 patients and found that S-specific IgG levels are correlated with immune activation, pulmonary function, and CT abnormalities. An S-specific IgG-based recovery score accurately predicted delayed pulmonary recovery after COVID-19. Therefore, S-specific IgG levels can serve as a useful immunological surrogate marker.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Rosanna W. Peeling, David L. Heymann, Yik-Ying Teo, Patricia J. Garcia
Summary: Diagnostics play a crucial role in the response to the COVID-19 pandemic. Molecular tests like PCR are recommended for confirming diagnosis in symptomatic individuals, while antigen rapid detection tests have the advantage of being easier to perform with faster results and lower cost. Antibody tests can inform public policy but should not be used as proof of immunity. All three types of tests continue to be important in transitioning from pandemic response to control.
Article
Immunology
Jiaqi Zhang, Shan Xing, Dan Liang, Wei Hu, Changwen Ke, Jinyong He, Runyu Yuan, Yile Huang, Yizhe Li, Dongdong Liu, Xuedong Zhang, Lin Li, Jianhua Lin, Weili Li, Xiangyun Teng, Yijun Liu, Wei Wen, Qiang Kang, Dawei Wang, Wanli Liu, Jianhua Xu
Summary: A study showed that 90.7% of vaccinated individuals had NAb seroconversion, with all participants who seroconverted after the first dose being females with relatively high prevaccine estradiol levels. Individuals without seroconversion tended to have lower lymphocyte counts and higher serum SAA levels. Additionally, young vaccine recipients had significantly higher peak NAb titers compared to elderly recipients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Editorial Material
Medicine, General & Internal
J-S Yen, I-K Wang, T-H Yen
Summary: Uremia affects all parts of the immune system, making dialysis patients more susceptible to COVID-19 infection. Different factors such as vaccine types, doses and individual characteristics can lead to varying response rates in dialysis patients. Vaccination against COVID-19 in this population is crucial for global public health.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Zhi-Bo Deng, Feng Cheng, Yong Zhang
Summary: This study analyzed the dynamic trend of specific antibodies in the serum of patients recovering from COVID-19 and assessed the protective effect of vaccination. The results showed that specific antibodies persisted for at least 1 year in recovered patients and vaccination increased the levels of neutralizing antibodies, indicating a lower risk of reinfection for these individuals.
EPIDEMIOLOGY AND INFECTION
(2022)
Article
Immunology
Wenye Xu, Yingzhi Liu, Xuan Zou, Huanle Luo, Weihua Wu, Junjie Xia, Matthew T. V. Chan, Shisong Fang, Yuelong Shu, William K. K. Wu, Lin Zhang
Summary: This study evaluated the serum zinc ion level in COVID-19 patients and found that it was significantly lower than that in healthy subjects. Furthermore, COVID-19 patients with severe hypozincemia showed higher levels of antibodies against the receptor-binding domain of SARS-CoV-2 spike protein.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuanling Yu, Meiyu Wang, Xiaoai Zhang, Shufen Li, Qingbin Lu, Haolong Zeng, Hongyan Hou, Hao Li, Mengyi Zhang, Fei Jiang, Jiajing Wu, Ruxia Ding, Zehua Zhou, Min Liu, Weixue Si, Tao Zhu, Hangwen Li, Jie Ma, Yuanyuan Gu, Guangbiao She, Xiaokun Li, Yulan Zhang, Ke Peng, Weijin Huang, Wei Liu, Youchun Wang
Summary: ADCC responses are antibody-regulated immune responses mediated through the Fc fragment, and it is unclear if they contribute to COVID-19 disease development. Interestingly, patients with severe COVID-19 had higher ADCC activities, with recovered patients showing higher levels than deceased patients. This highlights ADCC as a major trait of COVID-19 patients with potential implications for neutralization levels against the virus.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Cell Biology
Michelle K. Ash, Pavan P. Bhimalli, Byoung-Kyu Cho, Basil Baby Mattamana, Stephanie Gambut, Imad Tarhoni, Cristina L. Fhied, Anjelica F. Reyes, Samantha J. Welninski, Jaison Arivalagan, Fernanda Negrao, Renu Goel, Todd L. Beck, Thomas J. Hope, Beverly E. Sha, Young Ah Goo, Lena Al-Harthi, Joao I. Mamede, Jeffrey A. Borgia, Neil L. Kelleher, Jeffrey R. Schneider
Summary: This study investigated the impact of SARS-CoV-2 infection and vaccination on the immune response by measuring changes in IgG glycosylation. The results showed that hospitalized COVID-19 patients had elevated levels of inflammatory glycans, while mild patients had increased levels of anti-inflammatory glycans. Vaccinated individuals with low RBD antibody levels and low neutralization showed similar IgG glycan traits as hospitalized COVID-19 patients.
Article
Medicine, General & Internal
Einav G. Levin, Yaniv Lustig, Carmit Cohen, Ronen Fluss, Victoria Indenbaum, Sharon Amit, Ram Doolman, Keren Asraf, Ella Mendelson, Arnona Ziv, Carmit Rubin, Laurence Freedman, Yitshak Kreiss, Gili Regev-Yochay
Summary: A study in Israel revealed that waning immunity after receiving two doses of the BNT162b2 vaccine led to an increase in the incidence of SARS-CoV-2 infection. Levels of spike-binding IgG and neutralizing antibodies decreased more significantly in men, individuals aged 65 or older, and immunosuppressed individuals in a longitudinal study involving nearly 4000 healthcare workers.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Immunology
Xiaodong Tian, Ling Liu, Wenguo Jiang, He Zhang, Wenjun Liu, Jing Li
Summary: This study examined the antibody responses of 484 recovered patients to SARS-CoV-2, revealing that the majority of patients maintained antibodies against the virus post-recovery, with neutralization activities significantly correlated with antibody responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Biochemical Research Methods
Matthew C. Woodruff, Doan C. Nguyen, Caterina E. Faliti, Ankur Singh Saini, F. Eun-Hyung Lee, Ignacio Sanz
Summary: This article discusses the critical technological advances in rapidly investigating the immune responses triggered by the SARS-CoV-2 virus, which is responsible for the COVID-19 pandemic. It focuses on state-of-the-art methods used to analyze B-cell responses against the virus and their impact on the ongoing public health crisis.
Article
Immunology
Arianna Pani, Alessandra Romandini, Alice Schianchi, Michele Senatore, Oscar M. Gagliardi, Gianluca Gazzaniga, Stefano Agliardi, Tommaso Conti, Paolo A. Schenardi, Matteo Maggi, Stefano D'Onghia, Valentina Panetta, Silvia Renica, Silvia Nerini Molteni, Chiara Vismara, Daniela Campisi, Michaela Bertuzzi, Simona Giroldi, Laura Zoppini, Mauro Moreno, Marco Merli, Marco Bosio, Massimo Puoti, Francesco Scaglione
Summary: This study evaluated the increase in antibody titers 14 days after the booster dose of BNT162b2. The results showed a potent universal antibody response regardless of pre-booster vaccine seronegativity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Suzan Farhang-Sardroodi, Chapin S. Korosec, Samaneh Gholami, Morgan Craig, Iain R. Moyles, Mohammad Sajjad Ghaemi, Hsu Kiang Ooi, Jane M. Heffernan
Summary: During the global pandemic, vaccine distribution has been affected by supply chain logistics, leading to the need for adjusting dose administration strategies. Studies show that modifying dose intervals and amounts can help mitigate supply constraints and improve immunological outcomes.
Editorial Material
Hematology
Lee M. Greenberger, Gwen L. Nichols
Summary: In this issue of Blood, Mittelman et al(1) and Pagano et al(2) demonstrate that patients with hematologic malignancies who have been fully or partially vaccinated are at a higher risk of poor clinical outcomes after COVID-19 infection compared to matched controls or the general population.
Article
Economics
Przemyslaw Borkowski, Magdalena Jazdzewska-Gutta, Agnieszka Szmelter-Jarosz
Summary: The study observes significant decreases in travel times under epidemic conditions, which are similar regardless of age group and gender. The reduction in time depends on factors such as travel purposes, means of transport, household size, fear of coronavirus, main occupation, and changes caused by the epidemic. Respondents who were more afraid of coronavirus tended to shorten their travel times more.
JOURNAL OF TRANSPORT GEOGRAPHY
(2021)