Role of Aging and the Immune Response to Respiratory Viral Infections: Potential Implications for COVID-19

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

COVID-19 and the cardiovascular system

(2020) Ying-Ying Zheng et al.   Nature Reviews Cardiology

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

COVID-19 and its implications for thrombosis and anticoagulation

(2020) Jean Marie Connors et al.   BLOOD

Pathogenesis of SARS-CoV-2 in transgenic mice expressing human angiotensin-converting enzyme 2

(2020) Ren-Di Jiang et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

(2020) Shi-Hui Sun et al.   Cell Host & Microbe

Coronaviruses and the cardiovascular system: acute and long-term implications

(2020) Tian-Yuan Xiong et al.   EUROPEAN HEART JOURNAL

Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis

(2020) Jing Yang et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic

(2020) Elissa Driggin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly

(2020) Roel P. H. De Maeyer et al.   NATURE IMMUNOLOGY

Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19

(2020) Irani Thevarajan et al.   NATURE MEDICINE

Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19

(2020) Mandeep R. Mehra et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China

(2020) Shaobo Shi et al.   JAMA Cardiology

COVID-19 Illness and Heart Failure

(2020) Mandeep R. Mehra et al.   JACC-Heart Failure

Neutrophil extracellular traps in COVID-19

(2020) Yu Zuo et al.   JCI Insight

Influenza virus inoculum volume is critical to elucidate age-dependent mortality in mice

(2019) Candice A. Smith et al.   AGING CELL

Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality

(2019) Upasana Kulkarni et al.   Mucosal Immunology

Effect of vaccination, comorbidities and age on mortality and severe disease associated with influenza during the season 2016–2017 in a Spanish tertiary hospital

(2019) Enrique Gutiérrez-González et al.   Journal of Infection and Public Health

Inflammaging: Age and Systemic, Cellular, and Nuclear Inflammatory Biology in Older Adults

(2019) Dominique Piber et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Infection, Immunological Response, and Vaccine Development

(2019) Ayman Mubarak et al.   Journal of Immunology Research

Human Coronavirus: Host-Pathogen Interaction

(2019) To Sing Fung et al.   Annual Review of Microbiology

Neutrophils-related host factors associated with severe disease and fatality in patients with influenza infection

(2019) Benjamin M. Tang et al.   Nature Communications

Diminished antibody response to influenza vaccination is characterized by expansion of an age-associated B-cell population with low PAX5

(2018) Allison J. Nipper et al.   CLINICAL IMMUNOLOGY

Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza

(2018) Jake Dunning et al.   NATURE IMMUNOLOGY

Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection

(2018) Jeffrey C. Kwong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Decline in Primary CD8 + T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8 + T Cells

(2018) Kylie M. Quinn et al.   Cell Reports

Origin and evolution of pathogenic coronaviruses

(2018) Jie Cui et al.   NATURE REVIEWS MICROBIOLOGY

Transcriptomics in lung tissue upon respiratory syncytial virus infection reveals aging as important modulator of immune activation and matrix maintenance

(2018) Jeroen L. A. Pennings et al.   Scientific Reports

The Isoform Selective Roles of PI3Ks in Dendritic Cell Biology and Function

(2018) Ezra Aksoy et al.   Frontiers in Immunology

Aging and the immune response to organ transplantation

(2017) Monica M. Colvin et al.   JOURNAL OF CLINICAL INVESTIGATION

Respiratory syncytial virus hospitalization in middle-aged and older adults

(2017) Ryan E. Malosh et al.   JOURNAL OF CLINICAL VIROLOGY

Aging Impairs Alveolar Macrophage Phagocytosis and Increases Influenza-Induced Mortality in Mice

(2017) Christine K. Wong et al.   JOURNAL OF IMMUNOLOGY

Aging augments the impact of influenza respiratory tract infection on mobility impairments, muscle-localized inflammation, and muscle atrophy

(2016) Jenna M. Bartley et al.   Aging-US

Acute myocarditis associated with novel Middle East respiratory syndrome coronavirus

(2016) Tariq Alhogbani   ANNALS OF SAUDI MEDICINE

Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease

(2016) P. S. Pillai et al.   SCIENCE

The generation of memory B cells is maintained, but the antibody response is not, in the elderly after repeated influenza immunizations

(2016) Daniela Frasca et al.   VACCINE

T-Cell Immunity to Influenza in Older Adults: A Pathophysiological Framework for Development of More Effective Vaccines

(2016) Janet E. McElhaney et al.   Frontiers in Immunology

Age-related impairment of humoral response to influenza is associated with changes in antigen specific T follicular helper cell responses

(2016) Julie S Lefebvre et al.   Scientific Reports

Critical role of phospholipase A2group IID in age-related susceptibility to severe acute respiratory syndrome–CoV infection

(2015) Rahul Vijay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Paradoxical changes in innate immunity in aging: recent progress and new directions

(2015) Ruth R. Montgomery et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8+ T cells

(2015) Zhongfang Wang et al.   Nature Communications

Host Immunological Factors Enhancing Mortality of Young Adults during the 1918 Influenza Pandemic

(2015) Julie L. McAuley et al.   Frontiers in Immunology

Aging Impairs the Ability of Conventional Dendritic Cells to Cross-Prime CD8+ T Cells upon Stimulation with a TLR7 Ligand

(2015) Estefanía R. Zacca et al.   PLoS One

B cell function and influenza vaccine responses in healthy aging and disease

(2014) Daniela Frasca et al.   CURRENT OPINION IN IMMUNOLOGY

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

(2014) Sian M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

Lymphopenia Associated with Highly Virulent H5N1 Virus Infection Due to Plasmacytoid Dendritic Cell-Mediated Apoptosis of T Cells

(2014) K. Boonnak et al.   JOURNAL OF IMMUNOLOGY

Aging Delays Resolution of Acute Inflammation in Mice: Reprogramming the Host Response with Novel Nano-Proresolving Medicines

(2014) Hildur H. Arnardottir et al.   JOURNAL OF IMMUNOLOGY

Effects of Aging on Influenza Virus Infection Dynamics

(2014) E. A. Hernandez-Vargas et al.   JOURNAL OF VIROLOGY

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

(2014) Alessio Lanna et al.   NATURE IMMUNOLOGY

Immune Biomarkers Predictive of Respiratory Viral Infection in Elderly Nursing Home Residents

(2014) Jennie Johnstone et al.   PLoS One

Severe acute respiratory syndrome-coronavirus infection in aged nonhuman primates is associated with modulated pulmonary and systemic immune responses

(2014) Candice C Clay et al.   Immunity & Ageing

Myocardial dysfunction during H1N1 influenza infection

(2013) David Fagnoul et al.   JOURNAL OF CRITICAL CARE

Highly Pathological Influenza A Virus Infection Is Associated with Augmented Expression of PD-1 by Functionally Compromised Virus-Specific CD8+ T Cells

(2013) J. A. Rutigliano et al.   JOURNAL OF VIROLOGY

Novel Inflammatory Markers, Clinical Risk Factors and Virus Type Associated With Severe Respiratory Syncytial Virus Infection

(2013) Christy M. Tabarani et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Adults 65 Years Old and Older Have Reduced Numbers of Functional Memory T Cells to Respiratory Syncytial Virus Fusion Protein

(2012) Anu Cherukuri et al.   Clinical and Vaccine Immunology

Impaired NLRP3 Inflammasome Function in Elderly Mice during Influenza Infection Is Rescued by Treatment with Nigericin

(2012) H. W. Stout-Delgado et al.   JOURNAL OF IMMUNOLOGY

Increased Viral Loads and Exacerbated Innate Host Responses in Aged Macaques Infected with the 2009 Pandemic H1N1 Influenza A Virus

(2012) L. Josset et al.   JOURNAL OF VIROLOGY

SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon

(2012) Allison L Totura et al.   Current Opinion in Virology

Early Priming Minimizes the Age-Related Immune Compromise of CD8+ T Cell Diversity and Function

(2012) Sophie A. Valkenburg et al.   PLoS Pathogens

Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice

(2011) Jincun Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Decreased Innate Immune Cytokine Responses Correlate With Disease Severity in Children With Respiratory Syncytial Virus and Human Rhinovirus Bronchiolitis

(2011) Carla García et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Efficacy of a vaccine that links viral epitopes to flagellin in protecting aged mice from influenza viral infection

(2011) Jin Leng et al.   VACCINE

Ageing is associated with diminished apoptotic cell clearance in vivo

(2010) T. Aprahamian et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Aging of the innate immune system

(2010) Albert C Shaw et al.   CURRENT OPINION IN IMMUNOLOGY

Cell-Intrinsic Defects in the Proliferative Response of Antiviral Memory CD8 T Cells in Aged Mice upon Secondary Infection

(2010) V. Decman et al.   JOURNAL OF IMMUNOLOGY

Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human Primates

(2010) Saskia L. Smits et al.   PLoS Pathogens

Aging Enhances Susceptibility to Cigarette Smoke–Induced Inflammation through Bronchiolar Chemokines

(2009) Chinatsu Moriyama et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cellular Immune Responses to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection in Senescent BALB/c Mice: CD4+ T Cells Are Important in Control of SARS-CoV Infection

(2009) J. Chen et al.   JOURNAL OF VIROLOGY

Limited expansion of virus-specific CD8 T cells in the aged environment

(2009) Jiu Jiang et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Impaired Immune Response in Severe Human Lower Tract Respiratory Infection by Respiratory Syncytial Virus

(2009) Carmen L. Larrañaga et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

The SARS outbreak in a general hospital in Tianjin, China: clinical aspects and risk factors for disease outcome

(2009) Mao-Ti Wei et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells

(2008) R. H. Cho et al.   BLOOD

Characteristic features and outcomes of severe acute respiratory syndrome found in severe acute respiratory syndrome intensive care unit patients

(2008) Te-Cheng Lien et al.   JOURNAL OF CRITICAL CARE

Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus

(2008) Eric J. Yager et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Long-Term Care Facilities: A Cornucopia of Viral Pathogens

(2008) Ann R. Falsey et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Genomic Analysis Reveals Age-Dependent Innate Immune Responses to Severe Acute Respiratory Syndrome Coronavirus

(2008) T. Baas et al.   JOURNAL OF VIROLOGY