Integration of Sugar Metabolism and Proteoglycan Synthesis by UDP-glucose Dehydrogenase

Sirtuin 1 reduces hyaluronan synthase 2 expression by inhibiting nuclear translocation of NF-kB and expression of the long-non coding RNA HAS2-AS1

(2020) Ilaria Caon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy

(2020) Holger Hengel et al.   Nature Communications

A Missense Mutation in the UGDH Gene Is Associated With Developmental Delay and Axial Hypotonia

(2020) Kheloud M. Alhamoudi et al.   Frontiers in Pediatrics

SLC35B1 significantly contributes to the uptake of UDPGA into the endoplasmic reticulum for glucuronidation catalyzed by UDP-glucuronosyltransferases

(2020) Kyoko Ondo et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of glycosphingolipid biosynthesis reverts multidrug resistance by differentially modulating ABC transporters in chronic myeloid leukemias

(2020) Eduardo J. Salustiano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycogen metabolism regulates macrophage-mediated acute inflammatory responses

(2020) Jingwei Ma et al.   Nature Communications

UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells

(2020) Nina Schömel et al.   Scientific Reports

Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice

(2020) Maria Agustina Battistone et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinicopathological and prognostic significance of nuclear UGDH localization in lung adenocarcinoma

(2019) Daisuke HAGIUDA et al.   BIOMEDICAL RESEARCH-TOKYO

Catalytic mechanism of UDP-glucose dehydrogenase

(2019) Jun Chen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis

(2019) Xiongjun Wang et al.   NATURE

A hypomorphic allele of SLC35D1 results in Schneckenbecken-like dysplasia

(2019) Carsten Rautengarten et al.   HUMAN MOLECULAR GENETICS

Conservation of Atypical Allostery in C. elegans UDP-Glucose Dehydrogenase

(2019) Nathaniel R. Beattie et al.   ACS Omega

Targeting UDP-α-d-glucose 6-dehydrogenase inhibits glioblastoma growth and migration

(2018) Olutobi Oyinlade et al.   ONCOGENE

The entropic force generated by intrinsically disordered segments tunes protein function

(2018) Nicholas D. Keul et al.   NATURE

Inhibiting Hexamer Disassembly of Human UDP-Glucose Dehydrogenase by Photoactivated Amino Acid Cross-Linking

(2016) George Grady et al.   BIOCHEMISTRY

UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression

(2016) Ashik Jawahar Deen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Loss of exogenous androgen dependence by prostate tumor cells is associated with elevated glucuronidation potential

(2016) Brenna M . Zimmer et al.   Hormones & Cancer

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

Hysteresis in Human UDP-Glucose Dehydrogenase Is Due to a Restrained Hexameric Structure That Favors Feedback Inhibition

(2014) Renuka Kadirvelraj et al.   BIOCHEMISTRY

Analysis of maternal-zygotic ugdh mutants reveals divergent roles for HSPGs in vertebrate embryogenesis and provides new insight into the initiation of left–right asymmetry

(2014) Simone Superina et al.   DEVELOPMENTAL BIOLOGY

UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis

(2014) Yinxian Wen et al.   ARTHRITIS RESEARCH & THERAPY

Hysteresis and Negative Cooperativity in Human UDP-Glucose Dehydrogenase

(2013) Renuka Kadirvelraj et al.   BIOCHEMISTRY

UDP-glucose Dehydrogenase Activity and Optimal Downstream Cellular Function Require Dynamic Reorganization at the Dimer-Dimer Subunit Interfaces

(2013) Annastasia S. Hyde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UDP-N-acetylglucosamine Transporter (SLC35A3) Regulates Biosynthesis of Highly BranchedN-Glycans and Keratan Sulfate

(2013) Dorota Maszczak-Seneczko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective induction of P2Y14 receptor by RANKL promotes osteoclast formation

(2013) Seung Ah Lee et al.   MOLECULES AND CELLS

Krüppel-Like Factor 2 Is Required for Normal Mouse Cardiac Development

(2013) Aditi R. Chiplunkar et al.   PLoS One

Cofactor Binding Triggers a Molecular Switch To Allosterically Activate Human UDP-α-d-glucose 6-Dehydrogenase

(2012) Nicholas C. Sennett et al.   BIOCHEMISTRY

Developmental diseases caused by impaired nucleotide sugar transporters

(2012) Li Liu et al.   GLYCOCONJUGATE JOURNAL

UDP-glucose Dehydrogenase Polymorphisms from Patients with Congenital Heart Valve Defects Disrupt Enzyme Stability and Quaternary Assembly

(2012) Annastasia S. Hyde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Flexibility in the Allosteric Regulation of Human UDP-α-d-Glucose 6-Dehydrogenase

(2011) Nicholas C. Sennett et al.   BIOCHEMISTRY

Role of Packing Defects in the Evolution of Allostery and Induced Fit in Human UDP-Glucose Dehydrogenase

(2011) Renuka Kadirvelraj et al.   BIOCHEMISTRY

Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates

(2011) Sigrid Egger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Divergent Sp1 Protein Levels May Underlie Differential Expression of UDP-Glucose Dehydrogenase by Fibroblasts

(2011) Shanli Tsui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Mechanism of Human UDP-glucose 6-Dehydrogenase

(2011) Sigrid Egger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulation of UDP-glucuronic Acid Biosynthesis Leads to Swollen Plant Cell Walls and Severe Developmental Defects Associated with Changes in Pectic Polysaccharides

(2011) Rebecca Reboul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UDP-glucose dehydrogenase: structure and function of a potential drug target

(2010) Sigrid Egger et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

UDP xylose synthase 1 is required for morphogenesis and histogenesis of the craniofacial skeleton

(2010) B. Frank Eames et al.   DEVELOPMENTAL BIOLOGY

Regulation of UDP-glucose dehydrogenase is sufficient to modulate hyaluronan production and release, control sulfated GAG synthesis, and promote chondrogenesis

(2010) Claire E. Clarkin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Androgen-Stimulated UDP-Glucose Dehydrogenase Expression Limits Prostate Androgen Availability without Impacting Hyaluronan Levels

(2009) Q. Wei et al.   CANCER RESEARCH

Udp-glucose dehydrogenase as a novel field-specific candidate biomarker of prostate cancer

(2009) Dali Huang et al.   INTERNATIONAL JOURNAL OF CANCER

Functional UDP-xylose Transport across the Endoplasmic Reticulum/Golgi Membrane in a Chinese Hamster Ovary Cell Mutant Defective in UDP-xylose Synthase

(2008) Hans Bakker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY