Article
Biotechnology & Applied Microbiology
Luchan Gong, Tingting Li, Shuyi Lv, Xiaozhou Zou, Jun Wang, Bowen Wang
Summary: In this study, a novel GABA-producing strain, Lactobacillus hilgardii GZ2, was investigated. Silkworm pupae were used as a nitrogen source in the fermentation process, resulting in a high GABA titer and productivity.
FERMENTATION-BASEL
(2023)
Article
Food Science & Technology
Yue Zhang, Mengjiao Zhu, Wenjing Lu, Cen Zhang, Di Chen, Nagendra P. Shah, Chaogeng Xiao
Summary: Using soybean sprouts as a fermentation substrate enhances the ability of Levilactobacillus brevis NPS-QW 145 strain to produce gamma-aminobutyric acid (GABA), a non-protein amino acid with various physiological functions. The study achieved a GABA yield of up to 2.302 g L-1 by fermenting monosodium glutamate (MSG) with L. brevis NPS-QW 145 for 48 hours using 10 g L-1 glucose, with a soybean germination time of one day. This research provides a powerful technique for GABA production in foods and its use as a nutritional supplement for consumers.
Article
Neurosciences
Anouk Marsman, Anna Lind, Esben Thade Petersen, Mads Andersen, Vincent Oltman Boer
Summary: GABA and GSH play crucial roles in brain functioning and are involved in various neurodegenerative and psychiatric diseases. MRS is a unique non-invasive method to measure these neurometabolites, but motion stabilization is important, especially for specific patient groups. Spectral editing techniques are typically used for unambiguous detection of GABA and GSH, although they increase motion sensitivity.
Review
Nutrition & Dietetics
David J. Nutt, Robin J. Tyacke, Meg Spriggs, Vanessa Jacoby, Alan D. Borthwick, Delia Belelli
Summary: Alcohol consumption is associated with health harms and governments worldwide are trying to reduce them. One approach is to reduce alcohol consumption, leading to the development of non-alcoholic drinks. However, non-alcoholic drinks do not provide the social interaction that alcohol does. Therefore, the alternative approach is to develop functional drinks that mimic the positive effects of alcohol without the harms.
Article
Food Science & Technology
Yuling Ma, Aixia Wang, Mei Yang, Shanshan Wang, Lili Wang, Sumei Zhou, Christophe Blecker
Summary: The study showed that black mung bean varieties with heat and relative humidity treatment had higher GABA content compared to green varieties. Soaking increased GABA content in mung beans, but a portion of it was distributed in the soaking solution. After cooking, the GABA content in heat and humidity treated mung beans slightly degraded, but remained higher than untreated mung beans.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Review
Immunology
Yu Shan, Jianan Zhao, Yixin Zheng, Shicheng Guo, Steven J. Schrodi, Dongyi He
Summary: Rheumatoid arthritis (RA) is a disabling autoimmune disease with a complex pathological process. The GABAergic system in the nervous system may have immunomodulatory effects and regulate abnormal pain response in RA patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Ateequr Rehman, Giulio Di Benedetto, Julia K. Bird, Valentina Dabene, Lisa Vadakumchery, Ali May, Ghislain Schyns, Wilbert Sybesma, Tim N. Mak
Summary: This study focused on the selection and optimization of a bacterial strain with high GABA production for probiotic supplement development. Two biosensors capable of detecting GABA were developed and tested in gut-like conditions. The results provide valuable insights for the development of probiotic supplements and monitoring of GABA in the digestive system.
SCIENTIFIC REPORTS
(2023)
Review
Nutrition & Dietetics
Oliviero Bruni, Luigi Ferini-Strambi, Elena Giacomoni, Paolo Pellegrino
Summary: Sleep is crucial for physical and emotional wellbeing, but insomnia is a prevalent issue. The interest in using herbal medicines for treating or preventing insomnia has grown. Herbal extracts have been shown to improve sleep quality, potentially through interactions with GABA receptors in the brain.
Article
Plant Sciences
Canying Li, Jie Zhu, Lei Sun, Yuan Cheng, Jiabao Hou, Yiting Fan, Yonghong Ge
Summary: The study demonstrates that exogenous GABA has significant effects on quality parameters, ethylene anabolism, polyamine metabolism, and GABA shunt in 'Golden Delicious' apples, helping to maintain fruit quality by suppressing unfavorable factors.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
Zhen Wu, Pengyu Wang, Daodong Pan, Xiaoqun Zeng, Yuxing Guo, Guangsheng Zhao
Summary: The study demonstrated that GABA-enriched adzuki bean sprout fermented milk may alleviate and even prevent mild depression symptoms in mice by enhancing social interaction and pleasure derived from movement. The research also highlighted the involvement of the GABA(B)-cAMP-PKA-CREB signaling pathway and increased neurotransmitter levels in the hippocampus after treatment. This suggests a potential dietary therapy for chronic social stress.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Environmental Sciences
Qing Shan, Minghui Liu, Rui Li, Qinghua Shi, Yan Li, Biao Gong
Summary: In this study, we investigated the role of GABA in crops and found that exogenous application or endogenous regulation of GABA by gene-editing technology can promote pesticide detoxification and enhance crop tolerance. This is achieved by regulating the GABA shunt pathway and polyamine pathway in plants. Additionally, we unexpectedly discovered that GABA promotes stomatal closure, reducing pesticide absorption.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Agronomy
Zongyu Chi, Yuqin Dai, Shifeng Cao, Yingying Wei, Xingfeng Shao, Xiaosan Huang, Feng Xu, Hongfei Wang
Summary: The study found that calcium chloride treatment promotes GABA accumulation in fresh-cut pears, while lanthanum chloride treatment stimulates the GABA shunt and polyamine degradation pathway.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2021)
Article
Forestry
Xiao Chen, Na Li, Chenlu Liu, Hongtao Wang, Yuxing Li, Yuanmei Xie, Fengwang Ma, Jiakai Liang, Cuiying Li
Summary: Exogenous GABA improved the resistance of apple seedlings to long-term drought stress by enhancing GABA shunt and secondary cell wall biosynthesis.
Review
Food Science & Technology
X. Y. Lee, J. S. Tan, L. H. Cheng
Summary: This mini review discusses the biosynthetic pathways of GABA in plants and its presence in foods. Compared to animal-based foods, plant-based foods generally have lower levels of GABA, although germination and fermentation can increase GABA content. However, there is limited research on the stability of GABA during processing and storage, its bioavailability, and clinical implications.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Anling Kaplan, Abigail I. I. Nash, Amanda A. H. Freeman, Lauren G. G. Lewicki, David B. B. Rye, Lynn Marie Trotti, Asher L. L. Brandt, Andrew Jenkins
Summary: GABA(A) receptor-positive modulators induce sedation, sleep, and anesthesia, while GABA(A) receptor negative allosteric modulators increase arousal and can induce seizures. By screening 11 compounds known to modulate arousal, we found that they can modulate receptor activation through a GABA-related mechanism, providing new avenues for the treatment of patients with diminished CNS E/I balance.
Article
Biochemistry & Molecular Biology
Dan Shen, Yingjian Lu, Shuhua Tian, Shaotong Ma, Jing Sun, Qiaobin Hu, Xinyi Pang, Xiangfei Li
Summary: The study showed that L-arabinose can improve symptoms of diabetes mellitus in a mouse model of T2DM, including lowering blood glucose, alleviating steatosis, and repairing pancreatic islet cells. Furthermore, it was found to have a regulatory effect on gut microbiota.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Shaotong Ma, Shuhua Tian, Jing Sun, Xinyi Pang, Qiaobin Hu, Xiangfei Li, Yingjian Lu
Summary: This study demonstrates that lyophilized broccoli microgreens can regulate type 2 diabetes and improve the symptoms of mice with T2D induced by high-fat diet and streptozotocin. The effects include improvements in body weight, glucose homeostasis, blood lipid status, antioxidant indexes, inflammatory factors level, insulin resistance, pathological changes in organs, gut microbiota composition, and propionic acid production.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)