3D model of harlequin ichthyosis reveals inflammatory therapeutic targets

Discovery of the IL-23/IL-17 Signaling Pathway and the Treatment of Psoriasis

(2018) Jason E. Hawkes et al.   JOURNAL OF IMMUNOLOGY

An IL-17–dominant immune profile is shared across the major orphan forms of ichthyosis

(2017) Amy S. Paller et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effect of tofacitinib on lipid levels and lipid-related parameters in patients with moderate to severe psoriasis

(2017) Robert Wolk et al.   Journal of Clinical Lipidology

IL-36 Signaling Facilitates Activation of the NLRP3 Inflammasome and IL-23/IL-17 Axis in Renal Inflammation and Fibrosis

(2017) Hsi-Hua Chi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Immortalized N/TERT keratinocytes as an alternative cell source in 3D human epidermal models

(2017) Jos P. H. Smits et al.   Scientific Reports

Anti-interleukin and interleukin therapies for psoriasis: current evidence and clinical usefulness

(2017) Ya-Chu Tsai et al.   Therapeutic Advances in Musculoskeletal Disease

A novel molecular disease classifier for psoriasis and eczema

(2016) Natalie Garzorz-Stark et al.   EXPERIMENTAL DERMATOLOGY

Nitric oxide promotes epidermal stem cell migration via cGMP-Rho GTPase signalling

(2016) Rixing Zhan et al.   Scientific Reports

Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis

(2016) Lei Zhang et al.   PLoS One

New Drugs and Treatment Targets in Psoriasis

(2015) K Kofoed et al.   ACTA DERMATO-VENEREOLOGICA

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

(2015) John J. O'Shea et al.   Annual Review of Medicine

IL-17 intensifies IFN-γ-induced NOS2 upregulation in RAW 264.7 cells by further activating STAT1 and NF-κB

(2015) QIYUE GAO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Expression of IL-36 family cytokines and IL-37 but not IL-38 is altered in psoriatic skin

(2015) Maris Keermann et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

IL-37 Alleviates Rheumatoid Arthritis by Suppressing IL-17 and IL-17–Triggering Cytokine Production and Limiting Th17 Cell Proliferation

(2015) Liang Ye et al.   JOURNAL OF IMMUNOLOGY

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis

(2014) Denny L. Cottle et al.   HUMAN MOLECULAR GENETICS

Barrier Properties of an N/TERT-Based Human Skin Equivalent

(2014) Vincent van Drongelen et al.   TISSUE ENGINEERING PART A

Systemic retinoids in the management of ichthyoses and related skin types

(2013) John J. DiGiovanna et al.   Dermatologic Therapy

STAT1 expression and activation is increased in lesional psoriatic skin

(2012) A. Hald et al.   BRITISH JOURNAL OF DERMATOLOGY

IL-17A Upregulates Keratin 17 Expression in Keratinocytes through STAT1- and STAT3-Dependent Mechanisms

(2011) Xiaowei Shi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Self-Improvement of Keratinocyte Differentiation Defects During Skin Maturation in ABCA12-Deficient Harlequin Ichthyosis Model Mice

(2010) Teruki Yanagi et al.   AMERICAN JOURNAL OF PATHOLOGY

Interleukin-1 alpha blockade prevents hyperkeratosis in an in vitro model of lamellar ichthyosis

(2010) Ryan F.L. O'Shaughnessy et al.   HUMAN MOLECULAR GENETICS

Ichthyosis

(2009) Vinzenz Oji et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Premature Terminal Differentiation and a Reduction in Specific Proteases Associated with Loss of ABCA12 in Harlequin Ichthyosis

(2009) Anna C. Thomas et al.   AMERICAN JOURNAL OF PATHOLOGY

Harlequin ichthyosis model mouse reveals alveolar collapse and severe fetal skin barrier defects

(2008) T. Yanagi et al.   HUMAN MOLECULAR GENETICS

ABCA12 Maintains the Epidermal Lipid Permeability Barrier by Facilitating Formation of Ceramide Linoleic Esters

(2008) Ying Zuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thematic review series: Skin Lipids.Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism

(2008) Peter M. Elias et al.   JOURNAL OF LIPID RESEARCH

A Mouse Model of Harlequin Ichthyosis Delineates a Key Role for Abca12 in Lipid Homeostasis

(2008) Ian Smyth et al.   PLoS Genetics