Molecular characteristics and physiological roles of Na + –K + –Cl − cotransporter 2

Physiological roles and molecular mechanisms of K+ -Cl− cotransport in the mammalian kidney and cardiovascular system: where are we?

(2019) A. P. Garneau et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of Na+-K+-Cl− cotransporter type 2 by the with no lysine kinase-dependent signaling pathway

(2019) Andrée-Anne Marcoux et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Tyrosine phosphorylation modulates cell surface expression of chloride cotransporters NKCC2 and KCC3

(2019) Cláudia Almeida Loureiro et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Impaired glucose tolerance, glucagon and insulin responses in mice lacking the loop diuretic-sensitive Nkcc2a

(2019) Lisa Kelly et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

K+-Cl− cotransporter 1 (KCC1): a housekeeping membrane protein that plays key supplemental roles in hematopoietic and cancer cells

(2019) A. P. Garneau et al.   Journal of Hematology & Oncology

Endocytic recycling of Na + –K + –Cl − cotransporter type 2: importance of exon 4

(2019) Andrée‐Anne Marcoux et al.   JOURNAL OF PHYSIOLOGY-LONDON

The structure of Na+-K+-Cl− cotransporter 1

(2019) Alexandre P. Garneau et al.   Nature Reviews Nephrology

Renal-Specific Silencing of TNF (Tumor Necrosis Factor) Unmasks Salt-Dependent Increases in Blood Pressure via an NKCC2A (Na+-K+-2Cl−Cotransporter Isoform A)-Dependent MechanismNovelty and Significance

(2018) Shoujin Hao et al.   HYPERTENSION

C-terminal phosphorylation of SPAK and OSR1 kinases promotes their binding and activation by the scaffolding protein MO25

(2018) Youcef Mehellou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Contributions of rare coding variants in hypotension syndrome genes to population blood pressure variation

(2018) Priyanka Nandakumar et al.   MEDICINE

Vesicle-associated Membrane Protein 3 (VAMP3) Mediates Constitutive Trafficking of the Renal Co-transporter NKCC2 in Thick Ascending Limbs

(2016) Paulo S. Caceres et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule

(2016) Mohammed Z. Ferdaus et al.   JOURNAL OF PHYSIOLOGY-LONDON

Polyhydramnios, Transient Antenatal Bartter’s Syndrome, andMAGED2Mutations

(2016) Kamel Laghmani et al.   NEW ENGLAND JOURNAL OF MEDICINE

NKCC2 activity is inhibited by the Bartter's syndrome type 5 gain-of-function CaR-A843E mutant in renal cells

(2015) Monica Carmosino et al.   BIOLOGY OF THE CELL

Critical role of the SPAK protein kinase CCT domain in controlling blood pressure

(2015) Jinwei Zhang et al.   HUMAN MOLECULAR GENETICS

Osmoregulation Requires Brain Expression of the Renal Na-K-2Cl Cotransporter NKCC2

(2015) A. Konopacka et al.   JOURNAL OF NEUROSCIENCE

Expression of three isoforms of Na-K-2Cl cotransporter (NKCC2) in the kidney and regulation by dehydration

(2014) Kazuko Itoh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Novel Ste20-related Proline/Alanine-rich Kinase (SPAK)-independent Pathway Involving Calcium-binding Protein 39 (Cab39) and Serine Threonine Kinase with No Lysine Member 4 (WNK4) in the Activation of Na-K-Cl Cotransporters

(2014) Jose Ponce-Coria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Motions Involved in Na-K-Cl Cotransporter-mediated Ion Transport and Transporter Activation Revealed by Internal Cross-linking between Transmembrane Domains 10 and 11/12

(2014) Michelle Y. Monette et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters

(2014) D. R. Alessi et al.   Science Signaling

Validation of Uromodulin as a Candidate Gene for Human Essential Hypertension

(2013) Lesley A. Graham et al.   HYPERTENSION

Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression

(2013) Matteo Trudu et al.   NATURE MEDICINE

Functional Expression of Human NKCC1 from a Synthetic Cassette-Based cDNA: Introduction of Extracellular Epitope Tags and Removal of Cysteines

(2013) Suma Somasekharan et al.   PLoS One

Calcium-binding protein 39 facilitates molecular interaction between Ste20p proline alanine-rich kinase and oxidative stress response 1 monomers

(2012) José Ponce-Coria et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

WNK-OSR1/SPAK-NCC signal cascade has circadian rhythm dependent on aldosterone

(2012) Koichiro Susa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cellular distribution of NKCC2 in the gastric mucosa and its response to short-term osmotic shock

(2012) T. Ji et al.   CELL AND TISSUE RESEARCH

Expression of the Slc12a1 Gene in Pancreatic β-cells: Molecular Characterization and in silico Analysis

(2012) Saeed Alshahrani et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Loop Diuretic and Ion-binding Residues Revealed by Scanning Mutagenesis of Transmembrane Helix 3 (TM3) of Na-K-Cl Cotransporter (NKCC1)

(2012) Suma Somasekharan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SPAK Isoforms and OSR1 Regulate Sodium-Chloride Co-transporters in a Nephron-specific Manner

(2012) P. Richard Grimm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Key Residues Involved in the Dimerization of the Secretory Na+–K+–2Cl–Cotransporter NKCC1

(2011) Most. Nahid Parvin et al.   BIOCHEMISTRY

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

(2011) Beatrice M Filippi et al.   EMBO JOURNAL

Activation of the Bumetanide-sensitive Na+,K+,2Cl−Cotransporter (NKCC2) Is Facilitated by Tamm-Horsfall Protein in a Chloride-sensitive Manner

(2011) Kerim Mutig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

(2011) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Impaired phosphorylation of Na+-K+-2Cl- cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome

(2011) S.-H. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular localization of NKCC2 and its possible role in the Cl− absorption in the rat and human distal colonic epithelia

(2011) Jin-Xia Zhu et al.   Translational Research

Localization and functional characterization of the human NKCC2 isoforms

(2010) I. Carota et al.   Acta Physiologica

Role of the WNK-activated SPAK kinase in regulating blood pressure

(2010) Fatema H. Rafiqi et al.   EMBO Molecular Medicine

Tamm-Horsfall Glycoprotein Interacts with Renal Outer Medullary Potassium Channel ROMK2 and Regulates Its Function

(2010) Aparna Renigunta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rare mutations in SLC12A1 and SLC12A3 protect against hypertension by reducing the activity of renal salt cotransporters

(2010) Rocío Acuña et al.   JOURNAL OF HYPERTENSION

Angiotensin II induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter independent of aldosterone

(2010) Nils van der Lubbe et al.   KIDNEY INTERNATIONAL

SORLA/SORL1 Functionally Interacts with SPAK To Control Renal Activation of Na+-K+-Cl- Cotransporter 2

(2010) J. Reiche et al.   MOLECULAR AND CELLULAR BIOLOGY

Quantitative phosphoproteomic analysis reveals cAMP/vasopressin-dependent signaling pathways in native renal thick ascending limb cells

(2010) R. Gunaratne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hereditary tubular transport disorders: implications for renal handling of Ca2+and Mg2+

(2009) Henrik Dimke et al.   CLINICAL SCIENCE

cAMP Stimulates Apical Exocytosis of the Renal Na+-K+-2Cl−Cotransporter NKCC2 in the Thick Ascending Limb

(2009) Paulo S. Caceres et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CYP-omega-hydroxylation-dependent metabolites of arachidonic acid inhibit the basolateral 10pS chloride channel in the rat thick ascending limb

(2009) Rui-Min Gu et al.   KIDNEY INTERNATIONAL

Expression of NKCC2 in the rat gastrointestinal tract

(2009) h. xue et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway

(2008) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Rare independent mutations in renal salt handling genes contribute to blood pressure variation

(2008) Weizhen Ji et al.   NATURE GENETICS

Thick ascending limb: the Na+:K+:2Cl− co-transporter, NKCC2, and the calcium-sensing receptor, CaSR

(2008) Gerardo Gamba et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases

(2008) J. Ponce-Coria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Disease: the kidney-specific chloride channels ClCKA and ClCKB, the Barttin subunit, and their clinical relevance

(2007) Bernhard K Krämer et al.   Nature clinical practice. Nephrology