Article
Plant Sciences
Qing Meng, Zhiyuan Liu, Chunda Feng, Helong Zhang, Zhaosheng Xu, Xiaowu Wang, Jian Wu, Hongbing She, Wei Qian
Summary: In this study, a major quantitative trait locus (QTL) related to early bolting in spinach was identified, and two candidate genes associated with flowering regulatory pathways were proposed. This research provides a basis for understanding the molecular mechanisms of bolting in spinach.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Takashi Namba, Osamu Ichii, Tadashi Okamura, Kenta Nakano, Teppei Nakamura, Yuki Otani, Yasuhiro Kon
Summary: Systemic autoimmune diseases often lead to lupus nephritis, which alters the balance and expression of IL-36R ligands in the kidneys. In a mouse model of lupus nephritis, it was found that IL-36R knockout significantly improved renal pathology, particularly mesangial matrix expansion and fibrosis.
MICROSCOPY AND MICROANALYSIS
(2023)
Article
Horticulture
Yuansheng Chang, Wenyan Zheng, Sen Wang, Xiaowen He, Ping He, Huifeng Li, Haibo Wang, Linguang Li
Summary: Fruit size is an important indicator of apple quality, and it is influenced by various factors including cultivar management, plant hormones, and genetic factors. Genetic factors play a fundamental role in determining fruit size through cell division and expansion. This research identified multiple QTLs and candidate genes involved in regulating fruit size, providing evidence for developing gene markers for apple breeding.
SCIENTIA HORTICULTURAE
(2023)
Article
Biochemistry & Molecular Biology
Jurong Song, Bao Li, Yanke Cui, Chenjian Zhuo, Yuanguo Gu, Kaining Hu, Jing Wen, Bin Yi, Jinxiong Shen, Chaozhi Ma, Tingdong Fu, Jinxing Tu
Summary: By using a DH rapeseed population, five consensus QTLs, including two major ones, related to flowering time were identified. Through RNA-seq and DEG analysis, four candidate genes associated with flowering time were discovered, laying a foundation for genetic regulation of rapeseed flowering time.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Xueqian Jiang, Xijiang Yang, Fan Zhang, Tianhui Yang, Changfu Yang, Fei He, Ting Gao, Chuan Wang, Qingchuan Yang, Zhen Wang, Junmei Kang
Summary: This study investigated the key genes controlling leaf size in alfalfa using genetic mapping and molecular biology methods. The findings suggest that leaf width has a significant impact on leaf area. By identifying candidate genes, this study provides a theoretical basis for marker-assisted breeding in alfalfa.
Article
Biochemistry & Molecular Biology
Ting Wang, Fu Xu, Zhoutao Wang, Qibin Wu, Wei Cheng, Youxiong Que, Liping Xu
Summary: In this study, phenotypic data of 285 F-1 progenies from a cross of sugarcane varieties were collected to investigate the tillering and ratooning traits. The results showed that both traits had medium to medium-high heritability and were positively correlated. Furthermore, a total of 26 QTLs related to tillering and 11 QTLs associated with ratooning were identified, along with 25 candidate genes. These findings provide valuable information for genetic improvement of tillering and ratooning traits in sugarcane.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Yulin Jia, Melissa H. Jia, Zhongbu Yan
Summary: Rice blast caused by the fungus Magnaporthe oryzae is a major threat to rice production worldwide. The resistance of major resistance genes is often short-lived, while minor resistance genes provide more durable resistance. This study evaluated the disease reactions of two rice breeding parents and identified 10 resistance QTLs, providing genetic markers and resources for marker-assisted selection and further studies.
Article
Multidisciplinary Sciences
Ning Zhang, Xueqing Huang
Summary: The leaf angle of maize is a critical trait that influences plant architecture and crop yields. Through genetic mapping, this study identified eight QTL related to leaf angle, providing valuable insights into the genetic mechanism behind leaf angle formation and facilitating the development of novel maize varieties with ideal plant architecture.
Article
Plant Sciences
Firdissa E. Bokore, Richard D. Cuthbert, Ron E. Knox, Colin W. Hiebert, Curtis J. Pozniak, Samia Berraies, Yuefeng Ruan, Brad Meyer, Pierre Hucl, Brent D. McCallum
Summary: This study aimed to identify and map the leaf rust resistance of six Canadian Western Red Spring wheat cultivars. Three doubled haploid populations were evaluated for seedling resistance and adult plant disease response and genotyped with a SNP array. Multiple QTL for leaf rust resistance were found in each population, with contributions from different cultivars. The results provide valuable information for resistance breeding and expanding our knowledge of leaf rust resistance genes in Canadian wheat.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Yu Xu, Bingbing Zhang, Ning Ma, Xia Liu, Mengfan Qin, Yan Zhang, Kai Wang, Na Guo, Kaifeng Zuo, Xiang Liu, Miao Zhang, Zhen Huang, Aixia Xu
Summary: By utilizing SSR and SLAF-seq technologies, this study successfully mapped QTLs for flowering time in rapeseed and identified three target intervals. A total of 186 genes with genetic variations, including 14 related to flowering time pathways, were found in these intervals. Development of six InDel markers linked to flowering time indicates the credibility of the results for further genetic studies in Brassica napus L.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Yue Yang, Tiantian Zhao, Fengmin Wang, Luping Liu, Bingqiang Liu, Kai Zhang, Jun Qin, Chunyan Yang, Yake Qiao
Summary: In this study, two stable loci associated with soybean seed coat color and one stable locus related to seed hilum color were identified through hybrid breeding and gene association analysis. Potential candidate genes within these loci were also determined, providing a foundation for understanding the genetic mechanisms underlying these traits and aiding in marker-assisted breeding.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Agronomy
Yoon-Hee Jang, Jae-Ryoung Park, Eun-Gyeong Kim, Rahmatullah Jan, Saleem Asif, Muhammad Farooq, Dan-Dan Zhao, Kyung-Min Kim
Summary: The gelatinization temperature of rice plays a crucial role in its eating and cooking quality, as well as consumer preference. Alkali digestion value (ADV) is a commonly used method to assess rice quality and is highly correlated with gelatinization temperature. This study utilized QTL analysis to identify genetic factors related to ADV in brown and milled rice. Through this analysis, 12 QTLs related to ADV were identified, and a screening of candidate genes in the chromosome 6 region resulted in the selection of 20 genes. Among these, OsSS1q6 showed a high expression level and has been found to interact with starch biosynthesis-related proteins. Therefore, OsSS1q6 may play a role in regulating the gelatinization temperature of rice through the control of starch biosynthesis. This study provides valuable insights for breeding high-quality rice and offers a new genetic resource for improving rice palatability.
MOLECULAR BREEDING
(2023)
Article
Plant Sciences
Zigang Liu, Xiaoyun Dong, Guoqiang Zheng, Chunmei Xu, Jiaping Wei, Junmei Cui, Xiaodong Cao, Hui Li, Xinlin Fang, Ying Wang, Haiyan Tian
Summary: Flowering time is crucial for the yield and adaptation of oilseed rape. This study investigated the genetic and molecular regulation of flowering time in oilseed rape using RNA-seq analysis and QTL mapping. The results identified two QTLs associated with flowering time and revealed six candidate genes involved in the regulation of flowering time.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Horticulture
Shuang Jiang, Jun Luo, Xiaoqing Wang, Haishan An, Jiaying Zhang, Shuigen Li
Summary: This study explored the molecular mechanism underlying peel russeting in Pyrus pyrifolia by identifying QTLs and related genes for peel color through SLAFseq. The results revealed two QTLs related to peel color and provided insights into the genetic basis of peel russeting in Chinese pear fruits. Additionally, transcriptome analysis identified differentially expressed genes associated with peel russeting, including transcription factors and functional genes involved in fatty acid, glycerolipid, cutin, suberine, and wax biosynthesis.
SCIENTIA HORTICULTURAE
(2022)
Article
Biochemistry & Molecular Biology
Zhenjuan Liang, Na Xi, Hao Liu, Peng Liu, Chenchaoyang Xiang, Chen Zhang, Chaoying Zou, Xuyujuan Cheng, Hong Yu, Minyan Zhang, Zhong Chen, Guangtang Pan, Guangsheng Yuan, Shibin Gao, Langlang Ma, Yaou Shen
Summary: This study combined linkage mapping and genome-wide association study to reveal the genetic architecture of maize ear shank length, identified important genes related to ear shank elongation, and explored their roles in regulating cell division, expansion, and elongation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Khalaf Kridin, Ralf J. Ludwig
Summary: In this retrospective cohort study, patients with acne treated with isotretinoin had a lower risk of depression compared to those treated with oral antibiotics, but a comparable risk of major depressive disorder. The risk of suicidal attempts was similar between the two groups, but patients under isotretinoin had a higher risk of suicidal ideation. Patients under isotretinoin also had a lower risk of post-traumatic stress disorder, anxiety, bipolar disorder, schizophrenia, and adjustment disorder. The study suggests that isotretinoin may confer a lower risk of several psychiatric comorbidities.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Letter
Dermatology
Katharina Boch, Henner Zirpel, Diamant Thaci, Noor Mruwat, Detlef Zillikens, Ralf J. Ludwig, Khalaf Kridin
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Khalaf Kridin, Marie-Charlotte Brueggen, Sarah Walsh, Benoit Bensaid, Annamari Ranki, Eva Oppel, Damian Meyersburg, Ser-Ling Chua, Corsin Seeli, Heidi Sandberg, Lars E. French, Artem Vorobyev, Saskia Ingen-Housz-Oro
Summary: This study investigated the treatment approaches, disease course, prognostic factors, and culprit drugs of drug reaction with eosinophilia and systemic symptoms (DRESS) in Europe. The results showed that the most common cutaneous manifestation in the patients was morbilliform exanthem (78.0%), and 31.9% of the patients had severe DRESS based on systemic involvement. Most patients received glucocorticoid treatment (73%), and further research is needed to reduce the mortality and complications of DRESS.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Veterinary Sciences
Veronika Hartmann, William V. J. Hariton, Siavash Rahimi, Christoph M. Hammers, Ralf J. Ludwig, Eliane J. Mueller, Jennifer E. Hundt
Summary: Pemphigus is a severe autoimmune bullous disease that targets adhesion proteins desmoglein 3 and/or desmoglein 1. Current treatment involves systemic immunosuppression, and drug development focuses on B cells, autoantibodies, and tissue pathology. A human skin organ culture (HSOC) model has been established as an alternative to animal models for studying pemphigus, replicating key features of the disease.
LABORATORY ANIMALS
(2023)
Article
Dermatology
Khalaf Kridin, Noor Mruwat, Ralf J. Ludwig
Summary: Patients with pemphigus who were treated with rituximab had a lower risk of long-term cardiovascular and metabolic outcomes compared with those receiving first-line corticosteroid-sparing agents. Rituximab may be particularly preferred in patients with preexisting cardiovascular and metabolic risk factors.
Article
Immunology
Khalaf Kridin, Artem Vorobyev, Cristian Papara, David A. De Luca, Katja Bieber, Ralf J. Ludwig
Summary: Identification of risk factors and sequelae of diseases is crucial for primary prevention and disease management. This study used TriNetX to identify risk factors and sequelae of the rare autoimmune disease EBA. The findings revealed chronic inflammatory diseases, especially lupus erythematosus and lichen planus, as the highest risk factors for EBA development and metabolic and cardiovascular diseases, and thrombosis as the most common sequelae after EBA diagnosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Immunology
Jennifer E. Hundt, Markus H. Hoffmann, Kyle T. Amber, Ralf J. Ludwig
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Maria Shoykhet, Orsela Dervishi, Philipp Menauer, Matthias Hiermaier, Sina Moztarzadeh, Colin Osterloh, Ralf J. Ludwig, Tatjana Williams, Brenda Gerull, Stefan Kaab, Sebastian Clauss, Dominik Schuettler, Jens Waschke, Sunil Yeruva
Summary: Arrhythmogenic cardiomyopathy (AC) is a familial heart disease caused by impaired desmosome turnover, and stabilizing desmosome integrity through EGFR and ROCK inhibition may offer new treatment options. In this study, EGFR inhibition enhanced cardiomyocyte cohesion and increased DSG2 recruitment and binding at cell borders. Additionally, EGFR inhibition led to the upregulation of ROCK, and ROCK inhibition abolished the effects of EGFR inhibition on desmosome assembly and cardiomyocyte cohesion. These findings suggest that targeting EGFR and ROCK could be potential therapeutic strategies for AC.
Article
Biochemistry & Molecular Biology
Ulrike Raap, Maren M. M. Limberg, Khalaf Kridin, Ralf J. J. Ludwig
Summary: Autoimmune bullous skin diseases (AIBDs), such as bullous pemphigoid (BP) and pemphigus, are characterized by autoantibodies targeting structural proteins. Pruritus is common in patients with BP and pemphigus, and can be the sole symptom in some cases. The temporal relationship between pruritus and AIBDs is unclear, and the presence of pruritus in other AIBDs is also unknown.
Review
Medicine, General & Internal
Cristian Papara, David A. De Luca, Katja Bieber, Artem Vorobyev, Ralf J. Ludwig
Summary: Morphea, also known as localized scleroderma, is a chronic inflammatory connective tissue disorder that affects both adults and children. It is characterized by inflammation and fibrosis of the skin and underlying soft tissue, and in certain cases, can also affect surrounding structures. The etiology of morphea is still unknown, but genetic predisposition, vascular dysregulation, T(H)1/T(H)2 imbalance, cytokines, and certain environmental factors may contribute to its development. Proper assessment of disease activity and prompt initiation of treatment are crucial to prevent permanent damage.
FRONTIERS IN MEDICINE
(2023)
Review
Medicine, General & Internal
David A. De Luca, Cristian Papara, Artem Vorobyev, Hernan Staiger, Katja Bieber, Diamant Thaci, Ralf J. Ludwig
Summary: Lichen sclerosus (LS) is an inflammatory mucocutaneous condition primarily affecting postmenopausal women, with unknown etiology. LS is associated with factors such as hormonal status, trauma, and autoimmune diseases. LS pathogenesis involves genetic predisposition, immune-mediated mechanisms, tissue remodeling genes, and oxidative stress. LS presents as chronic whitish atrophic patches with itching and soreness in the genital and anal regions. Treatment options include topical corticosteroids and calcineurin inhibitors. LS is a common dermatological disease with an incompletely understood pathogenesis and limited treatment options.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Katja Bieber, Siegfried Bezdek, Yask Gupta, Artem Vorobyev, Tanya Sezin, Natalie Gross, Jasper Pruessmann, Jean-Paul Sayegh, Mareike Becker, Sadegh Mousavi, Ashref Hdnah, Sven Kuenzel, Saleh M. Ibrahim, Ralf J. Ludwig, Donald Gullberg, Christian D. Sadik
Summary: Psoriasis is a chronic inflammatory skin condition that can be induced in mice by applying Aldara & REG; cream. The severity of Aldara & REG;-induced psoriasiform dermatitis (AIPD) varies among different inbred mouse strains and is associated with polymorphisms in the Itga11 gene. Itga11 plays a critical role in promoting skin inflammation in AIPD and may be targeted for the development of new therapies for psoriasiform skin conditions.
JOURNAL OF PATHOLOGY
(2023)
Article
Dermatology
Ralf J. Ludwig, Esther von Stebut
Summary: The epidemiology and clinical presentation of inflammatory dermatoses vary considerably between people with different colors of skin. It is important to know the epidemiology and recognize key clinical characteristics of these diseases in patients with skin of color (SOC) in order to provide excellent dermatological care for all patients.
Article
Dermatology
Stefan Tukaj, Katja Bieber, Wiebke Pruessmann, Jasper N. Pruessmann, Enno Schmidt, Detlef Zillikens, Ralf J. Ludwig, Michael Kasperkiewicz
Summary: Healthy individuals with BP autoantibody reactivity have abnormal vitamin D levels and a specific cytokine profile.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Dermatology
Khalaf Kridin, Keren Lyakhovitsky, Erez Onn, Anna Lyakhovitsky, Ralf Ludwig, Orly Weinstein, Arnon D. Cohen
Summary: There is a bidirectional association between vitiligo and psoriasis.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)