Osteopontin as a candidate of therapeutic application for the acute brain injury

Risks associated with the stroke predisposition at young age: facts and hypotheses in light of individualized predictive and preventive approach

(2019) Jiri Polivka et al.   EPMA Journal

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Valery L Feigin et al.   LANCET NEUROLOGY

Acute intranasal osteopontin treatment in male rats following TBI increases the number of activated microglia but does not alter lesion characteristics

(2019) Amandine Jullienne et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Plasma osteopontin may predict neuroinflammation and the severity of pediatric traumatic brain injury

(2019) Ning Gao et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The role and therapeutic potential of heat shock proteins in haemorrhagic stroke

(2019) Anwen Shao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Osteopontin in the Cerebrospinal Fluid of Patients with Severe Aneurysmal Subarachnoid Hemorrhage

(2019) Maria Giulia Abate et al.   Cells

Advance of Stem Cell Treatment for Traumatic Brain Injury

(2019) Yunxiang Zhou et al.   Frontiers in Cellular Neuroscience

Osteopontin-Enhanced Autophagy Attenuates Early Brain Injury via FAK–ERK Pathway and Improves Long-Term Outcome after Subarachnoid Hemorrhage in Rats

(2019) Chengmei Sun et al.   Cells

Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

(2018) Emelia J. Benjamin et al.   CIRCULATION

The multiple functions and mechanisms of osteopontin

(2018) Mehmet Arif Icer et al.   CLINICAL BIOCHEMISTRY

Acute-Phase Plasma Osteopontin as an Independent Predictor for Poor Outcome After Aneurysmal Subarachnoid Hemorrhage

(2018) Yoshinari Nakatsuka et al.   MOLECULAR NEUROBIOLOGY

Osteopontin attenuates inflammation via JAK2/STAT1 pathway in hyperglycemic rats after intracerebral hemorrhage

(2018) Lei Gong et al.   NEUROPHARMACOLOGY

Neural stem cell therapies and hypoxic-ischemic brain injury

(2018) Lei Huang et al.   PROGRESS IN NEUROBIOLOGY

Radiologic Cerebral Reperfusion at 24 h Predicts Good Clinical Outcome

(2018) Federico Carbone et al.   Translational Stroke Research

Recombinant Osteopontin Improves Neurological Functional Recovery and Protects Against Apoptosis via PI3K/Akt/GSK-3β Pathway Following Intracerebral Hemorrhage

(2018) Wenqian Zhang et al.   MEDICAL SCIENCE MONITOR

Apolipoprotein E Exerts a Whole-Brain Protective Property by Promoting M1? Microglia Quiescence After Experimental Subarachnoid Hemorrhage in Mice

(2018) Jinwei Pang et al.   Translational Stroke Research

Matrix Metalloproteinase 9 and Osteopontin Interact to Support Synaptogenesis in the Olfactory Bulb after Mild Traumatic Brain Injury

(2018) Melissa A. Powell et al.   JOURNAL OF NEUROTRAUMA

Alterations in bone turnover markers in patients with noncardio-embolic ischemic stroke

(2018) K. Mathold et al.   PLoS One

The Role of Neurogenic Inflammation in Blood-Brain Barrier Disruption and Development of Cerebral Oedema Following Acute Central Nervous System (CNS) Injury

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research

(2017) Andrew I R Maas et al.   LANCET NEUROLOGY

Osteopontin Augments M2 Microglia Response and Separates M1- and M2-Polarized Microglial Activation in Permanent Focal Cerebral Ischemia

(2017) Anne Ladwig et al.   MEDIATORS OF INFLAMMATION

Osteopontin at the Crossroads of Inflammation and Tumor Progression

(2017) Luigi Mario Castello et al.   MEDIATORS OF INFLAMMATION

The nature of early astroglial protection—Fast activation and signaling

(2017) Julianna Kardos et al.   PROGRESS IN NEUROBIOLOGY

Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease

(2017) Aman P. Mann et al.   Nature Communications

Sodium Tanshinone IIA Sulfonate Enhances Effectiveness Rt-PA Treatment in Acute Ischemic Stroke Patients Associated with Ameliorating Blood-Brain Barrier Damage

(2017) Biying Ji et al.   Translational Stroke Research

PCMT1 Ameliorates Neuronal Apoptosis by Inhibiting the Activation of MST1 after Subarachnoid Hemorrhage in Rats

(2017) Ligen Shi et al.   Translational Stroke Research

Alpha-7 Nicotinic Receptor Signaling Pathway Participates in the Neurogenesis Induced by ChAT-Positive Neurons in the Subventricular Zone

(2017) Jianping Wang et al.   Translational Stroke Research

Baicalin Attenuates Blood-Brain Barrier Disruption and Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke Rats with Delayed t-PA Treatment: Involvement of ONOO−-MMP-9 Pathway

(2017) Hansen Chen et al.   Translational Stroke Research

Osteopontin as a Potential Therapeutic Target for Ischemic Stroke

(2017) Qiquan Zhu et al.   Current Drug Delivery

Role of Anti-Osteopontin Antibodies in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

(2017) Nausicaa Clemente et al.   Frontiers in Immunology

Monitoring the Neuroinflammatory Response Following Acute Brain Injury

(2017) Eric Peter Thelin et al.   Frontiers in Neurology

Plasma thrombin-cleaved osteopontin as a potential biomarker of acute atherothrombotic ischemic stroke

(2016) Saya Ozaki et al.   HYPERTENSION RESEARCH

Global stroke statistics

(2016) Amanda G Thrift et al.   International Journal of Stroke

Intranasal administration of vitamin D attenuates blood–brain barrier disruption through endogenous upregulation of osteopontin and activation of CD44/P-gp glycosylation signaling after subarachnoid hemorrhage in rats

(2016) Budbazar Enkhjargal et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Recombinant Osteopontin Stabilizes Smooth Muscle Cell Phenotype via Integrin Receptor/Integrin-Linked Kinase/Rac-1 Pathway After Subarachnoid Hemorrhage in Rats

(2016) Jiang Wu et al.   STROKE

Microglia Activation and Polarization After Intracerebral Hemorrhage in Mice: the Role of Protease-Activated Receptor-1

(2016) Shu Wan et al.   Translational Stroke Research

Inhibition of Blood-Brain Barrier Disruption by an Apolipoprotein E-Mimetic Peptide Ameliorates Early Brain Injury in Experimental Subarachnoid Hemorrhage

(2016) Jinwei Pang et al.   Translational Stroke Research

Severity-Dependent Long-Term Spatial Learning-Memory Impairment in a Mouse Model of Traumatic Brain Injury

(2016) Chengrui An et al.   Translational Stroke Research

Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases

(2016) Nausicaa Clemente et al.   Journal of Immunology Research

The P2X4 receptor is required for neuroprotection via ischemic preconditioning

(2016) Tomohiko Ozaki et al.   Scientific Reports

COX-2 regulation and TUNEL-positive cell death differ between genders in the secondary inflammatory response following experimental penetrating focal brain injury in rats

(2015) Mattias Günther et al.   ACTA NEUROCHIRURGICA

Recombinant osteopontin attenuates experimental cerebral vasospasm following subarachnoid hemorrhage in rats through an anti-apoptotic mechanism

(2015) Junchi He et al.   BRAIN RESEARCH

The Neonatal Brain Is Not Protected by Osteopontin Peptide Treatment after Hypoxia-Ischemia

(2015) Hilde J.C. Bonestroo et al.   DEVELOPMENTAL NEUROSCIENCE

Serum osteopontin levels are upregulated and predict disability after an ischaemic stroke

(2015) Federico Carbone et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

The dynamic blood-brain barrier

(2015) James Keaney et al.   FEBS Journal

Macrophage-derived osteopontin induces reactive astrocyte polarization and promotes re-establishment of the blood brain barrier after ischemic stroke

(2015) Michael Gliem et al.   GLIA

Astaxanthin as a Potential Neuroprotective Agent for Neurological Diseases

(2015) Haijian Wu et al.   Marine Drugs

Intranasal Delivery of RGD Motif-Containing Osteopontin Icosamer Confers Neuroprotection in the Postischemic Brain via αvβ3 Integrin Binding

(2015) Yin-Chuan Jin et al.   MOLECULAR NEUROBIOLOGY

The role of inflammation in perinatal brain injury

(2015) Henrik Hagberg et al.   Nature Reviews Neurology

Protective effects of Ephedra sinica extract on blood–brain barrier integrity and neurological function correlate with complement C3 reduction after subarachnoid hemorrhage in rats

(2015) Shilun Zuo et al.   NEUROSCIENCE LETTERS

Osteopontin mediates survival, proliferation and migration of neural stem cells through the chemokine receptor CXCR4

(2015) Monika Rabenstein et al.   Stem Cell Research & Therapy

Ginkgo biloba Extract Prevents Female Mice from Ischemic Brain Damage and the Mechanism Is Independent of the HO1/Wnt Pathway

(2015) Jatin Tulsulkar et al.   Translational Stroke Research

Biodegradable gelatin microspheres enhance the neuroprotective potency of osteopontin via quick and sustained release in the post-ischemic brain

(2014) Yinchuan Jin et al.   Acta Biomaterialia

Osteopontin expression in acute immune response mediates hippocampal synaptogenesis and adaptive outcome following cortical brain injury

(2014) Julie L. Chan et al.   EXPERIMENTAL NEUROLOGY

Increased Osteopontin Expression in Dendritic Cells Amplifies IL-17 Production by CD4+ T Cells in Experimental Autoimmune Encephalomyelitis and in Multiple Sclerosis

(2014) G. Murugaiyan et al.   JOURNAL OF IMMUNOLOGY

The effect of osteopontin and osteopontin-derived peptides on preterm brain injury

(2014) Anna-Maj Albertsson et al.   Journal of Neuroinflammation

Osteopontin Mediates Hyperbaric Oxygen Preconditioning-Induced Neuroprotection Against Ischemic Stroke

(2014) Sheng-Li Hu et al.   MOLECULAR NEUROBIOLOGY

Autophagy: a double-edged sword for neuronal survival after cerebral ischemia

(2014) Kangyong Liu et al.   Neural Regeneration Research

Neuronal autophagy in cerebral ischemia – a potential target for neuroprotective strategies?

(2014) Bożena Gabryel et al.   Pharmacological Reports

A Novel Cryptic Binding Motif, LRSKSRSFQVSDEQY, in the C-Terminal Fragment of MMP-3/7-Cleaved Osteopontin as a Novel Ligand for α9β1 Integrin Is Involved in the Anti-Type II Collagen Antibody-Induced Arthritis

(2014) Shigeyuki Kon et al.   PLoS One

Neuregulin1-β Decreases IL-1β-Induced Neutrophil Adhesion to Human Brain Microvascular Endothelial Cells

(2014) Limin Wu et al.   Translational Stroke Research

N-Terminal Rather Than Full-Length Osteopontin or Its C-Terminal Fragment Is Associated With Carotid-Plaque Inflammation in Hypertensive Patients

(2013) T. Wolak et al.   AMERICAN JOURNAL OF HYPERTENSION

OPN Gene Polymorphism and the Serum OPN Levels Confer the Susceptibility and Prognosis of Ischemic Stroke in Chinese Patients

(2013) Meng Jing et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mortality after hemorrhagic stroke: Data from general practice (The Health Improvement Network)

(2013) A. Gonzalez-Perez et al.   NEUROLOGY

Blood-Brain Barrier Alterations Provide Evidence of Subacute Diaschisis in an Ischemic Stroke Rat Model

(2013) Svitlana Garbuzova-Davis et al.   PLoS One

Nasal Administration of Recombinant Osteopontin Attenuates Early Brain Injury After Subarachnoid Hemorrhage

(2013) Basak Caner Topkoru et al.   STROKE

Role of Inflammation and Its Mediators in Acute Ischemic Stroke

(2013) Rong Jin et al.   Journal of Cardiovascular Translational Research

Osteopontin as a two-sided mediator in acute neuroinflammation in rat models

(2012) Taekyun Shin   ACTA HISTOCHEMICA

Human osteopontin splicing isoforms: Known roles, potential clinical applications and activated signaling pathways

(2012) E.R. Gimba et al.   CANCER LETTERS

Osteopontin increases the proliferation of neural progenitor cells

(2012) Haviryaji S.G. Kalluri et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Osteopontin mediates macrophage chemotaxis via α4and α9integrins and survival via the α4integrin

(2012) Susan Amanda Lund et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Fibroblast growth factors preserve blood–brain barrier integrity through RhoA inhibition after intracerebral hemorrhage in mice

(2012) Bin Huang et al.   NEUROBIOLOGY OF DISEASE

Osteopontin is upregulated after mechanical brain injury and stimulates neurite growth from hippocampal neurons through β1 integrin and CD44

(2012) Stefan Plantman   NEUROREPORT

Plasma thrombin-cleaved osteopontin elevation after carotid artery stenting in symptomatic ischemic stroke patients

(2011) Mie Kurata et al.   HYPERTENSION RESEARCH

Glycogen synthase kinase-3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production

(2011) Alessandra Valerio et al.   JOURNAL OF NEUROCHEMISTRY

Osteopontin Expression during Early Cerebral Ischemia-Reperfusion in Rats: Enhanced Expression in the Right Cortex Is Suppressed by Acetaminophen

(2011) Sunanda S. Baliga et al.   PLoS One

Osteopontin Enhances Endogenous Repair After Neonatal Hypoxic–Ischemic Brain Injury

(2011) Cindy T.J. van Velthoven et al.   STROKE

Osteopontin Reduced Hypoxia–Ischemia Neonatal Brain Injury by Suppression of Apoptosis in a Rat Pup Model

(2011) Wanqiu Chen et al.   STROKE

α7 Nicotinic Acetylcholine Receptor Agonism Confers Neuroprotection Through GSK-3β Inhibition in a Mouse Model of Intracerebral Hemorrhage

(2011) Paul R. Krafft et al.   STROKE

Recombinant osteopontin in cerebral vasospasm after subarachnoid hemorrhage

(2010) Hidenori Suzuki et al.   ANNALS OF NEUROLOGY

Protective effects of recombinant osteopontin on early brain injury after subarachnoid hemorrhage in rats*

(2010) Hidenori Suzuki et al.   CRITICAL CARE MEDICINE

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Recombinant Osteopontin Attenuates Brain Injury after Intracerebral Hemorrhage in Mice

(2010) Bihua Wu et al.   Neurocritical Care

Mechanisms of Osteopontin-Induced Stabilization of Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in Rats

(2010) Hidenori Suzuki et al.   STROKE

Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with  9 1 and  4 1 integrins

(2009) J. Grassinger et al.   BLOOD

Persistent migration of neuroblasts from the subventricular zone to the injured striatum mediated by osteopontin following intracerebral hemorrhage

(2009) Yi-Ping Yan et al.   JOURNAL OF NEUROCHEMISTRY

Osteopontin is a mediator of the lateral migration of neuroblasts from the subventricular zone after focal cerebral ischemia

(2009) Yi-Ping Yan et al.   NEUROCHEMISTRY INTERNATIONAL

Matrix metalloproteinase-9 potentiates early brain injury after subarachnoid hemorrhage

(2009) Zongduo Guo et al.   NEUROLOGICAL RESEARCH

Apoptotic Mechanisms After Cerebral Ischemia

(2009) Brad R.S. Broughton et al.   STROKE

The role of osteopontin in inflammatory processes

(2009) Susan Amanda Lund et al.   Journal of Cell Communication and Signaling

Post-translational modification and proteolytic processing of urinary osteopontin

(2008) Brian Christensen et al.   BIOCHEMICAL JOURNAL

Differential regulation of osteopontin receptors, CD44 and the α v and β 3 integrin subunits, in the rat hippocampus following transient forebrain ischemia

(2008) Wha-Sun Kang et al.   BRAIN RESEARCH

In vivo osteopontin-induced macrophage accumulation is dependent on CD44 expression

(2008) Maria Cecilia G. Marcondes et al.   CELLULAR IMMUNOLOGY

Osteopontin: Role in immune regulation and stress responses

(2008) Kathryn X. Wang et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Angiopoietin-1 Prevents VEGF-Induced Endothelial Permeability by Sequestering Src through mDia

(2008) Julie Gavard et al.   DEVELOPMENTAL CELL

Tissue Inhibitor of Metalloproteinases Protect Blood—Brain Barrier Disruption in Focal Cerebral Ischemia

(2008) Motoaki Fujimoto et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Nasal Administration of Osteopontin Peptide Mimetics Confers Neuroprotection in Stroke

(2008) Kristian P Doyle et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tight Junction Regulation by Morphine and HIV-1 Tat Modulates Blood–Brain Barrier Permeability

(2008) Supriya D. Mahajan et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The relationship between serum levels of vascular calcification inhibitors and carotid plaque vulnerability

(2008) Nikolaos P.E. Kadoglou et al.   JOURNAL OF VASCULAR SURGERY

The expression of osteopontin is increased in vessels with blood–brain barrier impairment

(2007) Y. Iwanaga et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY