Repurposing of FDA-approved antivirals, antibiotics, anthelmintics, antioxidants, and cell protectives against SARS-CoV-2 papain-like protease

Three Emerging Coronaviruses in Two Decades

(2020) Jeannette Guarner   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Small Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Fusion by Targeting Cavities on Heptad Repeat Trimers

(2020) Mahmoud Kandeel et al.   Biomolecules & Therapeutics

Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2

(2020) Zhixin Liu et al.   JOURNAL OF MEDICAL VIROLOGY

From SARS and MERS CoVs to SARS‐CoV‐2: Moving toward more biased codon usage in viral structural and nonstructural genes

(2020) Mahmoud Kandeel et al.   JOURNAL OF MEDICAL VIROLOGY

Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease

(2020) Mahmoud Kandeel et al.   LIFE SCIENCES

Oseltamivir-zanamivir combination therapy suppresses drug-resistant H1N1 influenza A viruses in the hollow fiber infection model (HFIM) system

(2018) Camilly P. Pires de Mello et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Effects of moroxydine hydrochloride and ribavirin on the cellular growth and immune responses by inhibition of GCRV proliferation

(2018) Xiao-Bo Yu et al.   RESEARCH IN VETERINARY SCIENCE

Molecular dynamics and inhibition of MERS CoV papain-like protease by small molecule imidazole and aminopurine derivatives

(2018) Mahmoud Kandeel et al.   Letters in Drug Design & Discovery

Multivalent zanamivir-bovine serum albumin conjugate as a potent influenza neuraminidase inhibitor

(2017) Teng-Fei Zhao et al.   JOURNAL OF CARBOHYDRATE CHEMISTRY

Moroxydine hydrochloride inhibits grass carp reovirus replication and suppresses apoptosis in Ctenopharyngodon idella kidney cells

(2016) Xiao-Bo Yu et al.   ANTIVIRAL RESEARCH

Role of Molecular Dynamics and Related Methods in Drug Discovery

(2016) Marco De Vivo et al.   JOURNAL OF MEDICINAL CHEMISTRY

The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds

(2015) Yahira M. Báez-Santos et al.   ANTIVIRAL RESEARCH

Rethinking the old antiviral drug moroxydine: Discovery of novel analogues as anti-hepatitis C virus (HCV) agents

(2015) Andrea Magri et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

Epitope-Based Vaccine Target Screening against Highly Pathogenic MERS-CoV: An In Silico Approach Applied to Emerging Infectious Diseases

(2015) Jiandong Shi et al.   PLoS One

Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features

(2014) Jian Lei et al.   ANTIVIRAL RESEARCH

Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression

(2014) Ben A. Bailey-Elkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Catalytic Function and Substrate Specificity of the Papain-Like Protease Domain of nsp3 from the Middle East Respiratory Syndrome Coronavirus

(2014) Y. M. Baez-Santos et al.   JOURNAL OF VIROLOGY

Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease

(2013) X. Yang et al.   JOURNAL OF GENERAL VIROLOGY

MERS-CoV papain-like protease has deISGylating and deubiquitinating activities

(2013) Anna M. Mielech et al.   VIROLOGY

Lopinavir/Ritonavir

(2010) Jamie D. Croxtall et al.   DRUGS