Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels

Interleukin-18 in Health and Disease

(2019) Koubun Yasuda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade

(2018) Mingxia Zhao et al.   Acta Pharmaceutica Sinica B

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1β

(2017) Qifan Zhu et al.   JOURNAL OF IMMUNOLOGY

Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis

(2017) Wenjie Guo et al.   Nature Communications

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome

(2016) Andrew J. Murphy et al.   Cell Metabolism

Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2016) Herbert Tilg et al.   HEPATOLOGY

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

(2016) Jorge Garcia Fortanet et al.   JOURNAL OF MEDICINAL CHEMISTRY

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

(2016) Ying-Nan P. Chen et al.   NATURE

Monounsaturated Fatty Acid–Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome–Mediated IL-1β Secretion and Insulin Resistance Despite Obesity

(2015) Orla M. Finucane et al.   DIABETES

Shp2 signaling in POMC neurons is important for leptin's actions on blood pressure, energy balance, and glucose regulation

(2014) Jussara M. do Carmo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Interleukin 18 accelerates the hepatic cell proliferation in rat liver regeneration after partial hepatectomy

(2014) Jihong Zhang et al.   GENE

LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity

(2014) Mylène Tajan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-18 null mutation increases weight and food intake and reduces energy expenditure and lipid substrate utilization in high-fat diet fed mice

(2013) Eric P. Zorrilla et al.   BRAIN BEHAVIOR AND IMMUNITY

Interleukin-18 Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice

(2013) Birgitte Lindegaard et al.   DIABETES

Hepatic Src Homology Phosphatase 2 Regulates Energy Balance in Mice

(2012) Naoto Nagata et al.   ENDOCRINOLOGY

Inflammation links excess fat to insulin resistance: the role of the interleukin-1 family

(2012) Cees J. Tack et al.   IMMUNOLOGICAL REVIEWS

Shp2 Controls Female Body Weight and Energy Balance by Integrating Leptin and Estrogen Signals

(2012) Z. He et al.   MOLECULAR AND CELLULAR BIOLOGY

NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8+ T cells

(2012) Andreas Kupz et al.   NATURE IMMUNOLOGY

Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice

(2011) Vinay Bhaskar et al.   ATHEROSCLEROSIS

Adipose-specific deletion of Src homology phosphatase 2 does not significantly alter systemic glucose homeostasis

(2011) Ahmed Bettaieb et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Injection-site reactions upon Kineret (anakinra) administration: experiences and explanations

(2011) Christina Kaiser et al.   RHEUMATOLOGY INTERNATIONAL

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Altered Glucose Homeostasis in Mice with Liver-specific Deletion of Src Homology Phosphatase 2

(2010) Kosuke Matsuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

IL-1 pathways in inflammation and human diseases

(2010) Cem Gabay et al.   Nature Reviews Rheumatology

Interleukin-1 beta targeted therapy for type 2 diabetes

(2009) Kathrin Maedler et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Deletion of Shp2 Tyrosine Phosphatase in Muscle Leads to Dilated Cardiomyopathy, Insulin Resistance, and Premature Death

(2008) F. Princen et al.   MOLECULAR AND CELLULAR BIOLOGY

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking

(2008) K. Hellmuth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA