Air Pollution Neurotoxicity in the Adult Brain: Emerging Concepts from Experimental Findings

Long-term exposure to ambient air pollution, APOE-ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan

(2020) Erin R. Kulick et al.   ENVIRONMENT INTERNATIONAL

Toxicity of urban air pollution particulate matter in developing and adult mouse brain: Comparison of total and filter-eluted nanoparticles

(2020) Amin Haghani et al.   ENVIRONMENT INTERNATIONAL

Reduced repressive epigenetic marks, increased DNA damage and Alzheimer's disease hallmarks in the brain of humans and mice exposed to particulate urban air pollution

(2020) Lilian Calderón-Garcidueñas et al.   ENVIRONMENTAL RESEARCH

Alzheimer disease starts in childhood in polluted Metropolitan Mexico City. A major health crisis in progress

(2020) Lilian Calderón-Garcidueñas et al.   ENVIRONMENTAL RESEARCH

Air pollution alters Caenorhabditis elegans development and lifespan: responses to traffic-related nanoparticulate matter (nPM)

(2019) Amin Haghani et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

PM2.5 exposure induces systemic inflammation and oxidative stress in an intracranial atherosclerosis rat model

(2019) Longfei Guan et al.   ENVIRONMENTAL TOXICOLOGY

Epigenetic marks of prenatal air pollution exposure found in multiple tissues relevant for child health

(2019) Christine Ladd-Acosta et al.   ENVIRONMENT INTERNATIONAL

Multiple organ injury in male C57BL/6J mice exposed to ambient particulate matter in a real-ambient PM exposure system in Shijiazhuang, China

(2019) Daochuan Li et al.   ENVIRONMENTAL POLLUTION

Cyclic O3 exposure synergizes with aging leading to memory impairment in male APOEε3, but not APOEε4, targeted replacement mice

(2019) Chunsun Jiang et al.   NEUROBIOLOGY OF AGING

Air Pollution, Stress, and Allostatic Load: Linking Systemic and Central Nervous System Impacts

(2019) Errol M. Thomson   JOURNAL OF ALZHEIMERS DISEASE

Cortisol, Amyloid-β, and Reserve Predicts Alzheimer’s Disease Progression for Cognitively Normal Older Adults

(2019) Chinedu T. Udeh-Momoh et al.   JOURNAL OF ALZHEIMERS DISEASE

Machine Learning-Based Integration of High-Resolution Wildfire Smoke Simulations and Observations for Regional Health Impact Assessment

(2019) Yufei Zou et al.   International Journal of Environmental Research and Public Health

Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure

(2019) Xiaobo Li et al.   Advanced Science

Evaluation of the Nose-to-Brain Transport of Different Physicochemical Forms of Uranium after Exposure via Inhalation of a UO4 Aerosol in the Rat

(2019) Chrystelle Ibanez et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Combustion and friction-derived nanoparticles and industrial-sourced nanoparticles: The culprit of Alzheimer and Parkinson's diseases.

(2019) Lilian Calderón-Garcidueñas et al.   ENVIRONMENTAL RESEARCH

Source-Apportioned PM2.5 and Cardiorespiratory Emergency Department Visits

(2019) Audrey Flak Pennington et al.   EPIDEMIOLOGY

The effects of nano-sized PbO on biomarkers of membrane disruption and DNA damage in a sub-chronic inhalation study on mice

(2019) Lucie Bláhová et al.   Nanotoxicology

Global mortality associated with seasonal influenza epidemics: New burden estimates and predictors from the GLaMOR Project

(2019) John Paget et al.   Journal of Global Health

Gallic acid affects blood-brain barrier permeability, behaviors, hippocampus local EEG, and brain oxidative stress in ischemic rats exposed to dusty particulate matter

(2019) Hamzeh Mirshekari Jahangiri et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Traffic-related air pollutants (TRAP-PM) promote neuronal amyloidogenesis through oxidative damage to lipid rafts

(2019) Mafalda Cacciottolo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cell-based assays that predict in vivo neurotoxicity of urban ambient nano-sized particulate matter

(2019) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Bioenergetics in Brain Following Ozone Exposure in Rats Maintained on Coconut, Fish and Olive Oil-Rich Diets

(2019) Matthew C. Valdez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exposure to ambient dusty particulate matter impairs spatial memory and hippocampal LTP by increasing brain inflammation and oxidative stress in rats

(2019) Somayeh Hajipour et al.   LIFE SCIENCES

Associations between long-term exposure to ambient air pollution and Parkinson's disease prevalence: A cross-sectional study

(2019) Farhad Salimi et al.   NEUROCHEMISTRY INTERNATIONAL

Short review: Air pollution, noise and lack of greenness as risk factors for Alzheimer's disease- epidemiologic and experimental evidence

(2019) Anna Oudin   NEUROCHEMISTRY INTERNATIONAL

Effect of Surface Chemistry and Associated Protein Corona on the Long-Term Biodegradation of Iron Oxide Nanoparticles In Vivo

(2018) Grazyna Stepien et al.   ACS Applied Materials & Interfaces

Acute exposure to diesel exhaust impairs adult neurogenesis in mice: prominence in males and protective effect of pioglitazone

(2018) Jacki L. Coburn et al.   ARCHIVES OF TOXICOLOGY

Alzheimer's disease and alpha-synuclein pathology in the olfactory bulbs of infants, children, teens and adults ≤ 40 years in Metropolitan Mexico City. APOE4 carriers at higher risk of suicide accelerate their olfactory bulb pathology

(2018) Lilian Calderón-Garcidueñas et al.   ENVIRONMENTAL RESEARCH

Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic-derived nanoparticles (‘vehicular smog’)

(2018) Laura C.D. Pomatto et al.   FREE RADICAL BIOLOGY AND MEDICINE

A critical review of assays for hazardous components of air pollution

(2018) Henry Jay Forman et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Lancet Commission on pollution and health

(2018) Philip J Landrigan et al.   LANCET

Impact of acute and subchronic inhalation exposure to PbO nanoparticles on mice

(2018) J. Lebedová et al.   Nanotoxicology

Stress induced neural reorganization: A conceptual framework linking depression and Alzheimer's disease

(2018) Jennifer A. Ross et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Wildland fire smoke and human health

(2018) Wayne E. Cascio   SCIENCE OF THE TOTAL ENVIRONMENT

Aging Exacerbates Neuroinflammatory Outcomes Induced by Acute Ozone Exposure

(2018) Christina R Tyler et al.   TOXICOLOGICAL SCIENCES

Central IKK2 Inhibition Ameliorates Air Pollution-Mediated Hepatic Glucose and Lipid Metabolism Dysfunction in Mice With Type II Diabetes

(2018) Qing Sun et al.   TOXICOLOGICAL SCIENCES

Adrenergic and glucocorticoid receptor antagonists reduce ozone-induced lung injury and inflammation

(2018) Andres R. Henriquez et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Global estimates of mortality associated with long-term exposure to outdoor fine particulate matter

(2018) Richard Burnett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exposure to nanoscale diesel exhaust particles: Oxidative stress, neuroinflammation, anxiety and depression on adult male mice

(2018) Mojtaba Ehsanifar et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Prolonged PM2.5 exposure elevates risk of oxidative stress-driven nonalcoholic fatty liver disease by triggering increase of dyslipidemia

(2018) Min-Xuan Xu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic pulmonary exposure to traffic-related fine particulate matter causes brain impairment in adult rats

(2018) Chi-Hsiang Shih et al.   Particle and Fibre Toxicology

Association between ambient air pollution and daily hospital admissions for ischemic stroke: A nationwide time-series analysis

(2018) Yaohua Tian et al.   PLOS MEDICINE

PM 2.5 -bound metal metabolic distribution and coupled lipid abnormality at different developmental windows

(2017) Tingting Ku et al.   ENVIRONMENTAL POLLUTION

Interactions between cigarette smoking and ambient PM 2.5 for cardiovascular mortality

(2017) Michelle C. Turner et al.   ENVIRONMENTAL RESEARCH

Neurotoxic effects of subchronic intratracheal Mn nanoparticle exposure alone and in combination with other welding fume metals in rats

(2017) Zsuzsanna Máté et al.   INHALATION TOXICOLOGY

Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo

(2017) Nicholas C. Woodward et al.   Journal of Neuroinflammation

Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015

(2017) Aaron J Cohen et al.   LANCET

Smoking prevalence and attributable disease burden in 195 countries and territories, 1990–2015: a systematic analysis from the Global Burden of Disease Study 2015

(2017) Marissa B Reitsma et al.   LANCET

Traffic-related air pollution impact on mouse brain accelerates myelin and neuritic aging changes with specificity for CA1 neurons

(2017) Nicholas C. Woodward et al.   NEUROBIOLOGY OF AGING

PM2.5 Exposure Suppresses Dendritic Maturation in Subgranular Zone in Aged Rats

(2017) Lewis Cheng et al.   NEUROTOXICITY RESEARCH

Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer’s disease

(2017) Maja Hullmann et al.   Particle and Fibre Toxicology

B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial

(2017) Jia Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repeated Iron–Soot Exposure and Nose-to-brain Transport of Inhaled Ultrafine Particles

(2017) Laurie E. Hopkins et al.   TOXICOLOGIC PATHOLOGY

Comparison of in vitro toxicological effects of biomass smoke from different sources of animal dung

(2017) Claire E. McCarthy et al.   TOXICOLOGY IN VITRO

PM2.5 inhalation induces intracranial atherosclerosis which may be ameliorated by omega 3 fatty acids

(2017) Longfei Guan et al.   Oncotarget

At seeming safe concentrations, synergistic effects of PM2.5 and formaldehyde co-exposure induces Alzheimer-like changes in mouse brain

(2017) Xudong Liu et al.   Oncotarget

Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models

(2017) M Cacciottolo et al.   Translational Psychiatry

NO 2 inhalation causes tauopathy by disturbing the insulin signaling pathway

(2016) Wei Yan et al.   CHEMOSPHERE

Nanoscale Particulate Matter from Urban Traffic Rapidly Induces Oxidative Stress and Inflammation in Olfactory Epithelium with Concomitant Effects on Brain

(2016) Hank Cheng et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Properties and cellular effects of particulate matter from direct emissions and ambient sources

(2016) Wenjie Jin et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING

Urban traffic-derived nanoparticulate matter reduces neurite outgrowth via TNFα in vitro

(2016) Hank Cheng et al.   Journal of Neuroinflammation

Contrasting biological potency of particulate matter collected at sites impacted by distinct industrial sources

(2016) Errol M. Thomson et al.   Particle and Fibre Toxicology

Stroke Damage Is Exacerbated by Nano-Size Particulate Matter in a Mouse Model

(2016) Qinghai Liu et al.   PLoS One

Ozone Inhalation Provokes Glucocorticoid-Dependent and -Independent Effects on Inflammatory and Metabolic Pathways

(2016) Errol M. Thomson et al.   TOXICOLOGICAL SCIENCES

Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain

(2016) Toby B. Cole et al.   TOXICOLOGY

Mexico City normal weight children exposed to high concentrations of ambient PM2.5 show high blood leptin and endothelin-1, vitamin D deficiency, and food reward hormone dysregulation versus low pollution controls. Relevance for obesity and Alzheimer disease

(2015) Lilian Calderón-Garcidueñas et al.   ENVIRONMENTAL RESEARCH

The contribution of outdoor air pollution sources to premature mortality on a global scale

(2015) J. Lelieveld et al.   NATURE

Cyclic Ozone Exposure Induces Gender-Dependent Neuropathology and Memory Decline in an Animal Model of Alzheimer’s Disease

(2015) Hasina Akhter et al.   TOXICOLOGICAL SCIENCES

Fine Particulate Matter Air Pollution and Cognitive Function Among Older US Adults

(2014) J. A. Ailshire et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Interactions Between Cigarette Smoking and Fine Particulate Matter in the Risk of Lung Cancer Mortality in Cancer Prevention Study II

(2014) Michelle C. Turner et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Parental smoking and childhood obesity: higher effect estimates for maternal smoking in pregnancy compared with paternal smoking--a meta-analysis

(2014) C. Riedel et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes

(2014) Cuiqing Liu et al.   Particle and Fibre Toxicology

Effects of Diesel Engine Exhaust Origin Secondary Organic Aerosols on Novel Object Recognition Ability and Maternal Behavior in BALB/C Mice

(2014) Tin-Tin Win-Shwe et al.   International Journal of Environmental Research and Public Health

Gene expression changes in rat brain after short and long exposures to particulate matter in Los Angeles basin air: Comparison with human brain tumors

(2013) Julia Y. Ljubimova et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Measurement Techniques for Respiratory Tract Deposition of Airborne Nanoparticles: A Critical Review

(2013) Jakob Löndahl et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Effect of lead sulfide nanoparticles exposure on calcium homeostasis in rat hippocampus neurons

(2013) Yanhua Cao et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Ambient ultrafine particles alter lipid metabolism and HDL anti-oxidant capacity in LDLR-null mice

(2013) Rongsong Li et al.   JOURNAL OF LIPID RESEARCH

The menopause and aging, a comparative perspective

(2013) Caleb E. Finch   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Intranasal exposure to uranium results in direct transfer to the brain along olfactory nerve bundles

(2013) Chrystelle Ibanez et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Milano Summer Particulate Matter (PM10) Triggers Lung Inflammation and Extra Pulmonary Adverse Events in Mice

(2013) Francesca Farina et al.   PLoS One

Ozone induces glucose intolerance and systemic metabolic effects in young and aged brown Norway rats

(2013) V. Bass et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments

(2012) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Combustion smoke-induced inflammation in the cerebellum and hippocampus of adult rats

(2012) Y-Y. Zou et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Differential effects of inhalation exposure to PM2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats

(2012) Priya Balasubramanian et al.   NEUROTOXICOLOGY

Glutamatergic Neurons in Rodent Models Respond to Nanoscale Particulate Urban Air Pollutants in Vivo and in Vitro

(2011) Todd E. Morgan et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Nervous system effects in rats on subacute exposure by lead-containing nanoparticles via the airways

(2011) Gábor Oszlánczi et al.   INHALATION TOXICOLOGY

Ozone inhalation activates stress-responsive regions of the CNS

(2011) Florian Gackière et al.   JOURNAL OF NEUROCHEMISTRY

Prolonged ozone exposure effects behaviour, hormones and respiratory muscles in young female rats

(2011) J.M. Martrette et al.   PHYSIOLOGY & BEHAVIOR

SO2 Inhalation Contributes to the Development and Progression of Ischemic Stroke in the Brain

(2010) Nan Sang et al.   TOXICOLOGICAL SCIENCES

Oxidative stress in the brain of mice caused by translocated nanoparticulate TiO2 delivered to the abdominal cavity

(2009) Linglan Ma et al.   BIOMATERIALS

Evaluation of In vitro Assays for Assessing the Toxicity of Cigarette Smoke and Smokeless Tobacco

(2009) M. D. Johnson et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Subacute intratracheal exposure of rats to manganese nanoparticles: Behavioral, electrophysiological, and general toxicological effects

(2009) Leila Sárközi et al.   INHALATION TOXICOLOGY

Oxidative Stress Caused by Ozone Exposure Induces Loss of Brain Repair in the Hippocampus of Adult Rats

(2009) Selva Rivas-Arancibia et al.   TOXICOLOGICAL SCIENCES

Role of the olfactory receptor neurons in the direct transport of inhaled uranium to the rat brain

(2009) Benjamin B. Tournier et al.   TOXICOLOGY LETTERS

Sub-acute administration of benzo[a]pyrene (B[a]P) reduces anxiety-related behaviour in adult mice and modulates regional expression of N-methyl-d-aspartate (NMDA) receptors genes in relevant brain regions

(2008) Nathalie Grova et al.   CHEMOSPHERE

Lipids and lifespans: Constants and contradictions

(2008) Caleb E. Finch   EXPERIMENTAL GERONTOLOGY

Effects of Metals within Ambient Air Particulate Matter (PM) on Human Health

(2008) Lung Chi Chen et al.   INHALATION TOXICOLOGY