Cytotoxic Effect of Vanicosides A and B from Reynoutria sachalinensis against Melanotic and Amelanotic Melanoma Cell Lines and in silico Evaluation for Inhibition of BRAFV600E and MEK1

Natural Polyphenols Targeting Senescence: A Novel Prevention and Therapy Strategy for Cancer

(2020) Yan Bian et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

3PO as a Selective Inhibitor of 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 in A375 Human Melanoma Cells

(2020) KRZYSZTOF KOTOWSKI et al.   ANTICANCER RESEARCH

Interstitial Leydig Cell Tumorigenesis—Leptin and Adiponectin Signaling in Relation to Aromatase Expression in the Human Testis

(2020) Michal Duliban et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phytochemicals modulate cancer aggressiveness: A review depicting the anticancer efficacy of dietary polyphenols and their combinations

(2020) Tulika Mitra et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Phytochemical Diversity in Rhizomes of Three Reynoutria Species and their Antioxidant Activity Correlations Elucidated by LC-ESI-MS/MS Analysis.

(2019) Izabela Nawrot-Hadzik et al.   MOLECULES

Amelanotic melanoma

(2019) Hui-Zi Gong et al.   MELANOMA RESEARCH

Chemical Composition of East Asian Invasive Knotweeds, their Cytotoxicity and Antimicrobial Efficacy Against Cariogenic Pathogens: An In-Vitro Study

(2019) Izabela Nawrot-Hadzik et al.   MEDICAL SCIENCE MONITOR

Diverse Mechanisms of BRAF Inhibitor Resistance in Melanoma Identified in Clinical and Preclinical Studies

(2019) Stephen A. Luebker et al.   Frontiers in Oncology

Searching New Structural Scaffolds for BRAF Inhibitors. An Integrative Study using theoretical and experimental techniques

(2019) Ludmila E. Campos et al.   BIOORGANIC CHEMISTRY

Antitumor Activity of Vanicoside B Isolated from Persicaria dissitiflora by Targeting CDK8 in Triple-Negative Breast Cancer Cells

(2019) Donghwa Kim et al.   JOURNAL OF NATURAL PRODUCTS

Mechanisms of antimelanoma effect of oat β-glucan supported by electroporation

(2018) Anna Choromanska et al.   BIOELECTROCHEMISTRY

Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery

(2018) Nicholas Thomford et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Isolation and Determination of Phenolic Glycosides and Anthraquinones from Rhizomes of Various Reynoutria Species

(2018) Izabela Nawrot-Hadzik et al.   PLANTA MEDICA

A real-time, bioluminescent annexin V assay for the assessment of apoptosis

(2018) Kevin Kupcho et al.   APOPTOSIS

Dimeric cinnamoylamide analogues for regulation of tyrosinase activity in melanoma cells: A role of diamide-link chain length

(2018) Ji hoon Ha et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A new sucrosephenylpropanoid ester from Polygonum pubescens Blume

(2017) Qiang Liu et al.   NATURAL PRODUCT RESEARCH

Targeted agents and immunotherapies: optimizing outcomes in melanoma

(2017) Jason J. Luke et al.   Nature Reviews Clinical Oncology

Metabolic strategies of melanoma cells: Mechanisms, interactions with the tumor microenvironment, and therapeutic implications

(2017) Grant M. Fischer et al.   Pigment Cell & Melanoma Research

Insights into the binding mode of MEK type-III inhibitors. A step towards discovering and designing allosteric kinase inhibitors across the human kinome

(2017) Zheng Zhao et al.   PLoS One

Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity

(2017) Anna Lewinska et al.   TOXICOLOGY LETTERS

Polyphenol compounds and PKC signaling

(2016) Joydip Das et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

BRAF-V600E expression in primary nodular melanoma is associated with aggressive tumour features and reduced survival

(2016) Emilia Hugdahl et al.   BRITISH JOURNAL OF CANCER

Allosteric modulators of MEK1: drug design and discovery

(2016) Jialin Shang et al.   Chemical Biology & Drug Design

Naturally Occurring Cinnamic Acid Sugar Ester Derivatives

(2016) Yuxin Tian et al.   MOLECULES

Identification of a novel compound that inhibits both mitochondria-mediated necrosis and apoptosis

(2015) Satoko Arakawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An Update on Oligosaccharides and Their Esters from Traditional Chinese Medicines: Chemical Structures and Biological Activities

(2015) Xiang-Yang Chen et al.   Evidence-based Complementary and Alternative Medicine

Pathways and therapeutic targets in melanoma

(2015) Emma Shtivelman et al.   Oncotarget

Inhibition of mTORC1/2 Overcomes Resistance to MAPK Pathway Inhibitors Mediated by PGC1  and Oxidative Phosphorylation in Melanoma

(2014) Y. N. V. Gopal et al.   CANCER RESEARCH

Fibroblast sources: Where can we get them?

(2014) I. R. Fernandes et al.   CYTOTECHNOLOGY

A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors

(2014) D. J. Konieczkowski et al.   Cancer Discovery

Novel antioxidants are not toxic to normal tissues but effectively kill cancer cells

(2013) Anna Kovalchuk et al.   CANCER BIOLOGY & THERAPY

Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting

(2012) Christoph Meier et al.   JOURNAL OF STRUCTURAL BIOLOGY

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

(2010) Gideon Bollag et al.   NATURE

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

(2008) J. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA