SIRT7 Deacetylates STRAP to Regulate p53 Activity and Stability

SIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle

(2020) Ya-Fei Lu et al.   ONCOGENE

Flagella-Associated WDR-Containing Protein CrFAP89 Regulates Growth and Lipid Accumulation in Chlamydomonas reinhardtii

(2018) Qiulan Luo et al.   Frontiers in Plant Science

MicroRNA-148b-3p is involved in regulating hypoxia/reoxygenation-induced injury of cardiomyocytes in vitro through modulating SIRT7/p53 signaling

(2018) Meng Sun et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Sirtuin 7–mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity

(2018) Hao Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Downregulation of STRAP promotes tumor growth and metastasis in hepatocellular carcinoma via reducing PTEN level

(2017) Qiong Wu et al.   IUBMB LIFE

Sirtuin7 is involved in protecting neurons against oxygen-glucose deprivation and reoxygenation-induced injury through regulation of the p53 signaling pathway

(2017) Jianrui Lv et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis

(2017) Xiaolong Tang et al.   Nature Communications

Downregulation of SIRT7 by 5-fluorouracil induces radiosensitivity in human colorectal cancer

(2017) Ming Tang et al.   Theranostics

Regulation of Serine-Threonine Kinase Akt Activation by NAD + -Dependent Deacetylase SIRT7

(2017) Jia Yu et al.   Cell Reports

SIRT7 promotes genome integrity and modulates non‐homologous end joining DNA repair

(2016) Berta N Vazquez et al.   EMBO JOURNAL

Sirtuin 7 promotes cellular survival following genomic stress by attenuation of DNA damage, SAPK activation and p53 response

(2015) Shashi Kiran et al.   EXPERIMENTAL CELL RESEARCH

Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents

(2015) Pei-Ying Zhang et al.   NUCLEIC ACIDS RESEARCH

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

(2015) M. Mohrin et al.   SCIENCE

A crucial role for the phosphorylation of STRAP at Ser188by MPK38 in STRAP-dependent cell death through ASK1, TGF-β, p53, and PI3K/PDK1 signaling pathways

(2014) Hyun-A Seong et al.   CELL CYCLE

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

(2014) Dongryeol Ryu et al.   Cell Metabolism

Repression of RNA Polymerase I upon Stress Is Caused by Inhibition of RNA-Dependent Deacetylation of PAF53 by SIRT7

(2013) Sifan Chen et al.   MOLECULAR CELL

SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

(2013) Jiyung Shin et al.   Cell Reports

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

(2012) Matthew F. Barber et al.   NATURE

Role of STRAP in regulating GSK3β function and Notch3 stabilization

(2011) Nilesh D. Kashikar et al.   CELL CYCLE

B-MYB Positively Regulates Serine-Threonine Kinase Receptor-associated Protein (STRAP) Activity through Direct Interaction

(2010) Hyun-A Seong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serine Threonine Receptor-Associated Protein (STRAP) plays a role in the maintenance of mesenchymal morphology

(2009) Nilesh D. Kashikar et al.   CELLULAR SIGNALLING

Serine-Threonine Kinase Receptor-associated Protein Inhibits Apoptosis Signal-regulating Kinase 1 Function through Direct Interaction

(2009) Haiyoung Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs

(2009) S. Kosugi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH