Detection of a G-Quadruplex as a Regulatory Element in Thymidylate synthase for Gene Silencing Using Polypurine Reverse Hoogsteen Hairpins

Targeting replication stress response using polypurine reverse hoogsteen hairpins directed against WEE1 and CHK1 genes in human cancer cells

(2020) Eva Aubets et al.   BIOCHEMICAL PHARMACOLOGY

Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy

(2019) Sefan Asamitsu et al.   MOLECULES

Silencing PD-1 and PD-L1: the potential of PolyPurine Reverse Hoogsteen hairpins for the elimination of tumor cells

(2019) Carlos J Ciudad et al.   Immunotherapy

First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematological Cancers: Results of a Phase I Dose Escalation Study

(2019) Amit Khot et al.   Cancer Discovery

Functional pharmacogenomics and toxicity of PolyPurine Reverse Hoogsteen hairpins directed against survivin in human cells

(2018) Alex J. Félix et al.   BIOCHEMICAL PHARMACOLOGY

APTO-253 Stabilizes G-quadruplex DNA, Inhibits MYC Expression, and Induces DNA Damage in Acute Myeloid Leukemia Cells

(2018) Andrea Local et al.   MOLECULAR CANCER THERAPEUTICS

Natural Alkaloids and Heterocycles as G-Quadruplex Ligands and Potential Anticancer Agents

(2018) et al.   MOLECULES

G-Quadruplex: A Regulator of Gene Expression and Its Chemical Targeting

(2018) Tian Tian et al.   Chem

Discovery of Small Molecules for Repressing Cap-Independent Translation of Human Vascular Endothelial Growth Factor (hVEGF) as Novel Antitumor Agents

(2017) Shi-Ke Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential

(2017) Robert Hänsel-Hertsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

(2017) Hong Xu et al.   Nature Communications

Polypurine reverse-Hoogsteen (PPRH) oligonucleotides can form triplexes with their target sequences even under conditions where they fold into G-quadruplexes

(2017) Anna Solé et al.   Scientific Reports

Silencing of CD47 and SIRPα by Polypurine reverse Hoogsteen hairpins to promote MCF-7 breast cancer cells death by PMA-differentiated THP-1 cells

(2016) Gizem Bener et al.   BMC IMMUNOLOGY

High-throughput sequencing of DNA G-quadruplex structures in the human genome

(2015) Vicki S Chambers et al.   NATURE BIOTECHNOLOGY

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Effect of Polypurine Reverse Hoogsteen Hairpins on Relevant Cancer Target Genes in Different Human Cell Lines

(2015) Xenia Villalobos et al.   Nucleic Acid Therapeutics

Analysis of mRNA recognition by human thymidylate synthase

(2014) Nicholas D. Brunn et al.   BIOSCIENCE REPORTS

HRASis silenced by two neighboring G-quadruplexes and activated by MAZ, a zinc-finger transcription factor with DNA unfolding property

(2014) Susanna Cogoi et al.   NUCLEIC ACIDS RESEARCH

Thioflavin T as a fluorescence light-up probe for G4 formation

(2014) Amandine Renaud de la Faverie et al.   NUCLEIC ACIDS RESEARCH

Polypurine reverse Hoogsteen hairpins as a gene therapy tool against survivin in human prostate cancer PC3 cells in vitro and in vivo

(2013) Laura Rodríguez et al.   BIOCHEMICAL PHARMACOLOGY

Mechanistic studies for the role of cellular nucleic-acid-binding protein (CNBP) in regulation of c-myc transcription

(2013) Siqi Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Stability and Immunogenicity Properties of the Gene-Silencing Polypurine Reverse Hoogsteen Hairpins

(2013) Xenia Villalobos et al.   MOLECULAR PHARMACEUTICS

Exploring mRNA 3′-UTR G-quadruplexes: evidence of roles in both alternative polyadenylation and mRNA shortening

(2013) Jean-Denis Beaudoin et al.   NUCLEIC ACIDS RESEARCH

Thioflavin T as an Efficient Inducer and Selective Fluorescent Sensor for the Human Telomeric G-Quadruplex DNA

(2012) Jyotirmayee Mohanty et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

5'-UTR RNA G-quadruplexes: translation regulation and targeting

(2012) A. Bugaut et al.   NUCLEIC ACIDS RESEARCH

Transcriptional Activation and Cell Cycle Block Are the Keys for 5-Fluorouracil Induced Up-Regulation of Human Thymidylate Synthase Expression

(2012) Alessio Ligabue et al.   PLoS One

Underexpression of miR-224 in methotrexate resistant human colon cancer cells

(2011) Núria Mencia et al.   BIOCHEMICAL PHARMACOLOGY

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Coding Polypurine Hairpins Cause Target-Induced Cell Death in Breast Cancer Cells

(2010) M. Cristina de Almagro et al.   HUMAN GENE THERAPY

Novel Approaches for Targeting Thymidylate Synthase To Overcome the Resistance and Toxicity of Anticancer Drugs

(2010) Divita Garg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

Polypurine Hairpins Directed against the Template Strand of DNA Knock Down the Expression of Mammalian Genes

(2009) M. Cristina de Almagro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies

(2008) Ning Zhang et al.   MOLECULES

Stability and kinetics of G-quadruplex structures

(2008) A. N. Lane et al.   NUCLEIC ACIDS RESEARCH