Interaction of Cu(i) with the Met-X3-Met motif of alpha-synuclein: binding ligands, affinity and structural features

Iron Redox Chemistry Promotes Antiparallel Oligomerization of α-Synuclein

(2018) Dinendra L. Abeyawardhane et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction

(2018) Janin Lautenschläger et al.   Nature Communications

Molecular Role of Ca2+ and Hard Divalent Metal Cations on Accelerated Fibrillation and Interfibrillar Aggregation of α-Synuclein

(2018) Jong Yoon Han et al.   Scientific Reports

Bioinorganic Chemistry of Parkinson’s Disease: Affinity and Structural Features of Cu(I) Binding to the Full-Length β-Synuclein Protein

(2017) Marco C. Miotto et al.   INORGANIC CHEMISTRY

Copper(I) Forms a Redox-Stable 1:2 Complex with α-Synuclein N-Terminal Peptide in a Membrane-Like Environment

(2016) Simone Dell’Acqua et al.   INORGANIC CHEMISTRY

Role of N-terminal methionine residues in the redox activity of copper bound to alpha-synuclein

(2016) Esaú E. Rodríguez et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity

(2016) Anna Villar-Piqué et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper Binding to the N-Terminally Acetylated, Naturally Occurring Form of Alpha-Synuclein Induces Local Helical Folding

(2015) Marco C. Miotto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Insights on the interaction of alpha-synuclein and metals in the pathophysiology of Parkinson's disease

(2015) Eleonora Carboni et al.   Metallomics

Metal Ions and Intrinsically Disordered Proteins and Peptides: From Cu/Zn Amyloid-β to General Principles

(2014) Peter Faller et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Revised Picture of the Cu(II)−α-Synuclein Complex: The Role of N-Terminal Acetylation

(2014) Gina M. Moriarty et al.   BIOCHEMISTRY

Site-Specific Copper-Catalyzed Oxidation of α-Synuclein: Tightening the Link between Metal Binding and Protein Oxidative Damage in Parkinson’s Disease

(2014) Marco C. Miotto et al.   INORGANIC CHEMISTRY

Bioinorganic chemistry of synucleinopathies: Deciphering the binding features of Met motifs and His-50 in AS–Cu(I) interactions

(2014) Marco C. Miotto et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Aging results in copper accumulations in glial fibrillary acidic protein-positive cells in the subventricular zone

(2013) Yulia Pushkar et al.   AGING CELL

Copper(I)-α-Synuclein Interaction: Structural Description of Two Independent and Competing Metal Binding Sites

(2013) Francesca Camponeschi et al.   INORGANIC CHEMISTRY

Role of Metal Ions in the Self-assembly of the Alzheimer’s Amyloid-β Peptide

(2013) Peter Faller et al.   INORGANIC CHEMISTRY

 -Synuclein in Parkinson's Disease

(2013) L. Stefanis   Cold Spring Harbor Perspectives in Medicine

Phosphorylation Variation during the Cell Cycle Scales with Structural Propensities of Proteins

(2013) Stefka Tyanova et al.   PLoS Computational Biology

Bioinorganic chemistry of copper coordination to alpha-synuclein: Relevance to Parkinson's disease

(2012) Andrés Binolfi et al.   COORDINATION CHEMISTRY REVIEWS

Characterization of Semisynthetic and NaturallyNα-Acetylated α-Synucleinin Vitroand in Intact Cells

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conversion of natively unstructured α-synuclein to its α-helical conformation significantly attenuates production of reactive oxygen species

(2012) Binbin Zhou et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Localization of copper and copper transporters in the human brain

(2012) Katherine M. Davies et al.   Metallomics

Misfolded proteins in Alzheimer's disease and type II diabetes

(2011) Alaina S. DeToma et al.   CHEMICAL SOCIETY REVIEWS

Metals in neurodegenerative disease

(2011) David R. Brown   Metallomics

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Mechanism of copper(II)-induced misfolding of Parkinson's disease protein

(2011) Frisco Rose et al.   Scientific Reports

Bioinorganic Chemistry of Parkinson’s Disease: Structural Determinants for the Copper-Mediated Amyloid Formation of Alpha-Synuclein

(2010) Andrés Binolfi et al.   INORGANIC CHEMISTRY

Copper binding regulates intracellular alpha-synuclein localisation, aggregation and toxicity

(2010) Xiaoyan Wang et al.   JOURNAL OF NEUROCHEMISTRY

Exploring the Structural Details of Cu(I) Binding to α-Synuclein by NMR Spectroscopy

(2010) Andres Binolfi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genome-wide association studies: the key to unlocking neurodegeneration?

(2010) Sonia Gandhi et al.   NATURE NEUROSCIENCE

Clinical utility of copper, ceruloplasmin, and metallothionein plasma determinations in human neurodegenerative patients and their first-degree relatives

(2009) Nathalie Arnal et al.   BRAIN RESEARCH

Risks of Copper and Iron Toxicity during Aging in Humans

(2009) George J. Brewer   CHEMICAL RESEARCH IN TOXICOLOGY

Unique copper-induced oligomers mediate alpha-synuclein toxicity

(2009) Josephine A. Wright et al.   FASEB JOURNAL

Metal Ion Physiopathology in Neurodegenerative Disorders

(2009) Silvia Bolognin et al.   NEUROMOLECULAR MEDICINE

Metals in Alzheimer's and Parkinson's Diseases

(2008) Kevin J Barnham et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Cu2+Binding Modes of Recombinant α-Synuclein − Insights from EPR Spectroscopy

(2008) Simon C. Drew et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-Specific Interactions of Cu(II) with α and β-Synuclein: Bridging the Molecular Gap between Metal Binding and Aggregation

(2008) Andrés Binolfi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper(II) Binding to α-Synuclein, the Parkinson’s Protein

(2008) Jennifer C. Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

(2008) Claire Henchcliffe et al.   Nature clinical practice. Neurology