Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer’s Disease Therapy

Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators

(2020) David Malinak et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Facts, Results, and Perspectives of the Current Alzheimer’s Disease Research

(2019) José Marco-Contelles   ACS Chemical Neuroscience

Chromenones as Multineurotargeting Inhibitors of Human Enzymes

(2019) Carina Lemke et al.   ACS Omega

Alzheimer’s Disease, the “One-Molecule, One-Target” Paradigm, and the Multitarget Directed Ligand Approach

(2018) María Jesús Oset-Gasque et al.   ACS Chemical Neuroscience

Contilisant, a Tetratarget Small Molecule for Alzheimer’s Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile

(2018) Óscar M. Bautista-Aguilera et al.   JOURNAL OF MEDICINAL CHEMISTRY

Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties

(2018) Pei Cai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification, Synthesis, and Control of Process-Related Impurities in the Antipsychotic Drug Substance Brexpiprazole

(2018) Rahul Tyagi et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Designing Irreversible Inhibitors-Worth the Effort?

(2015) Concepción González-Bello   ChemMedChem

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

(2014) Christiane Reitz et al.   BIOCHEMICAL PHARMACOLOGY

Alkynyl–coumarinyl ethers as MAO-B inhibitors

(2014) Matthias D. Mertens et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of a novel sigma-1 receptor antagonist based on 3,4-dihydro-2(1H)-quinolinone scaffold as a potential analgesic

(2014) Yu Lan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multifunctional compounds: Smart molecules for multifactorial diseases

(2014) Yogita Bansal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of monoamine oxidase by 3,4-dihydro-2(1H)-quinolinone derivatives

(2013) Letitia Meiring et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A remote-controlled adaptive medchem lab: an innovative approach to enable drug discovery in the 21st Century

(2013) Alexander G. Godfrey et al.   DRUG DISCOVERY TODAY

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Cholinesterase inhibitors and memantine for symptomatic treatment of dementia

(2012) J. Rodda et al.   BMJ-British Medical Journal

Chromone, a Privileged Scaffold for the Development of Monoamine Oxidase Inhibitors

(2011) Alexandra Gaspar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease

(2011) Rafael León et al.   MEDICINAL RESEARCH REVIEWS

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Chalcones: A Valid Scaffold for Monoamine Oxidases Inhibitors

(2009) Franco Chimenti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, physicochemical properties and antimicrobial evaluation of new (E)-chalcones

(2007) Z. Nowakowska et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY