Evolving concepts of pathogenesis of heparin‐induced thrombocytopenia: Diagnostic and therapeutic implications

Neutrophil Extracellular Traps in Arterial and Venous Thrombosis

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Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia

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Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway

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Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia

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Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity

(2017) Thi-Huong Nguyen et al.   Nature Communications

Atomic features of an autoantigen in heparin-induced thrombocytopenia (HIT)

(2016) Zheng Cai et al.   AUTOIMMUNITY REVIEWS

A Novel PF4-Dependent Platelet Activation Assay Identifies Patients Likely to Have Heparin-Induced Thrombocytopenia/Thrombosis

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Further insights into the anti-PF4/heparin IgM immune response

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Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia

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Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages

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Anti-platelet factor 4/heparin antibodies in patients with impaired graft function after liver transplantation

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Characterisation of the conformational changes in platelet factor 4 induced by polyanions: towards in vitro prediction of antigenicity

(2014) Sven Brandt et al.   THROMBOSIS AND HAEMOSTASIS

Critical role for mouse marginal zone B cells in PF4/heparin antibody production

(2013) Y. Zheng et al.   BLOOD

PF4/heparin-antibody complex induces monocyte tissue factor expression and release of tissue factor positive microparticles by activation of Fc RI

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Association of natural anti-platelet factor 4/heparin antibodies with periodontal disease

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Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia

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Heparin-induced thrombocytopenia: What clinicians need to know

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