Article
Medicine, General & Internal
Michael McGettrick, Alexander MacLellan, Paul McCaughey, Catherine Bagot, Melanie J. Brewis, Ninian N. Lang, M. K. Johnson, Alistair Colin Church
Summary: The study found an increased risk of pulmonary thromboembolism (PTE) in hospitalised patients with COVID-19 in both critical care and ward-based environments in Scotland. Increased right heart strain and requirement for critical care were associated with higher mortality risk.
Article
Immunology
Esther J. Nossent, Alex R. Schuurman, Tom D. Y. Reijnders, Anno Saris, Ilse Jongerius, Siebe G. Blok, Heder de Vries, JanWillem Duitman, Anton Vonk Noordegraaf, Lilian J. Meijboom, Rene Lutter, Leo Heunks, Harm Jan Bogaard, Tom van der Poll
Summary: This study evaluated the activation of host response pathways in the lung compartment of critically ill COVID-19 patients with persistent acute respiratory distress syndrome. The results showed strong local responses relating to coagulation, the complement system, cytokines, chemokines and growth factors in the bronchoalveolar compartment, with some biomarkers declining in levels at 3 to 4 weeks after mechanical ventilation initiation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Hanny Al-Samkari, Shruti Gupta, Rebecca Karp Leaf, Wei Wang, Rachel P. Rosovsky, Samantha K. Brenner, Salim S. Hayek, Hanna Berlin, Rajat Kapoor, Shahzad Shaefi, Michal L. Melamed, Anne Sutherland, Jared Radbel, Adam Green, Brian T. Garibaldi, Anand Srivastava, Amanda Leonberg-Yoo, Alexandre M. Shehata, Jennifer E. Flythe, Arash Rashidi, Nitender Goyal, Lili Chan, Kusum S. Mathews, S. Susan Hedayati, Rajany Dy, Stephanie M. Toth-Manikowski, Jingjing Zhang, Mary Mallappallil, Roberta E. Redfern, Amar D. Bansal, Samuel A. P. Short, Mark G. Vangel, Andrew J. Admon, Matthew W. Semler, Kenneth A. Bauer, Miguel A. Hernan, David E. Leaf
Summary: Among 3239 critically ill adults with COVID-19, 6.3% developed VTE and 2.8% experienced major bleeding. Early therapeutic anticoagulation did not impact survival in this cohort study.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Nouran Salem, Bassam Atallah, Wasim S. El Nekidy, Ziad G. Sadik, Woosup Michael Park, Jihad Mallat
Summary: In critically ill COVID-19 patients, a lower rate of hypercoagulable state was observed through thromboelastography study, and the hypercoagulable state was not associated with the occurrence of thrombotic events.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Medicine, Research & Experimental
Zili Zhang, Tao Wang, Fei Liu, Airu Zhu, Guoping Gu, Jieping Luo, Jingyi Xu, Jincun Zhao, Yiming Li, Yuanyuan Li, Xiaoqing Liu, Nanshan Zhong, Wenju Lu
Summary: This study conducted proteomic analyses of airway mucus from severe COVID-19 patients, revealing 92 differentially expressed proteins and 375 uniquely present proteins in COVID-19 patients. Enrichment analyses showed these proteins were associated with metabolic, complement and coagulation cascades, lysosome, cholesterol metabolism, amino acid degradation, amino acid metabolism, oxidative phosphorylation, phagosome, and cholesterol metabolism pathways.
Article
Medicine, General & Internal
Hernan Polo Friz, Elia Gelfi, Annalisa Orenti, Elena Motto, Laura Primitz, Tino Donzelli, Marcello Intotero, Paolo Scarpazza, Giuseppe Vighi, Claudio Cimminiello, Patrizia Boracchi
Summary: Among patients hospitalized for non-critical COVID-19 with clinical deterioration, there is a high prevalence of acute pulmonary embolism (APE). Traditional diagnostic tools may not be clinically useful for identifying high APE pre-test probability patients, suggesting a high index of suspicion for performing CTPA as the most appropriate diagnostic approach.
INTERNAL MEDICINE JOURNAL
(2021)
Article
Medicine, General & Internal
Santiago de Cossio, Diana Paredes-Ruiz, Covadonga Gomez-Cuervo, Jesus Gonzalez-Olmedo, Antonio Lalueza, Yolanda Revilla, Carlos Lumbreras, Carmen Diaz-Pedroche
Summary: The study found that COVID-19-associated PTE patients have different clinical characteristics compared to non-COVID-19 PTE patients, with milder symptoms and lower recurrence rate of venous thromboembolism.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
H. Carlo Maurer, David Schult, Plamena Koyumdzhieva, Sandra Reitmeier, Moritz Middelhoff, Sebastian Rasch, Markus List, Klaus-Peter Janssen, Katja Steiger, Ulrike Protzer, Roland M. Schmid, Klaus Neuhaus, Dirk Haller, Michael Quante, Tobias Lahmer
Summary: This study investigates the potential association between severe CAPA and alterations in the gut and bronchial microbial composition. The results suggest that COVID-19 patients with CAPA exhibit reduced gut microbial diversity and an increased abundance of Staphylococcus epidermidis in the gut, which may influence the host's immunological response. The analysis of bronchial samples did not yield significant results.
Article
Cardiac & Cardiovascular Systems
Agustin Clemente-Moragon, Juan Martinez-Milla, Eduardo Oliver, Arnoldo Santos, Javier Flandes, Iker Fernandez, Lorena Rodriguez-Gonzalez, Cristina Serrano del Castillo, Ana-Maria Ioan, Maria Lopez-Alvarez, Sandra Gomez-Talavera, Carlos Galan-Arriola, Valentin Fuster, Cesar Perez-Calvo, Borja Ibanez
Summary: In this study, metoprolol treatment in patients with COVID-19-associated ARDS was shown to be safe and effective in reducing lung inflammation and improving oxygenation, resulting in fewer days on invasive mechanical ventilation. Repurposing metoprolol for COVID-19-associated ARDS could be a cost-effective strategy to alleviate the burden of the pandemic.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Hematology
Dimitrios Giannis, Steven L. Allen, James Tsang, Sarah Flint, Tamir Pinhasov, Stephanie Williams, Gary Tan, Richa Thakur, Christian Leung, Matthew Snyder, Chirag Bhatia, David Garrett, Christina Cotte, Shelby Isaacs, Emma Gugerty, Anne Davidson, Galina S. Marder, Austin Schnitzer, Bradley Goldberg, Thomas McGinn, Karina W. Davidson, Matthew A. Barish, Michael Qiu, Meng Zhang, Mark Goldin, Miltiadis Matsagkas, Eleni Arnaoutoglou, Alex C. Spyropoulos
Summary: Thromboembolic events and mortality from subclinical thrombotic events frequently occur in COVID-19 inpatients. Postdischarge VTE, ATE, and ACM are common, with advanced age and cardiovascular risk factors increasing the risk. Postdischarge anticoagulation can significantly reduce the risk by 46%.
Article
Cardiac & Cardiovascular Systems
Vittorio Pavoni, Lara Gianesello, Andrew Horton
Summary: COVID-19 disease is associated with coagulation dysfunction, leading to an increased risk of arterial and venous thromboembolism, especially in critically ill patients. The mechanism of thrombosis in COVID-19 patients is complex and may be linked to the presence of antiphospholipid antibodies, but further research is needed to clarify their role.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Hematology
Jeeyune Bahk, Abdul Rehman, Kam Sing Ho, Bharat Narasimhan, Hafiza Noor Ul, Ain Baloch, Jiafang Zhang, Rowena Yip, Robert Lookstein, David J. Steiger
Summary: A retrospective case-control study found that 40.8% of COVID-19 patients had a pulmonary embolism (PE), and the presence of PE was associated with certain clinical characteristics and biomarkers. These findings can aid in the early identification and reduction of PE-related mortality in COVID-19 patients.
THROMBOSIS JOURNAL
(2023)
Article
Cell Biology
Alessandro Mauriello, Manuel Scimeca, Ivano Amelio, Renato Massoud, Antonio Novelli, Francesca Di Lorenzo, Susanna Finocchiaro, Carolina Cimino, Rossana Telesca, Marcello Chiocchi, Qiang Sun, Ying Wang, Yufang Shi, Giuseppe Novelli, Gerry Melino
Summary: Vaccination is crucial in reducing severe disease and death caused by SARS-CoV-2 infection, but concerns have been raised regarding unusual adverse drug reactions, including vaccine-induced immune thrombotic thrombocytopenia (VITT). While the overall safety of the vaccines is highlighted by low frequency of adverse reactions in the UK, some cases of fatal thrombotic events have been reported, with abnormalities in platelet counts and PF4 antibodies observed.
CELL DEATH & DISEASE
(2021)
Article
Critical Care Medicine
Connor L. Kenney, Austin R. Nelson, Ryan A. Fahey, Daniel J. Roubik, Remealle A. How, Jason S. Radowsky, Valerie G. Sams, Steven G. Schauer, Julie A. Rizzo
Summary: This study evaluated the rates of venous thromboembolism (VTE) in trauma patients with COVID-19 and found no significant difference in VTE rates between COVID-19-positive and -negative patients, as well as no difference in the type of VTE observed. However, COVID-19-positive patients had increased ICU and hospital length of stay, as well as higher mortality, likely due to multifactorial causes but primarily related to their underlying COVID-19 infection.
Article
Virology
Francesco Poletto, Luca Spiezia, Chiara Simion, Elena Campello, Fabio Dalla Valle, Daniela Tormene, Giuseppe Camporese, Paolo Simioni
Summary: Obesity and bilateral pulmonary infiltrates on imaging may be risk factors for in-hospital venous thromboembolism in patients with acute COVID-19 pneumonia. Prophylactic-dose heparin may not be sufficient in preventing VTE episodes.
